Details of the Target

General Information of Target

Target ID LDTP02216
Target Name Beta-hexosaminidase subunit beta (HEXB)
Gene Name HEXB
Gene ID 3074
Synonyms
Beta-hexosaminidase subunit beta; EC 3.2.1.52; Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B; Cervical cancer proto-oncogene 7 protein; HCC-7; N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LLVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 20 family
Subcellular location
Lysosome
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.
TTD ID
T63197
Uniprot ID
P07686
DrugMap ID
TTKIBKM
Ensemble ID
ENST00000261416.12
HGNC ID
HGNC:4879
ChEMBL ID
CHEMBL5877

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		12.00  LDD0387  [1]
Alkylaryl probe 2
 Probe Info  		11.00  LDD0391  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
OPA-S-S-alkyne
 Probe Info  		K517(2.41)  LDD3494  [3]
Probe 1
 Probe Info  		Y526(24.66)  LDD3495  [4]
P11
 Probe Info  		20.00  LDD0201  [5]
FBPP2
 Probe Info  		2.99  LDD0054  [6]
DBIA
 Probe Info  		C309(1.37)  LDD0080  [7]
1d-yne
 Probe Info  		N.A.  LDD0358  [8]
N1
 Probe Info  		E114(0.00); E117(0.00)  LDD0245  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C360(0.00); C309(0.00); C551(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C360(0.00); C309(0.00); C551(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C360(0.00); C309(0.00); C551(0.00)  LDD0037  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
NHS
 Probe Info  		K414(0.00); K465(0.00); K161(0.00); K476(0.00)  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		C309(0.00); H553(0.00); C551(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		7.10  LDD0443  [13]
MPP-AC
 Probe Info  		N.A.  LDD0428  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]
TPP-AC
 Probe Info  		N.A.  LDD0427  [14]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C045
 Probe Info  		5.58  LDD1744  [16]
C170
 Probe Info  		29.65  LDD1850  [16]
C171
 Probe Info  		5.58  LDD1851  [16]
C186
 Probe Info  		11.16  LDD1864  [16]
C197
 Probe Info  		6.77  LDD1873  [16]
C208
 Probe Info  		6.28  LDD1883  [16]
C221
 Probe Info  		5.90  LDD1895  [16]
C223
 Probe Info  		10.78  LDD1897  [16]
C281
 Probe Info  		5.50  LDD1951  [16]
C302
 Probe Info  		7.73  LDD1971  [16]
C310
 Probe Info  		12.73  LDD1977  [16]
C355
 Probe Info  		25.63  LDD2016  [16]
C378
 Probe Info  		9.00  LDD2037  [16]
C420
 Probe Info  		13.00  LDD2075  [16]
C425
 Probe Info  		10.48  LDD2080  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe12
 Probe Info  		20.00  LDD0473  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		16.70  LDD0477  [17]
FFF probe15
 Probe Info  		5.30  LDD0478  [17]
FFF probe3
 Probe Info  		7.62  LDD0464  [17]
FFF probe4
 Probe Info  		13.29  LDD0466  [17]
FFF probe9
 Probe Info  		20.00  LDD0470  [17]
JN0003
 Probe Info  		14.54  LDD0469  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
DA-2
 Probe Info  		N.A.  LDD0072  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C309(1.17)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C309(1.04)  LDD0532  [7]
 LDCM0216  AC100 PaTu 8988t C309(1.02)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C309(1.06)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C309(0.97)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C309(1.19)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C309(1.05)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C309(1.00)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C309(1.03)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C309(1.02)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C309(1.08)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C309(1.03)  LDD1104  [7]
 LDCM0226  AC11 HCT 116 C309(1.08)  LDD0543  [7]
 LDCM0227  AC110 PaTu 8988t C309(1.07)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C309(1.32)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C309(1.26)  LDD1108  [7]
 LDCM0230  AC113 HCT 116 C309(1.02)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C309(0.95)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C309(0.99)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C309(1.13)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C309(1.04)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C309(1.01)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C309(1.10)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C309(1.03)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C309(1.06)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C309(1.05)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C309(0.92)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C309(0.97)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C309(1.01)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C309(0.84)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C309(0.85)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C309(0.97)  LDD0562  [7]
 LDCM0246  AC128 PaTu 8988t C309(1.12)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C309(1.18)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C309(0.80)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C309(0.85)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C309(0.98)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C309(1.02)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C309(0.83)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C309(0.86)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C309(1.08)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C309(1.09)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C309(0.97)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C309(1.04)  LDD1137  [7]
 LDCM0259  AC14 HCT 116 C309(0.80)  LDD0576  [7]
 LDCM0260  AC140 PaTu 8988t C309(1.08)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C309(1.03)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C309(0.98)  LDD1141  [7]
 LDCM0263  AC143 HCT 116 C309(0.77)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C309(1.33)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C309(1.14)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C309(1.30)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C309(0.92)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C309(1.41)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C309(1.48)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C309(0.89)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C309(0.95)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C309(1.03)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C309(1.08)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C309(1.03)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C309(1.06)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C309(1.22)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C309(1.02)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C309(0.89)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C309(1.01)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C309(1.18)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C309(0.99)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C309(1.07)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C309(0.91)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C309(1.02)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C309(1.18)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C309(0.90)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C309(0.91)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C309(1.04)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C309(1.22)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C309(1.09)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C309(1.04)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C309(1.08)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C309(1.11)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C309(1.22)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C309(1.09)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C309(1.31)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C309(1.14)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C309(1.19)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C309(0.97)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C309(0.90)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C309(0.96)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C309(1.05)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C309(1.03)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C309(1.49)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C309(0.92)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C309(0.92)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C309(1.12)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C309(1.12)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C309(0.96)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C309(0.90)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C309(1.08); C360(1.19)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C309(1.11); C360(1.32)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C309(1.03); C360(1.67)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C360(0.76); C309(1.09)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C309(1.31)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C360(0.90); C309(1.19)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C309(1.16); C360(1.35)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C309(0.93); C360(1.17)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C360(1.15); C309(1.19)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C360(0.95); C309(1.01)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C360(0.79); C309(0.89)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C360(0.41); C309(1.03)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C309(1.35)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C309(1.20)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C309(1.22)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C309(1.04)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C309(1.26)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C309(1.33)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C309(1.29)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C309(1.42)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C309(1.59)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C309(1.36)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C309(1.45)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C309(1.30)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C309(0.99); C360(0.99)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C309(0.84); C360(0.91)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C309(0.99)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C360(0.72); C309(0.93)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C309(0.93); C360(1.02)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C360(0.87); C309(0.90)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C360(0.59); C309(1.09)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C360(0.62); C309(0.96)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C360(0.27); C309(1.20)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C309(0.90); C360(0.90)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C309(0.83); C360(1.09)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C309(1.01); C360(1.37)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C309(0.86); C360(1.10)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C309(1.02)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C360(1.12); C309(1.17)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C360(0.93); C309(1.07)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C360(0.08); C309(0.90)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C309(1.15)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C309(1.11)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C309(1.07)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C309(0.89)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C309(1.05)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C309(1.15)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C309(0.91)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C309(0.98)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C309(1.15)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C309(1.01)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C309(1.18)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C309(1.18)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C309(0.97)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C309(1.05)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C309(0.99)  LDD0681  [7]
 LDCM0365  AC98 PaTu 8988t C309(0.95)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C309(1.04)  LDD1245  [7]
 LDCM0248  AKOS034007472 HCT 116 C309(1.09)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C309(0.94)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C309(1.00)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C360(1.18); C309(1.03); C551(0.67)  LDD2171  [7]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [5]
 LDCM0108  Chloroacetamide HeLa C551(0.00); H553(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C309(1.21)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C309(1.18)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C309(1.09)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C309(0.97)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C309(0.83)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C309(1.11)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C309(0.83)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C309(0.97)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C309(0.96)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C309(1.05)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C309(1.03)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C309(1.03)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C309(1.06)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C309(1.00)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C309(0.97)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C309(0.97)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C309(1.19)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C309(1.13)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C309(1.23)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C309(1.12)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C309(1.02)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C309(0.96)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C309(1.09)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C309(1.33)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C309(1.06)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C360(0.88); C309(0.97)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C309(1.06); C360(1.30)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C309(0.91); C360(1.12)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C309(0.94); C360(1.02)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C309(1.35)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C309(1.20)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C309(1.05)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C309(1.32)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C309(1.27)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C309(1.18)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C309(1.31)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C360(0.89); C309(1.19)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C309(0.91); C360(1.03)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C309(1.06); C360(1.21)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C309(1.02); C360(1.13)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C309(1.05)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C360(0.84); C309(1.11)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C360(0.85); C309(1.11)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C360(0.32); C309(0.99)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C360(0.84); C309(0.98)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C360(0.61); C309(0.99)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C309(1.15); C360(0.75)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C309(1.00); C360(0.91)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C309(0.98); C360(1.19)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C309(1.06); C360(0.98)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C309(1.29); C360(0.87)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C309(1.31)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C309(0.89); C360(1.10)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C309(0.84); C360(1.07)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C309(0.79); C360(0.96)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C309(0.98); C360(1.03)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C309(0.78); C360(0.80)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C309(0.83); C360(0.67)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C309(0.98); C360(0.81)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C309(0.92); C360(0.64)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C309(1.10); C360(0.64)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C309(1.01)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C309(0.82); C360(0.83)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C309(0.93); C360(0.81)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C309(0.66); C360(0.31)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C309(1.11); C360(0.58)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C309(0.80); C360(0.90)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C309(0.82); C360(0.94)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C309(0.94); C360(1.24)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C309(0.97); C360(1.04)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C309(1.31); C360(1.01)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C309(1.27); C360(1.23)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C309(1.13)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C309(1.12); C360(1.32)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C309(1.18); C360(1.31)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C309(1.17); C360(1.74)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C309(1.12); C360(1.19)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C309(1.24); C360(1.01)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C309(1.12); C360(1.24)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C309(1.05); C360(0.95)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C309(1.22); C360(1.30)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C309(1.08); C360(1.28)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C309(1.25); C360(1.36)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C309(1.27)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C309(1.21); C360(1.44)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C309(1.34)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C309(1.11)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C309(1.29)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C309(1.30)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C309(1.40)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C309(1.48)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C309(1.30)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C309(1.25)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C309(1.09)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C309(1.52)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C309(1.28)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C309(1.24)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C309(1.21)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C309(1.17)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C309(1.39)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C309(1.07)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C309(0.93)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C309(1.14)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C309(1.10)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C309(1.07)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C309(1.22)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C309(1.07)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C309(1.03)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C309(0.97)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C309(1.04)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C309(1.29)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C309(1.15)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C309(1.10)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C309(1.14)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C309(1.03)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C309(1.28)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C309(0.80)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C309(1.06)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C309(0.93)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C309(1.11)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C309(1.37)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C309(1.44)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C309(1.09)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C309(1.00)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C309(1.03)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C309(1.19)  LDD0811  [7]
 LDCM0189  Compound 16 HEK-293T 44.44  LDD0492  [17]
 LDCM0185  Compound 17 HEK-293T 4.37  LDD0512  [17]
 LDCM0191  Compound 21 HEK-293T 20.41  LDD0493  [17]
 LDCM0190  Compound 34 HEK-293T 37.04  LDD0497  [17]
 LDCM0192  Compound 35 HEK-293T 4.40  LDD0509  [17]
 LDCM0193  Compound 36 HEK-293T 4.56  LDD0494  [17]
 LDCM0194  Compound 37 HEK-293T 29.41  LDD0498  [17]
 LDCM0495  E2913 HEK-293T C360(0.83); C551(1.03)  LDD1698  [20]
 LDCM0468  Fragment33 HCT 116 C309(1.37)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C309(0.70); C360(0.45)  LDD0744  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C309(1.37)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C309(1.20)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C309(1.19)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0388  [1]
 LDCM0021  THZ1 HCT 116 C360(1.18); C309(1.03); C551(0.67)  LDD2173  [7]
 LDCM0008  Tranylcypromine SH-SY5Y 2.99  LDD0054  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Beta-hexosaminidase subunit alpha (HEXA) Glycosyl hydrolase 20 family P06865
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Calpain-15 (CAPN15) Peptidase C2 family O75808
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
NEDD8-activating enzyme E1 regulatory subunit (NAE1) Ubiquitin-activating E1 family Q13564
E3 ubiquitin-protein ligase UBR1 (UBR1) UBR1 family Q8IWV7
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Ubiquitin-like protein 3 (UBL3) . O95164
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Nucleoporin Nup43 (NUP43) . Q8NFH3
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Nuclear RNA export factor 2 (NXF2; NXF2B) NXF family Q9GZY0
Transducin-like enhancer protein 1 (TLE1) WD repeat Groucho/TLE family Q04724
Kelch-like protein 36 (KLHL36) . Q8N4N3
RWD domain-containing protein 4 (RWDD4) . Q6NW29
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquilin-3 (UBQLN3) . Q9H347
Ubiquilin-like protein (UBQLNL) . Q8IYU4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyrimethamine Small molecular drug DB00205
Chondroitin Sulfate . DB09301
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2r3r4s5r)-2-acetamido-34-dihydroxy-5-hydroxymethyl-piperidine . DB03861
2-acetamido-2-deoxy-d-glucono-15-lactone . DB02813
N-acetyl-glucosamine Thiazoline . DB03747

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402