Details of the Target

General Information of Target

Target ID	LDTP01687
Target Name	Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Gene Name	AIFM1
Gene ID	9131
Synonyms	AIF; PDCD8; Apoptosis-inducing factor 1, mitochondrial; EC 1.6.99.-; Programmed cell death protein 8
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MFRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGAS GGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGLGLTPEQKQKKAALSASEG EEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELW FSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRD NMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREV KSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREG VKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGG FRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQS MFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASE ITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHED LNEVAKLFNIHED
Target Bioclass	Enzyme
Family	FAD-dependent oxidoreductase family
Subcellular location	Cytoplasm; Mitochondrion intermembrane space; Mitochondrion
Function	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import.; [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis.; [Isoform 5]: Pro-apoptotic isoform.
Uniprot ID	O95831
Ensemble ID	ENST00000287295.8
HGNC ID	HGNC:8768
ChEMBL ID	CHEMBL4295688

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
A2058	SNV: p.V460G	DBIA Probe Info
CAL148	SNV: p.H611Y	DBIA Probe Info
COLO792	SNV: p.S100L	DBIA Probe Info
IGROV1	SNV: p.T141A	DBIA Probe Info
NCIH1993	SNV: p.S532N	.
SNGM	SNV: p.G261Ter	DBIA Probe Info

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 28 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
11RK72 Probe Info	4.10	LDD0327	[1]
11RK73 Probe Info	3.32	LDD0328	[1]
C-Sul Probe Info	3.58	LDD0066	[2]
YN-1 Probe Info	100.00	LDD0444	[3]
YN-4 Probe Info	100.00	LDD0445	[3]
1oxF11yne Probe Info	N.A.	LDD0193	[4]
STPyne Probe Info	K109(10.00); K189(10.00); K199(0.67); K278(9.09)	LDD0277	[5]
Probe 1 Probe Info	Y253(10.73)	LDD3495	[6]
Alkylaryl probe 3 Probe Info	20.00	LDD0384	[7]
BTD Probe Info	C256(1.13)	LDD2090	[8]
Jackson_14 Probe Info	3.03	LDD0123	[9]
DBIA Probe Info	C441(1.41)	LDD0080	[10]
5E-2FA Probe Info	N.A.	LDD2235	[11]
AMP probe Probe Info	N.A.	LDD0200	[12]
ATP probe Probe Info	K593(0.00); K189(0.00); K109(0.00); K111(0.00)	LDD0199	[12]
m-APA Probe Info	H131(0.00); H598(0.00); H219(0.00)	LDD2231	[11]
4-Iodoacetamidophenylacetylene Probe Info	C317(0.00); C441(0.00); C256(0.00)	LDD0038	[13]
IA-alkyne Probe Info	N.A.	LDD0032	[14]
Lodoacetamide azide Probe Info	C256(0.00); C317(0.00); C441(0.00)	LDD0037	[13]
TFBX Probe Info	N.A.	LDD0027	[15]
1d-yne Probe Info	N.A.	LDD0356	[16]
IPM Probe Info	N.A.	LDD0147	[15]
NHS Probe Info	K112(0.00); K593(0.00); K189(0.00); K244(0.00)	LDD0010	[17]
Ox-W18 Probe Info	W180(0.00); W196(0.00); W351(0.00)	LDD2175	[18]
1c-yne Probe Info	K518(0.00); K112(0.00); K244(0.00); K342(0.00)	LDD0228	[16]
Acrolein Probe Info	N.A.	LDD0217	[19]
Crotonaldehyde Probe Info	H611(0.00); C256(0.00); H454(0.00)	LDD0219	[19]
NAIA_5 Probe Info	C256(0.00); C317(0.00); C441(0.00)	LDD2223	[20]

PAL-AfBPP Probe

Click To Hide/Show 108 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C006 Probe Info	6.15	LDD1715	[21]
C008 Probe Info	5.31	LDD1717	[21]
C017 Probe Info	5.86	LDD1725	[21]
C027 Probe Info	30.70	LDD1733	[21]
C040 Probe Info	13.93	LDD1740	[21]
C041 Probe Info	5.90	LDD1741	[21]
C055 Probe Info	11.96	LDD1752	[21]
C056 Probe Info	19.29	LDD1753	[21]
C059 Probe Info	6.23	LDD1756	[21]
C063 Probe Info	13.00	LDD1760	[21]
C070 Probe Info	12.73	LDD1766	[21]
C082 Probe Info	6.82	LDD1774	[21]
C087 Probe Info	16.11	LDD1779	[21]
C091 Probe Info	10.13	LDD1782	[21]
C100 Probe Info	5.54	LDD1789	[21]
C116 Probe Info	17.51	LDD1803	[21]
C138 Probe Info	13.00	LDD1820	[21]
C142 Probe Info	7.67	LDD1824	[21]
C145 Probe Info	22.16	LDD1827	[21]
C158 Probe Info	22.32	LDD1838	[21]
C161 Probe Info	14.22	LDD1841	[21]
C165 Probe Info	37.27	LDD1845	[21]
C170 Probe Info	8.17	LDD1850	[21]
C174 Probe Info	12.55	LDD1854	[21]
C177 Probe Info	8.00	LDD1856	[21]
C183 Probe Info	5.28	LDD1861	[21]
C185 Probe Info	6.87	LDD1863	[21]
C187 Probe Info	19.70	LDD1865	[21]
C191 Probe Info	11.31	LDD1868	[21]
C203 Probe Info	5.06	LDD1878	[21]
C210 Probe Info	39.95	LDD1884	[21]
C212 Probe Info	5.46	LDD1886	[21]
C215 Probe Info	5.03	LDD1889	[21]
C216 Probe Info	6.32	LDD1890	[21]
C218 Probe Info	33.13	LDD1892	[21]
C220 Probe Info	12.13	LDD1894	[21]
C228 Probe Info	16.11	LDD1901	[21]
C232 Probe Info	43.71	LDD1905	[21]
C238 Probe Info	13.18	LDD1911	[21]
C239 Probe Info	9.78	LDD1912	[21]
C244 Probe Info	38.32	LDD1917	[21]
C249 Probe Info	56.10	LDD1922	[21]
C250 Probe Info	5.06	LDD1923	[21]
C258 Probe Info	8.75	LDD1931	[21]
C269 Probe Info	17.03	LDD1939	[21]
C270 Probe Info	10.78	LDD1940	[21]
C271 Probe Info	7.46	LDD1941	[21]
C274 Probe Info	11.47	LDD1944	[21]
C282 Probe Info	16.45	LDD1952	[21]
C284 Probe Info	58.49	LDD1954	[21]
C287 Probe Info	9.19	LDD1957	[21]
C288 Probe Info	15.45	LDD1958	[21]
C289 Probe Info	27.28	LDD1959	[21]
C290 Probe Info	9.78	LDD1960	[21]
C296 Probe Info	45.57	LDD1966	[21]
C302 Probe Info	9.99	LDD1971	[21]
C305 Probe Info	40.50	LDD1974	[21]
C310 Probe Info	9.32	LDD1977	[21]
C314 Probe Info	22.16	LDD1981	[21]
C326 Probe Info	23.43	LDD1990	[21]
C338 Probe Info	23.92	LDD2001	[21]
C339 Probe Info	6.06	LDD2002	[21]
C343 Probe Info	12.55	LDD2005	[21]
C346 Probe Info	50.56	LDD2007	[21]
C348 Probe Info	65.34	LDD2009	[21]
C349 Probe Info	9.58	LDD2010	[21]
C350 Probe Info	36.25	LDD2011	[21]
C353 Probe Info	12.13	LDD2014	[21]
C354 Probe Info	9.78	LDD2015	[21]
C355 Probe Info	41.64	LDD2016	[21]
C356 Probe Info	8.82	LDD2017	[21]
C361 Probe Info	34.30	LDD2022	[21]
C362 Probe Info	39.67	LDD2023	[21]
C363 Probe Info	39.40	LDD2024	[21]
C364 Probe Info	22.63	LDD2025	[21]
C378 Probe Info	8.22	LDD2037	[21]
C380 Probe Info	6.11	LDD2039	[21]
C382 Probe Info	10.20	LDD2041	[21]
C383 Probe Info	17.03	LDD2042	[21]
C389 Probe Info	15.24	LDD2048	[21]
C390 Probe Info	23.26	LDD2049	[21]
C391 Probe Info	36.25	LDD2050	[21]
C394 Probe Info	6.50	LDD2053	[21]
C397 Probe Info	18.00	LDD2056	[21]
C403 Probe Info	13.93	LDD2061	[21]
C407 Probe Info	10.93	LDD2064	[21]
C413 Probe Info	22.01	LDD2069	[21]
C420 Probe Info	46.53	LDD2075	[21]
C424 Probe Info	13.36	LDD2079	[21]
C426 Probe Info	12.82	LDD2081	[21]
C430 Probe Info	7.16	LDD2085	[21]
C432 Probe Info	6.96	LDD2087	[21]
C433 Probe Info	8.69	LDD2088	[21]
FFF probe11 Probe Info	15.90	LDD0471	[22]
FFF probe12 Probe Info	13.86	LDD0473	[22]
FFF probe13 Probe Info	20.00	LDD0475	[22]
FFF probe14 Probe Info	20.00	LDD0477	[22]
FFF probe15 Probe Info	5.29	LDD0478	[22]
FFF probe2 Probe Info	20.00	LDD0463	[22]
FFF probe3 Probe Info	20.00	LDD0464	[22]
FFF probe4 Probe Info	12.98	LDD0466	[22]
FFF probe6 Probe Info	20.00	LDD0467	[22]
FFF probe9 Probe Info	15.98	LDD0470	[22]
JN0003 Probe Info	20.00	LDD0469	[22]
STS-2 Probe Info	N.A.	LDD0138	[23]
DA-2 Probe Info	N.A.	LDD0072	[24]
OEA-DA Probe Info	6.68	LDD0046	[25]
STS-1 Probe Info	N.A.	LDD0068	[26]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C256(0.20)	LDD2142	[8]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C256(0.46)	LDD2112	[8]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C256(0.89)	LDD2117	[8]
LDCM0214	AC1	HEK-293T	C317(0.83)	LDD0812	[10]
LDCM0215	AC10	HCT 116	C256(1.19); C441(0.86)	LDD0532	[10]
LDCM0216	AC100	HCT 116	C256(1.52); C441(0.73)	LDD0533	[10]
LDCM0217	AC101	HCT 116	C256(0.71); C441(0.70)	LDD0534	[10]
LDCM0218	AC102	HCT 116	C256(0.70); C441(0.71)	LDD0535	[10]
LDCM0219	AC103	HCT 116	C256(0.84); C441(0.57)	LDD0536	[10]
LDCM0220	AC104	HCT 116	C256(0.84); C441(0.72)	LDD0537	[10]
LDCM0221	AC105	HCT 116	C256(0.85); C441(0.59)	LDD0538	[10]
LDCM0222	AC106	HCT 116	C256(0.93); C441(0.64)	LDD0539	[10]
LDCM0223	AC107	HCT 116	C256(0.78); C441(0.64)	LDD0540	[10]
LDCM0224	AC108	HCT 116	C256(0.93); C441(0.59)	LDD0541	[10]
LDCM0225	AC109	HCT 116	C256(0.95); C441(0.72)	LDD0542	[10]
LDCM0226	AC11	HCT 116	C256(0.99); C441(0.78)	LDD0543	[10]
LDCM0227	AC110	HCT 116	C256(1.08); C441(0.55)	LDD0544	[10]
LDCM0228	AC111	HCT 116	C256(1.38); C441(0.62)	LDD0545	[10]
LDCM0229	AC112	HCT 116	C256(0.73); C441(0.51)	LDD0546	[10]
LDCM0230	AC113	HCT 116	C256(1.10); C441(1.05)	LDD0547	[10]
LDCM0231	AC114	HCT 116	C256(1.23); C441(0.92)	LDD0548	[10]
LDCM0232	AC115	HCT 116	C256(0.94); C441(0.81)	LDD0549	[10]
LDCM0233	AC116	HCT 116	C256(0.88); C441(0.84)	LDD0550	[10]
LDCM0234	AC117	HCT 116	C256(0.90); C441(0.86)	LDD0551	[10]
LDCM0235	AC118	HCT 116	C256(1.30); C441(0.87)	LDD0552	[10]
LDCM0236	AC119	HCT 116	C256(1.16); C441(0.89)	LDD0553	[10]
LDCM0237	AC12	HCT 116	C256(1.06); C441(0.99)	LDD0554	[10]
LDCM0238	AC120	HCT 116	C256(0.90); C441(0.84)	LDD0555	[10]
LDCM0239	AC121	HCT 116	C256(0.94); C441(0.79)	LDD0556	[10]
LDCM0240	AC122	HCT 116	C256(1.16); C441(0.84)	LDD0557	[10]
LDCM0241	AC123	HCT 116	C256(1.09); C441(0.89)	LDD0558	[10]
LDCM0242	AC124	HCT 116	C256(1.13); C441(0.85)	LDD0559	[10]
LDCM0243	AC125	HCT 116	C256(1.30); C441(1.05)	LDD0560	[10]
LDCM0244	AC126	HCT 116	C256(1.10); C441(0.90)	LDD0561	[10]
LDCM0245	AC127	HCT 116	C256(1.28); C441(0.91)	LDD0562	[10]
LDCM0246	AC128	HCT 116	C441(0.87)	LDD0563	[10]
LDCM0247	AC129	HCT 116	C441(1.43)	LDD0564	[10]
LDCM0249	AC130	HCT 116	C441(1.11)	LDD0566	[10]
LDCM0250	AC131	HCT 116	C441(1.52)	LDD0567	[10]
LDCM0251	AC132	HCT 116	C441(1.09)	LDD0568	[10]
LDCM0252	AC133	HCT 116	C441(0.99)	LDD0569	[10]
LDCM0253	AC134	HCT 116	C441(0.91)	LDD0570	[10]
LDCM0254	AC135	HCT 116	C441(0.94)	LDD0571	[10]
LDCM0255	AC136	HCT 116	C441(0.89)	LDD0572	[10]
LDCM0256	AC137	HCT 116	C441(0.90)	LDD0573	[10]
LDCM0257	AC138	HCT 116	C441(0.92)	LDD0574	[10]
LDCM0258	AC139	HCT 116	C441(1.14)	LDD0575	[10]
LDCM0259	AC14	HCT 116	C256(1.02); C441(0.86)	LDD0576	[10]
LDCM0260	AC140	HCT 116	C441(0.92)	LDD0577	[10]
LDCM0261	AC141	HCT 116	C441(0.92)	LDD0578	[10]
LDCM0262	AC142	HCT 116	C441(1.20)	LDD0579	[10]
LDCM0263	AC143	HCT 116	C256(0.82); C441(0.95)	LDD0580	[10]
LDCM0264	AC144	HCT 116	C256(0.79); C441(1.00)	LDD0581	[10]
LDCM0265	AC145	HCT 116	C441(0.89); C256(1.15)	LDD0582	[10]
LDCM0266	AC146	HCT 116	C441(1.09); C256(1.22)	LDD0583	[10]
LDCM0267	AC147	HCT 116	C256(0.94); C441(1.00)	LDD0584	[10]
LDCM0268	AC148	HCT 116	C256(0.74); C441(0.77)	LDD0585	[10]
LDCM0269	AC149	HCT 116	C441(0.98); C256(1.03)	LDD0586	[10]
LDCM0270	AC15	HCT 116	C441(0.88); C256(1.21)	LDD0587	[10]
LDCM0271	AC150	HCT 116	C441(0.94); C256(1.05)	LDD0588	[10]
LDCM0272	AC151	HCT 116	C256(0.85); C441(1.04)	LDD0589	[10]
LDCM0273	AC152	HCT 116	C256(0.73); C441(0.88)	LDD0590	[10]
LDCM0274	AC153	HCT 116	C441(0.71); C256(0.73)	LDD0591	[10]
LDCM0621	AC154	HCT 116	C256(0.90); C441(1.06)	LDD2158	[10]
LDCM0622	AC155	HCT 116	C256(0.79); C441(0.96)	LDD2159	[10]
LDCM0623	AC156	HCT 116	C256(0.89); C441(1.08)	LDD2160	[10]
LDCM0624	AC157	HCT 116	C256(0.70); C441(1.20)	LDD2161	[10]
LDCM0276	AC17	HCT 116	C441(0.95); C256(1.31)	LDD0593	[10]
LDCM0277	AC18	HCT 116	C441(0.67); C256(1.16)	LDD0594	[10]
LDCM0278	AC19	HCT 116	C441(0.83); C256(1.06)	LDD0595	[10]
LDCM0279	AC2	HEK-293T	C317(1.09)	LDD0877	[10]
LDCM0280	AC20	HCT 116	C441(0.90); C256(1.13)	LDD0597	[10]
LDCM0281	AC21	HCT 116	C441(1.00); C256(1.20)	LDD0598	[10]
LDCM0282	AC22	HCT 116	C441(1.03); C256(1.07)	LDD0599	[10]
LDCM0283	AC23	HCT 116	C441(0.88); C256(1.02)	LDD0600	[10]
LDCM0284	AC24	HCT 116	C441(0.96); C256(1.01)	LDD0601	[10]
LDCM0285	AC25	HCT 116	C441(0.93); C256(1.22)	LDD0602	[10]
LDCM0286	AC26	HCT 116	C441(0.90); C256(1.35)	LDD0603	[10]
LDCM0287	AC27	HCT 116	C441(0.90); C256(1.42)	LDD0604	[10]
LDCM0288	AC28	HCT 116	C441(0.77); C256(1.17)	LDD0605	[10]
LDCM0289	AC29	HCT 116	C441(0.88); C256(1.58)	LDD0606	[10]
LDCM0290	AC3	HEK-293T	C317(0.86)	LDD0888	[10]
LDCM0291	AC30	HCT 116	C441(0.75); C256(1.28)	LDD0608	[10]
LDCM0292	AC31	HCT 116	C441(0.89); C256(1.56)	LDD0609	[10]
LDCM0293	AC32	HCT 116	C441(0.71); C256(1.22)	LDD0610	[10]
LDCM0294	AC33	HCT 116	C441(0.80); C256(1.09)	LDD0611	[10]
LDCM0295	AC34	HCT 116	C441(0.80); C256(1.04)	LDD0612	[10]
LDCM0296	AC35	HCT 116	C441(1.11); C256(1.44)	LDD0613	[10]
LDCM0297	AC36	HCT 116	C441(1.00); C256(1.37)	LDD0614	[10]
LDCM0298	AC37	HCT 116	C441(1.08); C256(1.17)	LDD0615	[10]
LDCM0299	AC38	HCT 116	C256(0.95); C441(1.04)	LDD0616	[10]
LDCM0300	AC39	HCT 116	C441(0.84); C256(0.98)	LDD0617	[10]
LDCM0301	AC4	HEK-293T	C317(0.90)	LDD0899	[10]
LDCM0302	AC40	HCT 116	C256(0.84); C441(0.88)	LDD0619	[10]
LDCM0303	AC41	HCT 116	C441(0.89); C256(1.02)	LDD0620	[10]
LDCM0304	AC42	HCT 116	C441(0.79); C256(0.87)	LDD0621	[10]
LDCM0305	AC43	HCT 116	C441(0.88); C256(1.01)	LDD0622	[10]
LDCM0306	AC44	HCT 116	C441(0.78); C256(1.04)	LDD0623	[10]
LDCM0307	AC45	HCT 116	C441(0.72); C256(0.88)	LDD0624	[10]
LDCM0308	AC46	HCT 116	C256(1.00); C441(1.09)	LDD0625	[10]
LDCM0309	AC47	HCT 116	C441(1.08); C256(1.08)	LDD0626	[10]
LDCM0310	AC48	HCT 116	C441(1.22); C256(1.75)	LDD0627	[10]
LDCM0311	AC49	HCT 116	C256(0.79); C441(0.94)	LDD0628	[10]
LDCM0312	AC5	HEK-293T	C317(0.97)	LDD0910	[10]
LDCM0313	AC50	HCT 116	C441(0.97); C256(1.17)	LDD0630	[10]
LDCM0314	AC51	HCT 116	C441(1.08); C256(1.15)	LDD0631	[10]
LDCM0315	AC52	HCT 116	C441(1.03); C256(1.11)	LDD0632	[10]
LDCM0316	AC53	HCT 116	C441(1.06); C256(1.16)	LDD0633	[10]
LDCM0317	AC54	HCT 116	C441(0.92); C256(0.98)	LDD0634	[10]
LDCM0318	AC55	HCT 116	C441(0.97); C256(1.01)	LDD0635	[10]
LDCM0319	AC56	HCT 116	C256(0.67); C441(0.77)	LDD0636	[10]
LDCM0320	AC57	HCT 116	C441(1.20)	LDD0637	[10]
LDCM0321	AC58	HCT 116	C441(1.20)	LDD0638	[10]
LDCM0322	AC59	HCT 116	C441(1.12)	LDD0639	[10]
LDCM0323	AC6	HCT 116	C441(0.88); C256(1.22)	LDD0640	[10]
LDCM0324	AC60	HCT 116	C441(1.49)	LDD0641	[10]
LDCM0325	AC61	HCT 116	C441(1.30)	LDD0642	[10]
LDCM0326	AC62	HCT 116	C441(1.37)	LDD0643	[10]
LDCM0327	AC63	HCT 116	C441(1.23)	LDD0644	[10]
LDCM0328	AC64	HCT 116	C441(1.24)	LDD0645	[10]
LDCM0329	AC65	HCT 116	C441(1.23)	LDD0646	[10]
LDCM0330	AC66	HCT 116	C441(1.29)	LDD0647	[10]
LDCM0331	AC67	HCT 116	C441(1.07)	LDD0648	[10]
LDCM0332	AC68	HCT 116	C441(0.85)	LDD0649	[10]
LDCM0333	AC69	HCT 116	C441(0.89)	LDD0650	[10]
LDCM0334	AC7	HCT 116	C441(0.86); C256(1.26)	LDD0651	[10]
LDCM0335	AC70	HCT 116	C441(0.67)	LDD0652	[10]
LDCM0336	AC71	HCT 116	C441(0.78)	LDD0653	[10]
LDCM0337	AC72	HCT 116	C441(0.90)	LDD0654	[10]
LDCM0338	AC73	HCT 116	C441(0.59)	LDD0655	[10]
LDCM0339	AC74	HCT 116	C441(0.61)	LDD0656	[10]
LDCM0340	AC75	HCT 116	C441(0.61)	LDD0657	[10]
LDCM0341	AC76	HCT 116	C441(0.74)	LDD0658	[10]
LDCM0342	AC77	HCT 116	C441(0.78)	LDD0659	[10]
LDCM0343	AC78	HCT 116	C441(1.07)	LDD0660	[10]
LDCM0344	AC79	HCT 116	C441(0.88)	LDD0661	[10]
LDCM0345	AC8	HCT 116	C441(0.77); C256(0.97)	LDD0662	[10]
LDCM0346	AC80	HCT 116	C441(0.74)	LDD0663	[10]
LDCM0347	AC81	HCT 116	C441(0.89)	LDD0664	[10]
LDCM0348	AC82	HCT 116	C441(0.39)	LDD0665	[10]
LDCM0349	AC83	HEK-293T	C317(0.87); C441(0.87)	LDD0947	[10]
LDCM0350	AC84	HEK-293T	C317(1.10); C441(1.37)	LDD0948	[10]
LDCM0351	AC85	HEK-293T	C317(1.00); C441(1.14)	LDD0949	[10]
LDCM0352	AC86	HEK-293T	C317(1.08); C441(1.19)	LDD0950	[10]
LDCM0353	AC87	HEK-293T	C317(1.11); C441(1.26)	LDD0951	[10]
LDCM0354	AC88	HEK-293T	C317(1.12); C441(1.24)	LDD0952	[10]
LDCM0355	AC89	HEK-293T	C317(1.19); C441(2.06)	LDD0953	[10]
LDCM0357	AC90	HEK-293T	C317(1.28); C441(1.87)	LDD0955	[10]
LDCM0358	AC91	HEK-293T	C317(1.19); C441(1.04)	LDD0956	[10]
LDCM0359	AC92	HEK-293T	C317(1.06); C441(1.39)	LDD0957	[10]
LDCM0360	AC93	HEK-293T	C317(1.09); C441(1.68)	LDD0958	[10]
LDCM0361	AC94	HEK-293T	C317(1.15); C441(1.10)	LDD0959	[10]
LDCM0362	AC95	HEK-293T	C317(1.19); C441(1.17)	LDD0960	[10]
LDCM0363	AC96	HEK-293T	C317(1.04); C441(1.27)	LDD0961	[10]
LDCM0364	AC97	HEK-293T	C317(1.68); C441(2.33)	LDD0962	[10]
LDCM0365	AC98	HCT 116	C256(0.30); C441(0.38)	LDD0682	[10]
LDCM0366	AC99	HCT 116	C441(0.73); C256(0.81)	LDD0683	[10]
LDCM0248	AKOS034007472	HCT 116	C256(1.29); C441(0.96)	LDD0565	[10]
LDCM0356	AKOS034007680	HCT 116	C441(1.00); C256(1.24)	LDD0673	[10]
LDCM0275	AKOS034007705	HCT 116	C441(0.60); C256(0.93)	LDD0592	[10]
LDCM0020	ARS-1620	HCC44	C256(1.11); C441(1.01)	LDD2171	[10]
LDCM0108	Chloroacetamide	HeLa	H454(0.00); C256(0.00)	LDD0222	[19]
LDCM0367	CL1	HCT 116	C256(1.08); C441(1.73)	LDD0684	[10]
LDCM0368	CL10	HCT 116	C441(0.99); C256(1.28)	LDD0685	[10]
LDCM0369	CL100	HEK-293T	C317(1.15)	LDD0967	[10]
LDCM0370	CL101	HCT 116	C441(0.86); C256(1.06)	LDD0687	[10]
LDCM0371	CL102	HCT 116	C441(0.90); C256(1.15)	LDD0688	[10]
LDCM0372	CL103	HCT 116	C256(1.02); C441(1.08)	LDD0689	[10]
LDCM0373	CL104	HCT 116	C256(1.00); C441(1.00)	LDD0690	[10]
LDCM0374	CL105	HCT 116	C441(0.79); C256(0.93)	LDD0691	[10]
LDCM0375	CL106	HCT 116	C441(0.72); C256(1.06)	LDD0692	[10]
LDCM0376	CL107	HCT 116	C441(0.70); C256(0.95)	LDD0693	[10]
LDCM0377	CL108	HCT 116	C441(0.65); C256(0.83)	LDD0694	[10]
LDCM0378	CL109	HCT 116	C441(0.81); C256(0.95)	LDD0695	[10]
LDCM0379	CL11	HCT 116	C441(1.07); C256(1.14)	LDD0696	[10]
LDCM0380	CL110	HCT 116	C441(0.75); C256(0.89)	LDD0697	[10]
LDCM0381	CL111	HCT 116	C441(0.87); C256(0.99)	LDD0698	[10]
LDCM0382	CL112	HCT 116	C441(0.81); C256(1.00)	LDD0699	[10]
LDCM0383	CL113	HCT 116	C441(0.74); C256(1.13)	LDD0700	[10]
LDCM0384	CL114	HCT 116	C441(0.84); C256(1.25)	LDD0701	[10]
LDCM0385	CL115	HCT 116	C441(0.81); C256(1.14)	LDD0702	[10]
LDCM0386	CL116	HCT 116	C441(0.85); C256(1.25)	LDD0703	[10]
LDCM0387	CL117	HCT 116	C441(0.50); C256(0.62)	LDD0704	[10]
LDCM0388	CL118	HCT 116	C441(0.77); C256(1.14)	LDD0705	[10]
LDCM0389	CL119	HCT 116	C441(0.86); C256(1.18)	LDD0706	[10]
LDCM0390	CL12	HCT 116	C441(0.89); C256(0.91)	LDD0707	[10]
LDCM0391	CL120	HCT 116	C441(0.89); C256(1.31)	LDD0708	[10]
LDCM0392	CL121	HCT 116	C256(0.56); C441(0.82)	LDD0709	[10]
LDCM0393	CL122	HCT 116	C256(1.11); C441(1.15)	LDD0710	[10]
LDCM0394	CL123	HCT 116	C441(1.03); C256(1.08)	LDD0711	[10]
LDCM0395	CL124	HCT 116	C256(0.86); C441(0.93)	LDD0712	[10]
LDCM0396	CL125	HCT 116	C441(1.08)	LDD0713	[10]
LDCM0397	CL126	HCT 116	C441(1.19)	LDD0714	[10]
LDCM0398	CL127	HCT 116	C441(1.26)	LDD0715	[10]
LDCM0399	CL128	HCT 116	C441(1.20)	LDD0716	[10]
LDCM0400	CL13	HCT 116	C256(1.01); C441(1.32)	LDD0717	[10]
LDCM0401	CL14	HCT 116	C441(1.36); C256(1.44)	LDD0718	[10]
LDCM0402	CL15	HCT 116	C441(0.57); C256(1.22)	LDD0719	[10]
LDCM0403	CL16	HCT 116	C441(1.03)	LDD0720	[10]
LDCM0404	CL17	HCT 116	C441(1.10)	LDD0721	[10]
LDCM0405	CL18	HCT 116	C441(1.87)	LDD0722	[10]
LDCM0406	CL19	HCT 116	C441(0.96)	LDD0723	[10]
LDCM0407	CL2	HCT 116	C441(1.16); C256(1.18)	LDD0724	[10]
LDCM0408	CL20	HCT 116	C441(0.86)	LDD0725	[10]
LDCM0409	CL21	HCT 116	C441(0.78)	LDD0726	[10]
LDCM0410	CL22	HCT 116	C441(0.47)	LDD0727	[10]
LDCM0411	CL23	HCT 116	C441(1.15)	LDD0728	[10]
LDCM0412	CL24	HCT 116	C441(0.75)	LDD0729	[10]
LDCM0413	CL25	HCT 116	C441(0.79)	LDD0730	[10]
LDCM0414	CL26	HCT 116	C441(1.01)	LDD0731	[10]
LDCM0415	CL27	HCT 116	C441(0.99)	LDD0732	[10]
LDCM0416	CL28	HCT 116	C441(0.95)	LDD0733	[10]
LDCM0417	CL29	HCT 116	C441(0.81)	LDD0734	[10]
LDCM0418	CL3	HCT 116	C256(1.24); C441(1.88)	LDD0735	[10]
LDCM0419	CL30	HCT 116	C441(1.01)	LDD0736	[10]
LDCM0420	CL31	HCT 116	C441(0.95)	LDD0737	[10]
LDCM0421	CL32	HCT 116	C441(1.16)	LDD0738	[10]
LDCM0422	CL33	HCT 116	C441(0.99)	LDD0739	[10]
LDCM0423	CL34	HCT 116	C441(0.79)	LDD0740	[10]
LDCM0424	CL35	HCT 116	C441(0.87)	LDD0741	[10]
LDCM0425	CL36	HCT 116	C441(0.86)	LDD0742	[10]
LDCM0426	CL37	HCT 116	C441(0.80)	LDD0743	[10]
LDCM0428	CL39	HCT 116	C441(0.71)	LDD0745	[10]
LDCM0429	CL4	HCT 116	C256(1.44); C441(1.19)	LDD0746	[10]
LDCM0430	CL40	HCT 116	C441(0.82)	LDD0747	[10]
LDCM0431	CL41	HCT 116	C441(0.82)	LDD0748	[10]
LDCM0432	CL42	HCT 116	C441(0.51)	LDD0749	[10]
LDCM0433	CL43	HCT 116	C441(0.79)	LDD0750	[10]
LDCM0434	CL44	HCT 116	C441(0.95)	LDD0751	[10]
LDCM0435	CL45	HCT 116	C441(0.85)	LDD0752	[10]
LDCM0436	CL46	HEK-293T	C441(1.07)	LDD1034	[10]
LDCM0437	CL47	HEK-293T	C441(0.89)	LDD1035	[10]
LDCM0438	CL48	HEK-293T	C441(0.78)	LDD1036	[10]
LDCM0439	CL49	HEK-293T	C441(1.08)	LDD1037	[10]
LDCM0440	CL5	HCT 116	C256(1.21); C441(1.41)	LDD0757	[10]
LDCM0441	CL50	HEK-293T	C441(1.13)	LDD1039	[10]
LDCM0442	CL51	HEK-293T	C441(1.41)	LDD1040	[10]
LDCM0443	CL52	HEK-293T	C441(0.99)	LDD1041	[10]
LDCM0444	CL53	HEK-293T	C441(1.04)	LDD1042	[10]
LDCM0445	CL54	HEK-293T	C441(1.01)	LDD1043	[10]
LDCM0446	CL55	HEK-293T	C441(0.94)	LDD1044	[10]
LDCM0447	CL56	HEK-293T	C441(1.01)	LDD1045	[10]
LDCM0448	CL57	HEK-293T	C441(1.01)	LDD1046	[10]
LDCM0449	CL58	HEK-293T	C441(0.39)	LDD1047	[10]
LDCM0450	CL59	HEK-293T	C441(0.92)	LDD1048	[10]
LDCM0451	CL6	HCT 116	C256(1.38); C441(1.23)	LDD0768	[10]
LDCM0452	CL60	HEK-293T	C441(1.22)	LDD1050	[10]
LDCM0453	CL61	HCT 116	C256(1.25); C441(0.93)	LDD0770	[10]
LDCM0454	CL62	HCT 116	C256(1.92); C441(0.89)	LDD0771	[10]
LDCM0455	CL63	HCT 116	C256(1.20); C441(0.85)	LDD0772	[10]
LDCM0456	CL64	HCT 116	C256(1.05); C441(0.75)	LDD0773	[10]
LDCM0457	CL65	HCT 116	C256(1.31); C441(0.78)	LDD0774	[10]
LDCM0458	CL66	HCT 116	C256(0.84); C441(0.56)	LDD0775	[10]
LDCM0459	CL67	HCT 116	C256(1.02); C441(0.67)	LDD0776	[10]
LDCM0460	CL68	HCT 116	C256(1.09); C441(0.87)	LDD0777	[10]
LDCM0461	CL69	HCT 116	C256(2.60); C441(1.48)	LDD0778	[10]
LDCM0462	CL7	HCT 116	C256(1.08); C441(1.04)	LDD0779	[10]
LDCM0463	CL70	HCT 116	C256(1.26); C441(0.94)	LDD0780	[10]
LDCM0464	CL71	HCT 116	C256(1.24); C441(0.69)	LDD0781	[10]
LDCM0465	CL72	HCT 116	C256(0.97); C441(0.85)	LDD0782	[10]
LDCM0466	CL73	HCT 116	C256(1.07); C441(1.41)	LDD0783	[10]
LDCM0467	CL74	HCT 116	C256(1.17); C441(1.01)	LDD0784	[10]
LDCM0469	CL76	HCT 116	C441(1.02)	LDD0786	[10]
LDCM0470	CL77	HCT 116	C441(1.51)	LDD0787	[10]
LDCM0471	CL78	HCT 116	C441(0.80)	LDD0788	[10]
LDCM0472	CL79	HCT 116	C441(0.80)	LDD0789	[10]
LDCM0473	CL8	HCT 116	C256(0.92); C441(0.82)	LDD0790	[10]
LDCM0474	CL80	HCT 116	C441(1.26)	LDD0791	[10]
LDCM0475	CL81	HCT 116	C441(0.79)	LDD0792	[10]
LDCM0476	CL82	HCT 116	C441(0.62)	LDD0793	[10]
LDCM0477	CL83	HCT 116	C441(0.63)	LDD0794	[10]
LDCM0478	CL84	HCT 116	C441(0.51)	LDD0795	[10]
LDCM0479	CL85	HCT 116	C441(0.79)	LDD0796	[10]
LDCM0480	CL86	HCT 116	C441(0.84)	LDD0797	[10]
LDCM0481	CL87	HCT 116	C441(0.87)	LDD0798	[10]
LDCM0482	CL88	HCT 116	C441(0.74)	LDD0799	[10]
LDCM0483	CL89	HCT 116	C441(0.38)	LDD0800	[10]
LDCM0484	CL9	HCT 116	C256(1.06); C441(1.60)	LDD0801	[10]
LDCM0485	CL90	HCT 116	C441(0.85)	LDD0802	[10]
LDCM0486	CL91	HEK-293T	C317(1.29)	LDD1084	[10]
LDCM0487	CL92	HEK-293T	C317(1.69)	LDD1085	[10]
LDCM0488	CL93	HEK-293T	C317(1.32)	LDD1086	[10]
LDCM0489	CL94	HEK-293T	C317(2.24)	LDD1087	[10]
LDCM0490	CL95	HEK-293T	C317(2.44)	LDD1088	[10]
LDCM0491	CL96	HEK-293T	C317(1.31)	LDD1089	[10]
LDCM0492	CL97	HEK-293T	C317(1.37)	LDD1090	[10]
LDCM0493	CL98	HEK-293T	C317(1.30)	LDD1091	[10]
LDCM0494	CL99	HEK-293T	C317(1.23)	LDD1092	[10]
LDCM0189	Compound 16	HEK-293T	16.26	LDD0492	[22]
LDCM0182	Compound 18	HEK-293T	9.62	LDD0501	[22]
LDCM0191	Compound 21	HEK-293T	11.30	LDD0493	[22]
LDCM0190	Compound 34	HEK-293T	19.42	LDD0497	[22]
LDCM0192	Compound 35	HEK-293T	12.74	LDD0491	[22]
LDCM0193	Compound 36	HEK-293T	10.26	LDD0494	[22]
LDCM0194	Compound 37	HEK-293T	14.93	LDD0498	[22]
LDCM0195	Compound 38	HEK-293T	17.86	LDD0499	[22]
LDCM0196	Compound 39	HEK-293T	10.20	LDD0496	[22]
LDCM0197	Compound 40	HEK-293T	13.42	LDD0495	[22]
LDCM0181	Compound 41	HEK-293T	9.22	LDD0502	[22]
LDCM0183	Compound 42	HEK-293T	4.80	LDD0500	[22]
LDCM0495	E2913	HEK-293T	C256(0.85); C441(0.98); C317(1.12)	LDD1698	[27]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C256(1.07)	LDD1702	[8]
LDCM0572	Fragment10	Ramos	C256(1.40)	LDD2189	[28]
LDCM0573	Fragment11	Ramos	C256(0.91)	LDD2190	[28]
LDCM0574	Fragment12	Ramos	C256(1.31)	LDD2191	[28]
LDCM0575	Fragment13	Ramos	C256(1.32)	LDD2192	[28]
LDCM0576	Fragment14	Ramos	C256(0.90)	LDD2193	[28]
LDCM0579	Fragment20	Ramos	C256(0.97)	LDD2194	[28]
LDCM0580	Fragment21	Ramos	C256(0.98)	LDD2195	[28]
LDCM0582	Fragment23	Ramos	C256(1.43)	LDD2196	[28]
LDCM0578	Fragment27	Ramos	C256(1.00)	LDD2197	[28]
LDCM0588	Fragment30	Ramos	C256(1.53)	LDD2199	[28]
LDCM0589	Fragment31	Ramos	C256(1.31)	LDD2200	[28]
LDCM0590	Fragment32	Ramos	C256(0.82)	LDD2201	[28]
LDCM0468	Fragment33	HCT 116	C256(1.38); C441(0.73)	LDD0785	[10]
LDCM0596	Fragment38	Ramos	C256(1.32)	LDD2203	[28]
LDCM0427	Fragment51	HCT 116	C441(0.65)	LDD0744	[10]
LDCM0614	Fragment56	Ramos	C256(1.51)	LDD2205	[28]
LDCM0571	Fragment9	Ramos	C256(1.34)	LDD2188	[28]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[19]
LDCM0022	KB02	HCT 116	C441(1.41)	LDD0080	[10]
LDCM0023	KB03	HCT 116	C441(1.88)	LDD0081	[10]
LDCM0024	KB05	HCT 116	C441(1.41)	LDD0082	[10]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[19]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C256(1.13)	LDD2090	[8]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C256(0.22)	LDD2096	[8]
LDCM0505	Nucleophilic fragment 15b	MDA-MB-231	C256(0.70)	LDD2098	[8]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C256(0.88)	LDD2099	[8]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C256(0.51)	LDD2104	[8]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C256(0.31)	LDD2110	[8]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C256(0.29)	LDD2114	[8]
LDCM0525	Nucleophilic fragment 25b	MDA-MB-231	C256(0.52)	LDD2118	[8]
LDCM0529	Nucleophilic fragment 27b	MDA-MB-231	C256(0.31)	LDD2122	[8]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C256(0.97)	LDD2123	[8]
LDCM0533	Nucleophilic fragment 29b	MDA-MB-231	C256(0.35)	LDD2126	[8]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C256(0.78)	LDD2127	[8]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C256(0.88)	LDD2137	[8]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C256(0.34)	LDD2141	[8]
LDCM0557	Nucleophilic fragment 8b	MDA-MB-231	C256(0.36)	LDD2151	[8]
LDCM0099	Phenelzine	MDA-MB-231	20.00	LDD0384	[7]
LDCM0131	RA190	MM1.R	C441(1.11)	LDD0304	[29]
LDCM0016	Ranjitkar_cp1	MDA-MB-231	3.03	LDD0123	[9]
LDCM0021	THZ1	HCT 116	C256(1.11); C441(1.01)	LDD2173	[10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
TSC22 domain family protein 4 (TSC22D4)				TSC-22/Dip/Bun family	Q9Y3Q8

Other

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Eukaryotic translation initiation factor 3 subunit G (EIF3G)				EIF-3 subunit G family	O75821
KN motif and ankyrin repeat domain-containing protein 2 (KANK2)				.	Q63ZY3

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Flavin Adenine Dinucleotide				Small molecular drug	DB03147

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Mcc				.	DB05282

References

1	Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18. Mass spectrometry data entry: PXD021557 , PXD015828
2	Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4	An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
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6	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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9	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
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11	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
12	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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15	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
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28	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
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Prof. Feng Zhu

Prof. Feng Ni