Details of the Target

General Information of Target

Target ID LDTP04914
Target Name Large ribosomal subunit protein uL24 (RPL26)
Gene Name RPL26
Gene ID 6154
Synonyms
Large ribosomal subunit protein uL24; 60S ribosomal protein L26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRG
HYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILE
RKAKSRQVGKEKGKYKEETIEKMQE
Target Bioclass
Other
Family
Universal ribosomal protein uL24 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P61254
Ensemble ID
ENST00000582556.5
HGNC ID
HGNC:10327

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.21  LDD0215  [1]
AZ-9
 Probe Info  		4.39  LDD0393  [2]
C-Sul
 Probe Info  		4.15  LDD0066  [3]
TH211
 Probe Info  		Y74(20.00); Y78(13.67); Y135(10.70)  LDD0257  [4]
TH216
 Probe Info  		Y78(17.86); Y74(16.24); Y135(13.38)  LDD0259  [4]
STPyne
 Probe Info  		K110(4.40); K134(10.00); K136(6.67); K2(8.45)  LDD0277  [5]
ONAyne
 Probe Info  		K28(0.00); K36(0.00); K41(0.00); K51(0.00)  LDD0273  [5]
OPA-S-S-alkyne
 Probe Info  		K36(1.79); K51(2.85)  LDD3494  [6]
HHS-475
 Probe Info  		Y135(0.77)  LDD0264  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
AMP probe
 Probe Info  		N.A.  LDD0200  [9]
ATP probe
 Probe Info  		K36(0.00); K28(0.00); K51(0.00); K134(0.00)  LDD0199  [9]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
ATP probe
 Probe Info  		K134(0.00); K77(0.00); K103(0.00); K63(0.00)  LDD0035  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
OSF
 Probe Info  		Y74(0.00); H96(0.00)  LDD0029  [12]
SF
 Probe Info  		Y81(0.00); Y135(0.00); Y78(0.00); Y74(0.00)  LDD0028  [12]
Acrolein
 Probe Info  		H24(0.00); H18(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		H24(0.00); H18(0.00)  LDD0219  [13]
Methacrolein
 Probe Info  		H24(0.00); H18(0.00)  LDD0218  [13]
HHS-482
 Probe Info  		Y135(1.28)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		18.13  LDD1865  [15]
C191
 Probe Info  		14.32  LDD1868  [15]
C193
 Probe Info  		7.06  LDD1869  [15]
C405
 Probe Info  		5.70  LDD2063  [15]
C407
 Probe Info  		19.43  LDD2064  [15]
C408
 Probe Info  		6.06  LDD2065  [15]
C409
 Probe Info  		7.26  LDD2066  [15]
FFF probe4
 Probe Info  		6.61  LDD0466  [16]
STS-1
 Probe Info  		N.A.  LDD0137  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H24(0.00); H18(0.00)  LDD0222  [13]
 LDCM0116  HHS-0101 DM93 Y135(0.77)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y135(0.83)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y135(1.60)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y135(0.95)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y135(0.64)  LDD0268  [7]
 LDCM0107  IAA HeLa H24(0.00); H18(0.00)  LDD0221  [13]
 LDCM0109  NEM HeLa H24(0.00); H18(0.00)  LDD0223  [13]

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.