Details of the Target

General Information of Target

Target ID LDTP13449
Target Name Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)
Gene Name CPSF3
Gene ID 51692
Synonyms
CPSF73; Cleavage and polyadenylation specificity factor subunit 3; EC 3.1.27.-; Cleavage and polyadenylation specificity factor 73 kDa subunit; CPSF 73 kDa subunit; mRNA 3'-end-processing endonuclease CPSF-73
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Target Bioclass
Enzyme
Family
Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, CPSF3 subfamily
Subcellular location
Nucleus
Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively.
Uniprot ID
Q9UKF6
Ensemble ID
ENST00000238112.8
HGNC ID
HGNC:2326

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K295(10.00); K612(9.09)  LDD0277  [2]
P11
 Probe Info  		11.55  LDD0201  [3]
BTD
 Probe Info  		C223(1.06)  LDD2089  [4]
Sulforaphane-probe2
 Probe Info  		1.38  LDD0160  [5]
AHL-Pu-1
 Probe Info  		C655(4.20)  LDD0170  [6]
HHS-475
 Probe Info  		Y528(0.76); Y519(1.10)  LDD0264  [7]
HHS-465
 Probe Info  		Y528(5.95)  LDD2237  [8]
DBIA
 Probe Info  		C498(3.63); C527(1.13); C278(1.16)  LDD0080  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C345(0.00); C223(0.00); C498(0.00); C527(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C278(0.00); C345(0.00); C223(0.00); C498(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		C655(0.00); C345(0.00); C27(0.00); C498(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C345(0.00); C223(0.00); C278(0.00); C498(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
IPM
 Probe Info  		N.A.  LDD0005  [14]
Phosphinate-6
 Probe Info  		C498(0.00); C655(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		C655(0.00); C223(0.00); C345(0.00); H307(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C655(0.00); C223(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C655(0.00); C223(0.00)  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C345(0.00); C223(0.00); C358(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.13  LDD0471  [19]
FFF probe2
 Probe Info  		13.63  LDD0463  [19]
FFF probe3
 Probe Info  		7.93  LDD0465  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C223(1.09)  LDD2112  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C223(0.87)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C223(1.21)  LDD2117  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C223(0.91)  LDD2132  [4]
 LDCM0025  4SU-RNA DM93 C655(4.20)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C655(2.94)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C223(1.33); C278(0.98); C345(0.77)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C223(1.26); C278(0.85); C345(0.83); C527(0.99)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C223(1.00); C278(0.84); C345(0.68); C527(0.75)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C223(1.06); C278(0.90); C345(0.60); C527(0.79)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C223(1.00); C278(0.90); C345(0.61); C527(0.75)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C223(0.92); C278(1.01); C345(0.56); C527(0.92)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C223(1.13); C278(0.86); C345(0.76); C527(0.96)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C223(1.02); C278(0.86); C345(0.59); C527(0.71)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C223(1.02); C278(0.92); C345(0.62); C527(0.60)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C223(0.98); C278(0.82); C345(0.68); C527(0.92)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C223(1.13); C278(0.86); C345(0.68); C527(0.70)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C223(1.11); C278(0.81); C345(0.97); C527(0.73)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C223(1.36); C278(0.97); C345(0.60); C527(1.07)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C223(0.96); C278(0.92); C345(0.58); C527(0.78)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C223(0.87); C278(1.14); C345(0.54); C527(0.81)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C223(0.89); C278(0.92); C345(0.61); C527(0.79)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C223(1.07); C278(0.93); C345(1.00)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C223(1.06); C278(0.99); C345(0.98)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C223(1.03); C278(0.95); C345(1.01)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C223(0.89); C278(1.11); C345(2.12)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C223(0.97); C278(0.98); C345(1.16)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C223(1.21); C278(0.93); C345(0.92)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C223(1.03); C278(0.84); C345(1.15)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C223(1.53); C278(0.83); C345(1.03); C527(1.21)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C223(1.04); C278(0.94); C345(0.89)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C223(1.07); C278(0.93); C345(1.04)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C223(1.10); C278(0.93); C345(0.97)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C223(1.19); C278(1.01); C345(1.07)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C223(0.93); C278(0.89); C345(1.03)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C223(0.94); C278(1.13); C345(0.95)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C223(1.09); C278(1.02); C345(0.93)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C223(1.00); C278(1.02); C345(0.94)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C223(1.05); C278(1.38); C527(0.92)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C223(1.18); C278(0.92); C527(0.99)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C223(1.18); C278(1.05); C527(0.70)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C223(1.02); C278(1.08); C527(1.25)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C223(1.25); C278(0.99); C527(0.72)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C223(1.11); C278(1.08); C527(0.93)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C223(0.95); C278(1.17); C527(0.79)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C223(1.14); C278(1.34); C527(0.78)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C223(1.13); C278(0.98); C527(0.85)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C223(1.20); C278(0.96); C527(0.63)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C223(1.01); C278(1.01); C527(0.78)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C223(1.20); C278(1.01); C527(0.73)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C223(1.03); C278(1.06); C345(0.71); C527(1.05)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C223(1.12); C278(1.09); C527(0.61)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C223(1.11); C278(1.03); C527(0.83)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C223(1.10); C278(0.91); C527(0.80)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C223(0.94); C278(0.97); C527(0.99)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C527(0.88); C278(1.20); C223(1.43)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C527(0.82); C278(1.08); C223(1.48)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C527(0.69); C278(1.07); C223(1.11)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C527(0.88); C278(1.21); C223(1.34)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C527(0.84); C278(1.28); C223(1.54)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C527(0.68); C223(1.07); C278(1.10)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C223(0.89); C527(1.09); C278(1.11); C345(1.13)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C527(0.81); C278(0.96); C223(1.12)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C527(0.81); C223(0.90); C278(1.06)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C527(0.90); C223(0.91); C278(1.24)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C527(0.87); C278(1.47); C223(1.71)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C223(1.09); C278(1.21); C527(0.98)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C223(1.03); C278(1.18); C527(0.81)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C223(0.82); C278(1.01); C527(0.91)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C223(1.07); C278(1.02); C527(1.24)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C655(0.77); C278(0.98); C223(1.12); C527(1.34)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C223(1.01); C655(1.05); C278(1.19); C527(1.57)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C655(0.76); C223(1.00); C527(1.13); C278(1.14)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C345(0.60); C278(0.91); C223(1.04)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C655(0.71); C223(0.92); C278(1.00); C527(1.09)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C655(0.73); C278(1.00); C223(1.03); C527(1.29)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C655(0.65); C223(0.96); C278(1.01); C527(1.40)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C655(0.71); C223(1.00); C278(1.04); C527(1.16)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C655(0.75); C223(0.98); C278(1.03); C527(1.24)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C527(0.82); C278(0.94); C223(0.97); C345(1.18)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C527(0.77); C345(0.80); C278(0.95); C223(1.01)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C345(0.77); C223(0.93); C527(0.94); C278(1.13)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C345(0.84); C527(0.87); C223(1.03); C278(1.07)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C345(0.61); C223(0.87); C527(0.91); C278(1.17)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C345(0.75); C278(0.83); C223(1.34)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C345(0.64); C223(0.87); C527(0.95); C278(1.18)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C345(0.66); C527(0.80); C278(1.10); C223(1.17)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C345(0.60); C527(0.81); C223(1.06); C278(1.11)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C345(0.70); C223(0.90); C527(0.90); C278(1.20)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C345(0.65); C223(0.73); C527(0.96); C278(1.42)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C278(0.88); C223(0.95); C655(1.03); C345(1.09)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C345(0.78); C278(0.98); C223(0.99); C527(1.00)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C278(0.92); C527(0.99); C223(1.03); C345(1.07)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C655(0.87); C527(0.91); C278(1.00); C223(1.05)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C527(0.66); C278(0.86); C655(0.89); C223(0.91)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C345(0.85); C278(0.94); C223(1.63)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C223(0.86); C527(0.92); C655(1.07); C278(1.07)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C527(0.73); C223(0.78); C345(0.91); C655(0.96)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C527(0.94); C345(0.94); C655(0.95); C223(0.96)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C223(0.82); C527(0.89); C278(0.93); C345(1.03)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C527(0.89); C278(1.02); C223(1.03); C655(1.04)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C527(0.83); C223(0.88); C345(0.97); C655(1.11)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C527(0.73); C223(0.97); C345(1.06); C278(1.08)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C527(0.67); C345(0.93); C223(0.98); C278(1.01)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C527(0.44); C278(0.87); C223(0.89); C345(0.96)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C527(0.80); C223(0.95); C345(0.95); C278(1.09)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C345(0.82); C278(0.94); C223(1.52)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C527(0.66); C345(0.89); C223(0.92); C278(1.11)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C527(0.64); C223(0.88); C345(0.91); C278(1.02)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C527(0.84); C278(0.85); C345(0.92); C223(0.93)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C345(0.71); C527(0.90); C223(0.90); C278(1.13)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C527(0.85); C223(0.86); C345(0.91); C278(1.07)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C345(0.82); C527(0.85); C278(1.06); C223(1.10)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C345(0.71); C223(0.91); C278(0.91); C527(0.94)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C527(0.50); C345(0.82); C223(1.06); C278(1.16)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C345(0.70); C527(0.83); C223(0.88); C278(1.50)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C527(0.50); C345(0.86); C223(1.03); C278(1.34)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C345(0.76); C223(0.92); C278(0.98); C655(1.01)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C345(0.77); C527(0.83); C223(0.93); C278(1.19)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C527(0.40); C345(0.76); C223(0.89); C278(1.13)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C527(0.77); C345(0.78); C223(0.98); C278(1.35)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C345(0.77); C527(0.87); C223(1.05); C278(1.24)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C527(0.53); C345(0.83); C223(1.00); C278(1.31)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C527(0.51); C223(1.00); C345(1.07); C278(1.26)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C527(0.49); C223(0.98); C345(1.07); C278(1.39)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C527(0.42); C345(0.67); C223(0.77); C278(1.32)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C527(0.87); C223(0.98); C278(1.07)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C527(0.86); C223(1.06); C278(1.09)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C655(0.85); C345(0.91); C278(0.93); C223(0.96)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C527(0.73); C278(0.97); C223(1.05)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C527(0.87); C278(0.98); C223(1.01)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C527(0.98); C278(1.02); C223(1.07)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C223(0.97); C527(0.98); C278(1.22)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C527(0.95); C278(1.26); C223(1.34)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C527(0.98); C223(1.02); C278(1.32)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C527(0.89); C223(0.98); C278(1.11)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C527(0.77); C223(0.91); C278(1.09)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C527(0.82); C278(0.89); C223(1.08)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C527(0.86); C278(0.97); C223(1.06)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C345(0.80); C278(0.97); C223(1.00); C527(1.20)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C278(1.03); C223(1.05); C527(1.05)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C527(0.56); C278(0.90); C223(1.23)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C527(0.71); C278(1.04); C223(1.10)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C345(0.87); C223(1.09); C278(1.25)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C345(0.95); C223(1.05); C278(1.22)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C278(0.99); C345(1.11); C223(1.13)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C345(0.92); C278(1.04); C223(1.18)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C345(0.86); C278(0.88); C223(1.04)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C345(0.84); C278(0.96); C223(1.22)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C223(1.10); C345(1.15); C278(1.19)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C278(0.90); C345(0.92); C223(1.23)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C223(1.05); C278(1.33); C345(1.34)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C223(1.00); C278(1.10); C345(1.25)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C278(0.91); C345(0.97); C223(1.04)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C278(1.07); C223(1.08); C345(1.52)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C278(0.90); C345(0.97); C223(1.10)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C278(1.02); C223(1.09); C345(1.47)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C345(0.84); C223(1.00); C278(1.04)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C345(0.59); C527(0.63); C278(0.89); C223(0.95)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C345(0.60); C527(0.70); C278(0.84); C223(1.10)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C223(0.82)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C223(1.15); C278(0.86); C345(0.91); C527(1.18)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C345(0.71); C527(0.95); C278(0.95); C655(1.02)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C223(0.89); C345(0.99); C527(1.13); C278(1.18)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C498(1.09)  LDD2171  [9]
 LDCM0106  BDHI 18 Jurkat C27(18.80)  LDD0208  [20]
 LDCM0102  BDHI 8 Jurkat C27(18.80)  LDD0204  [20]
 LDCM0088  C45 HEK-293T 11.55  LDD0201  [3]
 LDCM0108  Chloroacetamide HeLa C655(0.00); C498(0.00); C223(0.00); C345(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C498(2.72); C527(1.09)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C223(0.74); C278(0.85); C527(1.04)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C527(0.74); C223(0.91); C278(0.93)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C345(0.82); C223(1.05); C278(1.06)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C345(0.82); C527(0.96); C223(1.01); C278(1.13)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C345(0.74); C655(0.87); C278(0.94); C223(1.03)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C345(0.84); C278(0.88); C527(0.97); C655(1.47)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C655(0.83); C345(0.85); C278(0.88); C223(1.04)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C655(0.83); C223(1.02); C527(1.02); C278(1.14)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C655(0.95); C223(1.21); C527(1.23); C278(1.27)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C655(0.93); C278(1.05); C223(1.09); C527(1.11)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C655(1.05); C223(1.23); C527(1.23); C278(1.38)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C223(0.88); C655(1.02); C278(1.13); C527(1.38)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C527(0.86); C278(0.95); C223(0.96)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C655(0.95); C527(1.06); C223(1.10); C278(1.14)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C655(0.81); C223(0.89); C278(1.20); C527(1.31)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C527(0.79); C345(0.81); C278(1.02); C223(1.16)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C345(0.50); C527(0.90); C223(0.95); C278(1.31)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C345(0.42); C223(0.81); C527(0.82); C278(1.22)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C345(0.57); C527(0.74); C223(0.88); C278(1.08)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C345(0.71); C527(0.77); C223(0.93); C278(1.04)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C223(0.79); C527(0.93); C345(0.98); C655(1.20)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C527(0.87); C223(0.94); C345(0.96); C278(0.97)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C223(0.85); C278(0.97); C527(1.03); C345(1.06)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C223(1.00); C527(1.00); C278(1.04)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C527(0.74); C278(0.89); C223(0.93); C345(1.11)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C345(0.67); C527(0.84); C223(0.86); C278(0.96)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C527(0.69); C345(0.75); C223(0.80); C278(0.86)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C527(0.75); C345(0.80); C223(0.86); C278(0.89)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C527(0.81); C345(0.81); C223(0.85); C278(0.96)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C527(0.78); C278(0.98); C223(1.03); C345(1.19)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C223(0.89); C527(1.06); C345(1.06); C278(1.09)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C527(0.51); C345(0.92); C223(0.99); C278(1.18)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C527(0.49); C345(0.89); C223(0.98); C278(1.30)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C527(0.91); C278(1.03); C223(1.06)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C527(0.84); C278(0.94); C223(1.07)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C527(0.75); C278(1.07); C223(1.16)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C223(0.78); C527(1.05); C278(1.15)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C223(0.76); C527(0.93); C278(1.15)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C223(0.87); C527(1.24); C278(1.43)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C223(0.84); C527(1.10); C278(1.28)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C278(0.80); C223(0.83); C527(0.92)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C223(0.90); C527(1.14); C278(1.29)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C223(0.87); C527(1.26); C278(1.44)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C223(1.03); C527(1.22); C278(1.81)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C223(0.88); C527(1.17); C278(1.36)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C223(0.82); C527(1.17); C278(1.37)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C223(0.92); C278(1.41); C527(1.02)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C223(0.80); C278(1.22); C527(1.17)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C223(1.04); C278(1.24); C527(0.78)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C223(0.87); C278(1.18); C527(0.96)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C223(0.99); C278(1.32); C527(1.06)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C223(1.14); C278(0.86); C527(0.92)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C223(0.84); C278(1.28); C527(1.11)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C223(0.91); C278(1.17)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C223(0.78); C278(1.30)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C223(0.80); C278(1.23)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C223(0.83); C278(1.38)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C223(0.89); C278(1.55)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C223(0.91); C278(1.44)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C223(0.94); C278(1.78)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C223(0.91); C278(1.46)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C223(0.91); C278(1.00); C527(0.91)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C223(0.81); C278(1.47)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C223(0.88); C278(1.43)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C223(0.78); C278(1.78)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C223(0.81); C278(1.63)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C223(0.78); C278(1.42)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C223(0.80); C278(1.54)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C223(1.10); C278(0.88); C345(0.85)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C223(0.96); C278(0.86); C345(0.73)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C223(0.98); C278(0.95); C345(1.04)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C223(1.11); C278(0.94); C345(1.11)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C223(1.06); C278(0.81); C527(0.84)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C223(1.11); C278(0.92); C345(1.04)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C223(1.16); C278(0.90); C345(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C223(1.10); C278(1.07); C345(0.77)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C223(1.00); C278(1.02); C345(0.61)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C223(0.91); C278(0.95); C345(0.77)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C223(0.91); C278(0.91); C345(0.90)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C223(0.94); C278(1.01); C345(0.71)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C223(1.05); C278(0.96); C345(0.73)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C223(1.03); C278(0.97); C345(0.91)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C223(1.00); C278(0.93); C345(0.94)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C223(0.95); C278(0.92); C527(0.69)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C223(0.96); C278(0.96); C345(0.95)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C223(1.06); C278(1.08); C527(0.99); C655(1.04)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C223(1.04); C278(1.08); C527(0.81); C655(0.87)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C223(1.06); C278(1.10); C527(0.74); C655(1.27)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C223(1.06); C278(1.23); C527(0.80); C655(1.03)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C223(1.05); C278(1.05); C527(0.76); C655(0.87)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C223(0.92); C278(1.23); C527(0.75); C655(1.35)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C223(1.22); C278(1.32); C527(1.00); C655(0.98)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C223(0.81); C278(1.50); C527(0.76); C655(1.47)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C223(0.82); C278(1.27); C527(0.86); C655(0.91)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C223(0.92); C278(0.85); C527(0.92)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C223(0.86); C278(1.19); C527(0.82); C655(1.26)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C223(0.89); C278(1.13); C527(0.81); C655(0.90)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C223(0.84); C278(1.10); C527(0.88); C655(0.92)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C223(0.94); C278(1.96); C527(1.15); C655(1.10)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C223(0.96); C278(1.53); C527(1.09); C655(1.22)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C223(1.09); C278(1.02)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C223(1.10); C278(1.64)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C223(1.11); C278(1.04)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C223(1.12); C278(1.30)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C223(1.11); C278(1.11); C527(0.94)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C223(1.26); C278(1.14)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C223(1.52); C278(1.01)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C223(1.50); C278(1.35)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C223(1.26); C278(1.17)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C223(0.93); C278(1.34)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C223(1.10); C278(1.02)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C223(1.15); C278(0.96)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C223(1.46); C278(1.09)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C223(1.58); C278(1.24)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C223(1.36); C278(1.26)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C223(0.76); C278(0.89); C527(1.04)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C223(1.11); C278(0.94)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C223(1.11); C278(0.88); C345(0.69)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C223(1.24); C278(1.08); C345(1.04)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C223(1.56); C278(1.24); C345(0.91)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C223(1.25); C278(1.08); C345(0.88)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C223(1.19); C278(1.07); C345(0.77)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C223(1.13); C278(0.91); C345(0.67)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C223(1.16); C278(1.01); C345(0.66)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C223(1.23); C278(0.90); C345(0.68)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C223(1.21); C278(0.83); C345(0.76)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C655(0.97); C223(0.95); C278(0.98); C358(1.10)  LDD1698  [21]
 LDCM0625  F8 Ramos C655(0.99); C278(1.63); C498(0.76)  LDD2187  [22]
 LDCM0572  Fragment10 MDA-MB-231 C498(4.50)  LDD1389  [23]
 LDCM0573  Fragment11 MDA-MB-231 C498(2.08)  LDD1391  [23]
 LDCM0574  Fragment12 MDA-MB-231 C498(2.08)  LDD1393  [23]
 LDCM0575  Fragment13 MDA-MB-231 C498(0.94)  LDD1395  [23]
 LDCM0576  Fragment14 MDA-MB-231 C498(1.97)  LDD1397  [23]
 LDCM0577  Fragment15 MDA-MB-231 C498(0.79)  LDD1399  [23]
 LDCM0579  Fragment20 Ramos C498(2.51)  LDD1403  [23]
 LDCM0580  Fragment21 MDA-MB-231 C498(1.40)  LDD1404  [23]
 LDCM0582  Fragment23 MDA-MB-231 C498(1.18)  LDD1408  [23]
 LDCM0583  Fragment24 Ramos C498(1.42)  LDD1410  [23]
 LDCM0584  Fragment25 MDA-MB-231 C498(1.06)  LDD1411  [23]
 LDCM0585  Fragment26 Ramos C498(1.03)  LDD1412  [23]
 LDCM0578  Fragment27 MDA-MB-231 C498(1.33)  LDD1401  [23]
 LDCM0586  Fragment28 MDA-MB-231 C498(1.06)  LDD1415  [23]
 LDCM0587  Fragment29 MDA-MB-231 C498(1.82)  LDD1417  [23]
 LDCM0588  Fragment30 MDA-MB-231 C498(0.90)  LDD1419  [23]
 LDCM0589  Fragment31 Ramos C498(1.77)  LDD1422  [23]
 LDCM0590  Fragment32 MDA-MB-231 C498(3.76)  LDD1423  [23]
 LDCM0468  Fragment33 HCT 116 C223(0.90); C278(1.28); C527(0.76); C655(0.86)  LDD0785  [9]
 LDCM0593  Fragment35 MDA-MB-231 C498(1.25)  LDD1429  [23]
 LDCM0594  Fragment36 MDA-MB-231 C498(2.07)  LDD1431  [23]
 LDCM0595  Fragment37 Ramos C498(0.92)  LDD1432  [23]
 LDCM0596  Fragment38 MDA-MB-231 C498(1.36)  LDD1433  [23]
 LDCM0566  Fragment4 MDA-MB-231 C498(2.00)  LDD1378  [23]
 LDCM0599  Fragment41 MDA-MB-231 C498(1.09)  LDD1438  [23]
 LDCM0600  Fragment42 Ramos C498(0.96)  LDD1440  [23]
 LDCM0601  Fragment43 MDA-MB-231 C498(13.88)  LDD1441  [23]
 LDCM0603  Fragment45 MDA-MB-231 C498(20.00)  LDD1482  [23]
 LDCM0604  Fragment46 MDA-MB-231 C498(0.90)  LDD1445  [23]
 LDCM0607  Fragment49 MDA-MB-231 C498(3.55)  LDD1448  [23]
 LDCM0608  Fragment50 MDA-MB-231 C498(2.09)  LDD1449  [23]
 LDCM0427  Fragment51 HCT 116 C223(0.79); C278(1.81)  LDD0744  [9]
 LDCM0610  Fragment52 MDA-MB-231 C498(1.10)  LDD1452  [23]
 LDCM0611  Fragment53 MDA-MB-231 C498(1.17)  LDD1454  [23]
 LDCM0614  Fragment56 MDA-MB-231 C498(1.17)  LDD1458  [23]
 LDCM0568  Fragment6 MDA-MB-231 C498(1.53)  LDD1382  [23]
 LDCM0569  Fragment7 MDA-MB-231 C498(2.06)  LDD1383  [23]
 LDCM0570  Fragment8 MDA-MB-231 C498(12.73)  LDD1385  [23]
 LDCM0571  Fragment9 MDA-MB-231 C498(1.27)  LDD1387  [23]
 LDCM0116  HHS-0101 DM93 Y528(0.76); Y519(1.10)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y528(0.59); Y519(1.56)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y528(0.63); Y519(1.99)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y528(0.67); Y519(1.31)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y528(0.63); Y519(1.85)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C498(3.63); C527(1.13); C278(1.16)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C498(1.82); C527(1.08); C278(0.99)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C498(2.64); C527(1.66); C278(1.46)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C223(1.06)  LDD2089  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C223(1.40)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C223(0.65)  LDD2100  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C223(1.14)  LDD2108  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C223(0.70)  LDD2114  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C223(1.38)  LDD2123  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C223(0.89)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C223(1.71)  LDD2135  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C223(1.05)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C223(1.27)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C223(0.66)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C223(2.39)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C223(1.20)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C223(1.31)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C223(0.99)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C223(0.88)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C498(10.26)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C498(8.52); C498(0.90)  LDD2207  [24]
 LDCM0003  Sulforaphane MDA-MB-231 1.38  LDD0160  [5]
 LDCM0021  THZ1 HCT 116 C498(1.09)  LDD2173  [9]
 LDCM0112  W16 Hep-G2 C498(0.63)  LDD0239  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.