Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment35					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	10.4
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	2.4
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.8
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.7
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.6
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.5
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.5
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.5
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.4
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	1.4
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	1.3
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.3
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.3
LDTP06211	Caspase-8 (CASP8)				C360	1.3
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	1.3
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.3
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.3
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	1.3
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.2
LDTP04374	Dynamin-2 (DNM2)				C27	1.2
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.2
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	1.2
LDTP05859	Integrin-linked protein kinase (ILK)				C346	1.2
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.1
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.1
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.1
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	1.1
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	1.1
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	1.1
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.1
LDTP09912	DNA repair protein RAD50 (RAD50)				C1302	1.1
LDTP01245	Enoyl-CoA delta isomerase 2 (ECI2)				C380	1.1
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.0
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.0
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	1.0
LDTP02672	Elongation factor 2 (EEF2)				C41	1.0
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.0
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.0
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.0
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.0
LDTP10177	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)				C64	1.0
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.0
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.0
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C193	0.9
LDTP04689	Adenosine kinase (ADK)				C353	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.9
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.9
LDTP04690	Double-stranded RNA-specific adenosine deaminase (ADAR)				C1224	0.9
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.9
LDTP04251	Elongation factor Tu, mitochondrial (TUFM)				C147	0.9
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	0.9
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	0.9
LDTP02733	Pyruvate kinase PKM (PKM)				C423	0.9
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	0.8
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	0.8
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	0.8
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	0.8
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11855	Pinin (PNN)				C249	2.1
LDTP03777	Nuclear pore complex protein Nup214 (NUP214)				C728	1.4
LDTP00501	Exportin-1 (XPO1)				C34	1.3
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.2
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.2
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.1
LDTP04662	Exportin-2 (CSE1L)				C842	1.1
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0
LDTP01574	Importin-7 (IPO7)				C757	1.0
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.9
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	0.9
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.8
LDTP00501	Exportin-1 (XPO1)				C528	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	1.4
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.1
LDTP02016	Glucocorticoid receptor (NR3C1)				C302	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	2.0
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.6
LDTP06244	Nuclear mitotic apparatus protein 1 (NUMA1)				C961	1.5
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.4
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	1.4
LDTP07755	Dynamin-binding protein (DNMBP)				C691	1.4
LDTP09549	Conserved oligomeric Golgi complex subunit 1 (COG1)				C513	1.3
LDTP05259	Heterogeneous nuclear ribonucleoprotein U (HNRNPU)				C562	1.3
LDTP04092	Crk-like protein (CRKL)				C249	1.2
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	1.2
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	1.2
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.2
LDTP11235	Protein PAXX (PAXX)				C180	1.2
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.2
LDTP01532	ZW10 interactor (ZWINT)				C54	1.2
LDTP02205	Tubulin beta chain (TUBB)				C239	1.2
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.1
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.1
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C280	1.1
LDTP13580	Coronin-1C (CORO1C)				C420	1.1
LDTP02511	cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)				C18	1.1
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.1
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.1
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	1.1
LDTP12443	Anillin (ANLN)				C712	1.0
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	1.0
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.0
LDTP10864	Calponin-2 (CNN2)				C215	1.0
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	1.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	1.0
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.0
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.0
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	1.0
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	1.0
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	1.0
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	1.0
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	1.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.0
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	1.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.0
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	1.0
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.0
LDTP13591	A-kinase anchor protein 8-like (AKAP8L)				C211	1.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.0
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.0
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	0.9
LDTP10284	Multivesicular body subunit 12A (MVB12A)				C231	0.9
LDTP13837	Trafficking protein particle complex subunit 4 (TRAPPC4)				C195	0.9
LDTP02205	Tubulin beta chain (TUBB)				C354	0.9
LDTP10864	Calponin-2 (CNN2)				C164	0.9
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	0.9
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	0.9
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	0.9
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	0.9
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	0.9
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	0.9
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	0.9
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	0.8
LDTP12571	LanC-like protein 2 (LANCL2)				C187	0.8
LDTP00768	Protein CBFA2T2 (CBFA2T2)				C111	0.8
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.8
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	0.8
LDTP00430	Transcription elongation regulator 1 (TCERG1)				C1062	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.7
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	0.7
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	0.6

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.