Details of the Target

General Information of Target

Target ID LDTP00768
Target Name Protein CBFA2T2 (CBFA2T2)
Gene Name CBFA2T2
Gene ID 9139
Synonyms
EHT; MTGR1; Protein CBFA2T2; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKESGISLKEIQVLARQWKVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPR
PVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLK
RFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKA
NLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPER
REENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIA
TSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIME
MVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDS
QREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQ
TIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHH
RLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAID
TNGL
Target Bioclass
Other
Family
CBFA2T family
Subcellular location
Nucleus
Function
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner. Can repress the expression of MMP7 in a ZBTB33-dependent manner. May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation.
Uniprot ID
O43439
Ensemble ID
ENST00000342704.11
HGNC ID
HGNC:1536

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C583(1.40)  LDD3367  [1]
IA-alkyne
 Probe Info  		C111(20.00)  LDD1374  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]
Compound 11
 Probe Info  		N.A.  LDD2213  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
1d-yne
 Probe Info  		N.A.  LDD0357  [6]
AOyne
 Probe Info  		12.30  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C573(1.16)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C573(1.00); C261(0.75)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C192(0.94); C573(1.05); C261(0.85)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C573(1.10)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C192(0.96); C573(0.93); C261(0.85)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C192(1.15); C573(1.09)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C573(1.03)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C573(1.03); C261(0.99)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C192(0.96); C573(1.34); C261(2.86)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C573(1.09); C261(0.77)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C573(1.14)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C192(1.05); C573(0.97); C111(1.05); C261(0.97)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C192(1.01); C573(0.95); C261(0.71)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C192(1.19); C573(0.92)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C192(0.93); C573(1.11)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C573(1.25)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C573(1.08); C261(0.97)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C192(0.98); C573(1.05); C261(1.07)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C573(1.06)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C192(1.10); C573(1.00); C111(0.93); C261(1.41)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C192(0.94); C573(1.00); C261(1.14)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C192(0.79); C573(1.02); C261(0.83)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C192(1.12); C573(0.93)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C192(1.18); C573(0.93)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C573(1.23)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C573(1.05); C261(1.01)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C192(0.97); C573(1.09); C261(0.76)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C573(1.08)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C192(1.12); C573(0.91); C111(1.12); C261(1.21)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C192(1.19); C573(1.00); C261(0.80)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C192(1.21); C573(1.23)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C573(0.97)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C192(0.96); C573(0.98)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C573(1.13)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C573(1.12); C261(0.77)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C192(0.98); C573(1.02); C261(0.96)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C573(1.11)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C192(1.00); C573(0.94); C111(1.07); C261(1.08)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C192(1.15); C573(1.04); C261(0.89)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C192(1.18); C573(1.27)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C192(1.35); C573(1.09)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C573(1.16)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C192(1.01); C573(1.00); C111(0.95); C261(1.09)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C573(1.03); C261(0.92)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C192(1.03); C573(1.00); C261(0.93)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C573(1.06)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C192(1.09); C573(0.93); C111(0.99); C261(1.23)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C192(1.05); C573(0.93); C261(1.00)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C192(1.18); C573(1.16)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C192(1.08); C573(1.09)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C573(1.26)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C573(1.06); C261(0.90)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C192(1.02); C573(1.02); C261(0.88)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C192(0.84); C573(0.94); C261(1.14)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C573(1.02)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C192(1.09); C573(1.08); C111(0.99); C261(0.95)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C192(0.96); C573(1.01); C261(0.71)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C192(1.20); C573(1.27)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C192(1.14); C573(1.03)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C192(1.16); C573(1.05)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C192(1.04); C573(1.01)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C192(1.09); C573(0.86); C111(1.02); C261(1.39)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C573(1.26)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C192(0.99); C573(1.13)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C192(0.97); C573(0.91); C111(1.15)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C192(0.72); C573(1.03); C261(1.29)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C573(0.90)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C192(0.95); C573(0.87); C111(0.97)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C192(0.98); C573(0.95); C261(1.02)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C192(1.01); C573(1.05); C261(0.69)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C573(0.95)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C192(0.94); C573(0.84); C111(1.03)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C192(1.00); C573(0.88); C261(1.29)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C192(0.90); C573(1.04); C261(0.67)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C573(0.97)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C192(0.91); C573(0.92); C111(0.98)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C192(1.03); C573(1.03)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C192(0.92); C573(0.78); C261(1.07)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C192(0.89); C573(1.02); C261(0.79)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C573(0.91)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C192(1.10); C573(1.08); C111(0.96)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C192(0.94); C573(1.00); C261(1.09)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C192(0.98); C573(0.92); C261(0.72)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C573(1.07)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C192(0.96); C573(0.99); C111(1.11)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C192(1.12); C573(1.09); C261(1.35)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C192(1.07); C573(0.99); C261(0.79)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C192(0.90); C573(1.22)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C573(1.06)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C192(1.05); C573(0.85); C111(1.04)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C192(1.02); C573(0.89); C261(1.33)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C192(0.98); C573(0.93); C261(0.93)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C573(1.00)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C192(0.97); C573(0.98); C111(1.20)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C192(1.01); C573(1.00); C261(0.90)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C192(1.03); C573(1.07); C261(0.79)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C573(1.02)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C192(0.96); C573(1.05); C111(1.16)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C192(1.15); C573(0.94); C261(1.02)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C192(0.93); C573(0.99); C261(0.66)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C573(0.91)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C573(1.11)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C573(1.08); C261(0.90)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C192(1.00); C573(1.08); C261(1.19)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C192(1.05); C573(0.88); C261(1.38)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C573(0.93)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C192(1.16); C573(0.88); C111(1.17); C261(1.45)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C192(0.91); C573(1.21); C261(1.81)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C192(1.25); C573(1.12)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C192(0.98); C573(1.26)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C192(0.90); C573(0.90); C111(0.90)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C192(1.05); C573(0.93); C261(1.02)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C192(0.95); C573(0.99); C261(0.50)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C573(0.86)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C573(1.21)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C192(0.96); C573(1.05); C261(0.72)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C573(1.08); C261(0.83)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C192(0.96); C573(1.12); C261(1.00)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C573(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C192(0.90); C573(0.87); C111(0.86); C261(1.34)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C192(1.02); C573(1.22); C261(1.13)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C192(1.16); C573(1.06)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C192(0.80); C573(1.05)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C192(0.94); C573(0.97); C111(1.14)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C192(1.00); C573(0.94); C261(0.66)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C573(0.95)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C573(1.10)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C573(1.14)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C573(1.21); C261(1.06)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C192(1.00); C573(0.98); C261(0.72)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C573(1.13)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C192(0.98); C573(0.99); C111(0.97); C261(0.91)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C192(1.01); C573(1.24); C261(1.24)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C192(1.06); C573(1.20)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C192(0.91); C573(1.11)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C192(0.95); C573(1.02); C111(1.12)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C573(1.17)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C192(1.06); C573(0.94); C261(1.00)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C573(0.98)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C573(1.16)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C573(0.99); C261(0.76)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C192(0.94); C573(1.00); C261(0.97)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C573(1.07)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C192(1.18); C573(1.05); C111(0.90); C261(1.35)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C192(1.06); C573(1.11); C261(1.19)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C192(1.19); C573(1.16)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C573(0.94); C261(0.91)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C192(1.16); C573(1.20)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C192(1.06); C573(0.93); C111(1.14)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C192(1.09); C573(1.05); C261(1.09)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C192(1.00); C573(1.01); C261(0.71)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C573(0.83)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C573(0.94)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C573(1.00); C261(0.87)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C192(1.12); C573(1.00); C261(1.10)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C573(1.25)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C192(1.01); C573(0.94); C111(0.88); C261(1.56)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C192(1.04); C573(1.07); C261(1.08)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C192(0.84); C573(1.10); C261(0.99)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C192(1.11); C573(0.87)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C192(1.10); C573(1.20)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C192(0.94); C573(0.82); C111(1.16)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C192(1.08); C573(0.92); C261(0.79)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C573(1.10)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C573(1.07)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C573(1.07); C261(0.75)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C192(0.95); C573(1.07); C261(1.31)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C573(0.89)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C573(1.06)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C192(1.08); C573(1.03); C111(0.97); C261(1.51)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C192(0.91); C573(1.10); C261(1.02)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C192(1.11); C573(1.23)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C192(0.98); C573(1.06)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C192(1.00); C573(0.83); C111(1.14)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C192(1.17); C573(0.94); C261(0.90)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C192(1.09); C573(1.03); C261(0.56)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C573(1.04)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C573(1.16)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C192(1.04); C573(1.00); C111(0.99); C261(1.44)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C573(0.95); C261(0.83)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C192(0.99); C573(1.09); C261(1.07)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C573(0.93)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C192(1.03); C573(1.08); C111(1.05); C261(1.09)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C192(0.91); C573(1.20); C261(1.03)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C192(1.03); C573(1.08)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C192(0.97); C573(1.00)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C192(1.01); C573(0.99); C111(1.01)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C192(0.94); C573(0.90); C261(1.33)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C192(0.96); C573(0.98); C261(0.68)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C192(0.91); C573(1.08); C261(0.73)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C261(2.25)  LDD1702  [9]
 LDCM0576  Fragment14 MDA-MB-231 C111(20.00)  LDD1397  [2]
 LDCM0579  Fragment20 MDA-MB-231 C111(5.31)  LDD1402  [2]
 LDCM0578  Fragment27 MDA-MB-231 C111(1.20)  LDD1401  [2]
 LDCM0587  Fragment29 MDA-MB-231 C111(0.86)  LDD1417  [2]
 LDCM0468  Fragment33 HEK-293T C192(1.04); C573(0.96); C261(0.83)  LDD1671  [8]
 LDCM0593  Fragment35 Ramos C111(0.82)  LDD1430  [2]
 LDCM0606  Fragment48 MDA-MB-231 C111(1.75)  LDD1447  [2]
 LDCM0427  Fragment51 HEK-293T C192(1.12); C573(1.04); C261(0.98)  LDD1631  [8]
 LDCM0022  KB02 MDA-MB-231 C111(20.00)  LDD1374  [2]
 LDCM0023  KB03 HEK-293T C573(1.02)  LDD1497  [8]
 LDCM0024  KB05 NUGC-3 C583(1.40)  LDD3367  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) PP2C family Q9P0J1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger C2HC domain-containing protein 1A (ZC2HC1A) ZC2HC1 family Q96GY0
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phagosome assembly factor 1 (PHAF1) PHAF1 family Q9BSU1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Suppressor of IKBKE 1 (SIKE1) SIKE family Q9BRV8
T-complex protein 1 subunit alpha (TCP1) TCP-1 chaperonin family P17987
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Melanoma-associated antigen 6 (MAGEA6) . P43360
Vinexin (SORBS3) . O60504

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761