Details of the Target

General Information of Target

Target ID LDTP12651
Target Name TBC1 domain family member 23 (TBC1D23)
Gene Name TBC1D23
Gene ID 55773
Synonyms
NS4ATP1; TBC1 domain family member 23; HCV non-structural protein 4A-transactivated protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCL
LFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSS
KYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFL
LKVWDGTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLR
IYSLHTKLQSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTAN
QHSDVICQSEPDDSFPSSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQY
RIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYD
SKIWTTKNQKGRKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGH
EDLELLDLSAPFLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQY
VFVMTFTLDDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAY
PWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI
Target Bioclass
Other
Subcellular location
Golgi apparatus, trans-Golgi network
Function
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge.
Uniprot ID
Q9NUY8
Ensemble ID
ENST00000344949.9
HGNC ID
HGNC:25622

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P264T .
HGC27 SNV: p.Q327Ter .
HT115 SNV: p.K495E .
ICC10 SNV: p.R518Ter .
ICC106 SNV: p.R518Ter .
ICC108 SNV: p.R518Ter .
JURKAT SNV: p.L416M .
LS180 SNV: p.E381D .
LS513 SNV: p.K647Q .
LUDLU1 SNV: p.K692R .
MFE319 SNV: p.G333R .
NUGC3 SNV: p.A382T .
SUPT1 SNV: p.M401V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.79  LDD0402  [1]
STPyne
 Probe Info  		K504(3.80); K587(1.09); K649(5.00); K684(0.09)  LDD0277  [2]
HHS-475
 Probe Info  		Y150(0.72)  LDD0264  [3]
HHS-465
 Probe Info  		Y150(10.00)  LDD2237  [4]
DBIA
 Probe Info  		C399(0.90)  LDD0532  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C86(0.00); C183(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C283(0.00); C148(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C148(0.00); C86(0.00); C183(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		13.50  LDD0443  [10]
NAIA_5
 Probe Info  		C31(0.00); C596(0.00); C148(0.00); C399(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C095
 Probe Info  		6.06  LDD1786  [11]
C160
 Probe Info  		7.06  LDD1840  [11]
C161
 Probe Info  		9.71  LDD1841  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C148(0.82)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C399(0.90)  LDD0532  [5]
 LDCM0216  AC100 PaTu 8988t C399(0.45)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C399(0.51)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C399(0.46)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C399(0.79)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C399(0.58)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C399(0.46)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C399(0.63)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C399(0.94)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C399(0.45)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C399(0.43)  LDD1104  [5]
 LDCM0226  AC11 HCT 116 C399(0.75)  LDD0543  [5]
 LDCM0227  AC110 PaTu 8988t C399(0.57)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C399(0.42)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C399(0.61)  LDD1108  [5]
 LDCM0230  AC113 PaTu 8988t C343(1.17); C399(1.06)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C343(0.97); C399(0.61)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C343(1.24); C399(0.65)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C343(1.42); C399(0.71)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C343(1.25); C399(1.28)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C343(0.89); C399(0.91)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C343(1.11); C399(0.87)  LDD1115  [5]
 LDCM0237  AC12 HCT 116 C399(0.66)  LDD0554  [5]
 LDCM0238  AC120 PaTu 8988t C343(1.03); C399(0.99)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C343(1.13); C399(0.78)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C343(1.01); C399(0.93)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C343(1.17); C399(0.94)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C343(1.14); C399(1.04)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C343(0.88); C399(0.89)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C343(1.01); C399(0.63)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C343(1.22); C399(0.85)  LDD1124  [5]
 LDCM0246  AC128 HCT 116 C343(1.22)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C343(1.15)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C343(1.25)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C343(0.99)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C343(1.42)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C343(1.21)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C343(1.03)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C343(1.11)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C343(1.07)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C343(1.17)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C343(1.02)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C343(1.16)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C399(0.84)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C343(1.30)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C343(1.26)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C343(1.12)  LDD0579  [5]
 LDCM0263  AC143 HEK-293T C148(0.96)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C148(1.28)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C148(1.33)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C148(1.27)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C148(1.39)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C148(1.32)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C148(0.94)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C399(0.79)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C148(1.24)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C148(1.26)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C148(1.11)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C148(1.05)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C148(1.01)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C148(1.06)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C148(1.35)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C148(1.59)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C399(0.84)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C399(1.19)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C399(0.67)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C148(0.79)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C399(0.57)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C399(0.86)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C399(1.16)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C399(0.83)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C399(1.00)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C148(1.69)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C148(1.25)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C148(1.22)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C148(1.27)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C148(1.25)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C148(0.79)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C148(1.33)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C148(1.37)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C148(1.19)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C148(1.26)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C148(1.32)  LDD0893  [5]
 LDCM0296  AC35 HCT 116 C399(0.79)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C399(0.87)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C399(0.77)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C399(1.19)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C399(0.95)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C148(0.79)  LDD0899  [5]
 LDCM0302  AC40 HCT 116 C399(1.26)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C399(1.03)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C399(1.02)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C399(1.19)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C399(0.79)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C399(0.94)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C148(0.87); C399(1.00)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C148(1.00); C399(1.01)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C399(0.88); C148(1.23)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C148(0.90); C399(1.11)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C148(0.81)  LDD0910  [5]
 LDCM0313  AC50 HCT 116 C399(0.98); C148(1.62)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C399(0.97); C148(1.63)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C399(1.00); C148(1.13)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C399(1.05); C148(1.57)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C399(1.08); C148(1.47)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C148(0.95); C399(1.03)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C399(0.94); C148(1.27)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C399(1.06)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C399(0.90)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C399(0.78)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C399(0.64)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C399(0.67)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C399(0.79)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C399(0.81)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C399(0.82)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C399(0.95)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C399(0.84)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C399(1.03)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C399(0.77)  LDD0648  [5]
 LDCM0332  AC68 HEK-293T C148(1.07); C343(0.86)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C148(1.10); C343(1.11)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C399(0.73)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C148(1.08); C343(1.46)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C148(1.16); C343(1.25)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C148(1.16); C343(1.01)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C148(1.12); C343(1.05)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C148(1.40); C343(1.45)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C148(1.25); C343(1.16)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C148(1.09); C343(0.98)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C148(1.18); C343(1.05)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C148(1.23); C343(0.95)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C148(1.14); C343(1.10)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C399(0.72)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C148(1.26); C343(0.97)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C148(1.25); C343(0.94)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C148(1.60); C343(1.06)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C148(0.85); C399(1.12)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C148(0.87); C399(1.22)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C148(0.72); C399(0.96)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C148(0.91); C399(1.00)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C148(0.94); C399(1.05)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C399(0.90); C148(1.07)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C148(0.81); C399(0.88)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C148(0.68); C399(1.64)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C148(0.77); C399(1.06)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C148(0.74); C399(1.29)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C148(0.66); C399(1.48)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C148(0.53); C399(1.26)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C148(0.71); C399(0.96)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C148(0.63); C399(0.93)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C148(0.55); C399(1.19)  LDD0681  [5]
 LDCM0365  AC98 PaTu 8988t C399(0.44)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C399(0.60)  LDD1245  [5]
 LDCM0248  AKOS034007472 HCT 116 C399(1.03)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C399(1.08)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C399(0.72)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C283(1.34)  LDD2214  [12]
 LDCM0108  Chloroacetamide HeLa C343(0.00); C31(0.00)  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C183(20.00); C148(20.00)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C343(0.81)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C343(1.00)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C148(0.97)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C399(0.62)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C399(0.67)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C399(0.61)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C399(0.68)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C399(0.92)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C399(0.99)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C399(0.89)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C399(0.92)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C399(0.83)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C343(0.97)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C399(0.85)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C399(1.10)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C148(1.17)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C148(1.20)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C148(1.12)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C148(1.24)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C148(1.48)  LDD0984  [5]
 LDCM0387  CL117 HCT 116 C399(0.89)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C399(1.01)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C399(1.05)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C343(1.05)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C399(1.18)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C148(0.86); C399(0.86)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C399(0.91); C148(1.19)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C399(0.91); C148(0.99)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C148(0.85); C399(0.88)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C399(0.72)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C399(0.56)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C399(1.04)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C399(0.78)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C343(0.88)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C343(0.88)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C343(0.78)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C343(1.04)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C343(0.98)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C343(0.79)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C343(0.85)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C343(0.87)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C343(1.00)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C343(0.79)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C343(0.98)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C343(0.87)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C343(1.14)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C343(0.92)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C343(0.85)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C343(1.04)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C343(0.98)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C343(1.19)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C343(0.78)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C343(0.92)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C343(0.70); C399(0.67)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C343(0.51); C399(0.84)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C343(0.52); C399(0.84)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C343(0.61); C399(0.90)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C343(0.73); C399(0.78)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C343(0.72); C399(0.67)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C343(0.69); C399(0.67)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C343(0.64); C399(0.97)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C343(0.84)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C343(0.70); C399(0.53)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C343(0.64); C399(0.73)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C343(0.63); C399(0.75)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C343(0.61); C399(0.78)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C343(0.52); C399(0.92)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C343(0.64); C399(0.84)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C148(1.51)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C148(1.24)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C148(2.02)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C148(1.48)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C343(0.92)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C148(1.27)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C148(1.24)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C148(1.32)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C148(1.44)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C148(1.25)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C148(1.55)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C148(1.01)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C148(1.20)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C148(1.41)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C148(1.10)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C343(0.76)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C148(1.26)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C148(0.82)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C148(0.85)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C148(0.70)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C148(0.74)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C148(0.82)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C148(0.68)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C148(0.83)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C148(0.78)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C148(0.99)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C343(0.96)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C148(0.68)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C148(0.76)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C148(0.81)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C148(1.45)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C148(0.99)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C399(0.88)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C399(1.62)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C399(0.86)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C399(1.09)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C343(0.79)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C399(0.90)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C399(1.07)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C399(1.18)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C399(1.00)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C399(1.05)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C399(0.82)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C399(1.06)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C399(1.23)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C399(0.96)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C399(1.22)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C343(0.84)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C399(0.89)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C148(0.73)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C148(0.77)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C148(0.78)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C148(0.98)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C148(0.94)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C148(0.87)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C148(0.87)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C148(0.94)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C148(0.84)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C399(0.97); C343(0.97); C183(0.91); C31(1.00)  LDD1698  [13]
 LDCM0625  F8 Ramos C530(0.67)  LDD2187  [14]
 LDCM0572  Fragment10 MDA-MB-231 C283(1.65)  LDD1389  [15]
 LDCM0573  Fragment11 MDA-MB-231 C283(20.00)  LDD1391  [15]
 LDCM0574  Fragment12 MDA-MB-231 C283(2.88)  LDD1468  [15]
 LDCM0575  Fragment13 MDA-MB-231 C283(1.25)  LDD1395  [15]
 LDCM0576  Fragment14 MDA-MB-231 C283(0.92)  LDD1397  [15]
 LDCM0579  Fragment20 Ramos C283(1.84)  LDD1403  [15]
 LDCM0580  Fragment21 MDA-MB-231 C283(1.54)  LDD1404  [15]
 LDCM0581  Fragment22 MDA-MB-231 C283(1.19)  LDD1406  [15]
 LDCM0582  Fragment23 MDA-MB-231 C283(0.91)  LDD1408  [15]
 LDCM0583  Fragment24 Ramos C283(2.05)  LDD1410  [15]
 LDCM0584  Fragment25 MDA-MB-231 C283(0.80)  LDD1411  [15]
 LDCM0585  Fragment26 Ramos C283(0.89)  LDD1412  [15]
 LDCM0578  Fragment27 MDA-MB-231 C283(0.80)  LDD1401  [15]
 LDCM0586  Fragment28 MDA-MB-231 C283(0.95)  LDD1415  [15]
 LDCM0587  Fragment29 MDA-MB-231 C283(1.19)  LDD1417  [15]
 LDCM0588  Fragment30 MDA-MB-231 C283(0.75)  LDD1419  [15]
 LDCM0589  Fragment31 MDA-MB-231 C283(0.96)  LDD1421  [15]
 LDCM0590  Fragment32 MDA-MB-231 C283(6.46)  LDD1423  [15]
 LDCM0468  Fragment33 HCT 116 C148(0.82)  LDD0785  [5]
 LDCM0592  Fragment34 Ramos C283(1.09)  LDD1428  [15]
 LDCM0593  Fragment35 MDA-MB-231 C283(0.76)  LDD1429  [15]
 LDCM0594  Fragment36 MDA-MB-231 C283(1.94)  LDD1431  [15]
 LDCM0595  Fragment37 Ramos C283(0.78)  LDD1432  [15]
 LDCM0596  Fragment38 MDA-MB-231 C283(0.92)  LDD1433  [15]
 LDCM0566  Fragment4 MDA-MB-231 C283(1.65)  LDD1378  [15]
 LDCM0598  Fragment40 MDA-MB-231 C283(0.75)  LDD1436  [15]
 LDCM0599  Fragment41 MDA-MB-231 C283(3.45)  LDD1438  [15]
 LDCM0601  Fragment43 MDA-MB-231 C283(20.00)  LDD1441  [15]
 LDCM0602  Fragment44 MDA-MB-231 C283(0.79)  LDD1443  [15]
 LDCM0603  Fragment45 MDA-MB-231 C283(2.29)  LDD1444  [15]
 LDCM0604  Fragment46 MDA-MB-231 C283(0.88)  LDD1445  [15]
 LDCM0605  Fragment47 MDA-MB-231 C283(1.07)  LDD1446  [15]
 LDCM0606  Fragment48 MDA-MB-231 C283(1.09)  LDD1447  [15]
 LDCM0607  Fragment49 MDA-MB-231 C283(1.59)  LDD1448  [15]
 LDCM0608  Fragment50 MDA-MB-231 C283(1.13)  LDD1449  [15]
 LDCM0427  Fragment51 HCT 116 C343(0.67); C399(0.49)  LDD0744  [5]
 LDCM0611  Fragment53 MDA-MB-231 C283(0.94)  LDD1454  [15]
 LDCM0612  Fragment54 MDA-MB-231 C283(1.05)  LDD1456  [15]
 LDCM0613  Fragment55 MDA-MB-231 C283(0.92)  LDD1457  [15]
 LDCM0614  Fragment56 MDA-MB-231 C283(0.77)  LDD1458  [15]
 LDCM0568  Fragment6 MDA-MB-231 C283(1.04)  LDD1382  [15]
 LDCM0569  Fragment7 MDA-MB-231 C283(1.64)  LDD1383  [15]
 LDCM0570  Fragment8 MDA-MB-231 C283(1.79)  LDD1385  [15]
 LDCM0571  Fragment9 MDA-MB-231 C283(1.05)  LDD1387  [15]
 LDCM0116  HHS-0101 DM93 Y150(0.72)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y150(0.55)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y150(0.66)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y150(0.81)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y150(0.78)  LDD0268  [3]
 LDCM0022  KB02 MDA-MB-231 C283(8.84)  LDD1374  [15]
 LDCM0023  KB03 MDA-MB-231 C283(3.31)  LDD1376  [15]
 LDCM0024  KB05 COLO792 C596(3.74)  LDD3310  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Cancer-associated gene 1 protein (CAGE1) . Q8TC20
Single-stranded DNA-binding protein 3 (SSBP3) . Q9BWW4
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
WD repeat-containing protein 62 (WDR62) . O43379

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840