Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment12					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05992	Bleomycin hydrolase (BLMH)				C73	20.0
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	20.0
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	20.0
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	19.5
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	11.5
LDTP02502	Thioredoxin (TXN)				C32	7.8
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	6.2
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	3.9
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	3.1
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	3.1
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	2.8
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	2.6
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	2.6
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	2.5
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	2.5
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	2.3
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	2.2
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	2.1
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	2.0
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	2.0
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.6
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.6
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.6
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.5
LDTP02672	Elongation factor 2 (EEF2)				C41	1.4
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.3
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	1.3
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.3
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.2
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	1.2
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.2
LDTP05289	AMP deaminase 2 (AMPD2)				C107	1.2
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.2
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.2
LDTP12960	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)				C149	1.2
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.1
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	1.1
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.1
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.1
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.1
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.1
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	1.1
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.1
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.1
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.1
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	1.0
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.0
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.0
LDTP04424	Galactokinase (GALK1)				C182	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.9
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	0.9
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	0.9
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.9
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	0.8
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	0.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.8
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	0.8
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.8
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	0.7
LDTP04689	Adenosine kinase (ADK)				C353	0.7
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	0.7
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.7
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	0.7
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.7
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	0.7
LDTP04374	Dynamin-2 (DNM2)				C27	0.7
LDTP02733	Pyruvate kinase PKM (PKM)				C423	0.7
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	0.6
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	0.6
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.6
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.6
LDTP10801	ATPase WRNIP1 (WRNIP1)				C272	0.5
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	0.5
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	0.5
LDTP02672	Elongation factor 2 (EEF2)				C136	0.4
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.4

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	10.4
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	8.2
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	6.7
LDTP04801	Gasdermin-D (GSDMD)				C268	2.0
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.7
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.6
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	0.8
LDTP00501	Exportin-1 (XPO1)				C34	0.7
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.7
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.5

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	2.4
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.6
LDTP02016	Glucocorticoid receptor (NR3C1)				C302	1.3
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.2
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	1.0
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.7

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12412	Reticulon-4 (RTN4)				C1101	20.0
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	4.3
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	3.3
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	3.2
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	2.6
LDTP13591	A-kinase anchor protein 8-like (AKAP8L)				C211	2.5
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	2.4
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	2.3
LDTP04092	Crk-like protein (CRKL)				C249	2.3
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	2.2
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	2.0
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	1.9
LDTP05867	Treacle protein (TCOF1)				C1298	1.9
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	1.7
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.6
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.5
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	1.5
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.4
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.4
LDTP10864	Calponin-2 (CNN2)				C164	1.4
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.4
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.3
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	1.3
LDTP00202	AH receptor-interacting protein (AIP)				C122	1.3
LDTP10864	Calponin-2 (CNN2)				C215	1.3
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.2
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	1.2
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.2
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.2
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	1.2
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	1.1
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.0
LDTP02205	Tubulin beta chain (TUBB)				C354	1.0
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	0.9
LDTP13580	Coronin-1C (CORO1C)				C420	0.9
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	0.9
LDTP02205	Tubulin beta chain (TUBB)				C239	0.9
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	0.9
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	0.9
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	0.9
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	0.8
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	0.8
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	0.8
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	0.8
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	0.7
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	0.7
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	0.7
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.7
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	0.6
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	0.5
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	0.5
LDTP03244	Cofilin-1 (CFL1)				C80	0.5
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.3

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.