Details of the Target

General Information of Target

Target ID LDTP14231
Target Name GTP-binding protein SAR1b (SAR1B)
Gene Name SAR1B
Gene ID 51128
Synonyms
SARA2; SARB; GTP-binding protein SAR1b; GTP-binding protein B; GTBPB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEMAELSELYEESSDLQMDVMPGEGDLPQMEVGSGSRELSLRPSRSGAQQLEEEGPMEE
EEAQPMAAPEGKRSLANGPNAGEQPGQVAGADFESEDEGEEFDDWEDDYDYPEEEQLSGA
GYRVSAALEEADKMFLRTREPALDGGFQMHYEKTPFDQLAFIEELFSLMVVNRLTEELGC
DEIIDRE
Target Bioclass
Enzyme
Family
Small GTPase superfamily, SAR1 family
Subcellular location
Endoplasmic reticulum membrane
Function
GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
Uniprot ID
Q9Y6B6
Ensemble ID
ENST00000402673.7
HGNC ID
HGNC:10535

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K27(9.68)  LDD0277  [1]
IPM
 Probe Info  		C178(0.00); C102(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y154(26.35)  LDD3495  [3]
DBIA
 Probe Info  		C102(0.91)  LDD0532  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C102(0.00); C178(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C178(0.00); C102(0.00)  LDD0037  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
AOyne
 Probe Info  		10.00  LDD0443  [8]
NAIA_5
 Probe Info  		C178(0.00); C102(0.00)  LDD2223  [9]
TER-AC
 Probe Info  		N.A.  LDD0426  [10]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		12.13  LDD1740  [11]
C095
 Probe Info  		4.92  LDD1786  [11]
C228
 Probe Info  		20.68  LDD1901  [11]
C278
 Probe Info  		52.35  LDD1948  [11]
C280
 Probe Info  		9.13  LDD1950  [11]
C282
 Probe Info  		19.16  LDD1952  [11]
C284
 Probe Info  		26.17  LDD1954  [11]
C289
 Probe Info  		28.64  LDD1959  [11]
C310
 Probe Info  		9.13  LDD1977  [11]
FFF probe11
 Probe Info  		8.22  LDD0471  [12]
FFF probe13
 Probe Info  		7.20  LDD0475  [12]
FFF probe2
 Probe Info  		7.39  LDD0463  [12]
A-DA
 Probe Info  		2.07  LDD0143  [13]
OEA-DA
 Probe Info  		7.37  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C102(0.80); C178(0.80)  LDD0812  [4]
 LDCM0215  AC10 HCT 116 C102(0.91)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C102(1.24); C178(1.24)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C102(1.09); C178(1.09)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C102(1.31); C178(1.31)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C102(1.02); C178(1.02)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C102(1.20); C178(1.20)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C102(0.94); C178(0.94)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C102(0.95); C178(0.95)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C102(0.88); C178(0.88)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C102(0.85); C178(0.85)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C102(1.01); C178(1.01)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C102(0.72)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C102(1.54); C178(1.54)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C102(1.84); C178(1.84)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C102(1.86); C178(1.86)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C102(0.92); C178(0.92)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C102(1.21); C178(1.21)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C102(0.91); C178(0.91)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C102(1.10); C178(1.10)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C102(1.11); C178(1.11)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C102(1.16); C178(1.16)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C102(1.38); C178(1.38)  LDD0834  [4]
 LDCM0237  AC12 HCT 116 C102(0.75)  LDD0554  [4]
 LDCM0238  AC120 HEK-293T C102(1.29); C178(1.29)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C102(1.24); C178(1.24)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C102(1.36); C178(1.36)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C102(1.46); C178(1.46)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C102(1.40); C178(1.40)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C102(1.44); C178(1.44)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C102(2.28); C178(2.28)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C102(2.15); C178(2.15)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C102(0.77); C178(0.77)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C102(1.14); C178(1.14)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C102(1.35); C178(1.35)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C102(1.04); C178(1.04)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C102(0.87); C178(0.87)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C102(1.04); C178(1.04)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C102(1.25); C178(1.25)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C102(1.07); C178(1.07)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C102(1.32); C178(1.32)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C102(1.95); C178(1.95)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C102(1.95); C178(1.95)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C102(1.58); C178(1.58)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C102(0.71)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C102(1.24); C178(1.24)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C102(1.39); C178(1.39)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C102(1.56); C178(1.56)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C102(1.06); C178(1.06)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C102(1.79); C178(1.79)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C102(1.47); C178(1.47)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C102(1.52); C178(1.52)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C102(1.53); C178(1.53)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C102(1.06); C178(1.06)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C102(1.07); C178(1.07)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C102(0.81)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C102(1.12); C178(1.12)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C102(1.36); C178(1.36)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C102(1.32); C178(1.32)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C102(1.27); C178(1.27)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C102(1.33); C178(1.33)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C102(1.23); C178(1.23)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C102(1.37); C178(1.37)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C102(1.96); C178(1.96)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C102(0.79)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C102(0.95)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C102(0.73)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C102(0.89); C178(0.89)  LDD0877  [4]
 LDCM0280  AC20 HCT 116 C102(0.78)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C102(0.81)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C102(0.70)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C102(0.64)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C102(0.92)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C102(0.76)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C102(0.86)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C102(1.00)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C102(0.97)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C102(1.17)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C102(0.69); C178(0.69)  LDD0888  [4]
 LDCM0291  AC30 HCT 116 C102(1.05)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C102(0.81)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C102(0.88)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C102(0.89)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C102(0.95)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C102(1.03)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C102(0.93)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C102(1.20)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C102(1.18)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C102(0.95)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C102(0.80); C178(0.80)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C102(0.98)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C102(0.99)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C102(0.93)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C102(1.25)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C102(1.26)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C102(1.14)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C102(0.67); C178(0.67)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C102(0.84); C178(0.84)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C102(0.80); C178(0.80)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C102(1.39); C178(1.39)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C102(1.17); C178(1.17)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C102(0.97); C178(0.97)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C102(1.19); C178(1.19)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C102(1.53); C178(1.53)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C102(1.05); C178(1.05)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C102(0.95); C178(0.95)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C102(0.88); C178(0.88)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C102(1.19); C178(1.19)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C102(1.02); C178(0.95)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C102(1.01); C178(1.09)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C102(0.98); C178(0.97)  LDD1561  [15]
 LDCM0323  AC6 HCT 116 C102(0.86)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C102(1.12); C178(0.98)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C178(1.02)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C102(1.02); C178(1.02)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C102(1.07); C178(0.98)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C102(0.92); C178(0.97)  LDD1567  [15]
 LDCM0332  AC68 HCT 116 C102(0.82)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C102(0.72)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C102(0.93)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C102(0.86)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C102(0.99)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C102(0.87)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C102(0.77)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C102(0.71)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C102(0.87)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C102(0.85)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C102(0.95)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C102(0.90)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C102(1.13)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C102(0.80)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C102(0.82)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C102(0.44)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C102(0.84)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C102(1.22); C178(1.22)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C102(1.81); C178(1.81)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C102(1.26); C178(1.26)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C102(1.31); C178(1.31)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C102(1.30); C178(1.30)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C102(1.55); C178(1.55)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C102(1.73); C178(1.73)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C102(1.75); C178(1.75)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C102(1.29); C178(1.29)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C102(1.42); C178(1.42)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C102(1.26); C178(1.26)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C102(1.43); C178(1.43)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C102(1.82); C178(1.82)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C102(1.76); C178(1.76)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C102(3.73); C178(3.73)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C102(0.76); C178(0.76)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C102(0.88); C178(0.88)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C102(1.04)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C102(1.08)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C102(0.75)  LDD0592  [4]
 LDCM0083  Avasimibe A-549 2.07  LDD0143  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C178(3.33); C178(0.88)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C102(1.69); C178(1.69)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C102(2.80); C178(2.80)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C102(1.14); C178(1.14)  LDD0967  [4]
 LDCM0370  CL101 HCT 116 C102(0.78)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C102(1.09)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C102(1.12)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C102(0.98)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C102(0.66)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C102(0.48)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C102(0.77)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C102(0.68)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C102(0.69)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C102(1.95); C178(1.95)  LDD0977  [4]
 LDCM0380  CL110 HCT 116 C102(0.59)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C102(0.74)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C102(0.79)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C102(0.88)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C102(1.03)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C102(0.94)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C102(0.80)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C102(0.98)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C102(1.02)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C102(0.93)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C102(1.11); C178(1.11)  LDD0988  [4]
 LDCM0391  CL120 HCT 116 C102(0.94)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C102(1.02); C178(1.02)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C102(1.06); C178(1.06)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C102(1.41); C178(1.41)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C102(1.08); C178(1.08)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C102(0.95); C178(0.99)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C102(0.95); C178(1.07)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C102(0.98); C178(1.10)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C102(1.13); C178(1.16)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C102(1.31); C178(1.31)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C102(1.45); C178(1.45)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C102(1.74); C178(1.74)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C102(1.35); C178(1.35)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C102(0.93); C178(0.93)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C102(1.42); C178(1.42)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C102(1.31); C178(1.31)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C102(1.25); C178(1.25)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C102(1.03); C178(1.03)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C102(1.43); C178(1.43)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C102(0.96); C178(0.96)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C102(0.75); C178(0.75)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C102(0.97); C178(0.97)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C102(1.02); C178(1.02)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C102(1.16); C178(1.16)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C102(0.91); C178(0.91)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C102(1.00); C178(1.00)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C102(0.92); C178(0.92)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C102(1.75); C178(1.75)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C102(1.18); C178(1.18)  LDD1017  [4]
 LDCM0420  CL31 PaTu 8988t C102(0.80)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C102(0.72)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C102(0.61)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C102(0.69)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C102(0.61)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C102(0.21)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C102(0.73)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C102(0.59)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C102(1.36); C178(1.36)  LDD1027  [4]
 LDCM0430  CL40 PaTu 8988t C102(0.87)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C102(0.74)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C102(0.79)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C102(0.67)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C102(0.50)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C102(0.58)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C102(1.79); C178(1.79)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C102(1.29); C178(1.29)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C102(1.11); C178(1.11)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C102(1.14); C178(1.14)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C102(1.32); C178(1.32)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C102(1.51); C178(1.51)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C102(1.17); C178(1.17)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C102(0.90); C178(0.90)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C102(1.18); C178(1.18)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C102(1.09); C178(1.09)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C102(1.42); C178(1.42)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C102(1.16); C178(1.16)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C102(1.22); C178(1.22)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C102(1.00); C178(1.00)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C102(1.37); C178(1.37)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C102(1.25); C178(1.25)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C102(1.71); C178(1.71)  LDD1050  [4]
 LDCM0453  CL61 PaTu 8988t C102(0.84)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C102(0.77)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C102(1.05)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C102(0.87)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C102(1.00)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C102(0.75)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C102(1.06)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C102(0.95)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C102(1.04)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C102(1.61); C178(1.61)  LDD1060  [4]
 LDCM0463  CL70 PaTu 8988t C102(0.90)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C102(0.73)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C102(1.02)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C102(0.72)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C102(0.80)  LDD1346  [4]
 LDCM0469  CL76 HEK-293T C102(1.34); C178(1.34)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C102(1.86); C178(1.86)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C102(1.82); C178(1.82)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C102(1.28); C178(1.28)  LDD1070  [4]
 LDCM0473  CL8 PaTu 8988t C102(0.68)  LDD1352  [4]
 LDCM0474  CL80 HEK-293T C102(1.31); C178(1.31)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C102(1.43); C178(1.43)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C102(1.00); C178(1.00)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C102(1.39); C178(1.39)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C102(2.17); C178(2.17)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C102(1.76); C178(1.76)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C102(1.68); C178(1.68)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C102(1.68); C178(1.68)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C102(1.62); C178(1.62)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C102(1.52); C178(1.52)  LDD1081  [4]
 LDCM0484  CL9 PaTu 8988t C102(0.80)  LDD1363  [4]
 LDCM0485  CL90 HEK-293T C102(1.95); C178(1.95)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C102(1.19); C178(1.19)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C102(1.17); C178(1.17)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C102(1.12); C178(1.12)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C102(1.99); C178(1.99)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C102(1.76); C178(1.76)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C102(1.29); C178(1.29)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C102(1.18); C178(1.18)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C102(1.04); C178(1.04)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C102(1.19); C178(1.19)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C102(1.02); C178(1.21)  LDD1698  [15]
 LDCM0625  F8 Ramos C178(0.92)  LDD2187  [16]
 LDCM0573  Fragment11 Ramos C178(0.57)  LDD2190  [16]
 LDCM0576  Fragment14 Ramos C178(0.52)  LDD2193  [16]
 LDCM0586  Fragment28 Ramos C178(1.23)  LDD2198  [16]
 LDCM0468  Fragment33 PaTu 8988t C102(1.04)  LDD1347  [4]
 LDCM0566  Fragment4 Ramos C178(0.62)  LDD2184  [16]
 LDCM0427  Fragment51 PaTu 8988t C102(0.73)  LDD1306  [4]
 LDCM0569  Fragment7 Ramos C178(0.27)  LDD2186  [16]
 LDCM0015  HNE MDA-MB-231 C178(1.07); C102(0.98)  LDD0346  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C178(1.09); C102(1.02)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C178(0.94); C102(1.01)  LDD1497  [15]
 LDCM0024  KB05 SKMEL24 C102(2.85)  LDD3323  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0084  Ro 48-8071 A-549 2.39  LDD0145  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840