Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C095  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 25.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 14.4
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 13.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 13.1
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 12.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 10.4
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 9.6
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 9.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 9.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 8.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 8.7
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.7
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 8.5
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 8.1
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.9
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 7.8
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 7.3
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 7.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 7.1
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 7.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 7.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 6.6
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 6.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.4
 LDTP06617  Ceramide glucosyltransferase (UGCG) 6.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 6.2
 LDTP10020  Ras-related protein Rab-24 (RAB24) 6.1
 LDTP10329  Ceramide synthase 2 (CERS2) 6.0
 LDTP03145  Catechol O-methyltransferase (COMT) 5.9
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 5.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.6
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 5.6
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 5.5
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 5.5
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 5.5
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 5.5
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 5.4
 LDTP04144  Cytochrome b-c1 complex subunit Rieske, mitochondrial (UQCRFS1) 5.4
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 5.4
 LDTP04689  Adenosine kinase (ADK) 5.3
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 5.2
 LDTP13453  Peroxisomal carnitine O-octanoyltransferase (CROT) 5.2
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 5.2
 LDTP06142  Squalene monooxygenase (SQLE) 5.1
 LDTP01641  STAM-binding protein (STAMBP) 5.1
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.1
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 5.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 5.0
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 5.0
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 5.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 5.0
 LDTP14231  GTP-binding protein SAR1b (SAR1B) 4.9
Transporter and channel
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 31.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 29.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 23.8
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 18.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 18.5
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 18.1
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 16.2
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.2
 LDTP05900  Metaxin-1 (MTX1) 14.5
 LDTP20002  Transmembrane protein 160 (TMEM160) 12.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 12.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 11.1
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 10.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 9.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 9.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 8.3
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.9
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 7.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 7.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 7.3
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 7.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.9
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 6.9
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.7
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 6.4
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 6.4
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 5.9
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 5.6
 LDTP00383  AP-3 complex subunit delta-1 (AP3D1) 5.5
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 5.4
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 5.3
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 5.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 5.2
 LDTP10343  Vacuole membrane protein 1 (VMP1) 5.2
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.2
 LDTP11245  Derlin-1 (DERL1) 5.0
 LDTP00405  Etoposide-induced protein 2.4 homolog (EI24) 4.9
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 4.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 5.1
Other
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03926  Centrin-2 (CETN2) 56.5
 LDTP01522  Reticulon-3 (RTN3) 21.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 21.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 17.9
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 16.0
 LDTP05160  Nucleobindin-2 (NUCB2) 13.8
 LDTP14259  Testis-expressed protein 264 (TEX264) 13.8
 LDTP11076  Apolipoprotein L2 (APOL2) 12.0
 LDTP10056  Protein FAM162A (FAM162A) 11.9
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 10.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 9.3
 LDTP05375  Nucleobindin-1 (NUCB1) 9.2
 LDTP01494  Protein YIF1A (YIF1A) 8.3
 LDTP13086  Syntaxin-18 (STX18) 8.3
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 8.2
 LDTP00859  Synaptogyrin-2 (SYNGR2) 7.8
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.3
 LDTP12412  Reticulon-4 (RTN4) 7.0
 LDTP15398  Protein FAM177A1 (FAM177A1) 6.9
 LDTP06097  Reticulocalbin-2 (RCN2) 6.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.5
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 6.3
 LDTP08224  Protein LYRIC (MTDH) 6.3
 LDTP10357  RUS family member 1 (RUSF1) 6.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) 6.1
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 6.0
 LDTP01167  Reticulon-2 (RTN2) 5.9
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 5.9
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 5.8
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 5.6
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 5.4
 LDTP16006  Optic atrophy 3 protein (OPA3) 5.2
 LDTP19625  Integral membrane protein GPR180 (GPR180) 5.2
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 5.1
 LDTP15714  Mdm2-binding protein (MTBP) 5.0
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587