Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C053  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 17.0
 LDTP09749  Titin (TTN) 14.9
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 14.7
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 14.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 13.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 13.1
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 12.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 11.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 11.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 9.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 9.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 8.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.7
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 8.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.2
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 7.8
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.5
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 7.5
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 7.3
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 7.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 7.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 6.9
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 6.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 6.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 6.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 6.5
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 6.0
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 5.9
 LDTP11127  ADP-dependent glucokinase (ADPGK) 5.9
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 5.8
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 5.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 5.6
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 5.4
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 5.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 5.3
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 5.3
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 5.2
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 5.2
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 5.1
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 5.1
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 5.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 5.1
 LDTP10329  Ceramide synthase 2 (CERS2) 5.0
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 5.0
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 5.0
 LDTP03145  Catechol O-methyltransferase (COMT) 5.0
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 4.9
Transporter and channel
Click to Show/Hide to Show 39 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 23.1
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 15.5
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 13.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 12.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 11.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 10.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 9.4
 LDTP15648  BRI3-binding protein (BRI3BP) 9.1
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 8.4
 LDTP02215  Prosaposin (PSAP) 8.2
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 8.1
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 7.8
 LDTP04237  Protein ERGIC-53 (LMAN1) 7.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 7.5
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 7.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 7.0
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 6.9
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 6.9
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 6.7
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 6.7
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 6.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 6.4
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 6.3
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.2
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 6.1
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 6.1
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 6.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 6.0
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 5.8
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 5.7
 LDTP11245  Derlin-1 (DERL1) 5.7
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 5.5
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.4
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.2
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 5.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 5.1
 LDTP11116  45 kDa calcium-binding protein (SDF4) 4.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 4.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 5.1
Other
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 22.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 19.6
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 17.3
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 16.1
 LDTP03926  Centrin-2 (CETN2) 15.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 15.5
 LDTP11076  Apolipoprotein L2 (APOL2) 14.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 14.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 13.5
 LDTP05375  Nucleobindin-1 (NUCB1) 10.6
 LDTP12412  Reticulon-4 (RTN4) 10.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 10.4
 LDTP10113  Mitochondrial import receptor subunit TOM6 homolog (TOMM6) 9.8
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 9.1
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 8.7
 LDTP02443  Calmodulin-3 (CALM3) 8.6
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 8.6
 LDTP06097  Reticulocalbin-2 (RCN2) 8.1
 LDTP10056  Protein FAM162A (FAM162A) 7.9
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 7.6
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 7.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 7.1
 LDTP13086  Syntaxin-18 (STX18) 7.0
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 6.9
 LDTP02297  Vimentin (VIM) 6.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 6.7
 LDTP01522  Reticulon-3 (RTN3) 6.7
 LDTP15398  Protein FAM177A1 (FAM177A1) 6.7
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 6.6
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 6.4
 LDTP02927  Ganglioside GM2 activator (GM2A) 6.3
 LDTP01494  Protein YIF1A (YIF1A) 6.1
 LDTP00859  Synaptogyrin-2 (SYNGR2) 5.9
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 5.9
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 5.7
 LDTP08594  Negative elongation factor C/D (NELFCD) 5.7
 LDTP05277  Protein SET (SET) 5.6
 LDTP02181  Neurofilament medium polypeptide (NEFM) 5.5
 LDTP19963  TraB domain-containing protein (TRABD) 5.5
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 5.4
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 5.1
 LDTP16006  Optic atrophy 3 protein (OPA3) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587