Details of the Target

General Information of Target

Target ID LDTP08594
Target Name Negative elongation factor C/D (NELFCD)
Gene Name NELFCD
Gene ID 51497
Synonyms
NELFD; TH1; TH1L; Negative elongation factor C/D; NELF-C/D; TH1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAVPGAIMDEDYYGSAAEWGDEADGGQQEDDSGEGEDDAEVQQECLHKFSTRDYIMEP
SIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLK
SLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLIS
DAGYQGEITSVSTACQQLEVFSRVLRTSLATILDGGEENLEKNLPEFAKMVCHGEHTYLF
AQAMMSVLAQEEQGGSAVRRIAQEVQRFAQEKGHDASQITLALGTAASYPRACQALGAML
SKGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSLFKPGARINQDHKHKYIHIL
AYAASVVETWKKNKRVSINKDELKSTSKAVETVHNLCCNENKGASELVAELSTLYQCIRF
PVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETE
HSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTDISLIRYFVTEVLDV
IAPPYTSDFVQLFLPILENDSIAGTIKTEGEHDPVTEFIAHCKSNFIMVN
Target Bioclass
Other
Family
NELF-D family
Subcellular location
Nucleus
Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Uniprot ID
Q8IXH7
Ensemble ID
ENST00000652272.2
HGNC ID
HGNC:15934

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.83  LDD0402  [1]
STPyne
 Probe Info  		K380(2.28); K67(5.00)  LDD0277  [2]
BTD
 Probe Info  		C293(2.85)  LDD2107  [3]
AHL-Pu-1
 Probe Info  		C169(2.17)  LDD0170  [4]
DBIA
 Probe Info  		C397(4.79); C398(4.79)  LDD0080  [5]
ATP probe
 Probe Info  		K388(0.00); K67(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		C293(0.00); C582(0.00)  LDD0162  [7]
JW-RF-010
 Probe Info  		C293(0.00); C195(0.00)  LDD0026  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		C293(0.00); C397(0.00); C398(0.00)  LDD0005  [9]
VSF
 Probe Info  		C398(0.00); C397(0.00)  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C293(0.00); C417(0.00); C232(0.00); C582(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 72 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		27.86  LDD1711  [13]
C022
 Probe Info  		12.47  LDD1728  [13]
C026
 Probe Info  		7.11  LDD1732  [13]
C040
 Probe Info  		8.28  LDD1740  [13]
C052
 Probe Info  		5.28  LDD1750  [13]
C053
 Probe Info  		5.70  LDD1751  [13]
C056
 Probe Info  		30.48  LDD1753  [13]
C060
 Probe Info  		4.99  LDD1757  [13]
C072
 Probe Info  		25.46  LDD1768  [13]
C092
 Probe Info  		40.79  LDD1783  [13]
C107
 Probe Info  		6.96  LDD1794  [13]
C112
 Probe Info  		36.00  LDD1799  [13]
C129
 Probe Info  		9.45  LDD1811  [13]
C140
 Probe Info  		8.17  LDD1822  [13]
C153
 Probe Info  		18.13  LDD1834  [13]
C161
 Probe Info  		39.40  LDD1841  [13]
C163
 Probe Info  		8.17  LDD1843  [13]
C165
 Probe Info  		38.85  LDD1845  [13]
C166
 Probe Info  		8.17  LDD1846  [13]
C169
 Probe Info  		22.16  LDD1849  [13]
C172
 Probe Info  		4.96  LDD1852  [13]
C186
 Probe Info  		19.43  LDD1864  [13]
C187
 Probe Info  		25.46  LDD1865  [13]
C194
 Probe Info  		10.41  LDD1870  [13]
C196
 Probe Info  		21.56  LDD1872  [13]
C197
 Probe Info  		4.96  LDD1873  [13]
C201
 Probe Info  		99.73  LDD1877  [13]
C207
 Probe Info  		22.16  LDD1882  [13]
C210
 Probe Info  		62.68  LDD1884  [13]
C220
 Probe Info  		76.11  LDD1894  [13]
C228
 Probe Info  		23.10  LDD1901  [13]
C231
 Probe Info  		11.79  LDD1904  [13]
C232
 Probe Info  		43.41  LDD1905  [13]
C238
 Probe Info  		14.62  LDD1911  [13]
C240
 Probe Info  		11.96  LDD1913  [13]
C244
 Probe Info  		45.25  LDD1917  [13]
C264
 Probe Info  		17.15  LDD1935  [13]
C282
 Probe Info  		66.26  LDD1952  [13]
C286
 Probe Info  		6.23  LDD1956  [13]
C288
 Probe Info  		13.64  LDD1958  [13]
C289
 Probe Info  		70.52  LDD1959  [13]
C305
 Probe Info  		9.92  LDD1974  [13]
C307
 Probe Info  		6.45  LDD1975  [13]
C310
 Probe Info  		7.57  LDD1977  [13]
C313
 Probe Info  		38.85  LDD1980  [13]
C322
 Probe Info  		8.06  LDD1988  [13]
C339
 Probe Info  		27.67  LDD2002  [13]
C348
 Probe Info  		9.85  LDD2009  [13]
C349
 Probe Info  		11.24  LDD2010  [13]
C350
 Probe Info  		42.22  LDD2011  [13]
C353
 Probe Info  		8.75  LDD2014  [13]
C356
 Probe Info  		14.93  LDD2017  [13]
C357
 Probe Info  		5.35  LDD2018  [13]
C362
 Probe Info  		88.65  LDD2023  [13]
C364
 Probe Info  		36.00  LDD2025  [13]
C366
 Probe Info  		5.90  LDD2027  [13]
C367
 Probe Info  		16.68  LDD2028  [13]
C382
 Probe Info  		16.34  LDD2041  [13]
C390
 Probe Info  		40.79  LDD2049  [13]
C391
 Probe Info  		13.83  LDD2050  [13]
C397
 Probe Info  		10.63  LDD2056  [13]
C409
 Probe Info  		9.06  LDD2066  [13]
C426
 Probe Info  		17.63  LDD2081  [13]
C430
 Probe Info  		5.17  LDD2085  [13]
FFF probe11
 Probe Info  		15.71  LDD0471  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe3
 Probe Info  		20.00  LDD0464  [14]
FFF probe6
 Probe Info  		7.57  LDD0467  [14]
JN0003
 Probe Info  		20.00  LDD0469  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C293(2.20)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C169(2.17)  LDD0170  [4]
 LDCM0214  AC1 HCT 116 C169(0.78); C195(1.07); C293(1.01); C397(1.06)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C169(0.96); C293(1.03); C397(0.99); C398(0.94)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C293(0.87); C397(0.82); C398(0.82)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C293(0.84); C397(0.69); C398(0.69)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C293(0.87); C397(0.71); C398(0.71)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C293(0.94); C397(0.80); C398(0.80)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C293(0.89); C397(0.74); C398(0.74)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C293(0.89); C397(0.79); C398(0.79)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C293(0.89); C397(0.84); C398(0.84)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C293(1.10); C397(0.78); C398(0.78)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C293(0.89); C397(0.87); C398(0.87)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C293(0.86); C397(0.77); C398(0.77)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C169(0.87); C293(1.05); C397(0.94); C398(0.94)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C293(0.88); C397(0.78); C398(0.78)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C293(0.92); C397(0.81); C398(0.81)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C293(1.04); C397(0.82); C398(0.82)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C293(0.93); C397(0.94); C398(0.96); C417(0.68)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C293(1.03); C397(0.99); C398(1.02); C417(0.67)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C293(1.08); C397(1.03); C398(1.10); C417(0.62)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C293(1.13); C397(0.96); C398(0.98); C417(0.63)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C293(1.01); C397(0.96); C398(0.95); C417(0.78)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C293(1.09); C397(1.02); C398(0.98); C417(0.60)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C293(0.96); C397(1.02); C398(1.09); C417(0.63)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C169(1.02); C293(1.07); C397(0.95); C398(0.95)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C293(1.24); C397(1.03); C398(1.02); C417(0.66)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C293(0.98); C397(1.09); C398(1.16); C417(0.56)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C293(1.03); C397(1.01); C398(1.12); C417(0.67)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C293(1.15); C397(0.99); C398(0.95); C417(0.77)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C293(0.98); C397(0.93); C398(0.98); C417(0.59)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C293(1.00); C397(0.98); C398(1.06); C417(1.12)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C293(1.08); C397(1.05); C398(1.04); C417(0.62)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C293(1.10); C397(1.06); C398(1.06); C417(0.77)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C169(1.43); C293(1.17); C397(1.40); C398(1.40)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C169(1.33); C293(1.14); C397(0.99); C398(0.99)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C169(1.20); C293(1.02); C397(1.05); C398(1.05)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C169(1.11); C293(0.99); C397(1.05); C398(1.05)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C169(1.19); C293(1.19); C397(1.03); C398(1.03)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C169(1.06); C293(1.06); C397(1.13); C398(1.13)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C169(1.45); C293(1.25); C397(1.17); C398(1.17)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C169(1.32); C293(1.19); C397(1.30); C398(1.30)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C169(1.16); C293(1.17); C397(1.12); C398(1.12)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C169(1.25); C293(1.37); C397(1.02); C398(1.02)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C169(1.62); C293(1.49); C397(1.24); C398(1.24)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C169(1.56); C293(1.25); C397(1.17); C398(1.17)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C169(0.94); C293(1.00); C397(0.92); C398(0.91)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C169(2.02); C293(1.42); C397(1.28); C398(1.28)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C169(1.70); C293(1.32); C397(1.10); C398(1.10)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C169(1.13); C293(1.20); C397(1.09); C398(1.09)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C398(0.91); C397(0.92); C293(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C397(0.84); C398(0.87); C293(1.10)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C397(0.82); C398(0.85); C293(0.91)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C397(0.92); C398(0.93); C293(1.01)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C397(0.93); C293(0.96); C398(1.00)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C397(1.04); C398(1.10); C293(1.32)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C397(1.04); C398(1.07); C293(1.08)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C397(0.90); C398(0.97); C169(0.99); C293(1.03)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C293(0.93); C397(0.97); C398(0.98)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C293(0.85); C397(0.91); C398(0.93)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C397(1.05); C398(1.06); C293(1.21)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C397(1.10); C398(1.16); C293(1.33)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C293(1.02); C397(0.94); C398(0.97)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C293(1.00); C397(1.02); C398(1.06)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C293(0.96); C397(1.09); C398(1.12)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C293(1.11); C397(0.97); C398(1.00)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C398(0.85); C293(1.00); C397(1.04); C169(1.08)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C398(0.99); C397(1.01); C195(1.21); C169(1.28)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C397(0.88); C398(0.90); C195(1.04); C293(1.04)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C169(0.75); C398(0.80); C293(0.98); C397(1.02)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C398(0.90); C397(0.93); C293(1.04); C169(1.12)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C398(0.92); C397(1.04); C169(1.06); C293(1.11)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C398(0.91); C397(0.95); C169(0.98); C293(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C398(0.94); C169(1.00); C397(1.01); C293(1.08)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C398(0.88); C195(0.91); C397(0.91); C293(0.99)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C397(0.96); C169(1.00); C398(1.01); C293(1.01)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C397(0.96); C293(1.01); C398(1.01); C169(1.04)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C398(0.91); C397(0.91); C293(1.02); C169(1.07)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C169(1.03); C397(1.05); C293(1.08); C398(1.20)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C397(0.98); C398(1.01); C293(1.05); C169(1.05)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C195(0.81); C169(0.84); C398(0.85); C293(0.97)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C398(1.01); C293(1.07); C397(1.07); C169(1.14)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C397(0.96); C398(0.99); C293(1.00); C169(1.00)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C397(0.97); C398(0.98); C293(1.16); C169(1.17)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C397(0.97); C398(0.98); C293(1.03); C169(1.09)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C397(0.90); C398(0.96); C293(1.15); C169(1.19)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C398(0.93); C397(0.93); C293(1.01); C195(1.28)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C398(0.95); C293(0.96); C397(1.02); C195(1.29)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C293(0.93); C397(0.97); C398(1.01); C195(1.22)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C398(0.91); C397(0.95); C293(1.00); C195(1.71)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C293(1.01); C398(1.03); C397(1.03); C195(2.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C398(0.86); C169(0.94); C293(1.06); C195(1.24)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C293(1.09); C398(1.09); C397(1.10); C195(2.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C398(0.98); C293(0.98); C397(1.01); C195(1.70)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C293(1.04); C398(1.04); C397(1.11); C195(1.51)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C293(1.00); C398(1.09); C397(1.10); C195(1.58)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C398(1.02); C397(1.04); C293(1.08); C195(1.42)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C293(1.08); C397(1.08); C398(1.13); C195(1.60)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C169(0.80); C293(1.06); C397(1.07); C398(1.12)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C169(0.89); C293(1.06); C398(1.13); C397(1.18)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C169(0.80); C293(0.97); C397(1.05); C398(1.13)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C169(1.06); C397(1.23); C293(1.30); C398(1.42)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C169(0.81); C398(1.03); C293(1.09); C195(1.35)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C169(0.99); C397(1.11); C398(1.20); C293(1.24)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C169(0.73); C397(0.90); C293(0.95); C398(0.99)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C169(0.81); C397(1.00); C293(1.06); C398(1.17)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C397(1.00); C169(1.02); C398(1.09); C293(1.15)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C397(0.98); C169(1.04); C398(1.08); C293(1.18)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C397(1.13); C169(1.18); C398(1.23); C293(1.28)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C397(1.20); C169(1.30); C398(1.40); C195(1.50)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C398(0.94); C169(1.00); C397(1.01); C293(1.13)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C398(0.93); C169(0.99); C397(1.00); C293(1.16)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C398(0.93); C169(1.01); C397(1.07); C293(1.16)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C398(0.95); C397(0.97); C293(1.02); C169(1.08)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C398(0.81); C397(0.93); C169(1.02); C293(1.07)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C169(0.86); C398(0.88); C397(0.98); C293(1.07)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C169(0.96); C398(1.02); C397(1.12); C293(1.20)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C169(0.94); C398(1.05); C293(1.11); C397(1.27)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C169(0.91); C398(0.95); C397(1.08); C293(1.23)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C398(0.98); C169(1.07); C397(1.13); C293(1.18)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C398(0.92); C169(1.07); C397(1.09); C293(1.16)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C169(0.93); C398(1.02); C293(1.23); C397(1.30)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C398(0.94); C397(0.94); C417(0.94); C293(1.10)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C397(1.03); C398(1.03); C417(1.10); C293(1.16)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C397(0.92); C398(0.98); C293(0.99); C169(1.01)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C417(0.91); C398(0.99); C397(1.01); C293(1.14)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C398(0.89); C417(0.91); C397(0.95); C293(1.27)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C397(0.90); C398(0.90); C417(1.03); C293(1.17)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C398(1.06); C397(1.07); C293(1.31); C417(1.36)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C398(1.18); C397(1.19); C293(1.27); C417(1.49)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C397(1.01); C398(1.04); C417(1.37); C293(1.38)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C398(0.96); C397(0.99); C417(1.11); C293(1.22)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C417(0.93); C397(1.12); C293(1.12); C398(1.15)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C417(0.85); C397(0.92); C398(0.93); C293(0.96)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C417(0.91); C397(1.05); C398(1.09); C293(1.20)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C398(0.97); C169(0.98); C397(0.98); C293(1.08)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C417(1.03); C397(1.10); C293(1.13); C398(1.14)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C417(0.52); C398(0.85); C397(0.87); C293(1.25)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C398(1.05); C397(1.06); C417(1.29); C293(1.39)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C398(1.09); C397(1.21); C293(1.32)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C398(1.12); C397(1.23); C293(1.26)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C398(1.02); C293(1.09); C397(1.10)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C293(1.07); C398(1.09); C397(1.11)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C398(0.96); C397(1.01); C293(1.02)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C398(0.96); C397(1.00); C293(1.11)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C398(1.02); C397(1.06); C293(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C397(1.01); C293(1.04); C398(1.11)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C398(1.11); C293(1.29); C397(1.46)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C398(1.11); C397(1.15); C293(1.25)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C397(0.95); C398(1.08); C293(1.13)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C398(1.10); C293(1.11); C397(1.17)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C293(0.94); C398(0.95); C397(1.02)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C398(1.10); C397(1.11); C293(1.16)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C398(1.08); C397(1.16); C293(1.16)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C397(1.02); C398(1.02); C293(1.07)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C397(0.81); C398(0.81); C293(0.87)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C169(0.93); C293(0.98); C397(1.05); C398(1.00)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C398(0.92); C169(0.93); C397(0.96); C293(0.98)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C398(1.04); C397(1.08); C169(1.14); C293(1.37)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.25  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C582(0.98); C293(0.87)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C417(0.95); C397(0.96); C398(1.00); C293(1.05)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C417(0.88); C397(0.95); C398(1.00); C293(1.10)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C398(0.83); C169(0.83); C293(1.02); C397(1.08)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C398(0.89); C397(1.01); C293(1.03); C169(1.12)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C397(0.75); C398(0.80); C169(0.87); C293(1.00)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C398(0.80); C397(0.91); C293(0.95); C169(0.99)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C397(0.94); C398(0.95); C293(0.98); C169(1.07)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C398(0.87); C397(0.95); C293(1.03); C169(1.08)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C398(1.11); C397(1.13); C293(1.28); C169(1.37)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C398(0.94); C397(1.03); C293(1.25); C195(1.31)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C398(0.93); C397(1.11); C293(1.21); C169(1.64)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C398(0.86); C397(0.88); C293(1.02); C169(1.08)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C417(0.99); C397(1.02); C398(1.08); C293(1.16)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C397(0.97); C398(1.04); C293(1.13); C169(1.15)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C398(0.93); C397(1.03); C293(1.12); C169(1.18)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C398(0.95); C169(0.95); C397(0.96); C293(1.02)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C397(1.02); C398(1.06); C293(1.11); C169(1.13)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C169(0.88); C397(1.04); C398(1.05); C293(1.09)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C398(0.94); C397(0.98); C293(0.98); C169(1.01)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C397(0.91); C398(0.91); C169(1.00); C293(1.01)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C397(1.20); C398(1.31); C293(1.37); C195(2.30)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C398(1.01); C293(1.06); C397(1.08); C195(1.45)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C397(1.04); C293(1.06); C398(1.07); C195(1.46)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C397(0.99); C417(1.04); C398(1.04); C293(1.27)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C293(0.98); C398(0.98); C397(1.02); C195(1.65)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C169(0.54); C397(0.83); C293(0.92); C398(0.94)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C169(0.96); C397(1.03); C195(1.08); C293(1.10)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C397(1.05); C169(1.08); C293(1.08); C398(1.17)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C397(1.08); C293(1.22); C398(1.25); C169(1.31)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C398(0.85); C397(0.91); C169(0.93); C293(1.02)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C398(0.89); C169(0.89); C397(0.90); C293(0.97)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C398(0.82); C397(0.85); C169(1.01); C293(1.03)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C398(0.89); C169(0.93); C397(1.10); C293(1.15)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C397(0.95); C398(0.98); C293(1.06); C417(1.20)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C397(0.77); C398(0.80); C417(0.87); C293(0.98)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C397(0.90); C398(0.93); C417(1.00); C293(1.12)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C398(0.89); C397(0.89); C293(0.96); C417(1.15)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C417(0.84); C293(0.86); C169(0.91); C398(0.96)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C169(0.91); C293(0.94); C397(1.01); C398(1.02)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C417(0.97); C293(0.98); C397(1.01); C398(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C397(0.87); C417(0.89); C293(0.90); C398(0.93)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C397(0.92); C398(0.93); C293(0.98); C169(0.99)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C169(0.94); C293(0.94); C398(1.03); C397(1.08)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C293(1.19); C169(1.24); C398(1.41); C417(1.42)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C398(1.04); C293(1.06); C397(1.07); C169(1.12)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C169(1.11); C397(1.12); C293(1.13); C398(1.15)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C169(1.13); C293(1.06); C397(1.27); C398(1.15)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C169(1.10); C293(0.96); C397(1.04); C398(1.01)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C169(1.17); C293(0.91); C397(0.99); C398(0.98)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C169(0.98); C293(0.93); C397(0.99); C398(0.96)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C169(1.14); C293(0.99); C397(1.11); C398(1.05)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C195(1.15); C293(0.95); C397(0.85); C398(0.88)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C169(0.99); C293(0.99); C397(0.99); C398(0.98)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C169(1.18); C195(1.02); C293(0.98); C397(0.98)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C169(1.20); C195(0.98); C293(1.02); C397(0.84)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C169(1.26); C195(0.95); C293(0.97); C397(0.81)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C169(1.28); C195(0.96); C293(1.13); C397(0.94)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C169(1.22); C195(1.28); C293(1.11); C397(0.94)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C169(1.37); C195(1.32); C293(1.11); C397(0.96)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C169(1.27); C195(1.11); C293(1.14); C397(0.97)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C169(1.26); C195(0.88); C293(1.25); C397(0.97)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C195(1.34); C293(0.99); C397(0.84); C398(0.87)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C169(1.39); C195(0.92); C293(1.14); C397(0.91)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C169(1.20); C195(1.20); C293(1.06); C397(0.86)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C169(1.11); C195(0.88); C293(1.42); C397(1.17)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C169(1.19); C195(1.17); C293(1.26); C397(0.98)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C169(1.15); C195(1.10); C293(1.11); C397(0.79)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C169(1.30); C195(1.22); C293(1.16); C397(0.92)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C169(0.90); C397(0.91); C398(0.91); C417(1.30)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C169(0.83); C397(0.94); C398(0.93); C417(1.24)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C169(0.97); C397(0.87); C398(0.87); C417(1.35)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C169(1.10); C397(0.90); C398(0.90); C417(1.44)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C195(1.22); C293(0.98); C397(0.87); C398(0.90)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C169(1.16); C397(0.88); C398(0.84); C417(1.28)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C169(1.06); C397(0.95); C398(0.92); C417(1.38)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C169(0.92); C397(0.94); C398(0.94); C417(1.12)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C169(0.96); C397(0.90); C398(0.86); C417(1.36)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C169(1.08); C397(0.86); C398(0.87); C417(1.67)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C169(1.07); C397(0.92); C398(0.99); C417(1.37)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C169(1.09); C397(0.92); C398(0.94); C417(1.20)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C169(1.28); C397(0.83); C398(0.82); C417(1.00)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C169(1.00); C397(0.87); C398(0.87); C417(1.35)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C169(0.95); C397(0.96); C398(0.92); C417(1.07)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C195(1.24); C293(0.98); C397(0.92); C398(0.94)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C169(0.95); C397(0.88); C398(0.87); C417(1.20)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C169(1.21); C293(0.86); C397(1.06); C398(1.07)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C169(1.20); C293(0.77); C397(0.95); C398(1.21)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C169(1.27); C293(0.74); C397(0.98); C398(0.99)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C169(1.15); C293(0.99); C397(1.04); C398(1.04)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C169(1.18); C293(0.79); C397(1.05); C398(1.09)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C169(1.10); C293(0.91); C397(1.02); C398(1.02)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C169(1.13); C293(1.02); C397(1.04); C398(1.05)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C169(1.14); C293(0.84); C397(1.10); C398(1.18)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C169(1.12); C293(0.77); C397(0.89); C398(0.85)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C195(1.54); C293(1.04); C397(0.98); C398(1.01)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C169(1.17); C293(0.90); C397(0.96); C398(1.06)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C169(1.19); C293(0.93); C397(1.14); C398(1.02)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C169(0.99); C293(0.82); C397(0.95); C398(0.99)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C169(1.14); C293(0.93); C397(1.10); C398(1.03)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C169(1.11); C293(0.92); C397(0.94); C398(0.88)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C195(1.56); C293(1.02); C397(0.94); C398(1.01)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C195(1.24); C293(1.00); C397(0.97); C398(0.94)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C195(0.97); C293(1.05); C397(0.96); C398(0.95)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C195(1.33); C293(1.16); C397(1.07); C398(1.00)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C195(1.67); C293(1.76); C397(1.02); C398(1.09)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C195(1.22); C293(1.01); C397(0.96); C398(0.88)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C195(0.93); C293(1.04); C397(1.05); C398(0.99)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C195(0.95); C293(1.30); C397(1.26); C398(1.14)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C195(1.00); C293(1.25); C397(1.27); C398(1.16)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C195(0.87); C293(1.44); C397(1.38); C398(1.31)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C195(0.98); C293(1.08); C397(1.09); C398(1.00)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C195(1.23); C293(1.04); C397(1.06); C398(0.99)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C195(1.28); C293(1.07); C397(1.08); C398(1.04)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C195(1.21); C293(1.19); C397(1.13); C398(1.17)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C195(0.92); C293(1.61); C397(1.51); C398(1.41)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C195(0.88); C293(1.00); C397(0.82); C398(0.88)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C195(1.18); C293(0.99); C397(1.15); C398(0.99)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C169(0.90); C195(0.97); C293(0.99); C397(1.13)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C169(0.96); C195(0.85); C293(1.00); C397(1.12)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C169(0.98); C195(1.04); C293(0.95); C397(1.12)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C169(0.89); C195(2.00); C293(0.96); C397(1.16)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C169(0.86); C195(0.94); C293(0.98); C397(1.06)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C169(0.83); C195(1.18); C293(0.96); C397(1.03)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C169(0.97); C195(1.08); C293(0.97); C397(1.02)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C169(0.78); C195(1.00); C293(1.04); C397(1.19)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C169(0.72); C195(0.95); C293(0.99); C397(0.97)  LDD0811  [5]
 LDCM0185  Compound 17 HEK-293T 5.09  LDD0512  [14]
 LDCM0191  Compound 21 HEK-293T 11.98  LDD0508  [14]
 LDCM0190  Compound 34 HEK-293T 9.13  LDD0510  [14]
 LDCM0192  Compound 35 HEK-293T 8.97  LDD0509  [14]
 LDCM0193  Compound 36 HEK-293T 10.20  LDD0511  [14]
 LDCM0495  E2913 HEK-293T C582(0.89); C293(0.88); C169(1.09); C195(1.01)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C293(8.38)  LDD1702  [3]
 LDCM0625  F8 Ramos C293(1.18); C519(0.71); C582(1.03); C169(2.12)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C293(1.42); C519(0.37)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C519(0.13); C582(11.58); C169(1.13)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C519(0.64)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C293(0.78); C519(0.61)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C293(6.83); C519(1.02); C169(2.68)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C519(0.50)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C293(0.91); C519(0.51); 0.98  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C293(1.25); C519(1.32); C169(0.82)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C293(1.24); C519(0.49); 0.84  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C293(0.91); C519(0.88); 0.82; C582(0.78)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C293(0.82); C519(0.49)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C293(1.74); C519(0.63)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C293(1.94); C519(0.35)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C169(0.99); C293(0.88); C397(0.96); C398(0.87)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C293(0.92); C519(0.70); 0.74  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C293(5.02); C519(0.72); C582(0.60)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C169(1.63); C195(1.33); C293(1.34); C397(1.19)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C293(0.82); C519(0.51)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C293(0.91); C519(0.54)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C293(2.09); C519(0.70); C582(1.96); C169(2.93)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C519(0.57)  LDD2188  [17]
 LDCM0022  KB02 HCT 116 C397(4.79); C398(4.79)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C397(7.46); C398(7.46)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C397(10.74); C398(10.74)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C293(0.95)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0225  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C293(2.85)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C293(2.55)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C398(1.04)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C397(1.16)  LDD2119  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C293(2.86)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C398(0.64)  LDD2129  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C293(1.67)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C293(2.43)  LDD2140  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C293(0.66); C169(0.12)  LDD2207  [18]
 LDCM0131  RA190 MM1.R C195(1.79)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Negative elongation factor A (NELFA) NELF-A family Q9H3P2
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.