Details of the Target

General Information of Target

Target ID LDTP10929
Target Name Cell cycle checkpoint control protein RAD9A (RAD9A)
Gene Name RAD9A
Gene ID 5883
Synonyms
Cell cycle checkpoint control protein RAD9A; hRAD9; EC 3.1.11.2; DNA repair exonuclease rad9 homolog A
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLT
SSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVN
KGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGD
DHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKR
NLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSK
HVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL
Target Bioclass
Enzyme
Family
Rad9 family
Subcellular location
Nucleus
Function
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.
Uniprot ID
Q99638
Ensemble ID
ENST00000307980.7
HGNC ID
HGNC:9827

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K15(4.95)  LDD0277  [1]
BTD
 Probe Info  		C3(0.93)  LDD2094  [2]
DBIA
 Probe Info  		C114(5.21)  LDD0204  [3]
IA-alkyne
 Probe Info  		C3(0.00); C114(0.00); C50(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C50(0.00); C114(0.00)  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C285
 Probe Info  		20.97  LDD1955  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C98(1.08)  LDD0812  [10]
 LDCM0215  AC10 HCT 116 C98(0.89)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C98(0.94)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C98(1.07)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C98(0.90)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C98(0.84)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C98(0.92)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C98(1.19)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C98(0.87)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C98(0.79)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C98(0.98)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C98(0.97)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C98(0.84)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C98(1.03)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C98(1.09)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C98(1.18)  LDD0546  [10]
 LDCM0230  AC113 PaTu 8988t C50(0.89)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C50(0.84)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C50(1.06)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C50(0.92)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C50(0.96)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C50(1.01)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C50(0.89)  LDD1115  [10]
 LDCM0237  AC12 HCT 116 C98(1.03)  LDD0554  [10]
 LDCM0238  AC120 PaTu 8988t C50(1.01)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C50(0.92)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C50(0.89)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C50(1.16)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C50(1.56)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C50(1.38)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C50(0.86)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C50(0.83)  LDD1124  [10]
 LDCM0259  AC14 HCT 116 C98(0.75)  LDD0576  [10]
 LDCM0270  AC15 HCT 116 C98(0.77)  LDD0587  [10]
 LDCM0276  AC17 HCT 116 C98(0.90)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C98(0.92)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C98(0.98)  LDD0595  [10]
 LDCM0279  AC2 HEK-293T C98(1.25)  LDD0877  [10]
 LDCM0280  AC20 HCT 116 C98(1.04)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C98(0.92)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C98(0.76)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C98(0.86)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C98(0.97)  LDD0601  [10]
 LDCM0285  AC25 PaTu 8988t C50(0.80)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C50(0.92)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C50(1.05)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C50(0.99)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C50(0.82)  LDD1168  [10]
 LDCM0290  AC3 HEK-293T C98(0.84)  LDD0888  [10]
 LDCM0291  AC30 PaTu 8988t C50(0.92)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C50(0.80)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C50(1.01)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C50(0.97)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C50(1.20)  LDD1174  [10]
 LDCM0296  AC35 HCT 116 C98(1.29)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C98(1.15)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C98(1.05)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C98(0.77)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C98(1.31)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C98(0.89)  LDD0899  [10]
 LDCM0302  AC40 HCT 116 C98(0.87)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C98(0.88)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C98(0.64)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C98(0.93)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C98(0.85)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C98(0.96)  LDD0624  [10]
 LDCM0308  AC46 HEK-293T C3(0.95); C114(0.93); C50(0.92); C98(1.01)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C3(0.90); C114(0.99); C98(1.00)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C3(1.07); C114(0.97); C98(0.96)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C3(1.07); C114(1.09); C98(1.02)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C98(0.93)  LDD0910  [10]
 LDCM0313  AC50 HEK-293T C3(0.97); C114(1.05); C98(0.93)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C3(1.04); C114(0.92); C141(1.01); C98(0.94)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C3(1.00); C114(0.97); C141(0.77); C98(0.88)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C3(1.01); C114(0.93); C50(1.00); C98(0.97)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C3(0.96); C114(0.95); C50(0.80); C98(0.95)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C3(0.94); C114(0.92); C98(1.02)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C3(0.99); C114(1.00); C98(0.90)  LDD1558  [11]
 LDCM0320  AC57 PaTu 8988t C50(0.66)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C50(0.91)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C50(0.78)  LDD1201  [10]
 LDCM0323  AC6 HCT 116 C98(1.22)  LDD0640  [10]
 LDCM0324  AC60 PaTu 8988t C50(0.72)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C50(0.78)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C50(0.67)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C50(0.72)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C50(0.90)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C50(0.82)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C50(0.89)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C50(0.88)  LDD1210  [10]
 LDCM0332  AC68 PaTu 8988t C50(0.97)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C50(1.07)  LDD1212  [10]
 LDCM0334  AC7 HCT 116 C98(0.70)  LDD0651  [10]
 LDCM0335  AC70 PaTu 8988t C50(1.44)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C50(0.73)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C50(0.99)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C50(1.06)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C50(0.89)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C50(1.04)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C50(0.78)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C50(0.96)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C50(1.04)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C50(1.31)  LDD1223  [10]
 LDCM0345  AC8 HCT 116 C98(0.90)  LDD0662  [10]
 LDCM0346  AC80 PaTu 8988t C50(0.88)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C50(1.17)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C50(0.95)  LDD1227  [10]
 LDCM0365  AC98 HCT 116 C98(1.33)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C98(0.93)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C98(0.98)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C98(0.83)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C98(1.07)  LDD0592  [10]
 LDCM0102  BDHI 8 Jurkat C114(5.21)  LDD0204  [3]
 LDCM0367  CL1 HEK-293T C3(1.04); C114(0.92); C98(1.10)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C3(1.08); C114(0.52); C50(0.62); C98(1.38)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C98(0.90)  LDD0967  [10]
 LDCM0370  CL101 HCT 116 C98(0.89)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C98(0.93)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C98(0.74)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C98(1.15)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C98(0.85)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C98(0.77)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C98(0.82)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C98(0.70)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C98(0.76)  LDD0695  [10]
 LDCM0379  CL11 HEK-293T C3(1.09); C114(0.68); C98(1.30)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C98(0.94)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C98(0.90)  LDD0698  [10]
 LDCM0382  CL112 PaTu 8988t C50(0.96)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C50(0.88)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C50(0.86)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C50(0.83)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C50(1.06)  LDD1265  [10]
 LDCM0387  CL117 HCT 116 C98(0.59)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C98(0.95)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C98(1.30)  LDD0706  [10]
 LDCM0390  CL12 HEK-293T C3(1.07); C114(0.72); C98(1.06)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C98(1.25)  LDD0708  [10]
 LDCM0392  CL121 HEK-293T C3(1.01); C114(1.14); C98(1.06)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C3(0.99); C114(0.99); C50(1.07); C98(0.89)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C3(1.05); C114(0.93); C98(1.09)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C3(1.07); C114(1.06); C50(1.03); C98(1.18)  LDD1599  [11]
 LDCM0396  CL125 PaTu 8988t C50(0.69)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C50(0.63)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C50(0.59)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C50(0.76)  LDD1278  [10]
 LDCM0400  CL13 HEK-293T C3(1.09); C114(0.85); C98(1.66)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C3(0.92); C114(0.99); C50(1.19); C98(0.98)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C3(1.02); C114(0.68); C98(0.93)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C3(0.95); C114(0.94); C50(1.04); C98(0.95)  LDD1607  [11]
 LDCM0404  CL17 HCT 116 C98(1.19)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C98(1.08)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C98(1.12)  LDD0723  [10]
 LDCM0407  CL2 HEK-293T C3(0.89); C114(0.99); C50(1.14); C98(0.93)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C98(1.45)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C98(1.23)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C98(0.81)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C98(0.71)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C98(0.98)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C98(0.96)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C98(0.98)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C98(1.08)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C98(1.54)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C98(0.93)  LDD0734  [10]
 LDCM0418  CL3 HEK-293T C3(0.96); C114(0.78); C98(0.94)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C98(1.20)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C98(0.95)  LDD0737  [10]
 LDCM0421  CL32 HEK-293T C3(1.11); C114(0.68); C141(0.85); C98(1.01)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C3(1.27); C114(0.69); C50(0.58); C98(1.06)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C3(1.10); C114(0.58); C50(0.87); C98(1.06)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C3(1.19); C114(0.64); C98(1.22)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C3(1.12); C114(0.60); C98(1.04)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C3(1.02); C114(1.15); C98(1.07)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C3(0.95); C114(0.93); C98(1.18)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C3(0.96); C114(1.00); C50(1.03); C98(0.98)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C3(1.00); C114(0.97); C50(1.07); C98(0.99)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C3(1.01); C114(0.87); C98(1.30)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C3(1.00); C114(0.83); C98(1.29)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C3(1.06); C114(0.62); C141(0.88); C98(1.04)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C3(1.12); C114(0.67); C141(0.96); C98(0.95)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C3(1.06); C114(0.77); C50(1.00); C98(1.29)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C3(1.05); C114(0.59); C50(1.01); C98(1.05)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C3(1.15); C114(0.67); C98(1.36)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C3(1.12); C114(0.62); C98(1.07)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C3(1.00); C114(1.28); C98(1.03)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C3(1.01); C114(0.98); C98(0.96)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C3(0.95); C114(0.96); C50(1.06); C98(1.00)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C3(0.96); C114(0.99); C50(0.91); C98(0.97)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C3(1.08); C114(0.98); C98(1.37)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C3(1.07); C114(0.77); C98(1.12)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C3(1.01); C114(0.64); C141(0.88); C98(1.05)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C3(1.04); C114(0.66); C141(0.86); C98(1.15)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C3(1.07); C114(0.73); C50(0.74); C98(1.11)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C3(1.22); C114(0.59); C50(0.83); C98(1.79)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C3(1.05); C114(0.76); C98(1.21)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C3(1.02); C114(0.79); C98(1.13)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C3(1.06); C114(0.63); C98(1.06)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C3(1.04); C114(1.23); C98(1.03)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C3(0.95); C114(0.95); C50(1.15); C98(0.92)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C3(0.98); C114(0.86); C98(1.03)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C3(1.11); C114(1.18); C50(0.90); C98(0.95)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C3(1.05); C114(0.91); C98(0.98)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C3(1.03); C114(0.84); C98(1.21)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C3(1.04); C114(0.68); C141(0.86); C98(1.08)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C3(1.06); C114(0.65); C141(0.90); C98(0.97)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C3(1.05); C114(0.76); C50(0.71); C98(1.10)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C3(1.01); C114(0.68); C141(0.91); C98(1.04)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C3(1.02); C114(0.58); C50(0.75); C98(0.99)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C3(1.10); C114(0.65); C98(1.36)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C3(1.08); C114(0.60); C98(0.93)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C3(1.00); C114(1.14); C98(1.04)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C3(0.92); C114(1.05); C50(1.10); C98(1.01)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C98(1.35)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C98(1.64)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C98(1.46)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C98(1.42)  LDD0789  [10]
 LDCM0473  CL8 HEK-293T C3(1.60); C114(0.61); C141(0.71); C98(1.94)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C98(1.76)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C98(1.49)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C98(1.13)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C98(0.91)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C98(1.09)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C98(1.01)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C98(0.95)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C98(1.07)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C98(1.04)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C98(1.26)  LDD0800  [10]
 LDCM0484  CL9 HEK-293T C3(1.09); C114(0.80); C50(0.87); C98(1.10)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C98(1.00)  LDD0802  [10]
 LDCM0486  CL91 HEK-293T C98(0.98)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C98(0.87)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C98(1.02)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C98(1.57)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C98(1.22)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C98(0.88)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C98(1.20)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C98(1.01)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C98(0.81)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C3(1.09); C114(1.05); C98(1.44)  LDD1698  [11]
 LDCM0625  F8 Ramos C114(1.41)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C114(0.77)  LDD2189  [12]
 LDCM0573  Fragment11 MDA-MB-231 C114(1.15)  LDD1391  [13]
 LDCM0574  Fragment12 Ramos C114(0.87)  LDD1394  [13]
 LDCM0575  Fragment13 Ramos C114(0.71)  LDD1396  [13]
 LDCM0576  Fragment14 MDA-MB-231 C114(1.03)  LDD1397  [13]
 LDCM0577  Fragment15 Ramos C114(0.94)  LDD1400  [13]
 LDCM0579  Fragment20 MDA-MB-231 C114(0.97)  LDD1402  [13]
 LDCM0580  Fragment21 Ramos C114(0.90)  LDD2195  [12]
 LDCM0581  Fragment22 Ramos C114(0.89)  LDD1407  [13]
 LDCM0582  Fragment23 Ramos C114(1.44)  LDD1409  [13]
 LDCM0583  Fragment24 Ramos C114(1.16)  LDD1410  [13]
 LDCM0584  Fragment25 MDA-MB-231 C114(1.08)  LDD1411  [13]
 LDCM0585  Fragment26 Ramos C114(1.01)  LDD1412  [13]
 LDCM0578  Fragment27 MDA-MB-231 C114(0.45)  LDD1401  [13]
 LDCM0586  Fragment28 MDA-MB-231 C114(0.80)  LDD1415  [13]
 LDCM0587  Fragment29 MDA-MB-231 C114(1.24)  LDD1417  [13]
 LDCM0588  Fragment30 Ramos C114(1.08)  LDD2199  [12]
 LDCM0589  Fragment31 MDA-MB-231 C114(1.26)  LDD1421  [13]
 LDCM0590  Fragment32 MDA-MB-231 C114(1.26)  LDD1423  [13]
 LDCM0468  Fragment33 HEK-293T C3(1.01); C114(0.92); C98(1.03)  LDD1671  [11]
 LDCM0596  Fragment38 MDA-MB-231 C114(0.92)  LDD1433  [13]
 LDCM0566  Fragment4 MDA-MB-231 C114(1.54)  LDD1378  [13]
 LDCM0598  Fragment40 Ramos C114(0.90)  LDD1437  [13]
 LDCM0599  Fragment41 MDA-MB-231 C114(0.83)  LDD1438  [13]
 LDCM0600  Fragment42 Ramos C114(0.99)  LDD1440  [13]
 LDCM0601  Fragment43 MDA-MB-231 C114(0.86)  LDD1441  [13]
 LDCM0604  Fragment46 MDA-MB-231 C114(0.86)  LDD1445  [13]
 LDCM0605  Fragment47 MDA-MB-231 C114(1.39)  LDD1446  [13]
 LDCM0427  Fragment51 HEK-293T C3(0.96); C114(0.98); C50(1.05); C98(0.89)  LDD1631  [11]
 LDCM0610  Fragment52 MDA-MB-231 C114(0.95)  LDD1452  [13]
 LDCM0611  Fragment53 MDA-MB-231 C114(0.95)  LDD1454  [13]
 LDCM0613  Fragment55 MDA-MB-231 C114(1.19)  LDD1457  [13]
 LDCM0614  Fragment56 MDA-MB-231 C114(1.30)  LDD1458  [13]
 LDCM0568  Fragment6 MDA-MB-231 C114(1.21)  LDD1382  [13]
 LDCM0569  Fragment7 Ramos C114(0.93)  LDD2186  [12]
 LDCM0570  Fragment8 MDA-MB-231 C114(1.32)  LDD1385  [13]
 LDCM0571  Fragment9 MDA-MB-231 C114(0.79)  LDD1387  [13]
 LDCM0022  KB02 MDA-MB-231 C114(12.02)  LDD1374  [13]
 LDCM0023  KB03 Jurkat C114(37.69)  LDD0209  [3]
 LDCM0024  KB05 HMCB C3(3.29)  LDD3312  [14]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C3(0.93)  LDD2094  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C98(0.61)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C98(0.57)  LDD2207  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell cycle checkpoint protein RAD1 (RAD1) Rad1 family O60671
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Checkpoint protein HUS1 (HUS1) HUS1 family O60921

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.