Details of the Target

General Information of Target

Target ID LDTP10056
Target Name Protein FAM162A (FAM162A)
Gene Name FAM162A
Gene ID 26355
Synonyms
C3orf28; E2IG5; Protein FAM162A; E2-induced gene 5 protein; Growth and transformation-dependent protein; HGTD-P
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCP
TCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVI
VQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLL
LHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHVLLHIQGTLTCSYLSHSEQLVFQ
SYEYVDCRGNASVPHQLTPHPP
Target Bioclass
Other
Family
UPF0389 family
Subcellular location
Mitochondrion membrane
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
Uniprot ID
Q96A26
Ensemble ID
ENST00000477892.5
HGNC ID
HGNC:17865

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		12.56  LDD0318  [1]
CHEMBL5175495
 Probe Info  		5.77  LDD0196  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y55(20.00)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
Jackson_14
 Probe Info  		2.56  LDD0123  [6]
5E-2FA
 Probe Info  		H129(0.00); H61(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
m-APA
 Probe Info  		H129(0.00); H61(0.00)  LDD2231  [7]
CY-1
 Probe Info  		K150(0.00); K152(0.00)  LDD0246  [3]
IPM
 Probe Info  		N.A.  LDD2156  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
STPyne
 Probe Info  		K98(0.00); K96(0.00)  LDD0009  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		H129(0.00); H61(0.00)  LDD0217  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 150 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		9.00  LDD1714  [14]
C007
 Probe Info  		5.06  LDD1716  [14]
C017
 Probe Info  		6.45  LDD1725  [14]
C022
 Probe Info  		29.45  LDD1728  [14]
C026
 Probe Info  		6.73  LDD1732  [14]
C027
 Probe Info  		5.54  LDD1733  [14]
C039
 Probe Info  		5.86  LDD1739  [14]
C040
 Probe Info  		41.36  LDD1740  [14]
C041
 Probe Info  		13.09  LDD1741  [14]
C049
 Probe Info  		8.17  LDD1747  [14]
C053
 Probe Info  		7.94  LDD1751  [14]
C055
 Probe Info  		45.25  LDD1752  [14]
C056
 Probe Info  		80.45  LDD1753  [14]
C063
 Probe Info  		27.10  LDD1760  [14]
C064
 Probe Info  		6.82  LDD1761  [14]
C070
 Probe Info  		18.51  LDD1766  [14]
C072
 Probe Info  		12.91  LDD1768  [14]
C082
 Probe Info  		6.54  LDD1774  [14]
C087
 Probe Info  		13.09  LDD1779  [14]
C091
 Probe Info  		64.89  LDD1782  [14]
C092
 Probe Info  		92.41  LDD1783  [14]
C094
 Probe Info  		99.73  LDD1785  [14]
C095
 Probe Info  		11.88  LDD1786  [14]
C100
 Probe Info  		13.93  LDD1789  [14]
C106
 Probe Info  		57.28  LDD1793  [14]
C107
 Probe Info  		9.32  LDD1794  [14]
C108
 Probe Info  		14.83  LDD1795  [14]
C112
 Probe Info  		72.00  LDD1799  [14]
C130
 Probe Info  		11.08  LDD1812  [14]
C134
 Probe Info  		67.18  LDD1816  [14]
C135
 Probe Info  		18.38  LDD1817  [14]
C139
 Probe Info  		14.32  LDD1821  [14]
C140
 Probe Info  		11.24  LDD1822  [14]
C141
 Probe Info  		19.16  LDD1823  [14]
C143
 Probe Info  		46.85  LDD1825  [14]
C147
 Probe Info  		7.31  LDD1829  [14]
C153
 Probe Info  		46.53  LDD1834  [14]
C159
 Probe Info  		10.78  LDD1839  [14]
C160
 Probe Info  		10.20  LDD1840  [14]
C161
 Probe Info  		19.56  LDD1841  [14]
C163
 Probe Info  		5.86  LDD1843  [14]
C165
 Probe Info  		12.55  LDD1845  [14]
C169
 Probe Info  		28.84  LDD1849  [14]
C177
 Probe Info  		8.17  LDD1856  [14]
C178
 Probe Info  		39.12  LDD1857  [14]
C183
 Probe Info  		4.99  LDD1861  [14]
C186
 Probe Info  		14.42  LDD1864  [14]
C187
 Probe Info  		42.52  LDD1865  [14]
C191
 Probe Info  		12.13  LDD1868  [14]
C193
 Probe Info  		5.70  LDD1869  [14]
C194
 Probe Info  		12.21  LDD1870  [14]
C196
 Probe Info  		11.47  LDD1872  [14]
C198
 Probe Info  		10.20  LDD1874  [14]
C201
 Probe Info  		93.70  LDD1877  [14]
C206
 Probe Info  		32.00  LDD1881  [14]
C210
 Probe Info  		99.73  LDD1884  [14]
C211
 Probe Info  		11.79  LDD1885  [14]
C213
 Probe Info  		38.85  LDD1887  [14]
C214
 Probe Info  		5.54  LDD1888  [14]
C216
 Probe Info  		8.82  LDD1890  [14]
C217
 Probe Info  		6.36  LDD1891  [14]
C218
 Probe Info  		99.73  LDD1892  [14]
C219
 Probe Info  		20.82  LDD1893  [14]
C220
 Probe Info  		99.73  LDD1894  [14]
C225
 Probe Info  		9.78  LDD1898  [14]
C226
 Probe Info  		10.41  LDD1899  [14]
C228
 Probe Info  		75.06  LDD1901  [14]
C229
 Probe Info  		36.50  LDD1902  [14]
C231
 Probe Info  		99.73  LDD1904  [14]
C232
 Probe Info  		99.73  LDD1905  [14]
C233
 Probe Info  		58.89  LDD1906  [14]
C234
 Probe Info  		32.67  LDD1907  [14]
C235
 Probe Info  		99.73  LDD1908  [14]
C238
 Probe Info  		36.25  LDD1911  [14]
C240
 Probe Info  		11.88  LDD1913  [14]
C243
 Probe Info  		19.84  LDD1916  [14]
C244
 Probe Info  		24.42  LDD1917  [14]
C245
 Probe Info  		5.78  LDD1918  [14]
C246
 Probe Info  		45.25  LDD1919  [14]
C249
 Probe Info  		16.91  LDD1922  [14]
C252
 Probe Info  		18.51  LDD1925  [14]
C258
 Probe Info  		5.35  LDD1931  [14]
C264
 Probe Info  		48.84  LDD1935  [14]
C265
 Probe Info  		26.35  LDD1936  [14]
C270
 Probe Info  		11.47  LDD1940  [14]
C273
 Probe Info  		6.36  LDD1943  [14]
C277
 Probe Info  		18.90  LDD1947  [14]
C278
 Probe Info  		99.73  LDD1948  [14]
C280
 Probe Info  		9.32  LDD1950  [14]
C282
 Probe Info  		33.59  LDD1952  [14]
C284
 Probe Info  		41.36  LDD1954  [14]
C285
 Probe Info  		65.80  LDD1955  [14]
C287
 Probe Info  		23.10  LDD1957  [14]
C288
 Probe Info  		11.39  LDD1958  [14]
C289
 Probe Info  		83.87  LDD1959  [14]
C293
 Probe Info  		37.53  LDD1963  [14]
C296
 Probe Info  		28.25  LDD1966  [14]
C299
 Probe Info  		12.13  LDD1968  [14]
C305
 Probe Info  		16.11  LDD1974  [14]
C307
 Probe Info  		5.31  LDD1975  [14]
C310
 Probe Info  		16.68  LDD1977  [14]
C313
 Probe Info  		21.41  LDD1980  [14]
C314
 Probe Info  		25.28  LDD1981  [14]
C322
 Probe Info  		6.54  LDD1988  [14]
C326
 Probe Info  		10.06  LDD1990  [14]
C338
 Probe Info  		15.67  LDD2001  [14]
C339
 Probe Info  		11.71  LDD2002  [14]
C343
 Probe Info  		37.27  LDD2005  [14]
C348
 Probe Info  		26.17  LDD2009  [14]
C349
 Probe Info  		38.85  LDD2010  [14]
C350
 Probe Info  		99.73  LDD2011  [14]
C353
 Probe Info  		6.15  LDD2014  [14]
C354
 Probe Info  		8.28  LDD2015  [14]
C355
 Probe Info  		38.59  LDD2016  [14]
C356
 Probe Info  		14.52  LDD2017  [14]
C357
 Probe Info  		7.41  LDD2018  [14]
C362
 Probe Info  		99.73  LDD2023  [14]
C363
 Probe Info  		50.91  LDD2024  [14]
C364
 Probe Info  		64.45  LDD2025  [14]
C366
 Probe Info  		18.90  LDD2027  [14]
C367
 Probe Info  		10.20  LDD2028  [14]
C373
 Probe Info  		7.94  LDD2033  [14]
C376
 Probe Info  		8.11  LDD2036  [14]
C382
 Probe Info  		11.24  LDD2041  [14]
C383
 Probe Info  		14.52  LDD2042  [14]
C386
 Probe Info  		7.06  LDD2045  [14]
C388
 Probe Info  		99.73  LDD2047  [14]
C390
 Probe Info  		99.73  LDD2049  [14]
C391
 Probe Info  		13.09  LDD2050  [14]
C397
 Probe Info  		11.47  LDD2056  [14]
C399
 Probe Info  		13.45  LDD2058  [14]
C403
 Probe Info  		41.93  LDD2061  [14]
C405
 Probe Info  		7.41  LDD2063  [14]
C407
 Probe Info  		84.45  LDD2064  [14]
C408
 Probe Info  		6.15  LDD2065  [14]
C409
 Probe Info  		10.63  LDD2066  [14]
C419
 Probe Info  		14.62  LDD2074  [14]
C420
 Probe Info  		18.77  LDD2075  [14]
C423
 Probe Info  		9.45  LDD2078  [14]
C424
 Probe Info  		11.00  LDD2079  [14]
C426
 Probe Info  		33.59  LDD2081  [14]
C429
 Probe Info  		19.84  LDD2084  [14]
C431
 Probe Info  		28.25  LDD2086  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
JN0003
 Probe Info  		20.00  LDD0469  [15]
OEA-DA
 Probe Info  		17.38  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H61(0.00); H129(0.00)  LDD0222  [12]
 LDCM0107  IAA HeLa H129(0.00); H61(0.00)  LDD0221  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.56  LDD0123  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570