Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment37  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 72 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.3
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.2
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.2
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.2
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.2
 LDTP02502  Thioredoxin (TXN) C32 1.2
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.1
 LDTP04689  Adenosine kinase (ADK) C353 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.1
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.1
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.0
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.0
 LDTP06211  Caspase-8 (CASP8) C360 1.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 1.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.0
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.0
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 1.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.9
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 0.9
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 0.9
 LDTP04374  Dynamin-2 (DNM2) C27 0.9
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.9
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.9
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.9
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.9
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.9
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.9
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.9
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.9
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.9
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.8
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.8
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.8
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 0.8
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 0.8
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
 LDTP02672  Elongation factor 2 (EEF2) C136 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 0.8
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.7
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 0.7
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 0.6
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.5
Transporter and channel
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.2
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 1.2
 LDTP04801  Gasdermin-D (GSDMD) C268 1.2
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.0
 LDTP04662  Exportin-2 (CSE1L) C842 1.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.0
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.0
 LDTP00501  Exportin-1 (XPO1) C528 0.9
 LDTP04707  Protein SEC13 homolog (SEC13) C187 0.9
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 0.9
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
 LDTP00501  Exportin-1 (XPO1) C34 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.8
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 0.9
 LDTP02016  Glucocorticoid receptor (NR3C1) C302 0.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.9
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 0.8
Other
Click to Show/Hide to Show 66 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.4
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.3
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.3
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 1.2
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.1
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 1.1
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.1
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.1
 LDTP01532  ZW10 interactor (ZWINT) C54 1.1
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.0
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.0
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.0
 LDTP04092  Crk-like protein (CRKL) C249 1.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.0
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.0
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.0
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 0.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP11235  Protein PAXX (PAXX) C180 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.9
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 0.9
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 0.9
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) C513 0.9
 LDTP13580  Coronin-1C (CORO1C) C420 0.9
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.9
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 0.9
 LDTP02205  Tubulin beta chain (TUBB) C354 0.9
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.9
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.9
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 0.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 0.9
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 0.9
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 0.9
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.9
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 0.9
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.9
 LDTP10864  Calponin-2 (CNN2) C164 0.8
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.8
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.8
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.8
 LDTP10864  Calponin-2 (CNN2) C215 0.8
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 0.8
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.8
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 0.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.8
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 0.8
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.8
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.