Details of the Target

General Information of Target

Target ID LDTP02807
Target Name Arylsulfatase B (ARSB)
Gene Name ARSB
Gene ID 411
Synonyms
Arylsulfatase B; ASB; EC 3.1.6.12; N-acetylgalactosamine-4-sulfatase; G4S
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD
PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Target Type
Successful
Target Bioclass
Enzyme
Family
Sulfatase family
Subcellular location
Lysosome
Function
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels.
TTD ID
T02119
Uniprot ID
P15848
DrugMap ID
TTESQTG
Ensemble ID
ENST00000264914.10
HGNC ID
HGNC:714
ChEMBL ID
CHEMBL2399

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.Y138H .
KMS27 SNV: p.L187V .
MCC13 SNV: p.D198G .
NCIH358 SNV: p.V495F .
T24 SNV: p.R489K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.09  LDD0054  [1]
DBIA
 Probe Info  		C117(0.99); C121(0.99)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C117(1.45); C121(1.45)  LDD0532  [2]
 LDCM0216  AC100 PaTu 8988t C117(0.78); C121(0.78)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C117(0.77); C121(0.77)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C117(0.63); C121(0.63)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C117(0.98); C121(0.98)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C117(0.66); C121(0.66)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C117(0.67); C121(0.67)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C117(0.79); C121(0.79)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C117(0.84); C121(0.84)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C117(0.89); C121(0.89)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C117(1.06); C121(1.06)  LDD1104  [2]
 LDCM0226  AC11 HCT 116 C117(1.25); C121(1.25)  LDD0543  [2]
 LDCM0227  AC110 PaTu 8988t C117(0.81); C121(0.81)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C117(0.90); C121(0.90)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C117(0.93); C121(0.93)  LDD1108  [2]
 LDCM0237  AC12 HCT 116 C117(1.07); C121(1.07)  LDD0554  [2]
 LDCM0246  AC128 PaTu 8988t C117(1.09); C121(1.09)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C117(1.32); C121(1.32)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C117(1.41); C121(1.41)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C117(1.22); C121(1.22)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C117(1.16); C121(1.16)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C117(1.18); C121(1.18)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C117(1.20); C121(1.20)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C117(1.39); C121(1.39)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C117(1.35); C121(1.35)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C117(1.44); C121(1.44)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C117(1.23); C121(1.23)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C117(1.43); C121(1.43)  LDD1137  [2]
 LDCM0259  AC14 HCT 116 C117(1.02); C121(1.02)  LDD0576  [2]
 LDCM0260  AC140 PaTu 8988t C117(1.29); C121(1.29)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C117(1.09); C121(1.09)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C117(1.13); C121(1.13)  LDD1141  [2]
 LDCM0270  AC15 HCT 116 C117(1.19); C121(1.19)  LDD0587  [2]
 LDCM0276  AC17 PaTu 8988t C117(1.11); C121(1.11)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C117(0.99); C121(0.99)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C117(0.83); C121(0.83)  LDD1157  [2]
 LDCM0280  AC20 PaTu 8988t C117(1.15); C121(1.15)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C117(0.92); C121(0.92)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C117(1.03); C121(1.03)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C117(1.23); C121(1.23)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C117(1.10); C121(1.10)  LDD1163  [2]
 LDCM0308  AC46 PaTu 8988t C117(1.28); C121(1.28)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C117(1.15); C121(1.15)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C117(1.39); C121(1.39)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C117(1.49); C121(1.49)  LDD1190  [2]
 LDCM0313  AC50 PaTu 8988t C117(1.56); C121(1.56)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C117(0.48); C121(0.48)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C117(1.46); C121(1.46)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C117(1.97); C121(1.97)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C117(1.77); C121(1.77)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C117(1.26); C121(1.26)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C117(1.53); C121(1.53)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C117(1.02); C121(1.02)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C117(1.23); C121(1.23)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C117(1.12); C121(1.12)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C117(1.26); C121(1.26)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C117(1.03); C121(1.03)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C117(1.11); C121(1.11)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C117(1.22); C121(1.22)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C117(1.05); C121(1.05)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C117(1.18); C121(1.18)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C117(1.05); C121(1.05)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C117(1.32); C121(1.32)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C117(1.11); C121(1.11)  LDD0648  [2]
 LDCM0332  AC68 PaTu 8988t C117(1.17); C121(1.17)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C117(1.09); C121(1.09)  LDD1212  [2]
 LDCM0334  AC7 HCT 116 C117(1.20); C121(1.20)  LDD0651  [2]
 LDCM0335  AC70 PaTu 8988t C117(1.23); C121(1.23)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C117(1.00); C121(1.00)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C117(1.01); C121(1.01)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C117(0.94); C121(0.94)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C117(1.11); C121(1.11)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C117(1.32); C121(1.32)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C117(0.98); C121(0.98)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C117(1.09); C121(1.09)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C117(1.05); C121(1.05)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C117(1.23); C121(1.23)  LDD1223  [2]
 LDCM0345  AC8 HCT 116 C117(1.37); C121(1.37)  LDD0662  [2]
 LDCM0346  AC80 PaTu 8988t C117(1.28); C121(1.28)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C117(1.23); C121(1.23)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C117(1.13); C121(1.13)  LDD1227  [2]
 LDCM0365  AC98 PaTu 8988t C117(0.80); C121(0.80)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C117(0.76); C121(0.76)  LDD1245  [2]
 LDCM0248  AKOS034007472 HCT 116 C117(1.29); C121(1.29)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C117(1.08); C121(1.08)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C117(1.50); C121(1.50)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C117(0.99); C121(0.99)  LDD0078  [2]
 LDCM0370  CL101 HCT 116 C117(1.39); C121(1.39)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C117(1.37); C121(1.37)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C117(1.33); C121(1.33)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C117(1.40); C121(1.40)  LDD0690  [2]
 LDCM0374  CL105 PaTu 8988t C117(0.91); C121(0.91)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C117(1.15); C121(1.15)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C117(1.04); C121(1.04)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C117(1.28); C121(1.28)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C117(1.06); C121(1.06)  LDD1257  [2]
 LDCM0380  CL110 PaTu 8988t C117(1.23); C121(1.23)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C117(1.21); C121(1.21)  LDD1260  [2]
 LDCM0392  CL121 PaTu 8988t C117(1.51); C121(1.51)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C117(1.35); C121(1.35)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C117(1.51); C121(1.51)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C117(1.82); C121(1.82)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C117(1.14); C121(1.14)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C117(1.23); C121(1.23)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C117(1.05); C121(1.05)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C117(1.15); C121(1.15)  LDD0716  [2]
 LDCM0403  CL16 HCT 116 C117(1.09); C121(1.09)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C117(1.21); C121(1.21)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C117(1.10); C121(1.10)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C117(1.35); C121(1.35)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C117(1.21); C121(1.21)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C117(1.42); C121(1.42)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C117(1.33); C121(1.33)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C117(1.14); C121(1.14)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C117(1.23); C121(1.23)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C117(1.57); C121(1.57)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C117(1.17); C121(1.17)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C117(1.13); C121(1.13)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C117(1.30); C121(1.30)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C117(1.07); C121(1.07)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C117(0.99); C121(0.99)  LDD0736  [2]
 LDCM0453  CL61 HCT 116 C117(1.10); C121(1.10)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C117(1.20); C121(1.20)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C117(1.24); C121(1.24)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C117(1.41); C121(1.41)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C117(1.25); C121(1.25)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C117(1.25); C121(1.25)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C117(1.32); C121(1.32)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C117(1.35); C121(1.35)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C117(1.13); C121(1.13)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C117(1.25); C121(1.25)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C117(1.22); C121(1.22)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C117(1.30); C121(1.30)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C117(1.35); C121(1.35)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C117(1.32); C121(1.32)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C117(1.03); C121(1.03)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C117(1.31); C121(1.31)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C117(1.62); C121(1.62)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C117(1.38); C121(1.38)  LDD1351  [2]
 LDCM0474  CL80 PaTu 8988t C117(1.26); C121(1.26)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C117(1.48); C121(1.48)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C117(1.41); C121(1.41)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C117(1.28); C121(1.28)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C117(1.27); C121(1.27)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C117(1.15); C121(1.15)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C117(1.25); C121(1.25)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C117(1.34); C121(1.34)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C117(1.32); C121(1.32)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C117(1.23); C121(1.23)  LDD1362  [2]
 LDCM0485  CL90 PaTu 8988t C117(1.76); C121(1.76)  LDD1364  [2]
 LDCM0468  Fragment33 HCT 116 C117(1.26); C121(1.26)  LDD0785  [2]
 LDCM0022  KB02 MGG123 C405(2.04)  LDD2469  [6]
 LDCM0023  KB03 MGG75 C405(1.77)  LDD2888  [6]
 LDCM0024  KB05 MGG75 C405(1.22)  LDD3305  [6]
 LDCM0008  Tranylcypromine SH-SY5Y 2.09  LDD0054  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chondroitin Sulfate . DB09301
Galsulfase . D05UHF

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840