Details of the Target

General Information of Target

Target ID LDTP06082
Target Name Dynactin subunit 1 (DCTN1)
Gene Name DCTN1
Gene ID 1639
Synonyms
Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE
GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG
SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH
RLVLTQEQLHQLHSRLIS
Target Bioclass
Other
Family
Dynactin 150 kDa subunit family
Subcellular location
Cytoplasm
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation.
Uniprot ID
Q14203
Ensemble ID
ENST00000394003.7
HGNC ID
HGNC:2711

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.D779N DBIA    Probe Info 
HCT116 SNV: p.G493D DBIA    Probe Info 
JHH6 SNV: p.E218G DBIA    Probe Info 
JURKAT SNV: p.A142T Compound 10    Probe Info 
KYSE510 SNV: p.E691Q DBIA    Probe Info 
MFE319 SNV: p.C791Y DBIA    Probe Info 
NCIH358 Deletion: p.E648SfsTer13 DBIA    Probe Info 
SUPT1 SNV: p.T1198A DBIA    Probe Info 
SW1271 SNV: p.E437K DBIA    Probe Info 
SW403 SNV: p.Q1258K DBIA    Probe Info 
SW837 SNV: p.M470L DBIA    Probe Info 
TOV21G SNV: p.P1176H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.50  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y1149(13.77)  LDD0257  [3]
TH214
 Probe Info  		Y1149(5.05)  LDD0258  [3]
TH216
 Probe Info  		Y1149(16.64); Y1244(15.25)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
Probe 1
 Probe Info  		Y358(22.44); Y513(20.18); Y912(9.85); Y1244(18.63)  LDD3495  [5]
AHL-Pu-1
 Probe Info  		C636(2.31)  LDD0168  [6]
HHS-482
 Probe Info  		Y1149(0.69)  LDD0285  [7]
HHS-475
 Probe Info  		Y1149(0.84)  LDD0264  [8]
HHS-465
 Probe Info  		Y1149(9.58); Y1244(2.78); Y513(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C1252(1.23); C888(1.04); C677(0.90)  LDD0078  [10]
5E-2FA
 Probe Info  		H1270(0.00); H526(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K68(0.00); K262(0.00); K264(0.00); K518(0.00)  LDD0199  [12]
1d-yne
 Probe Info  		K1201(0.00); K1151(0.00)  LDD0358  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C888(0.00); C791(0.00); C759(0.00); C81(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		C742(0.00); C791(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C888(0.00); C636(0.00); C759(0.00); C677(0.00)  LDD0037  [14]
BTD
 Probe Info  		N.A.  LDD0004  [17]
JW-RF-010
 Probe Info  		C1252(0.00); C888(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
TFBX
 Probe Info  		C791(0.00); C1252(0.00); C888(0.00)  LDD0027  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		C888(0.00); C791(0.00)  LDD0022  [17]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
ENE
 Probe Info  		C888(0.00); C636(0.00); C791(0.00)  LDD0006  [17]
IPM
 Probe Info  		C636(0.00); C1252(0.00)  LDD0005  [17]
NHS
 Probe Info  		K722(0.00); K262(0.00); K518(0.00)  LDD0010  [17]
SF
 Probe Info  		Y1149(0.00); K398(0.00)  LDD0028  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [22]
1c-yne
 Probe Info  		K1179(0.00); K1151(0.00)  LDD0228  [13]
Acrolein
 Probe Info  		C759(0.00); C677(0.00); C888(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		C888(0.00); C791(0.00); C830(0.00); C1252(0.00)  LDD0236  [24]
AOyne
 Probe Info  		10.50  LDD0443  [25]
NAIA_5
 Probe Info  		C791(0.00); C636(0.00); C759(0.00); C677(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		8.59  LDD0471  [26]
FFF probe13
 Probe Info  		8.27  LDD0475  [26]
FFF probe14
 Probe Info  		20.00  LDD0477  [26]
FFF probe2
 Probe Info  		7.59  LDD0463  [26]
FFF probe3
 Probe Info  		7.45  LDD0465  [26]
FFF probe9
 Probe Info  		12.28  LDD0470  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C636(0.62)  LDD2142  [28]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C636(0.97)  LDD2112  [28]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C888(1.13); C1252(1.00)  LDD2117  [28]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C636(1.13)  LDD2152  [28]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C636(0.79)  LDD2103  [28]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C636(0.67)  LDD2132  [28]
 LDCM0025  4SU-RNA HEK-293T C636(2.31)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C636(2.40); C1252(3.03)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C1252(0.92); C636(0.95); C677(0.99); C759(1.20)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C1252(1.84); C636(1.12); C677(0.92); C759(0.79)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C1252(1.27); C636(0.88); C677(0.81); C759(1.04)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C1252(1.18); C636(0.93); C677(0.70); C759(0.91)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C1252(1.10); C636(0.87); C677(0.70); C759(1.05)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C1252(1.68); C636(0.96); C677(0.78); C759(1.38)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C1252(1.77); C636(0.99); C677(0.84); C759(0.96)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C1252(1.23); C636(0.98); C677(0.69); C759(0.97)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C1252(1.65); C636(0.98); C677(0.74); C759(1.29)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C1252(1.55); C636(0.77); C677(0.73); C759(1.08)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C1252(1.20); C636(0.89); C677(0.79); C759(0.86)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C1252(1.14); C636(0.97); C677(0.84); C759(0.82)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C1252(1.13); C636(1.07); C677(1.04); C759(1.04)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C1252(1.15); C636(1.03); C677(0.73); C759(1.05)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C1252(1.13); C636(0.94); C677(0.71); C759(1.03)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C1252(1.41); C636(0.79); C677(0.74); C759(0.90)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C1252(1.07); C636(0.85); C677(0.91); C759(1.01)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C1252(1.11); C636(1.00); C677(0.86); C759(1.06)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C1252(1.26); C636(1.01); C677(1.00); C759(0.90)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C1252(0.97); C636(1.16); C677(1.04); C759(1.44)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C1252(1.42); C636(1.06); C677(1.02); C759(0.98)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C1252(1.00); C636(0.96); C677(1.04); C759(1.03)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C1252(1.26); C636(0.83); C677(0.91); C759(1.06)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C1252(1.11); C636(1.05); C677(1.01); C759(0.93)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C1252(0.79); C636(0.95); C677(1.06); C759(0.98)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C1252(1.04); C636(0.98); C677(0.99); C759(1.02)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C1252(1.41); C636(0.93); C677(1.02); C759(1.16)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C1252(1.07); C636(1.00); C677(1.01); C759(1.10)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C1252(1.28); C636(1.06); C677(0.97); C759(1.09)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C1252(0.96); C636(1.00); C677(0.90); C759(0.91)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C1252(0.80); C636(1.01); C677(1.05); C759(1.17)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C1252(1.01); C636(1.11); C677(0.99); C759(1.01)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C1252(0.47); C636(1.28); C677(1.26); C759(1.40)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C1252(0.53); C636(1.07); C677(1.00); C759(0.82)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C1252(0.60); C636(1.20); C677(1.06); C759(1.13)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C1252(0.58); C636(1.05); C677(1.04); C759(0.90)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C1252(0.66); C636(1.09); C677(1.10); C759(1.02)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C1252(0.62); C636(1.25); C677(1.09); C759(0.98)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C1252(0.75); C636(1.29); C677(1.10); C759(0.98)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C1252(0.58); C636(1.03); C677(1.13); C759(1.02)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C1252(0.65); C636(1.25); C677(1.13); C759(1.04)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C1252(0.65); C636(1.10); C677(1.08); C759(1.02)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C1252(0.90); C636(1.11); C677(1.15); C759(1.05)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C1252(0.80); C636(1.23); C677(1.09); C759(1.08)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C1252(1.62); C636(0.98); C677(1.02); C759(0.89)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C1252(0.88); C636(1.48); C677(1.11); C759(1.13)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C1252(0.89); C636(1.26); C677(1.02); C759(1.05)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C1252(0.73); C636(1.20); C677(1.03); C759(0.95)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C1252(1.11); C636(0.99); C677(0.86); C759(0.94)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C1252(0.78); C677(0.90); C888(1.08); C636(1.12)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C677(0.78); C636(0.95); C1252(1.03); C888(1.04)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C677(0.92); C888(1.03); C759(1.12); C636(1.12)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C677(1.07); C759(1.15); C888(1.19); C636(1.20)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C1252(0.80); C677(1.33); C636(1.39); C888(1.41)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C1252(0.97); C636(1.03); C677(1.06); C888(1.14)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C759(0.92); C677(0.93); C791(0.96); C636(0.97)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C677(0.80); C636(0.96); C888(0.98); C759(1.04)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C677(0.79); C759(0.92); C888(1.03); C636(1.17)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C677(0.98); C1252(1.04); C759(1.05); C636(1.08)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C1252(1.05); C677(1.34); C636(1.47); C888(1.55)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C1252(1.01); C636(1.16); C677(0.87); C759(1.19)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C1252(0.95); C636(1.08); C677(0.81); C759(1.11)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C1252(1.57); C636(1.11); C677(0.81); C759(1.35)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C1252(0.88); C636(0.96); C677(0.77); C759(1.03)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C791(0.78); C81(0.87); C677(0.90); C759(0.92)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C81(0.91); C791(0.92); C759(0.93); C636(1.16)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C791(0.80); C81(0.84); C636(0.93); C759(0.94)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C1252(0.99); C81(1.01); C636(1.04); C791(1.07)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C791(0.73); C759(0.79); C636(0.87); C677(0.87)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C81(0.83); C791(0.86); C759(0.92); C677(0.96)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C791(0.73); C81(0.87); C759(0.91); C677(0.92)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C81(0.83); C791(0.84); C677(0.92); C759(0.92)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C81(0.73); C791(0.85); C677(0.92); C1252(0.94)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C677(0.88); C888(1.00); C636(1.01); C1252(1.02)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C791(0.92); C677(0.93); C636(1.07); C888(1.08)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C677(0.88); C791(1.02); C888(1.10); C636(1.24)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C791(0.98); C677(1.15); C759(1.22); C636(1.24)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C677(0.92); C791(0.95); C888(1.06); C636(1.06)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C1252(0.84); C888(0.95); C636(0.95); C81(0.99)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C677(0.86); C791(0.89); C888(1.10); C759(1.11)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C677(0.87); C791(0.88); C888(1.00); C636(1.19)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C791(0.87); C677(0.94); C888(1.10); C1252(1.12)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C677(0.88); C888(1.04); C791(1.06); C759(1.23)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C791(0.90); C677(0.98); C888(1.24); C636(1.33)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C1252(0.87); C888(0.91); C759(0.93); C636(0.96)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C888(0.93); C636(0.94); C677(0.98); C1252(0.98)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C888(0.87); C1252(0.89); C759(0.90); C636(0.93)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C677(0.93); C888(0.94); C636(0.98); C759(0.98)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C888(1.04); C1252(1.07); C677(1.08); C636(1.09)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C81(0.82); C1252(0.90); C677(1.10); C791(1.11)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C636(0.96); C888(0.97); C677(1.05); C791(1.06)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C888(0.88); C677(0.93); C791(0.97); C759(0.97)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C888(0.91); C677(0.92); C636(1.05); C759(1.06)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C791(0.91); C636(1.00); C888(1.02); C677(1.04)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C677(0.99); C636(1.04); C759(1.07); C888(1.07)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C677(1.03); C636(1.04); C888(1.06); C759(1.10)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C677(0.95); C791(0.97); C759(1.06); C888(1.08)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C677(0.91); C1252(0.97); C888(1.01); C759(1.04)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C677(0.91); C759(1.06); C791(1.08); C636(1.11)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C759(1.08); C791(1.08); C636(1.22); C677(1.22)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C1252(0.75); C81(0.82); C791(1.06); C636(1.16)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C677(0.99); C1252(1.12); C791(1.14); C759(1.14)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C677(0.85); C888(0.93); C791(0.98); C1252(1.04)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C677(0.86); C791(0.97); C759(0.98); C888(1.10)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C677(0.93); C759(1.05); C791(1.05); C888(1.11)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C677(1.01); C1252(1.14); C759(1.17); C636(1.19)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C677(1.04); C791(1.06); C759(1.08); C1252(1.20)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C791(1.12); C677(1.22); C759(1.37); C1252(1.41)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C677(1.00); C888(1.04); C1252(1.14); C791(1.21)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C791(0.89); C888(1.01); C677(1.02); C759(1.06)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C791(0.88); C677(1.07); C888(1.08); C636(1.16)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C636(0.91); C677(0.93); C759(1.01); C888(1.10)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C1252(0.88); C791(0.98); C677(1.01); C888(1.02)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C677(0.97); C888(1.05); C1252(1.09); C791(1.10)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C677(0.98); C791(1.04); C888(1.10); C1252(1.16)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C677(0.87); C1252(0.92); C888(0.93); C791(0.99)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C1252(0.91); C677(1.06); C791(1.10); C888(1.27)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C791(0.87); C677(1.02); C888(1.13); C1252(1.24)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C791(0.94); C1252(1.02); C677(1.06); C888(1.08)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C1252(1.05); C791(1.09); C677(1.12); C888(1.22)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C1252(0.84); C888(0.98); C677(1.05); C791(1.06)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C1252(0.77); C888(0.98); C759(1.06); C636(1.12)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C759(0.91); C677(0.91); C791(0.96); C888(1.02)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C636(0.93); C888(0.99); C759(1.11); C791(1.15)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C636(0.99); C888(1.03); C791(1.11); C759(1.15)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C1252(0.93); C791(1.01); C677(1.04); C888(1.04)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C791(1.34); C677(1.35); C759(1.39); C636(1.42)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C1252(0.64); C791(1.34); C888(1.34); C636(1.36)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C636(1.22); C791(1.35); C759(1.46); C1252(1.47)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C1252(0.98); C636(1.09); C888(1.20); C677(1.21)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C1252(0.85); C791(0.98); C636(1.00); C888(1.03)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C888(0.89); C1252(0.93); C636(0.96); C677(0.99)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C1252(0.91); C888(1.00); C636(1.07); C677(1.17)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C759(0.86); C791(0.91); C636(1.01); C677(1.07)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C636(1.01); C888(1.03); C791(1.08); C759(1.13)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C636(0.96); C759(1.06); C791(1.21); C677(1.26)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C1252(1.15); C791(1.32); C888(1.50); C636(1.53)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C888(0.87); C791(0.91); C81(0.93); C677(1.09)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C791(0.84); C888(0.91); C677(1.05); C81(1.06)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C888(0.68); C791(0.75); C759(0.98); C677(0.99)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C791(0.76); C888(0.80); C677(0.91); C759(1.01)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C888(0.70); C791(0.93); C677(1.03); C1252(1.07)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C791(0.82); C888(0.88); C677(0.93); C636(1.06)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C791(0.89); C677(0.90); C888(0.92); C759(1.11)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C791(0.81); C888(0.85); C677(0.98); C759(0.98)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C888(0.79); C791(0.82); C636(1.07); C677(1.10)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C791(0.76); C888(0.90); C677(1.02); C759(1.18)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C888(0.80); C791(0.81); C677(0.94); C759(1.03)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C791(0.65); C888(0.92); C677(1.05); C636(1.08)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C888(0.63); C791(0.81); C677(0.86); C759(0.99)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C888(0.81); C791(0.85); C677(0.95); C759(1.02)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C791(0.76); C888(0.91); C677(0.94); C759(0.95)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C791(0.91); C677(0.93); C636(1.00); C888(1.11)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C791(0.72); C677(0.76); C636(0.79); C888(0.92)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C636(0.33)  LDD2113  [28]
 LDCM0248  AKOS034007472 HCT 116 C1252(1.52); C636(0.92); C677(0.86); C759(0.94)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C677(0.93); C888(1.02); C759(1.10); C636(1.11)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C677(1.04); C759(1.11); C791(1.13); C888(1.21)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C1252(1.23); C888(1.04); C677(0.90)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C636(0.54)  LDD2091  [28]
 LDCM0630  CCW28-3 231MFP C1252(1.56)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa H1165(0.00); H1273(0.00); C636(0.00); C893(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C1252(20.00); C636(2.15); C759(2.09); C791(1.11)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C791(0.83); C888(0.89); C759(0.93); C677(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C888(0.91); C791(0.97); C636(1.01); C759(1.02)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C81(0.71); C1252(0.95); C677(1.07); C636(1.09)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C759(0.90); C677(0.92); C636(0.97); C791(1.07)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C759(0.89); C677(0.93); C636(0.97); C888(1.07)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C888(0.92); C636(0.92); C677(0.93); C759(0.97)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C677(0.90); C636(1.02); C888(1.05); C791(1.08)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C791(0.83); C81(0.85); C759(0.91); C636(0.91)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C81(0.88); C791(0.91); C759(1.02); C636(1.11)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C81(0.84); C791(0.91); C759(1.00); C677(1.13)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C81(0.85); C791(0.88); C636(1.03); C759(1.23)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C791(0.73); C81(0.86); C759(0.86); C677(0.88)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C888(0.98); C791(1.03); C759(1.11); C636(1.16)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C81(0.82); C791(0.85); C759(1.00); C636(1.01)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C81(0.68); C791(0.85); C759(0.90); C636(0.91)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C791(0.76); C677(1.00); C636(1.02); C888(1.07)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C677(0.86); C791(0.93); C888(1.16); C1252(1.28)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C677(0.85); C791(0.88); C759(0.96); C888(1.00)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C677(0.89); C791(0.91); C888(0.99); C636(1.12)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C677(0.92); C791(0.94); C888(1.01); C636(1.08)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C888(1.06); C1252(1.16); C636(1.20); C677(1.26)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C791(0.96); C1252(0.97); C677(1.04); C888(1.04)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C677(1.00); C791(1.01); C636(1.03); C1252(1.04)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C888(1.04); C677(1.17); C1252(1.18); C636(1.19)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C677(0.91); C636(0.98); C888(1.01); C759(1.01)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C759(0.89); C677(0.90); C888(0.90); C636(0.96)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C791(1.05); C759(1.06); C677(1.07); C636(1.20)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C791(1.02); C677(1.06); C759(1.12); C888(1.15)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C759(1.00); C677(1.06); C791(1.13); C636(1.27)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C677(0.85); C888(0.91); C791(0.93); C759(0.96)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C677(0.90); C888(0.90); C791(0.91); C1252(0.95)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C791(0.85); C677(0.88); C888(0.95); C1252(1.05)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C677(0.99); C888(1.03); C759(1.05); C1252(1.14)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C888(0.91); C791(0.98); C759(1.01); C677(1.06)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C888(0.77); C791(0.83); C677(0.92); C759(0.96)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C888(0.80); C791(0.93); C759(0.95); C1252(1.04)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C636(0.95); C791(1.00); C888(1.00); C759(1.09)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C759(0.65); C677(0.66); C791(0.79); C888(0.82)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C677(0.63); C791(0.94); C888(0.97); C636(1.07)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C677(0.63); C759(1.03); C791(1.05); C888(1.07)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C888(0.91); C791(0.92); C759(0.93); C1252(1.01)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C759(0.74); C677(0.75); C791(0.80); C888(1.13)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C677(0.62); C888(0.88); C791(0.92); C1252(1.16)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C677(0.66); C759(0.85); C791(0.94); C888(1.26)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C677(0.77); C759(0.81); C791(0.90); C636(0.95)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C677(0.66); C759(1.07); C888(1.09); C791(1.10)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C1252(1.25); C636(1.07); C677(0.92); C759(0.95)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C1252(1.24); C636(1.21); C677(0.94); C759(0.86)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C1252(1.28); C636(1.33); C677(0.82); C759(0.73)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C1252(1.35); C636(1.24); C677(0.98); C759(0.78)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C1252(1.09); C636(1.27); C677(0.59); C759(0.77)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C1252(0.97); C636(1.03); C677(1.11); C759(0.91)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C1252(1.02); C636(0.96); C677(1.27); C759(0.64)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C1252(1.41); C636(1.16); C677(1.05); C759(1.02)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C1252(0.99); C636(0.98); C677(1.00); C759(1.04)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C1252(0.99); C636(1.01); C677(0.97); C759(0.95)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C1252(1.17); C636(0.96); C677(1.21); C759(1.22)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C1252(1.48); C636(0.87); C677(0.97); C759(1.18)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C1252(1.14); C636(1.05); C677(0.97); C759(1.20)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C1252(1.02); C636(0.92); C677(0.98); C759(1.28)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C1252(1.27); C636(0.87); C677(1.11); C759(1.16)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C1252(1.29); C636(1.10); C677(0.93); C759(0.88)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C1252(1.76); C636(1.04); C677(0.81); C759(1.10)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C1252(1.23); C636(0.87); C677(1.03); C759(1.13)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C1252(1.15); C636(0.82); C677(0.86); C759(1.45)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C1252(0.93); C636(1.05); C677(1.01); C759(1.24)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C1252(1.44); C636(0.85); C677(0.97); C759(1.14)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C1252(1.14); C636(0.94); C677(0.99); C759(1.19)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C1252(1.07); C636(0.80); C677(0.92); C759(0.92)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C1252(0.98); C636(0.90); C677(0.87); C759(0.83)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C1252(0.98); C636(0.97); C677(0.88); C759(0.86)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C1252(0.96); C636(0.79); C677(1.19); C759(1.03)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C1252(1.01); C636(0.93); C677(1.10); C759(0.99)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C1252(0.94); C636(0.89); C677(0.89); C759(0.98)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C1252(0.92); C636(0.88); C677(1.04); C759(1.14)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C1252(0.96); C636(0.72); C677(1.02); C759(0.91)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C1252(1.04); C636(0.66); C677(1.05); C759(0.95)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C1252(1.24); C636(0.66); C677(0.78); C759(1.02)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C1252(0.93); C636(0.86); C677(0.92); C759(1.05)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C1252(1.02); C636(0.78); C677(0.88); C759(0.89)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C1252(1.14); C636(0.79); C677(0.90); C759(1.03)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C1252(1.07); C636(0.73); C677(0.93); C759(0.98)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C1252(0.98); C636(0.70); C677(0.87); C759(1.10)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C1252(0.90); C636(1.29); C677(1.12); C759(0.92)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C1252(1.25); C636(0.78); C677(0.93); C759(0.91)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C1252(0.93); C636(0.91); C677(1.08); C759(1.03)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C1252(0.90); C636(1.14); C677(1.05); C759(0.95)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C1252(0.87); C636(1.02); C677(1.03); C759(1.01)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C1252(1.23); C636(1.04); C677(1.11); C759(1.16)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C1252(1.14); C636(1.09); C677(1.02); C759(1.10)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C1252(0.92); C636(1.29); C677(1.10); C759(1.37)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C1252(0.83); C636(1.06); C677(1.03); C759(1.35)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C1252(1.08); C636(0.88); C677(1.13); C759(1.08)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C1252(0.92); C636(1.05); C677(1.10); C759(0.88)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C1252(1.17); C636(1.28); C677(1.30); C759(1.05)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C1252(1.12); C636(1.22); C677(1.05); C759(1.14)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C1252(1.06); C636(1.09); C677(1.11); C759(1.29)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C1252(1.03); C636(1.03); C677(1.01); C759(1.10)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C1252(1.08); C636(0.97); C677(1.05); C759(0.95)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C1252(0.91); C636(1.17); C677(0.93); C759(1.13)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C1252(0.88); C636(0.92); C759(1.11); C791(0.89)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C1252(0.86); C636(0.93); C759(1.09); C791(0.98)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C1252(1.19); C636(1.01); C759(1.01); C791(1.08)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C1252(0.89); C636(1.06); C759(1.38); C791(1.06)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C1252(1.46); C636(1.31); C677(1.23); C759(1.05)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C1252(1.07); C636(0.86); C759(1.23); C791(1.07)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C1252(0.89); C636(1.17); C759(1.08); C791(1.07)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C1252(0.89); C636(1.22); C759(1.14); C791(1.10)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C1252(1.07); C636(1.13); C759(1.23); C791(1.04)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C1252(1.28); C636(1.54); C759(1.15); C791(1.10)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C1252(1.22); C636(1.03); C759(1.15); C791(1.07)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C1252(0.96); C636(0.94); C759(1.16); C791(1.02)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C1252(0.90); C636(1.69); C759(1.13); C791(1.00)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C1252(0.98); C636(1.05); C759(1.21); C791(0.99)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C1252(0.89); C636(1.60); C759(1.27); C791(1.17)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C1252(1.25); C636(1.14); C677(1.04); C759(0.98)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C1252(1.12); C636(0.81); C759(1.01); C791(0.97)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C1252(0.88); C636(0.99); C677(1.05); C759(1.26)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C1252(0.96); C636(1.04); C677(1.07); C759(1.15)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C1252(1.05); C636(1.02); C677(1.06); C759(1.24)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C1252(0.99); C636(1.04); C677(0.92); C759(1.01)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C1252(1.17); C636(0.99); C677(0.91); C759(1.07)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C1252(0.94); C636(0.87); C677(0.95); C759(1.32)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C1252(0.73); C636(1.04); C677(0.98); C759(1.31)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C1252(0.89); C636(1.31); C677(1.07); C759(1.07)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C1252(0.94); C636(1.17); C677(1.04); C759(1.16)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C791(0.85); C636(1.03); C677(0.96); C888(1.06)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1252(1.18); C677(1.05); C636(1.04)  LDD1702  [28]
 LDCM0625  F8 Ramos C1252(0.99)  LDD2187  [31]
 LDCM0572  Fragment10 MDA-MB-231 C1252(1.62)  LDD1389  [32]
 LDCM0573  Fragment11 Ramos C1252(2.70)  LDD1392  [32]
 LDCM0574  Fragment12 Ramos C1252(0.88)  LDD1394  [32]
 LDCM0575  Fragment13 MDA-MB-231 C1252(0.71)  LDD1395  [32]
 LDCM0576  Fragment14 MDA-MB-231 C1252(0.98)  LDD1397  [32]
 LDCM0577  Fragment15 Ramos C1252(0.91)  LDD1400  [32]
 LDCM0579  Fragment20 MDA-MB-231 C1252(1.20)  LDD1402  [32]
 LDCM0580  Fragment21 MDA-MB-231 C1252(1.27)  LDD1404  [32]
 LDCM0582  Fragment23 MDA-MB-231 C1252(1.62)  LDD1408  [32]
 LDCM0583  Fragment24 Ramos C1252(3.19)  LDD1410  [32]
 LDCM0584  Fragment25 MDA-MB-231 C1252(0.99)  LDD1411  [32]
 LDCM0578  Fragment27 MDA-MB-231 C1252(0.89)  LDD1401  [32]
 LDCM0586  Fragment28 MDA-MB-231 C1252(0.89)  LDD1415  [32]
 LDCM0587  Fragment29 MDA-MB-231 C1252(1.00)  LDD1417  [32]
 LDCM0588  Fragment30 MDA-MB-231 C1252(0.90)  LDD1419  [32]
 LDCM0589  Fragment31 MDA-MB-231 C1252(1.70)  LDD1421  [32]
 LDCM0590  Fragment32 Ramos C1252(5.94)  LDD1424  [32]
 LDCM0468  Fragment33 HCT 116 C1252(1.00); C636(1.04); C677(0.98); C759(0.98)  LDD0785  [10]
 LDCM0593  Fragment35 Ramos C1252(0.94)  LDD1430  [32]
 LDCM0595  Fragment37 Ramos C1252(1.28)  LDD1432  [32]
 LDCM0596  Fragment38 MDA-MB-231 C1252(1.26)  LDD1433  [32]
 LDCM0597  Fragment39 MDA-MB-231 C1252(2.28)  LDD1435  [32]
 LDCM0566  Fragment4 MDA-MB-231 C1252(1.75)  LDD1378  [32]
 LDCM0598  Fragment40 MDA-MB-231 C1252(0.91)  LDD1436  [32]
 LDCM0599  Fragment41 MDA-MB-231 C1252(1.13)  LDD1438  [32]
 LDCM0600  Fragment42 Ramos C1252(0.82)  LDD1440  [32]
 LDCM0601  Fragment43 MDA-MB-231 C1252(6.39)  LDD1441  [32]
 LDCM0607  Fragment49 MDA-MB-231 C1252(12.85)  LDD1448  [32]
 LDCM0427  Fragment51 HCT 116 C1252(1.80); C636(1.06); C677(0.96); C759(1.32)  LDD0744  [10]
 LDCM0610  Fragment52 MDA-MB-231 C1252(1.11)  LDD1452  [32]
 LDCM0611  Fragment53 MDA-MB-231 C1252(0.94)  LDD1454  [32]
 LDCM0613  Fragment55 MDA-MB-231 C1252(0.98)  LDD1457  [32]
 LDCM0614  Fragment56 MDA-MB-231 C1252(1.01)  LDD1458  [32]
 LDCM0569  Fragment7 Ramos C1252(0.88); C636(0.68)  LDD2186  [31]
 LDCM0570  Fragment8 MDA-MB-231 C1252(1.58)  LDD1385  [32]
 LDCM0571  Fragment9 MDA-MB-231 C1252(1.01)  LDD1387  [32]
 LDCM0116  HHS-0101 DM93 Y1149(0.84)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y1149(0.85); Y513(1.55)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y1149(0.79); Y513(2.26)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y1149(0.85)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y1149(0.81); Y513(2.68)  LDD0268  [8]
 LDCM0107  IAA HeLa H1273(0.00); H1136(0.00); H1270(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y1149(0.69)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y1149(0.47)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y1149(0.62)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y1149(1.58)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y1149(0.83)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y1149(0.46)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y1149(0.93)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y1149(0.58)  LDD0292  [7]
 LDCM0022  KB02 HCT 116 C759(2.59); C677(2.06); C888(1.76)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C759(4.69); C677(2.79); C888(1.46)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C759(4.12); C677(3.36); C888(1.29)  LDD0082  [10]
 LDCM0109  NEM HeLa H1270(0.00); H1273(0.00)  LDD0223  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C636(0.93)  LDD2090  [28]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C636(0.73)  LDD2092  [28]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C636(0.93)  LDD2093  [28]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C636(0.91)  LDD2094  [28]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C893(0.21)  LDD2096  [28]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C636(0.57)  LDD2098  [28]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C677(1.42); C1252(0.77)  LDD2099  [28]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C636(0.68)  LDD2100  [28]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C677(1.42); C636(1.11)  LDD2104  [28]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C636(0.93)  LDD2105  [28]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C636(0.62)  LDD2106  [28]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C677(0.93); C636(0.97); C888(0.98); C791(1.47)  LDD2107  [28]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C636(0.92)  LDD2108  [28]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C677(0.65); C636(0.64); C893(0.41)  LDD2109  [28]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C636(1.54)  LDD2110  [28]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C677(1.27); C636(1.08)  LDD2111  [28]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C677(1.36); C636(0.82)  LDD2114  [28]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C636(0.86); C893(0.30)  LDD2118  [28]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C636(1.40)  LDD2119  [28]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C636(1.03)  LDD2120  [28]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C636(1.13); C893(0.28)  LDD2122  [28]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C888(1.12); C1252(0.77); C893(0.69)  LDD2123  [28]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C636(0.78)  LDD2124  [28]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C677(0.93); C636(0.87); C888(1.01); C1252(0.63)  LDD2125  [28]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C636(0.84)  LDD2126  [28]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C677(1.03); C636(1.03); C1252(0.61); C893(0.90)  LDD2127  [28]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C636(0.93)  LDD2128  [28]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C677(1.11); C636(0.91)  LDD2129  [28]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C888(1.52)  LDD2134  [28]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C677(1.63)  LDD2135  [28]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C677(1.25); C888(1.16); C893(1.01)  LDD2136  [28]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C677(1.13); C636(0.98); C888(1.02)  LDD2137  [28]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C636(1.33)  LDD1700  [28]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C677(1.20)  LDD2140  [28]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C636(0.79)  LDD2141  [28]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C636(1.01)  LDD2143  [28]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C677(1.37); C636(2.01); C759(1.88)  LDD2144  [28]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C636(0.93)  LDD2146  [28]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C636(2.68)  LDD2147  [28]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C677(0.47)  LDD2148  [28]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C893(0.36)  LDD2149  [28]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C636(0.49)  LDD2150  [28]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C636(1.07)  LDD2153  [28]
 LDCM0627  NUDT7-COV-1 HEK-293T C791(0.65); C1252(0.33)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C791(0.82); C1252(0.79)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C1252(1.36)  LDD0304  [34]
 LDCM0021  THZ1 HCT 116 C636(1.03); C888(1.31); C1252(1.18)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 6A (PSMC3) AAA ATPase family P17980
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7
L-lactate dehydrogenase A-like 6B (LDHAL6B) LDH family Q9BYZ2
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) Maf family O95671
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) L-isoaspartyl/D-aspartyl protein methyltransferase family Q9NV79
Caspase-3 (CASP3) Peptidase C14A family P42574
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
MPN domain-containing protein (MPND) Peptidase M67 family Q8N594
E3 ubiquitin-protein ligase RNF168 (RNF168) RNF168 family Q8IYW5
RING finger protein 112 (RNF112) GB1/RHD3 GTPase family Q9ULX5
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Bardet-Biedl syndrome 4 protein (BBS4) BBS4 family Q96RK4
Sorting nexin-6 (SNX6) Sorting nexin family Q9UNH7
Bardet-Biedl syndrome 1 protein (BBS1) . Q8NFJ9
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Homeobox protein DLX-3 (DLX3) Distal-less homeobox family O60479
Twist-related protein 2 (TWIST2) . Q8WVJ9
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-centractin (ACTR1B) Actin family P42025
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
KIF-binding protein (KIFBP) KIF-binding protein family Q96EK5
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
U6 snRNA-associated Sm-like protein LSm8 (LSM8) SnRNP Sm proteins family O95777
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) Ubiquitin family; Eukaryotic ribosomal protein eL40 family P62987
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
Enkurin (ENKUR) . Q8TC29
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Melanoma-associated antigen 6 (MAGEA6) . P43360
RING1 and YY1-binding protein (RYBP) . Q8N488
Superkiller complex protein 8 (SKIC8) . Q9GZS3
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
34 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.