Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C258  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 19.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 11.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 11.8
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 10.9
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.3
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 10.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 9.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 9.3
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 9.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 9.0
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 9.0
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.9
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 8.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 7.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 7.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.0
 LDTP02362  Dihydrolipoyl dehydrogenase, mitochondrial (DLD) 6.6
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 6.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 6.4
 LDTP09110  NAD(P)H-hydrate epimerase (NAXE) 6.2
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 6.1
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 6.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 6.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 5.8
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.7
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 5.6
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 5.5
 LDTP04183  Lanosterol synthase (LSS) 5.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 5.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.4
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 5.3
 LDTP13751  Exonuclease 1 (EXO1) 5.2
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 5.2
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 5.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.2
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 5.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.1
Transporter and channel
Click to Show/Hide to Show 29 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 43.1
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 18.9
 LDTP01804  ATP synthase subunit a (MT-ATP6) 11.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 11.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 11.1
 LDTP07236  Protein GPR107 (GPR107) 9.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 8.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.3
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 8.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 8.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.2
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 7.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 7.7
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 7.7
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.6
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 7.0
 LDTP16813  Tetraspanin-3 (TSPAN3) 6.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 6.6
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 6.6
 LDTP05900  Metaxin-1 (MTX1) 6.5
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 6.2
 LDTP15481  Transmembrane protein 87A (TMEM87A) 6.1
 LDTP02215  Prosaposin (PSAP) 5.7
 LDTP03546  Translocator protein (TSPO) 5.6
 LDTP15648  BRI3-binding protein (BRI3BP) 5.5
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 5.4
 LDTP08881  Transmembrane protein 199 (TMEM199) 5.4
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 5.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 5.1
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 14.7
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 10.5
 LDTP11076  Apolipoprotein L2 (APOL2) 9.3
 LDTP15623  Neuferricin (CYB5D2) 8.8
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 8.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.4
 LDTP01522  Reticulon-3 (RTN3) 7.3
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 7.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.0
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 5.7
 LDTP01652  Centrosomal protein 43 (CEP43) 5.6
 LDTP04558  Arfaptin-1 (ARFIP1) 5.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 5.4
 LDTP10056  Protein FAM162A (FAM162A) 5.4
 LDTP13086  Syntaxin-18 (STX18) 5.4
 LDTP08000  Dymeclin (DYM) 5.2
 LDTP12412  Reticulon-4 (RTN4) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587