Details of the Target

General Information of Target

Target ID LDTP09773
Target Name Protein FAM3C (FAM3C)
Gene Name FAM3C
Gene ID 10447
Synonyms
ILEI; Protein FAM3C; Interleukin-like EMT inducer
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSC
IGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEII
LGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK
FIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSL
GVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQ
EILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN
Target Bioclass
Other
Family
FAM3 family
Subcellular location
Secreted
Function May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Uniprot ID
Q92520
Ensemble ID
ENST00000359943.8
HGNC ID
HGNC:18664

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.39  LDD0402  [1]
STPyne
 Probe Info  		K193(4.12); K97(7.69)  LDD0277  [2]
BTD
 Probe Info  		C58(0.74)  LDD2089  [3]
Jackson_14
 Probe Info  		2.00  LDD0123  [4]
DBIA
 Probe Info  		C185(1.37)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C185(0.00); C86(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C185(0.00); C86(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C185(0.00); C86(0.00)  LDD0037  [6]
ATP probe
 Probe Info  		K97(0.00); K67(0.00); K193(0.00)  LDD0035  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		C64(0.00); C185(0.00); C86(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		19.29  LDD1740  [10]
C055
 Probe Info  		17.15  LDD1752  [10]
C056
 Probe Info  		38.05  LDD1753  [10]
C063
 Probe Info  		24.93  LDD1760  [10]
C070
 Probe Info  		8.57  LDD1766  [10]
C091
 Probe Info  		29.86  LDD1782  [10]
C092
 Probe Info  		51.27  LDD1783  [10]
C094
 Probe Info  		51.27  LDD1785  [10]
C112
 Probe Info  		39.12  LDD1799  [10]
C134
 Probe Info  		53.08  LDD1816  [10]
C135
 Probe Info  		18.13  LDD1817  [10]
C139
 Probe Info  		13.18  LDD1821  [10]
C140
 Probe Info  		8.88  LDD1822  [10]
C143
 Probe Info  		13.27  LDD1825  [10]
C159
 Probe Info  		7.62  LDD1839  [10]
C161
 Probe Info  		12.13  LDD1841  [10]
C169
 Probe Info  		29.04  LDD1849  [10]
C183
 Probe Info  		4.92  LDD1861  [10]
C186
 Probe Info  		7.89  LDD1864  [10]
C228
 Probe Info  		16.00  LDD1901  [10]
C238
 Probe Info  		13.09  LDD1911  [10]
C264
 Probe Info  		28.25  LDD1935  [10]
C265
 Probe Info  		15.03  LDD1936  [10]
C270
 Probe Info  		6.45  LDD1940  [10]
C278
 Probe Info  		56.49  LDD1948  [10]
C282
 Probe Info  		20.39  LDD1952  [10]
C284
 Probe Info  		21.11  LDD1954  [10]
C285
 Probe Info  		21.86  LDD1955  [10]
C287
 Probe Info  		9.38  LDD1957  [10]
C289
 Probe Info  		42.22  LDD1959  [10]
C293
 Probe Info  		22.63  LDD1963  [10]
C348
 Probe Info  		12.73  LDD2009  [10]
C349
 Probe Info  		22.32  LDD2010  [10]
C350
 Probe Info  		66.26  LDD2011  [10]
C376
 Probe Info  		6.50  LDD2036  [10]
C382
 Probe Info  		8.82  LDD2041  [10]
C388
 Probe Info  		79.34  LDD2047  [10]
C390
 Probe Info  		51.27  LDD2049  [10]
C399
 Probe Info  		9.38  LDD2058  [10]
C403
 Probe Info  		30.48  LDD2061  [10]
C405
 Probe Info  		4.96  LDD2063  [10]
C407
 Probe Info  		29.04  LDD2064  [10]
C409
 Probe Info  		5.28  LDD2066  [10]
C429
 Probe Info  		14.62  LDD2084  [10]
FFF probe11
 Probe Info  		20.00  LDD0471  [11]
FFF probe12
 Probe Info  		6.41  LDD0473  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]
Alk-rapa
 Probe Info  		3.16  LDD0213  [12]
OEA-DA
 Probe Info  		17.07  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C58(0.89)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C58(1.01)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C185(1.07)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C185(1.08)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C185(0.75)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C185(0.80)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C185(0.86)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C185(0.72)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C185(1.05)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C185(0.80)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C185(0.76)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C185(0.87)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C185(0.67)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C185(0.98)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C185(0.98)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C185(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C185(0.59)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C185(0.57)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C185(1.39)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C185(1.19)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C185(0.97)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C185(0.95)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C185(1.22)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C185(1.34)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C185(1.10)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C185(1.21)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C185(1.24)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C185(1.36)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C185(1.12)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C185(1.41)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C185(1.22)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C185(1.39)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C185(0.97)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C185(1.14)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C185(0.77)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C185(1.17)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C185(0.93)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C185(1.27)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C185(1.03)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C185(0.99)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C185(0.69)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C185(0.76)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C185(0.93)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C185(1.01)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C185(0.60)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C185(0.71)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C185(1.06)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C185(0.56)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C185(0.64)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C185(0.97)  LDD0579  [5]
 LDCM0263  AC143 HEK-293T C185(1.08)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C185(0.85)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C185(0.94)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C185(1.02)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C185(0.87)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C185(0.93)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C185(0.92)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C185(1.08)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C185(0.90)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C185(0.83)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C185(1.19)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C185(0.87)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C185(0.87)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C185(0.92)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C185(0.94)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C185(1.01)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C185(1.24)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C185(1.24)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C185(1.15)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C185(0.93)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C185(1.05)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C185(1.09)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C185(1.06)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C185(1.19)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C185(1.19)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C185(1.10)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C185(0.69)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C185(0.89)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C185(0.71)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C185(0.49)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C185(0.97)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C185(0.49)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C185(0.62)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C185(0.44)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C185(0.94)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C185(0.87)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C185(1.46)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C185(1.26)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C185(1.67)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C185(1.05)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C185(0.93)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C185(1.01)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C185(0.78)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C185(1.14)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C185(0.94)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C185(0.86)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C185(1.37)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C185(1.10)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C185(1.01)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C185(0.96)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C185(1.02)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C185(0.47)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C185(1.00)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C185(0.50)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C185(1.39)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C185(0.94)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C185(0.77)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C185(0.70)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C185(0.63)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C185(0.36)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C185(0.92)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C185(0.79)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C185(0.54)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C185(0.86)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C185(0.73)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C185(1.02)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C185(0.44)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C185(0.80)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C185(0.58)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C185(0.67)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C185(0.78)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C185(0.39)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C185(0.83)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C185(0.94)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C185(1.11)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C185(0.77)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C185(1.38)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C185(0.98)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C185(0.55)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C185(0.62)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C185(0.73)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C185(0.67)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C185(0.79)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C185(1.27)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C185(1.01)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C185(0.93)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C185(0.82)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C185(1.08)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C185(0.59)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C185(0.48)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C185(0.50)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C185(0.96)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C185(0.84)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C185(0.99)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C185(0.92)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C185(0.70)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C185(2.45)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C185(0.44)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C185(0.36)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C185(0.91)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C185(1.25)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C185(1.19)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C185(0.75)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C185(0.60)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C185(0.67)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C185(0.69)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C58(0.62)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C58(1.17)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C185(1.24)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C185(1.11)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C185(0.62)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.59  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C58(0.55)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C185(0.97)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C185(0.75)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C185(0.99)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C185(1.00)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C185(1.20)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C185(1.21)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C185(1.30)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C185(1.31)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C185(1.04)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C185(1.12)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C185(1.09)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C185(1.21)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C185(0.59)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C185(1.09)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C185(0.93)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C185(0.74)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C185(0.48)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C185(0.46)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C185(0.69)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C185(0.87)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C185(0.44)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C185(0.86)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C185(0.81)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C185(0.49)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C185(0.94)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C185(0.80)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C185(0.88)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C185(0.68)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C185(0.53)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C185(1.82)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C185(0.98)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C185(0.92)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C185(0.66)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C185(0.83)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C185(0.90)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C185(0.63)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C185(0.78)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C185(0.96)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C185(1.33)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C185(0.85)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C185(1.03)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C185(0.70)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C185(0.59)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C185(0.62)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C185(0.67)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C185(0.48)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C185(0.59)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C185(0.56)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C185(0.90)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C185(0.66)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C185(0.68)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C185(1.01)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C185(0.96)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C185(0.86)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C185(0.99)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C185(0.89)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C185(0.45)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C185(0.48)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C185(0.60)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C185(0.41)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C185(0.48)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C185(0.90)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C185(0.54)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C185(0.66)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C185(0.37)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C185(0.40)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C185(0.66)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C185(0.49)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C185(0.98)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C185(0.90)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C185(1.00)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C185(1.22)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C185(0.98)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C185(1.12)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C185(0.95)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C185(0.92)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C185(0.96)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C185(0.96)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C185(0.98)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C185(0.89)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C185(1.12)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C185(0.93)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C185(1.09)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C185(1.01)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C185(1.15)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C185(1.43)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C185(1.47)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C185(1.52)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C185(1.59)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C185(1.37)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C185(1.42)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C185(1.45)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C185(1.20)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C185(1.31)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C185(0.79)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C185(1.16)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C185(1.30)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C185(1.32)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C185(1.15)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C185(1.47)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C185(0.96)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C185(0.68)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C185(0.78)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C185(0.63)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C185(0.51)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C185(1.19)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C185(0.81)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C185(0.49)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C185(0.46)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C185(0.33)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C185(0.83)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C185(1.71)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C185(0.92)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C185(0.48)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C185(0.37)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C185(0.82)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C185(0.65)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C185(0.86)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C185(0.95)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C185(1.05)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C185(0.96)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C185(1.01)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C185(0.94)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C185(0.86)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C185(0.97)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C185(0.96)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C185(1.20); C86(1.07)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C185(1.51)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C185(0.38)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C185(1.37)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C185(1.88)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C185(1.57)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C58(0.60)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C58(0.74)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C58(1.34)  LDD2093  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C58(0.67)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C58(0.88)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C58(0.89); C86(1.16)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C185(0.26)  LDD2100  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C58(0.63); C86(0.89)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C58(1.79)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C58(0.81)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C58(0.75)  LDD2115  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C58(1.11)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C58(0.91)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C58(0.92); C86(1.12)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C58(0.96)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C58(0.99)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C58(0.99)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C58(0.58)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C58(0.98); C86(1.10)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C58(0.92); C86(1.17)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C58(1.01); C86(1.00)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C185(0.41)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C58(2.52)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C58(0.79)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C58(0.82)  LDD2148  [3]
 LDCM0131  RA190 MM1.R C185(1.07)  LDD0304  [15]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [4]
 LDCM0090  Rapamycin JHH-7 3.16  LDD0213  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Glutathione hydrolase 6 (GGT6) Gamma-glutamyltransferase family Q6P531
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Ribonuclease H1 (RNASEH1) RNase H family O60930
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Syncytin-2 (ERVFRD-1) Gamma type-C retroviral envelope protein family P60508
Transmembrane 4 L6 family member 18 (TM4SF18) L6 tetraspanin family Q96CE8
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Syntaxin-1A (STX1A) Syntaxin family Q16623
Sortilin (SORT1) VPS10-related sortilin family Q99523
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Immunoglobulin
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
IgG receptor FcRn large subunit p51 (FCGRT) Immunoglobulin superfamily P55899
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) Immunoglobulin superfamily P12314
Nectin-1 (NECTIN1) Nectin family Q15223
Coxsackievirus and adenovirus receptor (CXADR) . P78310
HERV-H LTR-associating protein 2 (HHLA2) . Q9UM44
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-7 receptor subunit alpha (IL7R) Type I cytokine receptor family P16871
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction beta-5 protein (GJB5) Connexin family O95377
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RELT-like protein 2 (RELL2) RELT family Q8NC24
Regulator of microtubule dynamics protein 3 (RMDN3) RMDN family Q96TC7
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
Bcl-2-interacting killer (BIK) . Q13323
C-type lectin domain family 17, member A (CLEC17A) . Q6ZS10
C-type lectin domain family 4 member E (CLEC4E) . Q9ULY5
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Testis-expressed protein 29 (TEX29) . Q8N6K0
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.