Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 36  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 13.2
 LDTP02198  Cathepsin D (CTSD) 12.9
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 12.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 12.5
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 11.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.6
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 11.2
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 10.3
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 9.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.9
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 8.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 8.8
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 8.6
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 8.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 7.6
 LDTP13751  Exonuclease 1 (EXO1) 7.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 7.4
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 7.3
 LDTP04183  Lanosterol synthase (LSS) 7.2
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 6.9
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 6.7
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 6.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 6.4
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 6.3
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 6.3
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 6.2
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 6.1
 LDTP04689  Adenosine kinase (ADK) 6.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 5.6
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 5.5
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 4.7
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 4.7
 LDTP02837  Beta-galactosidase (GLB1) 4.7
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 4.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 4.5
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 3.9
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 3.5
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 3.1
Transporter and channel
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 12.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 10.9
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 9.4
 LDTP02215  Prosaposin (PSAP) 8.4
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 8.3
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 6.8
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 5.2
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13630  Neudesin (NENF) 7.8
 LDTP08224  Protein LYRIC (MTDH) 6.6
 LDTP05922  Dynactin subunit 2 (DCTN2) 6.1
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 5.5
 LDTP05904  Tubulin beta-3 chain (TUBB3) 5.4
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 5.3
 LDTP11233  Tubulin beta-6 chain (TUBB6) 5.3
 LDTP02205  Tubulin beta chain (TUBB) 5.2
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 4.0
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 3.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 3.5

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.