Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment13  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 20.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 20.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 17.7
 LDTP05992  Bleomycin hydrolase (BLMH) C73 7.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 7.3
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 5.6
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 3.3
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 3.3
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 3.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 2.7
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 2.4
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 2.3
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 2.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.9
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.7
 LDTP02502  Thioredoxin (TXN) C32 1.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.6
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.5
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.5
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.4
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.4
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C453 1.4
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.4
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.3
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.2
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.2
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 1.2
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.2
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.2
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.1
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.1
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.1
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.0
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.0
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 1.0
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.0
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.0
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 0.9
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 0.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.9
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.9
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.8
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.8
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.8
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 0.8
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.8
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.8
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.8
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 0.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.8
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.8
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.8
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 0.8
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.8
 LDTP02672  Elongation factor 2 (EEF2) C41 0.8
 LDTP04424  Galactokinase (GALK1) C182 0.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 0.7
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.7
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.7
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.7
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 0.7
 LDTP04689  Adenosine kinase (ADK) C353 0.7
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.7
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.7
 LDTP04374  Dynamin-2 (DNM2) C27 0.7
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 0.7
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.7
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.6
 LDTP02672  Elongation factor 2 (EEF2) C136 0.6
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.6
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.6
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 0.6
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.6
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 0.4
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11855  Pinin (PNN) C249 2.1
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.6
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.5
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.3
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.2
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.9
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 0.9
 LDTP04662  Exportin-2 (CSE1L) C842 0.8
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.8
 LDTP00501  Exportin-1 (XPO1) C34 0.7
 LDTP01574  Importin-7 (IPO7) C757 0.7
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.7
 LDTP00501  Exportin-1 (XPO1) C528 0.5
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.1
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 0.9
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.8
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 0.8
Other
Click to Show/Hide to Show 91 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1059 1.6
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.6
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.6
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.5
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.5
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 1.4
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.2
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.2
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.2
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.2
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.2
 LDTP04092  Crk-like protein (CRKL) C249 1.2
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) C211 1.2
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.2
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.1
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.1
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 1.1
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.1
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.1
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.1
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 1.1
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C660 1.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.0
 LDTP11718  Cleavage stimulation factor subunit 2 tau variant (CSTF2T) C150 1.0
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 0.9
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 0.9
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 0.9
 LDTP01532  ZW10 interactor (ZWINT) C54 0.9
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 0.9
 LDTP00202  AH receptor-interacting protein (AIP) C122 0.9
 LDTP10864  Calponin-2 (CNN2) C215 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.9
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 0.9
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 0.9
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.9
 LDTP05867  Treacle protein (TCOF1) C38 0.9
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.9
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 0.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 0.8
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 0.8
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 0.8
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 0.8
 LDTP05867  Treacle protein (TCOF1) C1298 0.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 0.8
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 0.8
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.8
 LDTP10864  Calponin-2 (CNN2) C164 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.8
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.8
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.8
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 0.8
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 0.8
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.8
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 0.8
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.8
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.7
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.7
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.7
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 0.7
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 0.7
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 0.7
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.7
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.7
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 0.7
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 0.7
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 0.7
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.7
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.7
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.7
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.7
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.7
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.6
 LDTP04487  Cyclin-H (CCNH) C244 0.6
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.6
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.