Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment20  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 102 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 20.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 20.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 20.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 20.0
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 20.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 20.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 19.1
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 18.2
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 18.1
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 16.3
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 14.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 14.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 12.4
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 9.5
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 5.7
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 5.1
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 4.2
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 3.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 3.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 3.6
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 3.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 3.5
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 3.4
 LDTP04424  Galactokinase (GALK1) C182 3.3
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 3.2
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 3.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 2.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 2.9
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 2.9
 LDTP03786  Glutaredoxin-1 (GLRX) C23 2.9
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 2.9
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.7
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 2.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.6
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 2.6
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.5
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 2.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.5
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 2.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 2.4
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 2.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 2.3
 LDTP03400  Deoxycytidine kinase (DCK) C45 2.2
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 2.2
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 2.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 2.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 2.1
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 2.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 2.0
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 2.0
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 2.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.9
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.9
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.8
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.8
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.8
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.7
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.7
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.7
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.7
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.6
 LDTP02672  Elongation factor 2 (EEF2) C41 1.6
 LDTP04689  Adenosine kinase (ADK) C353 1.6
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.6
 LDTP06211  Caspase-8 (CASP8) C360 1.5
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.5
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 1.5
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 1.4
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.4
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 1.4
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.4
 LDTP02502  Thioredoxin (TXN) C32 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.3
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 1.3
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.3
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 1.3
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.2
 LDTP04374  Dynamin-2 (DNM2) C27 1.2
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.2
 LDTP12190  NmrA-like family domain-containing protein 1 (NMRAL1) C154 1.1
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.1
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.9
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.8
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.8
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 0.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.7
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 0.6
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.6
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.5
Transporter and channel
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11855  Pinin (PNN) C249 20.0
 LDTP04801  Gasdermin-D (GSDMD) C268 12.2
 LDTP00501  Exportin-1 (XPO1) C528 4.0
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 2.7
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 2.5
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 2.2
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 2.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.4
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.2
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.1
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.1
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.0
 LDTP01574  Importin-7 (IPO7) C757 1.0
 LDTP04662  Exportin-2 (CSE1L) C842 0.7
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 4.0
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 3.9
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 3.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.7
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 20.0
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 20.0
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 20.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 14.0
 LDTP07755  Dynamin-binding protein (DNMBP) C691 8.2
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 6.2
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 5.9
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 5.2
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 4.9
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 3.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 3.8
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 3.8
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 3.5
 LDTP04092  Crk-like protein (CRKL) C249 3.4
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 3.0
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 3.0
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C660 3.0
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 2.9
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 2.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 2.8
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.8
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 2.5
 LDTP01532  ZW10 interactor (ZWINT) C54 2.4
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 2.4
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 2.4
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.3
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 2.3
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 2.3
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 2.3
 LDTP00202  AH receptor-interacting protein (AIP) C122 2.2
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.2
 LDTP02205  Tubulin beta chain (TUBB) C354 2.2
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 2.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 2.0
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 2.0
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 2.0
 LDTP04487  Cyclin-H (CCNH) C244 2.0
 LDTP05867  Treacle protein (TCOF1) C38 2.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 2.0
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.9
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 1.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.9
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.9
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.8
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 1.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.8
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 1.7
 LDTP13580  Coronin-1C (CORO1C) C420 1.7
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.7
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.7
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.7
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.7
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.6
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.6
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.6
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.5
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.5
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.5
 LDTP10864  Calponin-2 (CNN2) C215 1.5
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) C513 1.5
 LDTP10864  Calponin-2 (CNN2) C164 1.5
 LDTP02205  Tubulin beta chain (TUBB) C239 1.4
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 1.4
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.3
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.3
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.3
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 1.3
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.3
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.3
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C1117 1.3
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.3
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.2
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.2
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.2
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.2
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.2
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.2
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.1
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.1
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.1
 LDTP13580  Coronin-1C (CORO1C) C456 1.1
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.1
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.0
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.9
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 0.8
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 0.7
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 0.7
 LDTP03244  Cofilin-1 (CFL1) C80 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.