Details of the Target

General Information of Target

Target ID LDTP09968
Target Name V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1)
Gene Name ATP6V0A1
Gene ID 535
Synonyms
ATP6N1; ATP6N1A; VPP1; V-type proton ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a 1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP
PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA
LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
Target Bioclass
Transporter and channel
Family
V-ATPase 116 kDa subunit family
Subcellular location
Cytoplasmic vesicle, clathrin-coated vesicle membrane
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment. Required for assembly and activity of the vacuolar ATPase. Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons.
Uniprot ID
Q93050
Ensemble ID
ENST00000264649.10
HGNC ID
HGNC:865

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		N.A.  LDD0273  [1]
IPM
 Probe Info  		C58(0.00); C247(0.00)  LDD0241  [2]
OPA-S-S-alkyne
 Probe Info  		K70(0.55)  LDD3494  [3]
DBIA
 Probe Info  		C244(4.60)  LDD3310  [4]
BTD
 Probe Info  		C58(0.60)  LDD2091  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C310(0.00); C247(0.00); C237(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C310(0.00); C247(0.00); C237(0.00)  LDD0037  [6]
STPyne
 Probe Info  		N.A.  LDD0009  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
W1
 Probe Info  		N.A.  LDD0236  [2]
NAIA_5
 Probe Info  		C310(0.00); C58(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 143 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.54  LDD1711  [11]
C004
 Probe Info  		6.23  LDD1714  [11]
C018
 Probe Info  		5.21  LDD1726  [11]
C022
 Probe Info  		9.71  LDD1728  [11]
C039
 Probe Info  		12.73  LDD1739  [11]
C040
 Probe Info  		20.82  LDD1740  [11]
C041
 Probe Info  		8.11  LDD1741  [11]
C052
 Probe Info  		6.15  LDD1750  [11]
C053
 Probe Info  		7.78  LDD1751  [11]
C055
 Probe Info  		20.39  LDD1752  [11]
C063
 Probe Info  		19.16  LDD1760  [11]
C070
 Probe Info  		14.83  LDD1766  [11]
C082
 Probe Info  		19.70  LDD1774  [11]
C087
 Probe Info  		10.13  LDD1779  [11]
C091
 Probe Info  		21.71  LDD1782  [11]
C092
 Probe Info  		39.95  LDD1783  [11]
C095
 Probe Info  		8.34  LDD1786  [11]
C106
 Probe Info  		17.88  LDD1793  [11]
C112
 Probe Info  		26.17  LDD1799  [11]
C129
 Probe Info  		14.62  LDD1811  [11]
C134
 Probe Info  		31.12  LDD1816  [11]
C135
 Probe Info  		9.58  LDD1817  [11]
C139
 Probe Info  		11.39  LDD1821  [11]
C140
 Probe Info  		15.67  LDD1822  [11]
C142
 Probe Info  		7.94  LDD1824  [11]
C143
 Probe Info  		29.04  LDD1825  [11]
C145
 Probe Info  		9.25  LDD1827  [11]
C147
 Probe Info  		12.73  LDD1829  [11]
C153
 Probe Info  		14.93  LDD1834  [11]
C159
 Probe Info  		16.80  LDD1839  [11]
C160
 Probe Info  		7.26  LDD1840  [11]
C161
 Probe Info  		31.12  LDD1841  [11]
C165
 Probe Info  		31.12  LDD1845  [11]
C166
 Probe Info  		13.09  LDD1846  [11]
C169
 Probe Info  		27.67  LDD1849  [11]
C170
 Probe Info  		7.62  LDD1850  [11]
C173
 Probe Info  		5.94  LDD1853  [11]
C174
 Probe Info  		6.36  LDD1854  [11]
C177
 Probe Info  		14.62  LDD1856  [11]
C183
 Probe Info  		9.25  LDD1861  [11]
C185
 Probe Info  		6.82  LDD1863  [11]
C186
 Probe Info  		19.29  LDD1864  [11]
C187
 Probe Info  		38.85  LDD1865  [11]
C193
 Probe Info  		9.92  LDD1869  [11]
C197
 Probe Info  		9.65  LDD1873  [11]
C198
 Probe Info  		12.64  LDD1874  [11]
C201
 Probe Info  		52.71  LDD1877  [11]
C204
 Probe Info  		5.58  LDD1879  [11]
C205
 Probe Info  		11.63  LDD1880  [11]
C206
 Probe Info  		26.17  LDD1881  [11]
C210
 Probe Info  		46.85  LDD1884  [11]
C213
 Probe Info  		19.84  LDD1887  [11]
C218
 Probe Info  		17.03  LDD1892  [11]
C219
 Probe Info  		5.86  LDD1893  [11]
C220
 Probe Info  		31.56  LDD1894  [11]
C225
 Probe Info  		9.92  LDD1898  [11]
C228
 Probe Info  		48.17  LDD1901  [11]
C229
 Probe Info  		17.51  LDD1902  [11]
C231
 Probe Info  		41.36  LDD1904  [11]
C232
 Probe Info  		47.18  LDD1905  [11]
C233
 Probe Info  		16.34  LDD1906  [11]
C235
 Probe Info  		22.47  LDD1908  [11]
C240
 Probe Info  		12.64  LDD1913  [11]
C244
 Probe Info  		24.59  LDD1917  [11]
C246
 Probe Info  		22.63  LDD1919  [11]
C249
 Probe Info  		18.13  LDD1922  [11]
C252
 Probe Info  		15.67  LDD1925  [11]
C260
 Probe Info  		5.17  LDD1932  [11]
C264
 Probe Info  		30.06  LDD1935  [11]
C265
 Probe Info  		17.88  LDD1936  [11]
C270
 Probe Info  		6.82  LDD1940  [11]
C273
 Probe Info  		9.71  LDD1943  [11]
C280
 Probe Info  		11.24  LDD1950  [11]
C282
 Probe Info  		22.01  LDD1952  [11]
C284
 Probe Info  		24.76  LDD1954  [11]
C286
 Probe Info  		15.78  LDD1956  [11]
C287
 Probe Info  		23.75  LDD1957  [11]
C288
 Probe Info  		6.23  LDD1958  [11]
C290
 Probe Info  		6.77  LDD1960  [11]
C293
 Probe Info  		22.16  LDD1963  [11]
C296
 Probe Info  		19.16  LDD1966  [11]
C299
 Probe Info  		6.02  LDD1968  [11]
C305
 Probe Info  		23.75  LDD1974  [11]
C307
 Probe Info  		5.21  LDD1975  [11]
C310
 Probe Info  		14.52  LDD1977  [11]
C313
 Probe Info  		19.16  LDD1980  [11]
C314
 Probe Info  		23.59  LDD1981  [11]
C317
 Probe Info  		9.65  LDD1983  [11]
C320
 Probe Info  		5.70  LDD1986  [11]
C322
 Probe Info  		10.48  LDD1988  [11]
C326
 Probe Info  		8.88  LDD1990  [11]
C337
 Probe Info  		5.28  LDD2000  [11]
C338
 Probe Info  		17.03  LDD2001  [11]
C339
 Probe Info  		16.22  LDD2002  [11]
C343
 Probe Info  		13.74  LDD2005  [11]
C346
 Probe Info  		12.30  LDD2007  [11]
C348
 Probe Info  		66.26  LDD2009  [11]
C349
 Probe Info  		18.51  LDD2010  [11]
C350
 Probe Info  		59.30  LDD2011  [11]
C353
 Probe Info  		17.39  LDD2014  [11]
C354
 Probe Info  		8.34  LDD2015  [11]
C355
 Probe Info  		38.32  LDD2016  [11]
C356
 Probe Info  		34.06  LDD2017  [11]
C357
 Probe Info  		5.54  LDD2018  [11]
C362
 Probe Info  		32.67  LDD2023  [11]
C363
 Probe Info  		32.00  LDD2024  [11]
C364
 Probe Info  		24.08  LDD2025  [11]
C367
 Probe Info  		8.75  LDD2028  [11]
C378
 Probe Info  		6.15  LDD2037  [11]
C379
 Probe Info  		5.86  LDD2038  [11]
C380
 Probe Info  		6.32  LDD2039  [11]
C382
 Probe Info  		18.90  LDD2041  [11]
C383
 Probe Info  		15.14  LDD2042  [11]
C390
 Probe Info  		61.39  LDD2049  [11]
C391
 Probe Info  		20.97  LDD2050  [11]
C399
 Probe Info  		7.46  LDD2058  [11]
C403
 Probe Info  		36.50  LDD2061  [11]
C405
 Probe Info  		5.35  LDD2063  [11]
C407
 Probe Info  		14.83  LDD2064  [11]
C408
 Probe Info  		5.94  LDD2065  [11]
C413
 Probe Info  		45.89  LDD2069  [11]
C419
 Probe Info  		24.42  LDD2074  [11]
C420
 Probe Info  		18.64  LDD2075  [11]
C423
 Probe Info  		7.11  LDD2078  [11]
C426
 Probe Info  		26.91  LDD2081  [11]
C429
 Probe Info  		15.45  LDD2084  [11]
C431
 Probe Info  		20.25  LDD2086  [11]
C433
 Probe Info  		25.99  LDD2088  [11]
FFF probe11
 Probe Info  		20.00  LDD0471  [12]
FFF probe12
 Probe Info  		13.06  LDD0473  [12]
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe14
 Probe Info  		16.84  LDD0477  [12]
FFF probe15
 Probe Info  		15.00  LDD0478  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]
FFF probe3
 Probe Info  		16.75  LDD0464  [12]
FFF probe6
 Probe Info  		6.60  LDD0467  [12]
FFF probe7
 Probe Info  		8.48  LDD0483  [12]
FFF probe9
 Probe Info  		9.04  LDD0470  [12]
JN0003
 Probe Info  		20.00  LDD0469  [12]
STS-1
 Probe Info  		N.A.  LDD0136  [13]
STS-2
 Probe Info  		N.A.  LDD0138  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]
OEA-DA
 Probe Info  		20.00  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C58(1.26)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C237(1.04); C58(1.20)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C237(1.04)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C237(1.27)  LDD2103  [5]
 LDCM0214  AC1 HEK-293T C247(0.90); C310(0.92); C58(0.91); C325(1.22)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C247(1.02); C310(0.97); C318(1.44)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C247(1.08); C310(0.88); C325(0.93); C24(1.02)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C247(0.94); C310(0.99); C325(0.95)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C247(1.31); C310(0.94); C58(1.07); C325(1.09)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C247(1.08); C310(0.86); C58(1.07); C325(1.30)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C247(0.84); C310(0.91); C58(1.05); C325(1.34)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C247(1.08); C310(0.89); C318(1.00)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C247(0.96); C310(1.02); C325(0.76); C24(0.85)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C247(1.06); C310(0.98); C318(0.97)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C247(0.99); C310(0.97); C325(1.02)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C247(1.04); C310(1.00); C325(0.88)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C247(1.23); C310(1.11); C58(0.62); C325(1.15)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C247(1.08); C310(0.93); C58(1.08); C325(1.08)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C247(0.95); C310(0.98); C58(1.07); C325(0.98)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C247(0.92); C310(0.94); C58(1.00); C325(1.18)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C247(1.02); C310(0.89); C318(1.35)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C247(0.99); C310(1.03); C325(0.90); C24(0.87)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C247(0.96); C310(0.99); C325(1.10)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C247(1.07); C310(0.98); C325(0.89)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C247(0.98); C310(0.90); C325(0.94); C24(0.97)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C247(1.09); C310(1.00); C58(1.06); C325(1.12)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C247(1.03); C310(0.87); C58(1.08); C325(1.24)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C247(0.81); C310(1.00); C58(1.00); C325(1.06)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C247(0.92); C310(1.00); C58(1.00); C325(1.08)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C247(1.03); C310(0.85); C318(1.08)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C247(1.04); C310(0.91); C325(0.81); C24(1.02)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C247(1.03); C310(1.00); C325(1.06)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C247(1.14); C310(1.05); C325(0.90)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C247(1.20); C310(0.99); C58(1.16); C325(1.22)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C247(1.08); C310(0.99); C58(1.11); C325(1.00)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C247(0.99); C310(0.99); C325(1.00)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C247(0.97); C310(1.04); C58(1.01); C325(1.00)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C247(0.89); C310(0.97); C58(1.02); C325(1.40)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C247(1.03); C310(0.82); C318(1.03)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C247(1.04); C310(0.97); C325(1.05); C24(1.15)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C247(1.04); C310(0.98); C325(1.09)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C247(1.14); C310(0.97); C325(0.96)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C247(1.28); C310(0.96); C58(1.19); C325(1.07)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C247(1.08); C310(0.89); C58(1.09); C325(1.19)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C247(0.91); C310(1.01); C58(1.07); C325(1.16)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C247(0.91); C310(0.95); C58(1.05); C325(0.98)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C247(1.03); C310(0.96); C325(0.97)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C247(1.00); C310(0.97); C318(0.82)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C247(1.17); C310(0.97); C325(0.96); C24(0.89)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C247(1.04); C310(1.00); C325(0.89)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C247(1.05); C310(1.04); C325(1.00)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C247(1.23); C310(1.02); C58(1.15); C325(1.13)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C247(1.14); C310(0.89); C58(1.06); C325(0.94)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C247(0.93); C310(0.94); C58(1.02); C325(0.98)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C247(0.82); C310(0.88); C58(1.00); C325(1.02)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C247(1.09); C310(0.87); C318(1.11)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C247(1.10); C310(0.95); C325(0.98); C24(1.14)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C247(1.27); C310(0.92); C58(1.07); C325(1.04)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C247(1.00); C310(0.98); C325(1.09)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C247(1.05); C310(0.93); C325(0.98)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C247(1.07); C310(1.07); C58(1.01); C325(1.14)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C247(1.02); C310(0.97); C58(1.12); C325(1.03)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C247(0.87); C310(1.02); C58(1.03); C325(1.04)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C247(1.02); C310(1.04); C58(1.00); C325(0.96)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C247(0.95); C310(0.94); C58(1.03); C325(1.37)  LDD1569  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C237(0.64)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C247(1.16); C310(1.00); C325(0.94)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C247(0.87); C310(0.91); C58(0.96); C325(1.01)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C247(0.85); C310(0.95); C58(1.11); C325(1.00)  LDD1514  [16]
 LDCM0498  BS-3668 MDA-MB-231 C58(0.60)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C247(1.07); C310(0.93); C24(0.95)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C247(1.29); C310(1.33); C58(1.03); C325(1.01)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C247(0.92); C310(1.02); C58(1.08); C325(1.02)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C247(1.02); C310(0.93); C24(0.99)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C247(0.94); C310(0.95); C325(0.88); C24(0.87)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C247(1.04); C310(1.01); C325(1.02)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C247(1.09); C310(0.78); C58(1.15); C325(1.43)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C247(1.08); C310(0.91); C24(0.89)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C247(0.97); C310(0.92); C325(0.85); C24(0.94)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C247(1.07); C310(0.98); C325(0.82)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C247(0.94); C310(0.81); C58(1.03); C325(1.13)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C247(1.03); C310(0.94); C24(0.97)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C247(1.07); C310(1.12); C58(1.16); C325(1.13)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C247(0.93); C310(0.91); C325(0.83); C24(0.86)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C247(0.99); C310(0.97); C325(1.11)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C247(0.93); C310(0.51); C58(0.93); C325(1.16)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C247(1.02); C310(0.98); C24(1.05)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C247(0.95); C310(0.99); C325(0.89); C24(0.86)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C247(1.13); C310(0.85); C325(1.24)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C247(0.99); C310(1.02); C58(1.04); C325(1.10)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C247(1.08); C310(0.94); C24(1.04)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C247(1.08); C310(1.08); C325(0.83); C24(0.91)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C247(1.06); C310(0.86); C325(0.97)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C247(0.98); C310(1.44); C58(1.08); C325(1.04)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C247(1.09); C310(0.85); C58(1.01); C325(1.29)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C247(1.03); C310(0.93); C24(1.05)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C247(1.09); C310(0.97); C325(1.03); C24(0.92)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C247(1.03); C310(0.86); C325(0.85)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C247(0.96); C310(0.92); C58(1.02); C325(1.28)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C247(0.98); C310(1.07); C24(1.03)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C247(1.04); C310(1.11); C325(0.89); C24(0.88)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C247(0.87); C310(1.01); C325(0.95)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C247(0.87); C310(0.85); C58(0.94); C325(1.39)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C247(0.96); C310(0.91); C24(1.04)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C247(1.12); C310(1.10); C325(0.99); C24(1.03)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C247(1.01); C310(0.87); C325(0.90)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C247(0.96); C310(0.85); C58(1.18); C325(1.27)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C247(0.81); C310(0.85); C58(0.98); C325(0.93)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C247(1.02); C310(1.01); C318(1.35)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C247(1.14); C310(1.04); C325(1.05); C24(1.04)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C247(0.98); C310(0.97); C325(0.79); C24(0.93)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C247(1.05); C310(1.17); C325(1.19)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C247(0.98); C310(1.11); C325(0.89)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C247(1.50); C310(1.23); C58(1.14); C325(0.98)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C247(1.25); C310(1.23); C58(1.13); C325(1.09)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C247(0.99); C310(1.21); C58(1.03); C325(0.97)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C247(1.03); C310(0.98); C24(1.01)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C247(0.96); C310(1.06); C325(0.84); C24(0.93)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C247(0.96); C310(0.98); C325(0.99)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C247(0.94); C310(0.86); C58(1.06); C325(1.57)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C247(0.93); C310(0.96); C58(1.09); C325(1.11)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C247(1.05); C310(0.94); C325(1.01)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C247(1.09); C310(1.01); C318(0.94)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C247(1.01); C310(1.10); C325(0.66); C24(0.92)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C247(1.05); C310(1.14); C325(0.97)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C247(1.01); C310(1.19); C325(0.73)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C247(1.41); C310(1.15); C58(1.15); C325(0.97)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C247(1.08); C310(1.18); C58(1.26); C325(1.09)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C247(0.93); C310(1.22); C58(1.07); C325(1.01)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C247(1.11); C310(1.01); C24(1.07)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C247(1.00); C310(0.89); C325(1.08)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C247(0.86); C310(0.95); C58(0.87); C325(1.23)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C247(1.10); C310(0.91); C58(1.20); C325(1.34)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C247(0.83); C310(0.93); C58(1.05); C325(1.43)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C247(1.09); C310(1.08); C318(1.07)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C247(1.23); C310(1.11); C325(0.86); C24(1.07)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C247(1.04); C310(0.97); C325(0.96)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C247(1.21); C310(1.05); C325(0.93)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C247(1.31); C310(1.21); C58(1.23); C325(1.15)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C247(1.08); C310(1.11); C58(1.19); C325(0.95)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C247(1.03); C310(1.37); C58(1.02); C325(1.08)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C247(1.11); C310(1.00); C24(1.06)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C247(0.93); C310(1.02); C58(1.09); C325(1.09)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C247(0.98); C310(0.88); C325(0.98); C24(0.93)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C247(0.98); C310(0.70); C58(1.14); C325(1.39)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C247(0.88); C310(0.93); C58(0.99); C325(0.88)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C247(1.07); C310(0.86); C318(1.13)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C247(1.23); C310(1.07); C325(0.96); C24(1.25)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C247(1.01); C310(1.16); C325(1.15)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C247(0.97); C310(1.00); C325(0.80)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C247(1.22); C310(1.20); C58(1.34); C325(1.07)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C247(1.12); C310(1.06); C58(1.14); C325(1.26)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C247(0.99); C310(1.01); C318(1.03)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C247(0.96); C310(1.33); C58(1.07); C325(1.06)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C247(1.15); C310(1.08); C24(0.98)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C247(0.99); C310(0.93); C325(1.11); C24(0.91)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C247(1.07); C310(1.00); C325(1.05)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C247(0.94); C310(0.81); C58(1.01); C325(1.35)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C247(0.91); C310(1.02); C58(1.08); C325(1.17)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C247(1.09); C310(0.90); C318(1.38)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C247(1.10); C310(1.10); C325(0.89); C24(1.12)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C247(0.99); C310(1.04); C325(1.04)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C247(1.05); C310(0.94); C325(0.96)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C247(1.14); C310(1.03); C325(0.85); C24(1.03)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C247(1.28); C310(1.09); C58(1.20); C325(1.08)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C247(1.15); C310(1.02); C58(1.23); C325(1.22)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C247(0.97); C310(1.20); C58(1.02); C325(1.03)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C247(1.05); C310(0.99); C24(1.03)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C247(1.12); C310(1.12); C325(0.91); C24(0.95)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C247(0.93); C310(0.83); C58(1.06); C325(1.43)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C247(0.77); C310(1.05); C58(1.00); C325(0.89)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C247(1.10); C310(0.95); C318(1.20)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C247(1.19); C310(0.98); C325(0.70); C24(1.11)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C247(0.88); C310(1.28); C325(0.91)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C247(1.06); C310(1.05); C325(0.99)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C247(1.15); C310(1.10); C325(0.95)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C247(1.34); C310(1.09); C58(1.29); C325(1.05)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C247(1.29); C310(1.11); C58(1.21); C325(1.16)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C247(0.97); C310(1.13); C58(1.13); C325(1.13)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C247(0.98); C310(1.11); C24(1.18)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C247(1.03); C310(1.07); C325(0.90); C24(0.95)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C247(0.91); C310(0.94); C325(0.93)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C247(1.04); C310(0.99); C58(0.94); C325(1.36)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C247(0.89); C310(1.00); C58(1.13); C325(1.16)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C247(1.11); C310(1.12); C325(0.93)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C247(0.96); C310(1.00); C318(1.00)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C247(1.20); C310(1.10); C325(0.89); C24(0.94)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C247(1.04); C310(0.98); C325(1.14)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C247(1.05); C310(1.11); C325(0.68)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C247(1.35); C310(0.98); C58(1.25); C325(1.28)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C247(1.05); C310(0.95); C58(1.04); C325(0.95)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C247(0.96); C310(1.29); C58(1.03); C325(1.09)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C247(1.05); C310(0.99); C24(1.22)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C247(0.97); C310(1.10); C325(0.81); C24(0.89)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C247(0.98); C310(0.96); C325(1.04)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C247(1.02); C310(1.00); C325(1.28)  LDD1698  [16]
 LDCM0468  Fragment33 HEK-293T C247(1.04); C310(1.01); C325(1.28)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C247(1.01); C310(1.09); C325(0.99); C24(1.09)  LDD1631  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C58(0.89); C247(1.07); C310(0.99); C318(1.08)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C58(1.11); C247(1.12); C310(0.99); C318(1.23)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C244(4.60)  LDD3310  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C237(0.59)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C237(1.07); C58(0.98)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C237(0.90)  LDD2094  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C237(0.85)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C237(1.08)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C237(1.33)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C237(0.69)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C237(0.32); C58(0.62)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C237(1.10)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C237(1.35)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C58(0.72)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C237(0.74); C58(0.87)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C237(0.98)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C237(0.46); C58(0.78)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C237(0.41)  LDD2115  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C237(1.00); C58(1.22)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C237(0.91); C58(0.98)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C237(0.57)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C237(0.99); C58(1.43)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C237(1.34)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C237(0.39)  LDD2134  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C237(1.51)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C237(1.24); C58(1.41)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C237(1.01)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C237(0.65)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C237(2.07)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C237(0.88)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C237(0.46)  LDD2148  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C237(2.94)  LDD2153  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tiludronic Acid Small molecular drug DB01133

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402