Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C405  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 20.7
 LDTP01329  Lathosterol oxidase (SC5D) 18.1
 LDTP00076  Plasmanylethanolamine desaturase 1 (PEDS1) 16.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 16.1
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 11.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 8.9
 LDTP01769  Dihydrofolate reductase (DHFR) 8.3
 LDTP06617  Ceramide glucosyltransferase (UGCG) 7.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.5
 LDTP02505  Lysosomal protective protein (CTSA) 7.2
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.1
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 6.9
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 6.9
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 6.8
 LDTP03842  Squalene synthase (FDFT1) 6.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 6.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 6.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 5.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.4
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 5.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 5.3
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 5.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.1
Transporter and channel
Click to Show/Hide to Show 24 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 31.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 21.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 15.5
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 12.9
 LDTP08881  Transmembrane protein 199 (TMEM199) 10.9
 LDTP12383  Protein GPR108 (GPR108) 10.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 10.1
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 9.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 9.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 9.3
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 8.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 8.2
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 7.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 7.3
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 6.7
 LDTP02215  Prosaposin (PSAP) 6.3
 LDTP07236  Protein GPR107 (GPR107) 6.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 6.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 5.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 5.5
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.5
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.4
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 5.4
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02775  Interferon gamma receptor 1 (IFNGR1) 11.3
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 38.1
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 19.2
 LDTP05160  Nucleobindin-2 (NUCB2) 18.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 13.8
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 12.8
 LDTP11076  Apolipoprotein L2 (APOL2) 12.1
 LDTP05375  Nucleobindin-1 (NUCB1) 12.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 9.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 9.1
 LDTP18883  Protein CEBPZOS (CEBPZOS) 8.8
 LDTP10056  Protein FAM162A (FAM162A) 7.4
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 7.4
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 7.0
 LDTP04914  Large ribosomal subunit protein uL24 (RPL26) 5.7
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.6
 LDTP06154  Desmocollin-3 (DSC3) 5.1
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 5.1
 LDTP09773  Protein FAM3C (FAM3C) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587