Details of the Target

General Information of Target

Target ID LDTP13591
Target Name A-kinase anchor protein 8-like (AKAP8L)
Gene Name AKAP8L
Gene ID 26993
Synonyms
NAKAP; NAKAP95; A-kinase anchor protein 8-like; AKAP8-like protein; Helicase A-binding protein 95; HAP95; Homologous to AKAP95 protein; HA95; Neighbor of A-kinase-anchoring protein 95; Neighbor of AKAP95
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRPALSVTSFCHRLGKRERKQSFMGNSGNSWSHTPFPKLELGLGPQPMAPRELPTCSIC
LERLRDPISLDCGHDFCIRCFSTHRLPGCEPPCCPECRKICKQKRGLRSLGEKMKLLPQR
PLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHS
GKSFLLNHLLQGLPGLESGEGGRPRGGEASLQGCRWGANGLARGIWMWSHPFLLGKEGKK
VAVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEV
MGKHYGMVPIQHLDLLVRDSSHPNKAGQGHVGNIFQRLSGRYPKVQELLQGKRARCCLLP
APGRRRMNQGHASPGDTDDDFRHLLGAYVSDVLSAAPQHAKSRCQGYWNEGRAVARGDRR
LLTGQQLAQEIKNLSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDVATK
RIFSALRVLPDTMRNLLSTQKDAILARHGVALLCKGRDQTLEALEAELQATAKAFMDSYT
MRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGV
GAGLAATVGCMEKEEDERLLEGDREPLLQEE
Target Bioclass
Other
Family
AKAP95 family
Subcellular location
Nucleus
Function
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing.; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
Uniprot ID
Q9ULX6
Ensemble ID
ENST00000397410.10
HGNC ID
HGNC:29857

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.K441R .
CASKI SNV: p.E556Q DBIA    Probe Info 
CHL1 SNV: p.T65N DBIA    Probe Info 
HCT15 SNV: p.G350R DBIA    Probe Info 
HT115 SNV: p.T398P DBIA    Probe Info 
MCC13 Substitution: p.L489F DBIA    Probe Info 
MDAMB231 SNV: p.Q372H IA-alkyne    Probe Info 
MDAMB453 SNV: p.Q24E DBIA    Probe Info 
MEC1 SNV: p.P219L DBIA    Probe Info 
P31FUJ SNV: p.S68Y DBIA    Probe Info 
REH SNV: p.M472T DBIA    Probe Info 
RL952 SNV: p.M514V DBIA    Probe Info 
TOV21G SNV: p.E555Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K264(6.67); K439(0.81); K503(5.36); K519(1.43)  LDD0277  [2]
Probe 1
 Probe Info  		Y435(9.02)  LDD3495  [3]
BTD
 Probe Info  		C211(1.00)  LDD2090  [4]
Sulforaphane-probe2
 Probe Info  		1.75  LDD0160  [5]
AHL-Pu-1
 Probe Info  		C128(2.97)  LDD0169  [6]
HPAP
 Probe Info  		3.06  LDD0062  [7]
EA-probe
 Probe Info  		N.A.  LDD0440  [8]
DBIA
 Probe Info  		C128(1.01); C211(0.85)  LDD0078  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C211(0.00); C128(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C211(0.00); C487(0.00); C484(0.00); C128(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C128(0.00); C211(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
Compound 10
 Probe Info  		C128(0.00); C211(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C128(0.00); C211(0.00)  LDD2213  [13]
IPM
 Probe Info  		N.A.  LDD0005  [12]
TFBX
 Probe Info  		C128(0.00); C211(0.00)  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C128(0.00); C211(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C128(0.00); C211(0.00)  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		14.72  LDD1845  [19]
C206
 Probe Info  		15.24  LDD1881  [19]
C361
 Probe Info  		18.77  LDD2022  [19]
FFF probe11
 Probe Info  		13.14  LDD0472  [20]
FFF probe12
 Probe Info  		20.00  LDD0473  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0465  [20]
FFF probe6
 Probe Info  		5.55  LDD0467  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C211(0.92)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C211(1.03)  LDD2152  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C128(2.97)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C128(0.94); C211(0.90); C391(1.10); C394(1.03)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C128(1.02); C211(0.95); C394(1.00); C484(0.62)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C128(0.95); C211(1.31); C391(0.99); C394(0.83)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C128(1.08); C211(1.49); C391(0.96); C394(0.84)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C128(1.12); C211(1.36); C391(0.86); C394(0.76)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C128(1.41); C211(1.24); C391(0.93); C394(0.80)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C128(1.09); C211(1.03); C391(1.11); C394(0.93)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C128(1.17); C211(1.58); C391(0.97); C394(0.91)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C128(1.40); C211(1.62); C391(0.93); C394(0.77)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C128(1.21); C211(1.44); C391(0.97); C394(0.84)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C128(1.29); C211(1.36); C391(1.19); C394(0.93)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C128(1.33); C211(1.16); C391(1.23); C394(1.03)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C128(1.36); C211(1.27); C394(0.96); C484(0.59)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C128(1.25); C211(1.35); C391(0.85); C394(0.71)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C128(1.22); C211(1.50); C391(0.99); C394(0.79)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C128(1.20); C211(1.65); C391(0.98); C394(0.77)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C128(1.07); C211(0.85); C394(1.01)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C128(1.44); C211(0.80); C394(1.10)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C128(1.50); C211(1.04); C394(1.00)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C128(1.31); C211(0.85); C394(1.05)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C128(1.31); C211(0.96); C394(0.96)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C128(1.35); C211(0.87); C394(1.09)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C128(1.28); C211(0.79); C394(1.00)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C128(1.32); C211(0.99); C394(1.04); C484(0.65)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C128(1.22); C211(0.96); C394(1.06)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C128(1.35); C211(0.73); C394(0.94)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C128(1.28); C211(0.78); C394(1.07)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C128(1.32); C211(0.77); C394(0.92)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C128(1.20); C211(0.81); C394(0.96)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C128(1.38); C211(0.90); C394(1.22)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C128(1.68); C211(0.67); C394(1.05)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C128(1.59); C211(0.90); C394(1.02)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C128(0.80); C211(0.64)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C128(0.76); C211(0.75)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C128(0.91); C211(0.80)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C128(0.75); C211(0.71)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C128(0.73); C211(0.87)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C128(0.74); C211(0.76)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C128(0.94); C211(0.87)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C128(0.90); C211(0.70)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C128(0.76); C211(0.89)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C128(0.76); C211(0.86)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C128(0.87); C211(0.73)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C128(0.84); C211(0.90)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C128(0.86); C211(0.91); C394(1.66); C484(0.63)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C128(0.86); C211(1.05)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C128(0.92); C211(0.95)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C128(0.69); C211(0.81)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C128(1.14); C211(1.28)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C128(1.23); C211(1.37)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C128(1.29); C211(1.30)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C128(1.42); C211(1.43)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C128(1.16); C211(1.43)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C128(1.52); C211(1.60)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C211(1.44); C128(1.63)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C484(0.58); C487(0.58); C211(1.11); C128(1.11)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C128(1.05); C211(1.31)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C128(1.17); C211(1.50)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C128(1.21); C211(1.62)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C128(1.99); C211(2.34)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C128(1.20); C211(1.66)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C128(1.06); C211(1.84)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C128(1.12); C211(1.70)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C128(1.41); C211(1.42)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C211(0.89); C484(0.96); C487(0.96); C394(1.05)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C484(0.82); C487(0.82); C211(0.93); C394(1.01)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C394(0.96); C211(1.14); C484(1.17); C487(1.17)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C484(0.84); C487(0.84); C211(0.93); C128(1.12)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C211(0.88); C394(0.88); C484(1.10); C487(1.10)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C211(0.85); C394(0.89); C484(1.07); C487(1.07)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C394(0.82); C211(0.99); C128(1.37); C484(1.40)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C394(0.89); C211(0.98); C484(1.13); C487(1.13)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C211(1.00); C128(1.08); C394(1.15); C484(1.16)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C394(1.13); C211(1.18); C128(1.46)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C394(0.80); C211(1.29); C128(1.51)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C394(0.85); C211(1.06); C128(1.68)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C394(0.86); C211(1.41); C128(2.06)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C394(0.63); C211(1.60); C128(2.39)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C484(0.75); C487(0.75); C128(0.87); C211(0.91)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C394(0.98); C211(1.51); C128(1.68)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C211(1.15); C394(1.41); C128(1.56)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C394(1.14); C128(1.52); C211(1.57)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C394(1.08); C211(1.16); C128(2.24)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C394(0.69); C211(1.59); C128(2.52)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C394(0.90); C128(1.07); C484(1.11); C487(1.11)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C394(0.81); C128(0.97); C484(1.02); C487(1.02)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C394(0.77); C128(0.95); C484(0.97); C487(0.97)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C394(0.84); C484(1.03); C487(1.03); C128(1.12)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C394(0.67); C484(0.78); C487(0.78); C128(1.02)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C484(0.66); C487(0.66); C211(0.90); C128(0.90)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C394(0.53); C484(1.05); C487(1.05); C128(1.11)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C394(0.75); C484(0.83); C487(0.83); C128(1.06)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C484(0.83); C487(0.83); C394(0.86); C128(1.05)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C484(0.81); C487(0.81); C394(0.82); C128(1.05)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C394(0.55); C484(0.92); C487(0.92); C128(1.01)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C394(0.52); C484(0.81); C487(0.81); C128(1.24)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C484(0.78); C487(0.78); C394(0.88); C391(1.02)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C484(0.84); C487(0.84); C394(0.84); C391(0.94)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C484(0.78); C487(0.78); C211(0.82); C394(0.88)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C484(0.80); C487(0.80); C394(0.85); C391(0.90)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C484(0.65); C487(0.65); C211(0.75); C128(0.88)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C391(0.90); C394(0.91); C484(0.95); C487(0.95)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C211(0.86); C484(0.98); C487(0.98); C128(1.17)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C484(0.88); C487(0.88); C211(0.92); C394(1.01)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C484(0.86); C487(0.86); C394(0.88); C391(1.03)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C211(0.85); C394(0.86); C391(0.96); C484(1.03)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C394(0.73); C391(0.90); C484(0.90); C487(0.90)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C394(0.66); C391(0.78); C211(0.83); C484(0.88)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C484(0.52); C487(0.52); C394(0.83); C391(0.86)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C484(0.56); C487(0.56); C211(1.07); C391(1.12)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C484(0.52); C487(0.52); C391(0.99); C394(1.02)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C484(0.72); C487(0.72); C211(0.97); C394(1.14)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C484(0.50); C487(0.50); C394(0.86); C391(0.88)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C484(0.54); C487(0.54); C128(0.88); C211(1.00)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C484(0.62); C487(0.62); C394(0.92); C391(0.92)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C484(0.48); C487(0.48); C394(0.90); C391(0.92)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C484(0.58); C487(0.58); C394(1.03); C391(1.07)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C484(0.45); C487(0.45); C128(0.68); C394(1.05)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C484(0.43); C487(0.43); C128(0.60); C391(1.11)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C484(0.37); C487(0.37); C128(0.83); C394(0.95)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C484(0.96); C487(0.96); C394(1.03); C391(1.04)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C394(1.04); C484(1.05); C487(1.05); C391(1.08)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C484(0.79); C487(0.79); C128(0.87); C211(0.91)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C484(0.86); C487(0.86); C391(1.08); C394(1.12)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C484(0.97); C487(0.97); C128(1.09); C391(1.10)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C394(1.00); C391(1.08); C484(1.09); C487(1.09)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C391(0.92); C394(0.98); C484(1.36); C487(1.36)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C391(1.08); C394(1.14); C484(1.27); C487(1.27)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C394(0.87); C391(0.94); C484(1.28); C487(1.28)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C391(0.91); C394(1.08); C484(1.14); C487(1.14)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C394(0.88); C391(0.90); C484(1.08); C487(1.08)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C391(0.88); C394(1.03); C484(1.05); C487(1.05)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C391(0.94); C394(0.99); C484(1.00); C487(1.00)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C484(0.66); C487(0.66); C211(1.20); C394(1.20)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C391(0.98); C484(1.03); C487(1.03); C394(1.08)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C484(0.75); C487(0.75); C391(0.92); C394(0.95)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C394(1.09); C391(1.11); C484(1.21); C487(1.21)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C484(0.68); C487(0.68); C394(1.02); C211(1.70)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C484(0.59); C487(0.59); C394(1.11); C128(1.57)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C484(0.60); C487(0.60); C394(1.01); C211(1.28)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C484(0.66); C487(0.66); C394(0.96); C128(1.23)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C484(0.73); C487(0.73); C211(0.89); C394(1.02)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C484(0.84); C487(0.84); C394(0.96); C211(1.28)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C484(0.70); C487(0.70); C394(0.98); C211(1.43)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C484(0.85); C487(0.85); C211(0.99); C394(1.01)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C484(0.69); C487(0.69); C394(1.02); C211(1.92)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C484(0.59); C487(0.59); C394(0.98); C128(1.72)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C484(0.80); C487(0.80); C394(0.90); C211(1.22)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C484(0.93); C487(0.93); C394(0.97); C211(1.30)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C484(0.68); C487(0.68); C394(1.15); C211(1.28)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C484(0.87); C487(0.87); C394(1.05); C128(1.75)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C484(0.65); C487(0.65); C394(0.88); C211(1.67)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C394(0.84); C391(1.00); C211(1.91); C128(1.98)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C394(0.80); C391(0.91); C128(1.03); C211(1.15)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C128(0.88); C211(0.80); C394(1.20); C484(0.61)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C484(0.77); C487(0.77); C211(0.92); C394(0.95)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C484(0.50); C487(0.50); C211(1.10); C394(1.41)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C128(1.01); C211(0.85)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C128(20.00)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C128(0.94); C394(1.10); C391(1.16); C484(1.21)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C484(0.82); C487(0.82); C211(0.97); C394(1.24)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C484(0.66); C487(0.66); C394(0.85); C391(0.94)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C484(0.62); C487(0.62); C128(0.98); C211(1.09)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C484(0.73); C487(0.73); C128(0.87); C211(1.13)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C484(0.84); C487(0.84); C211(0.96); C128(0.97)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C484(0.75); C487(0.75); C128(0.92); C211(1.06)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C394(0.83); C211(0.88); C484(1.01); C487(1.01)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C211(0.63); C484(0.81); C487(0.81); C394(0.89)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C484(0.77); C487(0.77); C394(0.85); C211(1.02)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C484(0.75); C487(0.75); C211(0.89); C394(1.10)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C394(0.80); C484(0.96); C487(0.96); C211(1.20)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C484(0.85); C487(0.85); C394(1.10); C391(1.26)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C484(0.87); C487(0.87); C211(0.93); C394(1.01)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C394(0.81); C211(0.90); C484(0.94); C487(0.94)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C394(1.01); C128(1.22); C211(1.85)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C394(0.98); C211(1.59); C128(1.92)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C394(0.97); C128(1.81); C211(1.93)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C394(0.81); C211(1.26); C128(1.79)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C211(0.97); C394(1.17); C128(1.80)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C394(0.66); C484(0.78); C487(0.78); C211(1.64)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C484(0.76); C487(0.76); C394(0.86); C128(0.99)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C394(0.71); C484(0.99); C487(0.99); C128(1.18)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C484(0.79); C487(0.79); C394(0.98); C211(1.07)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C484(0.79); C487(0.79); C394(0.81); C128(1.01)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C211(0.91); C128(1.06); C391(1.15); C394(1.30)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C484(0.82); C487(0.82); C394(0.93); C391(0.95)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C394(0.73); C484(0.81); C487(0.81); C391(0.89)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C394(0.73); C484(0.89); C487(0.89); C391(0.95)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C484(0.67); C487(0.67); C128(0.86); C394(0.99)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C128(0.85); C484(0.94); C487(0.94); C391(1.05)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C484(0.75); C487(0.75); C128(0.83); C394(0.99)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C484(0.61); C487(0.61); C394(1.02); C391(1.04)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C484(0.85); C487(0.85); C211(1.20); C391(1.24)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C484(0.99); C487(0.99); C211(1.06); C391(1.10)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C484(0.85); C487(0.85); C128(1.34); C391(1.42)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C211(0.73); C391(0.86); C394(0.86); C484(1.17)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C211(0.29); C484(0.99); C487(0.99); C128(1.03)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C211(0.42); C484(0.88); C487(0.88); C394(0.90)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C211(0.37); C484(0.97); C487(0.97); C394(1.02)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C128(0.94); C391(0.95); C394(1.06); C484(1.07)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C211(0.43); C484(1.02); C487(1.02); C394(1.19)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C211(0.59); C484(0.73); C487(0.73); C394(1.30)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C211(0.30); C484(0.79); C487(0.79); C394(1.74)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C211(0.35); C394(0.70); C484(0.85); C487(0.85)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C211(0.50); C394(0.58); C484(0.96); C487(0.96)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C128(1.49); C211(0.53); C394(0.68); C484(0.89)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C128(1.27); C211(0.48); C394(0.84); C484(0.97)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C128(1.32); C211(0.30); C394(1.00); C484(0.95)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C128(1.87); C211(0.42); C394(0.98); C484(0.82)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C128(1.66); C211(0.36); C394(0.93); C484(0.80)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C128(1.10); C211(1.14); C391(1.27); C394(1.29)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C128(1.30); C211(0.38); C394(1.11); C484(1.23)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C128(1.19); C211(1.41); C484(0.91); C487(0.91)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C128(1.29); C211(1.23); C391(0.87); C394(0.88)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C128(1.37); C211(2.27); C391(0.83); C394(0.80)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C128(1.44); C211(1.26); C391(0.96); C394(0.91)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C128(1.96); C211(1.13); C391(0.97); C394(0.90)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C128(1.43); C211(1.28); C391(1.18); C394(1.35)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C128(1.77); C211(1.29); C391(0.98); C394(1.01)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C128(1.66); C211(1.22); C391(0.85); C394(0.81)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C128(1.23); C211(2.35); C391(1.08); C394(1.30)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C128(1.58); C211(2.64); C391(0.93); C394(1.04)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C128(1.53); C211(1.44); C391(1.10); C394(1.06)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C128(2.64); C211(1.27); C391(1.30); C394(1.43)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C128(1.97); C211(1.49); C391(1.09); C394(1.22)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C128(1.45); C211(1.17); C391(1.21); C394(1.44)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C128(1.92); C211(1.40); C391(1.11); C394(1.20)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C128(0.88); C211(0.85); C391(0.96); C394(0.90)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C128(0.81); C211(0.77); C391(1.27); C394(1.23)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C128(0.84); C211(0.90); C391(1.17); C394(1.31)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C128(0.78); C211(0.92); C391(1.34); C394(1.42)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C128(1.12); C211(1.01); C391(1.61); C394(1.85)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C128(0.91); C211(0.73); C391(1.34); C394(1.40)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C128(1.03); C211(0.96); C391(1.35); C394(1.31)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C128(1.05); C211(1.14); C391(1.61); C394(1.56)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C128(0.96); C211(0.80); C391(0.95); C394(0.99)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C128(0.95); C211(0.80); C391(1.50); C394(1.37)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C128(0.91); C211(0.98); C391(0.92); C394(0.87)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C128(1.10); C211(0.92); C391(1.47); C394(1.47)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C128(0.89); C211(0.71); C391(1.62); C394(1.50)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C128(1.12); C211(1.07); C391(1.31); C394(1.36)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C128(0.99); C211(0.95); C391(1.38); C394(1.18)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C128(1.31); C211(1.20); C391(1.23); C394(1.36)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C128(0.97); C211(1.07); C391(1.62); C394(1.54)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C128(1.08); C211(1.39); C394(0.98); C484(0.82)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C128(1.25); C211(1.41); C394(1.05); C484(0.73)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C128(1.26); C211(2.24); C394(1.25); C484(0.71)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C128(1.19); C211(1.65); C394(1.03); C484(0.79)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C128(1.12); C211(1.49); C394(1.12); C484(0.73)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C128(1.48); C211(1.42); C394(1.24); C484(0.58)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C128(1.24); C211(1.57); C394(1.22); C484(0.74)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C128(1.63); C211(1.39); C394(1.10); C484(0.57)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C128(1.21); C211(2.19); C394(1.06); C484(0.70)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C128(1.41); C211(1.02); C391(1.45); C394(1.52)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C128(1.25); C211(1.33); C394(0.76); C484(0.72)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C128(1.19); C211(2.91); C394(0.90); C484(0.63)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C128(1.06); C211(1.57); C394(0.82); C484(0.82)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C128(1.30); C211(1.98); C394(1.07); C484(0.80)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C128(1.60); C211(1.48); C394(1.00); C484(0.75)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C128(1.43); C211(0.92); C391(0.79); C394(0.84)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C128(1.20); C211(0.88); C391(1.27); C394(1.32)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C128(1.37); C211(1.19); C391(0.86); C394(0.81)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C128(1.99); C211(0.99); C391(0.84); C394(1.02)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C128(1.88); C211(2.29); C391(1.07); C394(1.10)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C128(1.44); C211(0.84); C391(1.00); C394(0.97)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C128(2.15); C211(1.00); C391(1.26); C394(1.46)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C128(2.22); C211(0.86); C391(1.10); C394(1.25)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C128(1.59); C211(1.03); C391(0.83); C394(0.91)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C128(2.03); C211(0.99); C391(1.03); C394(0.95)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C128(1.32); C211(1.03); C391(0.94); C394(0.85)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C128(1.18); C211(1.08); C391(0.88); C394(0.93)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C128(1.30); C211(0.89); C391(1.09); C394(1.01)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C128(1.62); C211(1.00); C391(1.15); C394(1.23)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C128(4.60); C211(0.91); C391(1.07); C394(1.21)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C128(1.27); C211(1.02); C391(1.19); C394(1.25)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C128(1.04); C211(1.29); C391(0.99); C394(1.01)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C128(1.28); C211(1.12); C391(0.92); C394(1.20)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C128(1.12); C211(1.28); C391(1.03); C394(1.29)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C128(1.05); C211(1.04); C391(1.14); C394(1.13)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C128(1.40); C211(0.94); C391(1.22); C394(1.35)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C128(1.32); C211(1.74); C391(1.12); C394(1.33)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C128(1.19); C211(1.41); C391(1.29); C394(1.70)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C128(0.97); C211(1.04); C391(1.31); C394(1.67)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C128(0.94); C211(1.21); C391(0.81); C394(0.82)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C128(1.06); C211(0.97); C391(1.02); C394(0.94)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C211(1.07); C128(1.04); C391(0.92); C487(0.93)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C211(3.83)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [8]
 LDCM0625  F8 Ramos C211(1.63)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C211(6.72)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C211(2.96)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C211(2.48)  LDD1394  [23]
 LDCM0575  Fragment13 MDA-MB-231 C211(1.09)  LDD1395  [23]
 LDCM0576  Fragment14 Ramos C211(1.45)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C211(7.83)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C211(1.63)  LDD1405  [23]
 LDCM0582  Fragment23 Ramos C211(1.07)  LDD2196  [22]
 LDCM0584  Fragment25 MDA-MB-231 C211(1.19)  LDD1411  [23]
 LDCM0578  Fragment27 Ramos C211(0.97)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C211(0.80)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C211(1.98)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C211(1.29)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C211(5.56)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C128(1.99); C211(1.54); C394(1.12); C484(0.74)  LDD0785  [9]
 LDCM0593  Fragment35 Ramos C211(0.95)  LDD1430  [23]
 LDCM0596  Fragment38 MDA-MB-231 C211(1.13)  LDD1433  [23]
 LDCM0566  Fragment4 Ramos C211(2.44)  LDD2184  [22]
 LDCM0599  Fragment41 MDA-MB-231 C211(1.36)  LDD1438  [23]
 LDCM0601  Fragment43 Ramos C211(1.73)  LDD1442  [23]
 LDCM0427  Fragment51 HCT 116 C128(3.02); C211(2.58); C391(0.90); C394(0.93)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C211(1.91)  LDD2204  [22]
 LDCM0614  Fragment56 MDA-MB-231 C211(2.07)  LDD1458  [23]
 LDCM0569  Fragment7 Ramos C211(5.27)  LDD2186  [22]
 LDCM0570  Fragment8 Ramos C211(1.79)  LDD1386  [23]
 LDCM0571  Fragment9 Ramos C211(7.66)  LDD2188  [22]
 LDCM0015  HNE MDA-MB-231 C211(1.03)  LDD0346  [22]
 LDCM0022  KB02 MDA-MB-231 C211(20.00)  LDD1374  [23]
 LDCM0023  KB03 Jurkat C128(10.56); C211(9.87)  LDD0209  [24]
 LDCM0024  KB05 COLO792 C211(4.33)  LDD3310  [25]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C211(0.47)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C211(1.00)  LDD2090  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C211(0.81)  LDD2099  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C211(1.07)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C211(0.72)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C211(1.25)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C211(0.27)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C211(0.96)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C211(0.74)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C211(0.95)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C211(1.15)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C211(1.13)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C211(1.15)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C211(1.01)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C211(0.89)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C211(0.56)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C211(2.20)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C211(1.04)  LDD2146  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C211(0.59)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C128(0.49)  LDD2207  [26]
 LDCM0014  Panhematin HEK-293T 3.06  LDD0062  [7]
 LDCM0003  Sulforaphane MDA-MB-231 1.75  LDD0160  [5]
 LDCM0021  THZ1 HCT 116 C211(1.02)  LDD2173  [9]
 LDCM0112  W16 Hep-G2 C128(0.76)  LDD0239  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 3 (HDAC3) Histone deacetylase family O15379
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Non-receptor tyrosine-protein kinase TYK2 (TYK2) Tyr protein kinase family P29597
MTRF1L release factor glutamine methyltransferase (HEMK1) Protein N5-glutamine methyltransferase family Q9Y5R4
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) SH3RF family Q8TEC5
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
E3 ubiquitin-protein ligase RNF43 (RNF43) ZNRF3 family Q68DV7
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Forkhead box protein D4 (FOXD4) . Q12950
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Zinc finger protein 366 (ZNF366) . Q8N895
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
EKC/KEOPS complex subunit LAGE3 (LAGE3) CTAG/PCC1 family Q14657
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Protein DGCR6 (DGCR6) Gonadal family Q14129
Protein INCA1 (INCA1) INCA family Q0VD86
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
Tektin-4 (TEKT4) Tektin family Q8WW24
Tektin-5 (TEKT5) Tektin family Q96M29
Thymosin beta-4 (TMSB4X) Thymosin beta family P62328
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Calcium-regulated heat-stable protein 1 (CARHSP1) . Q9Y2V2
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Cleavage stimulation factor subunit 2 tau variant (CSTF2T) . Q9H0L4
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
G protein pathway suppressor 2 (GPS2) . Q13227
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Keratinocyte proline-rich protein (KPRP) . Q5T749
M-phase-specific PLK1-interacting protein (MPLKIP) . Q8TAP9
Peflin (PEF1) . Q9UBV8
Protocadherin beta-14 (PCDHB14) . Q9Y5E9
Receptor-transporting protein 5 (RTP5) . Q14D33
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
24 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.