Details of the Target

General Information of Target

Target ID LDTP13174
Target Name Mitochondrial dicarboxylate carrier (SLC25A10)
Gene Name SLC25A10
Gene ID 1468
Synonyms
DIC; Mitochondrial dicarboxylate carrier; DIC; Solute carrier family 25 member 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF
AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA
YAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLA
PPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQ
EPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRAL
LEEL
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane. Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity.
Uniprot ID
Q9UBX3
Ensemble ID
ENST00000331531.9
HGNC ID
HGNC:10980

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.N140T DBIA    Probe Info 
COLO792 SNV: p.P98S DBIA    Probe Info 
HCT15 SNV: p.T244I DBIA    Probe Info 
HEC1 SNV: p.R262H DBIA    Probe Info 
HEC1B SNV: p.R262H .
MCC13 SNV: p.F79L DBIA    Probe Info 
SUPT1 SNV: p.A185T DBIA    Probe Info 
WM2664 SNV: p.R158K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		5.20  LDD0196  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
W1
 Probe Info  		12.32  LDD0235  [4]
TH211
 Probe Info  		Y149(20.00)  LDD0260  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K132(0.52); K279(10.00)  LDD0277  [7]
DBIA
 Probe Info  		C249(2.16); C69(1.92)  LDD3310  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
BTD
 Probe Info  		C240(1.46)  LDD2111  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C181(0.00); C240(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C181(0.00); C240(0.00); C69(0.00); C22(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C181(0.00); C240(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		C69(0.00); C181(0.00)  LDD0026  [12]
TFBX
 Probe Info  		C240(0.00); C181(0.00); C69(0.00)  LDD0027  [12]
IPM
 Probe Info  		C181(0.00); C240(0.00)  LDD0005  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
1c-yne
 Probe Info  		K102(0.00); K254(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C240(0.00); H100(0.00); C181(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		C181(0.00); C240(0.00); C212(0.00); C69(0.00)  LDD2223  [18]
TER-AC
 Probe Info  		N.A.  LDD0426  [19]
PAL-AfBPP Probe
Click To Hide/Show 150 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		20.11  LDD1714  [20]
C007
 Probe Info  		7.16  LDD1716  [20]
C008
 Probe Info  		7.06  LDD1717  [20]
C010
 Probe Info  		5.31  LDD1719  [20]
C017
 Probe Info  		6.68  LDD1725  [20]
C022
 Probe Info  		20.68  LDD1728  [20]
C026
 Probe Info  		8.82  LDD1732  [20]
C040
 Probe Info  		18.51  LDD1740  [20]
C041
 Probe Info  		7.41  LDD1741  [20]
C049
 Probe Info  		10.63  LDD1747  [20]
C053
 Probe Info  		5.98  LDD1751  [20]
C055
 Probe Info  		35.26  LDD1752  [20]
C056
 Probe Info  		43.71  LDD1753  [20]
C063
 Probe Info  		17.15  LDD1760  [20]
C067
 Probe Info  		5.10  LDD1763  [20]
C070
 Probe Info  		14.83  LDD1766  [20]
C072
 Probe Info  		9.78  LDD1768  [20]
C082
 Probe Info  		8.06  LDD1774  [20]
C087
 Probe Info  		9.19  LDD1779  [20]
C091
 Probe Info  		45.89  LDD1782  [20]
C092
 Probe Info  		45.25  LDD1783  [20]
C094
 Probe Info  		54.95  LDD1785  [20]
C095
 Probe Info  		8.51  LDD1786  [20]
C100
 Probe Info  		7.16  LDD1789  [20]
C106
 Probe Info  		39.40  LDD1793  [20]
C107
 Probe Info  		9.13  LDD1794  [20]
C108
 Probe Info  		14.93  LDD1795  [20]
C112
 Probe Info  		39.12  LDD1799  [20]
C129
 Probe Info  		6.54  LDD1811  [20]
C130
 Probe Info  		8.46  LDD1812  [20]
C134
 Probe Info  		56.10  LDD1816  [20]
C135
 Probe Info  		24.59  LDD1817  [20]
C139
 Probe Info  		13.27  LDD1821  [20]
C140
 Probe Info  		9.45  LDD1822  [20]
C141
 Probe Info  		23.75  LDD1823  [20]
C143
 Probe Info  		39.95  LDD1825  [20]
C147
 Probe Info  		8.17  LDD1829  [20]
C153
 Probe Info  		29.86  LDD1834  [20]
C159
 Probe Info  		20.39  LDD1839  [20]
C160
 Probe Info  		17.75  LDD1840  [20]
C161
 Probe Info  		35.02  LDD1841  [20]
C163
 Probe Info  		17.03  LDD1843  [20]
C165
 Probe Info  		20.53  LDD1845  [20]
C166
 Probe Info  		9.38  LDD1846  [20]
C169
 Probe Info  		51.98  LDD1849  [20]
C177
 Probe Info  		7.21  LDD1856  [20]
C178
 Probe Info  		46.53  LDD1857  [20]
C183
 Probe Info  		5.86  LDD1861  [20]
C186
 Probe Info  		19.03  LDD1864  [20]
C187
 Probe Info  		33.13  LDD1865  [20]
C191
 Probe Info  		13.36  LDD1868  [20]
C193
 Probe Info  		4.96  LDD1869  [20]
C194
 Probe Info  		21.11  LDD1870  [20]
C196
 Probe Info  		18.77  LDD1872  [20]
C198
 Probe Info  		20.11  LDD1874  [20]
C201
 Probe Info  		51.63  LDD1877  [20]
C206
 Probe Info  		36.50  LDD1881  [20]
C210
 Probe Info  		46.85  LDD1884  [20]
C213
 Probe Info  		17.27  LDD1887  [20]
C218
 Probe Info  		35.51  LDD1892  [20]
C219
 Probe Info  		10.78  LDD1893  [20]
C220
 Probe Info  		59.71  LDD1894  [20]
C225
 Probe Info  		11.00  LDD1898  [20]
C226
 Probe Info  		9.19  LDD1899  [20]
C228
 Probe Info  		47.84  LDD1901  [20]
C229
 Probe Info  		12.64  LDD1902  [20]
C231
 Probe Info  		46.53  LDD1904  [20]
C232
 Probe Info  		58.49  LDD1905  [20]
C233
 Probe Info  		20.39  LDD1906  [20]
C234
 Probe Info  		9.00  LDD1907  [20]
C235
 Probe Info  		50.21  LDD1908  [20]
C238
 Probe Info  		33.13  LDD1911  [20]
C240
 Probe Info  		13.55  LDD1913  [20]
C243
 Probe Info  		26.72  LDD1916  [20]
C244
 Probe Info  		24.59  LDD1917  [20]
C245
 Probe Info  		8.82  LDD1918  [20]
C246
 Probe Info  		48.17  LDD1919  [20]
C249
 Probe Info  		23.10  LDD1922  [20]
C252
 Probe Info  		20.82  LDD1925  [20]
C258
 Probe Info  		5.10  LDD1931  [20]
C264
 Probe Info  		33.59  LDD1935  [20]
C265
 Probe Info  		22.78  LDD1936  [20]
C270
 Probe Info  		10.41  LDD1940  [20]
C273
 Probe Info  		7.94  LDD1943  [20]
C277
 Probe Info  		24.25  LDD1947  [20]
C278
 Probe Info  		99.73  LDD1948  [20]
C280
 Probe Info  		14.22  LDD1950  [20]
C282
 Probe Info  		43.41  LDD1952  [20]
C284
 Probe Info  		61.82  LDD1954  [20]
C285
 Probe Info  		39.95  LDD1955  [20]
C287
 Probe Info  		21.86  LDD1957  [20]
C288
 Probe Info  		11.71  LDD1958  [20]
C289
 Probe Info  		49.18  LDD1959  [20]
C290
 Probe Info  		6.54  LDD1960  [20]
C293
 Probe Info  		41.64  LDD1963  [20]
C296
 Probe Info  		22.94  LDD1966  [20]
C299
 Probe Info  		8.06  LDD1968  [20]
C305
 Probe Info  		11.47  LDD1974  [20]
C307
 Probe Info  		8.75  LDD1975  [20]
C310
 Probe Info  		18.90  LDD1977  [20]
C313
 Probe Info  		13.45  LDD1980  [20]
C314
 Probe Info  		34.54  LDD1981  [20]
C317
 Probe Info  		5.86  LDD1983  [20]
C322
 Probe Info  		8.69  LDD1988  [20]
C326
 Probe Info  		16.11  LDD1990  [20]
C339
 Probe Info  		13.00  LDD2002  [20]
C343
 Probe Info  		21.41  LDD2005  [20]
C348
 Probe Info  		16.56  LDD2009  [20]
C349
 Probe Info  		37.53  LDD2010  [20]
C350
 Probe Info  		73.52  LDD2011  [20]
C353
 Probe Info  		5.78  LDD2014  [20]
C355
 Probe Info  		32.90  LDD2016  [20]
C356
 Probe Info  		19.70  LDD2017  [20]
C357
 Probe Info  		9.45  LDD2018  [20]
C362
 Probe Info  		65.34  LDD2023  [20]
C363
 Probe Info  		34.54  LDD2024  [20]
C364
 Probe Info  		26.54  LDD2025  [20]
C366
 Probe Info  		22.94  LDD2027  [20]
C367
 Probe Info  		13.09  LDD2028  [20]
C373
 Probe Info  		7.41  LDD2033  [20]
C376
 Probe Info  		23.10  LDD2036  [20]
C378
 Probe Info  		8.06  LDD2037  [20]
C382
 Probe Info  		19.97  LDD2041  [20]
C383
 Probe Info  		19.97  LDD2042  [20]
C386
 Probe Info  		8.88  LDD2045  [20]
C388
 Probe Info  		53.82  LDD2047  [20]
C390
 Probe Info  		63.12  LDD2049  [20]
C399
 Probe Info  		12.55  LDD2058  [20]
C403
 Probe Info  		35.75  LDD2061  [20]
C407
 Probe Info  		46.21  LDD2064  [20]
C409
 Probe Info  		6.28  LDD2066  [20]
C413
 Probe Info  		18.77  LDD2069  [20]
C419
 Probe Info  		13.00  LDD2074  [20]
C420
 Probe Info  		14.03  LDD2075  [20]
C423
 Probe Info  		9.71  LDD2078  [20]
C424
 Probe Info  		12.21  LDD2079  [20]
C426
 Probe Info  		24.42  LDD2081  [20]
C429
 Probe Info  		30.91  LDD2084  [20]
C430
 Probe Info  		5.94  LDD2085  [20]
C431
 Probe Info  		67.18  LDD2086  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe15
 Probe Info  		18.32  LDD0478  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [21]
FFF probe4
 Probe Info  		18.47  LDD0466  [21]
FFF probe6
 Probe Info  		6.88  LDD0468  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
OEA-DA
 Probe Info  		20.00  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C181(0.95); C69(0.86); C240(1.14); C23(0.87)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C181(0.93); C69(1.08); C23(1.03)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C181(1.04); C69(0.99); C240(1.06); C23(1.09)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C181(1.02); C69(0.99); C240(1.04); C23(0.97)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C181(0.90); C69(1.11); C240(1.05); C23(0.97)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C181(0.94); C69(0.98); C240(1.05); C23(0.96)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C181(0.98); C69(0.94); C240(1.10); C23(1.04)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C181(0.94); C69(1.02); C23(1.03)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C181(1.05); C69(0.94); C240(1.13); C23(0.85)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C181(0.94); C69(0.93); C23(0.97)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C181(0.97); C69(1.00); C240(1.03); C23(0.91)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C181(0.96); C69(1.04); C240(0.95); C23(0.93)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C181(0.91); C69(1.08); C240(1.00); C23(0.95)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C181(0.89); C69(0.93); C240(0.98); C23(0.95)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C181(1.04); C69(0.87); C240(0.96); C23(0.91)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C181(0.96); C69(0.88); C240(1.09); C23(0.97)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C181(0.94); C69(1.02); C23(1.08)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C181(0.93); C69(0.97); C240(1.08); C23(1.09)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C181(1.11); C69(0.92); C240(0.98); C23(1.00)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C181(0.96); C69(1.03); C240(1.01); C23(0.95)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C181(1.02); C69(1.01); C240(1.12); C23(0.93)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C181(0.98); C69(1.06); C240(0.98); C23(0.93)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C181(0.99); C69(1.08); C240(0.99); C23(0.90)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C181(1.01); C69(0.91); C240(1.01); C23(0.93)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C181(0.87); C69(0.92); C240(1.11); C23(0.86)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C181(0.94); C69(1.04); C23(1.21)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C181(0.94); C69(0.94); C240(1.04); C23(1.07)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C181(0.83); C69(0.95); C240(0.95); C23(1.04)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C181(0.92); C69(0.93); C240(0.91); C23(0.91)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C181(0.91); C69(1.01); C240(0.95); C23(0.95)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C181(0.88); C69(1.02); C240(0.97); C23(0.96)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C181(0.91); C69(0.97); C240(0.94); C23(0.98)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C181(0.92); C69(0.95); C240(1.00); C23(0.96)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C181(0.87); C69(0.90); C240(1.08); C23(0.95)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C181(0.89); C69(1.10); C23(0.96)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C181(0.94); C69(0.95); C240(1.00); C23(0.77)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C181(0.99); C69(1.04); C240(0.95); C23(0.98)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C181(0.91); C69(0.96); C240(0.95); C23(0.93)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C181(0.95); C69(1.01); C240(0.97); C23(0.89)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C181(0.90); C69(0.87); C240(1.00); C23(0.86)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C181(0.91); C69(0.89); C240(0.90); C23(0.89)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C181(0.91); C69(1.02); C240(1.08); C23(0.84)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C181(0.98); C69(0.96); C240(1.02); C23(0.93)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C181(0.94); C69(0.92); C23(0.86)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C181(0.96); C69(1.03); C240(1.04); C23(0.91)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C181(0.87); C69(0.96); C240(0.98); C23(0.94)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C181(0.90); C69(1.03); C240(0.92); C23(0.91)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C181(0.90); C69(1.05); C240(0.95); C23(0.82)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C181(0.90); C69(0.97); C240(1.05); C23(0.91)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C181(1.01); C69(0.99); C240(0.99); C23(0.92)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C181(0.87); C69(0.99); C240(1.01); C23(1.03)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C181(0.96); C69(1.02); C23(0.98)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C181(0.99); C69(0.98); C240(1.08); C23(1.12)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C181(0.98); C69(1.08); C240(0.98); C23(0.92)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C181(0.95); C69(1.04); C240(0.99); C23(1.10)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C181(0.98); C69(1.12); C240(0.95); C23(1.08)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C181(0.91); C69(1.07); C240(0.99); C23(0.97)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C181(0.97); C69(1.08); C240(1.02); C23(0.97)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C181(1.02); C69(1.02); C240(0.95); C23(1.00)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C181(0.98); C69(1.00); C240(0.99); C23(0.91)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C181(0.92); C69(0.90); C240(0.98); C23(1.02)  LDD1569  [23]
 LDCM0248  AKOS034007472 HEK-293T C181(0.98); C69(1.07); C240(0.93); C23(0.95)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C181(0.97); C69(0.85); C240(1.08); C23(0.89)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C181(1.00); C69(0.93); C240(0.99); C23(0.93)  LDD1514  [23]
 LDCM0108  Chloroacetamide HeLa C240(0.00); H33(0.00); H100(0.00); H143(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C181(1.91); C240(1.05)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C181(1.09); C69(0.91); C18(1.17)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C181(1.32); C69(1.45); C240(2.00); C23(1.63)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C181(1.05); C69(1.09); C240(1.10); C23(1.09)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C181(1.02); C69(0.93); C18(1.19)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C181(1.07); C69(1.04); C240(1.04); C23(1.16)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C181(0.93); C69(1.01); C240(1.00); C23(1.15)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C181(0.94); C69(1.13); C240(1.05); C23(0.87)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C181(1.05); C69(0.90); C18(0.90)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C181(1.01); C69(0.93); C240(1.04); C23(1.05)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C181(0.94); C69(1.01); C240(1.07); C23(1.03)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C181(0.96); C69(0.96); C240(1.08); C23(0.96)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C181(1.05); C69(0.97); C18(1.10)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C181(1.25); C69(1.25); C240(1.36); C23(1.32)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C181(1.14); C69(1.05); C240(1.17); C23(1.13)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C181(1.02); C69(1.00); C240(1.13); C23(1.21)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C181(0.90); C69(1.09); C240(1.12); C23(0.97)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C181(1.05); C69(0.85); C18(1.10)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C181(1.08); C69(1.11); C240(1.05); C23(1.19)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C181(0.91); C69(0.90); C240(0.98); C23(0.98)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C181(0.91); C69(1.14); C240(1.01); C23(0.91)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C181(1.03); C69(1.00); C18(1.07)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C181(0.95); C69(1.02); C240(0.85); C23(0.91)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C181(0.96); C69(0.97); C240(0.95); C23(1.03)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C181(1.18); C69(1.10); C240(1.13); C23(1.15)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C181(0.86); C69(1.11); C240(1.00); C23(0.81)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C181(1.09); C69(0.98); C18(1.03)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C181(1.02); C69(1.00); C240(0.92); C23(1.00)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C181(1.16); C69(1.12); C240(1.37); C23(1.20)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C181(1.02); C69(1.11); C240(1.10); C23(0.90)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C181(1.44); C69(1.09); C18(1.10)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C181(1.00); C69(1.08); C240(0.97); C23(1.01)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C181(0.99); C69(1.03); C240(0.93); C23(1.23)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C181(0.92); C69(1.22); C240(1.04); C23(0.93)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C181(1.08); C69(0.88); C18(1.40)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C181(1.00); C69(0.97); C240(0.90); C23(1.10)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C181(1.15); C69(1.12); C240(1.43); C23(1.36)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C181(0.99); C69(1.15); C240(1.04); C23(0.97)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C181(1.16); C69(0.98); C240(1.84); C23(1.20)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C181(1.08); C69(1.11); C23(1.11)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C181(1.03); C69(1.05); C240(1.15); C23(1.02)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C181(1.00); C69(1.07); C240(0.96); C23(1.07)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C181(1.09); C69(1.21); C240(1.07); C23(1.14)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C181(1.46); C69(1.48); C240(1.35); C23(1.15)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C181(1.10); C69(1.30); C240(1.08); C23(1.05)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C181(1.12); C69(1.22); C240(1.21); C23(1.14)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C181(1.32); C69(1.13); C240(1.04); C23(1.09)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C181(1.18); C69(0.89); C18(1.31)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C181(0.93); C69(1.04); C240(0.97); C23(1.03)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C181(0.95); C69(0.95); C240(1.05); C23(1.05)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C181(0.92); C69(1.00); C240(1.14); C23(0.94)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C181(1.04); C69(0.94); C240(1.02); C23(1.06)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C181(1.12); C69(0.98); C240(1.16); C23(1.13)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C181(1.03); C69(1.05); C23(1.05)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C181(1.05); C69(1.19); C240(1.19); C23(1.10)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C181(1.15); C69(1.04); C240(1.04); C23(1.20)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C181(1.60); C69(1.50); C240(1.58); C23(1.59)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C181(1.15); C69(1.45); C240(1.29); C23(1.09)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C181(1.18); C69(1.22); C240(1.02); C23(1.14)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C181(1.26); C69(1.30); C240(1.10); C23(1.16)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C181(1.18); C69(1.00); C18(1.04)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C181(1.05); C69(0.95); C240(1.17); C23(1.12)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C181(1.01); C69(1.11); C240(1.11); C23(1.03)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C181(0.95); C69(1.07); C240(0.94); C23(0.92)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C181(1.04); C69(0.99); C240(1.24); C23(1.11)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C181(0.96); C69(1.08); C23(1.04)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C181(1.04); C69(1.10); C240(1.11); C23(0.92)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C181(1.14); C69(1.22); C240(1.03); C23(1.06)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C181(1.16); C69(1.36); C240(1.21); C23(1.13)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C181(1.13); C69(1.30); C240(1.02); C23(1.09)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C181(1.14); C69(1.24); C240(1.06); C23(1.07)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C181(1.32); C69(1.24); C240(1.06); C23(1.17)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C181(1.23); C69(0.92); C18(1.10)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C181(1.03); C69(0.92); C240(1.20); C23(1.01)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C181(0.90); C69(0.95); C240(0.99); C23(1.01)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C181(0.89); C69(1.01); C240(1.08); C23(0.82)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C181(1.09); C69(1.02); C240(1.46); C23(0.98)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C181(1.15); C69(1.37); C23(1.35)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C181(1.03); C69(1.00); C240(1.07); C23(0.96)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C181(1.02); C69(1.19); C240(1.02); C23(1.19)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C181(1.15); C69(1.17); C240(1.22); C23(1.01)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C181(1.04); C69(1.30); C240(1.23); C23(1.06)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C181(1.12); C69(1.20); C240(1.08); C23(0.94)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C181(1.15); C69(1.30); C23(1.41)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C181(1.10); C69(1.18); C240(1.02); C23(1.08)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C181(1.20); C69(1.15); C18(1.20)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C181(0.93); C69(0.94); C240(0.91); C23(0.93)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C181(0.95); C69(0.91); C240(0.97); C23(1.00)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C181(1.07); C69(1.20); C240(1.31); C23(1.14)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C181(0.86); C69(0.90); C240(1.08); C23(0.87)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C181(0.90); C69(1.07); C23(0.95)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C181(1.03); C69(1.08); C240(1.06); C23(0.91)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C181(1.11); C69(1.16); C240(1.03); C23(1.03)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C181(1.16); C69(1.19); C240(1.03); C23(0.92)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C181(1.10); C69(1.14); C240(1.18); C23(1.03)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C181(1.06); C69(1.26); C240(0.97); C23(1.03)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C181(1.08); C69(1.14); C240(1.03); C23(0.99)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C181(1.15); C69(1.07); C240(1.00); C23(1.13)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C181(1.27); C69(0.88); C18(1.06)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C181(0.99); C69(1.06); C240(0.88); C23(0.91)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C181(1.01); C69(1.05); C240(0.96); C23(0.89)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C181(1.04); C69(0.93); C240(1.56); C23(1.08)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C181(0.95); C69(1.05); C23(0.93)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C181(1.02); C69(1.02); C240(1.06); C23(1.05)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C181(2.00); C69(1.51); C240(2.93); C23(2.07)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C181(1.05); C69(1.15); C240(0.95); C23(1.05)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C181(1.03); C69(1.22); C240(0.98); C23(0.92)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C181(0.97); C69(1.04); C240(1.00); C23(0.96)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C181(1.21); C69(1.17); C240(1.04); C23(1.08)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C181(1.32); C69(1.21); C240(1.15); C23(1.16)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C181(1.35); C69(0.96); C18(1.17)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C181(0.97); C69(1.06); C240(0.95); C23(1.07)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C181(0.96); C69(1.02); C240(1.01); C23(1.27)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C181(0.94); C69(1.10); C240(0.98); C23(0.85)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C181(1.06); C69(0.92); C240(1.01); C23(0.87)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C181(1.12); C69(1.34); C240(1.11); C23(0.99)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C181(1.29); C69(1.58); C23(1.75)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C181(1.05); C69(1.05); C240(1.10); C23(0.93)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C181(1.15); C69(1.24); C240(1.22); C23(1.23)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C181(1.12); C69(1.42); C240(1.11); C23(1.09)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C181(0.96); C69(1.33); C240(1.05); C23(1.02)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C181(1.40); C69(1.42); C240(1.94); C23(1.58)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C181(1.31); C69(1.29); C240(1.14); C23(1.31)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C181(1.08); C69(0.97); C18(1.24)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C181(1.02); C69(1.03); C240(1.00); C23(1.23)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C181(0.99); C69(0.98); C240(1.07); C23(1.13)  LDD1697  [23]
 LDCM0185  Compound 17 HEK-293T 6.13  LDD0512  [21]
 LDCM0191  Compound 21 HEK-293T 9.66  LDD0508  [21]
 LDCM0190  Compound 34 HEK-293T 13.61  LDD0510  [21]
 LDCM0192  Compound 35 HEK-293T 6.99  LDD0509  [21]
 LDCM0193  Compound 36 HEK-293T 10.47  LDD0511  [21]
 LDCM0495  E2913 HEK-293T C181(1.00); C69(1.07); C240(1.17); C23(1.11)  LDD1698  [23]
 LDCM0468  Fragment33 HEK-293T C181(0.93); C69(1.01); C240(1.03); C23(1.01)  LDD1671  [23]
 LDCM0427  Fragment51 HEK-293T C181(0.94); C69(1.01); C240(0.95); C23(0.93)  LDD1631  [23]
 LDCM0107  IAA HeLa H239(0.00); H33(0.00); H100(0.00)  LDD0221  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HEK-293T C240(0.94); C181(1.02); C23(1.03); C69(0.91)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C240(0.96); C181(0.98); C23(1.07); C69(1.05)  LDD1497  [23]
 LDCM0024  KB05 COLO792 C249(2.16); C69(1.92)  LDD3310  [8]
 LDCM0109  NEM HeLa H143(0.00); H33(0.00); H100(0.00)  LDD0223  [16]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C240(1.46)  LDD2111  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C240(1.24)  LDD2118  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C240(1.19)  LDD2123  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C240(1.36)  LDD2127  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C240(1.62)  LDD2129  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C240(2.43)  LDD2144  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C69(0.95); C240(0.18)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C240(1.43); C69(1.37); C240(1.10); C22(0.79)  LDD2207  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Succinic Acid Small molecular drug DB00139

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.