Details of the Target

General Information of Target

Target ID LDTP01191
Target Name Zinc finger protein 217 (ZNF217)
Gene Name ZNF217
Gene ID 7764
Synonyms
ZABC1; Zinc finger protein 217
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIE
GYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKE
KNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNG
KSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTK
KTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQ
LATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPS
VDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTC
SPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFF
RSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQ
DTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQ
DFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLE
VSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTF
YPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAF
PAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSE
MFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYF
CNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCV
YPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQ
HLSNSMAQKRNYENFIGNAHYRPNDKKT
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
TTD ID
T70278
Uniprot ID
O75362
DrugMap ID
TTY3BRA
Ensemble ID
ENST00000302342.3
HGNC ID
HGNC:13009

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C93(0.96)  LDD2107  [2]
Sulforaphane-probe2
 Probe Info  		2.92  LDD0042  [3]
HPAP
 Probe Info  		7.02  LDD0062  [4]
DBIA
 Probe Info  		C641(1.22); C674(1.19)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C286(0.00); C641(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		C641(0.00); C674(0.00); C959(0.00)  LDD2226  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
W1
 Probe Info  		C641(0.00); C697(0.00); C674(0.00)  LDD0236  [9]
NAIA_5
 Probe Info  		C286(0.00); C351(0.00); C674(0.00); C310(0.00)  LDD2223  [7]
HHS-465
 Probe Info  		K497(0.00); K500(0.00); Y499(0.00)  LDD2240  [10]
HHS-475
 Probe Info  		Y499(0.91)  LDD2238  [11]
HHS-482
 Probe Info  		Y499(0.87)  LDD2239  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C674(2.12); C218(0.65); C221(0.65); C712(0.92)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C341(3.13)  LDD0532  [5]
 LDCM0216  AC100 PaTu 8988t C130(0.72); C133(0.72); C341(1.96)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C130(0.94); C133(0.94); C341(1.10)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C130(0.82); C133(0.82); C341(1.40)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C130(0.64); C133(0.64); C341(1.32)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C130(0.86); C133(0.86); C341(1.40)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C130(0.57); C133(0.57); C341(1.34)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C130(0.86); C133(0.86); C341(1.40)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C130(0.67); C133(0.67); C341(1.11)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C130(0.80); C133(0.80); C341(1.22)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C130(0.81); C133(0.81); C341(2.07)  LDD1104  [5]
 LDCM0226  AC11 HCT 116 C341(1.48)  LDD0543  [5]
 LDCM0227  AC110 PaTu 8988t C130(0.63); C133(0.63); C341(1.89)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C130(0.83); C133(0.83); C341(1.89)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C130(0.63); C133(0.63); C341(2.00)  LDD1108  [5]
 LDCM0230  AC113 HCT 116 C674(0.94)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C674(1.34)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C674(1.29)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C674(1.72)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C674(0.75)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C674(0.85)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C674(1.17)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C341(1.19)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C674(1.18)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C674(1.14)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C674(1.23)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C674(0.64)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C674(1.05)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C674(1.65)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C674(1.56)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C674(1.49)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C674(1.70); C712(1.00); C715(1.00)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C674(1.67); C712(1.09); C715(1.09)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C674(1.64); C712(0.99); C715(0.99)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C674(1.56); C712(1.23); C715(1.23)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C674(1.35); C712(0.77); C715(0.77)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C674(3.62); C712(0.85); C715(0.85)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C674(1.54); C712(1.02); C715(1.02)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C674(2.34); C712(1.06); C715(1.06)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C674(2.02); C712(0.95); C715(0.95)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C674(2.29); C712(1.02); C715(1.02)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C674(1.26); C712(0.95); C715(0.95)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C674(1.57); C712(0.99); C715(0.99)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C341(1.45)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C674(1.06); C712(0.95); C715(0.95)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C674(0.89); C712(1.06); C715(1.06)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C674(1.15); C712(0.88); C715(0.88)  LDD1141  [5]
 LDCM0263  AC143 HCT 116 C674(0.97)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C674(1.19)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C674(0.92)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C674(1.07)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C674(1.52)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C674(2.08)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C674(1.89)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C341(1.33)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C674(1.40)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C674(1.37)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C674(1.41)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C674(3.42)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C674(2.63)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C674(2.04)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C674(1.52)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C674(1.53)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C674(1.34); C341(1.49)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C341(1.34); C674(1.73)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C674(1.14); C341(1.59)  LDD0595  [5]
 LDCM0279  AC2 PaTu 8988t C674(1.45); C218(0.67); C221(0.67); C712(0.94)  LDD1158  [5]
 LDCM0280  AC20 HCT 116 C341(0.92); C674(1.50)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C341(1.19); C674(3.82)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C674(1.42); C341(1.44)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C674(0.90); C341(1.09)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C341(1.16); C674(1.56)  LDD0601  [5]
 LDCM0285  AC25 PaTu 8988t C130(0.63); C310(0.72); C133(0.63); C341(1.26)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C130(0.67); C310(0.75); C133(0.67); C341(1.08)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C130(1.01); C310(1.37); C133(1.01); C341(1.30)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C130(0.60); C310(2.51); C133(0.60); C341(2.42)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C130(0.60); C310(1.41); C133(0.60); C341(1.20)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C674(2.01); C218(0.88); C221(0.88); C712(0.99)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C130(0.65); C310(0.86); C133(0.65); C341(1.07)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C130(0.67); C310(1.02); C133(0.67); C341(1.25)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C130(0.92); C310(1.22); C133(0.92); C341(1.70)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C130(0.84); C310(1.18); C133(0.84); C341(2.05)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C130(0.58); C310(1.40); C133(0.58); C341(1.49)  LDD1174  [5]
 LDCM0296  AC35 HCT 116 C341(0.70)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C341(0.83)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C341(0.93)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C341(0.67)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C341(0.99)  LDD0617  [5]
 LDCM0301  AC4 PaTu 8988t C674(1.55); C218(0.83); C221(0.83); C712(0.89)  LDD1180  [5]
 LDCM0302  AC40 HCT 116 C341(0.95)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C341(0.61)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C341(1.31)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C341(0.89)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C341(0.90)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C341(0.85)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C341(1.06)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C341(0.90)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C341(0.98)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C341(1.05)  LDD0628  [5]
 LDCM0312  AC5 PaTu 8988t C674(2.59); C218(0.84); C221(0.84); C712(1.02)  LDD1191  [5]
 LDCM0313  AC50 HCT 116 C341(0.92)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C341(0.96)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C341(0.91)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C341(1.11)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C341(0.74)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C341(1.32)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C341(1.05)  LDD0636  [5]
 LDCM0320  AC57 PaTu 8988t C674(0.69); C712(1.18); C715(1.18)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C674(0.90); C712(1.15); C715(1.15)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C674(0.71); C712(1.06); C715(1.06)  LDD1201  [5]
 LDCM0323  AC6 HCT 116 C341(1.03)  LDD0640  [5]
 LDCM0324  AC60 PaTu 8988t C674(0.96); C712(1.00); C715(1.00)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C674(0.73); C712(1.16); C715(1.16)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C674(0.72); C712(1.09); C715(1.09)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C674(0.39); C712(0.98); C715(0.98)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C674(0.43); C712(1.07); C715(1.07)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C674(0.40); C712(0.96); C715(0.96)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C674(0.38); C712(1.09); C715(1.09)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C674(0.47); C712(1.20); C715(1.20)  LDD1210  [5]
 LDCM0332  AC68 HCT 116 C674(0.70)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C674(0.76)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C341(1.35)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C674(0.73)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C674(0.79)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C674(0.94)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C674(0.66)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C674(1.05)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C674(0.85)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C674(0.98)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C674(1.00)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C674(0.61)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C674(1.06)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C341(2.12)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C674(1.42)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C674(0.46)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C674(1.21)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C674(2.86)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C674(1.70)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C674(1.19)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C674(1.14)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C674(1.47)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C674(2.40)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C674(4.01)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C674(1.00)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C674(2.69)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C674(4.98)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C674(1.92)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C674(1.58)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C674(2.15)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C674(3.02)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C674(2.51)  LDD0681  [5]
 LDCM0365  AC98 PaTu 8988t C130(0.71); C133(0.71); C341(1.10)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C130(0.83); C133(0.83); C341(1.19)  LDD1245  [5]
 LDCM0248  AKOS034007472 HCT 116 C341(1.37)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C341(1.59)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C341(1.81)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C641(1.22); C674(1.19)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C674(20.00); C310(1.55); C351(1.08); C674(0.81)  LDD2227  [7]
 LDCM0367  CL1 PaTu 8988t C133(0.95); C341(1.00)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C133(0.90); C341(1.22)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C674(1.78); C218(0.77); C221(0.77); C712(0.86)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C341(1.22)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C341(0.97)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C341(1.10)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C341(1.30)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C674(0.90); C341(1.26)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C341(1.40); C674(2.10)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C674(1.31); C341(1.44)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C674(1.47); C341(2.57)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C674(1.14); C341(1.58)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C133(1.01); C341(1.21)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C341(1.23); C674(1.98)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C674(1.20); C341(1.29)  LDD0698  [5]
 LDCM0382  CL112 PaTu 8988t C130(0.76); C310(1.22); C133(0.76); C341(1.44)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C130(0.87); C310(1.04); C133(0.87); C341(1.64)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C130(0.60); C310(1.02); C133(0.60); C341(1.57)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C130(0.82); C310(1.18); C133(0.82); C341(1.11)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C130(1.06); C310(1.40); C133(1.06); C341(1.36)  LDD1265  [5]
 LDCM0387  CL117 HCT 116 C341(2.45)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C341(0.65)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C341(1.17)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C133(1.11); C341(1.50)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C341(0.79)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C341(1.11)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C341(1.15)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C341(0.90)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C341(0.95)  LDD0712  [5]
 LDCM0396  CL125 PaTu 8988t C674(0.53); C712(1.06); C715(1.06)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C674(0.55); C712(0.86); C715(0.86)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C674(0.51); C712(1.16); C715(1.16)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C674(0.84); C712(1.25); C715(1.25)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C133(0.98); C341(2.60)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C133(0.86); C341(2.12)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C133(0.78); C341(1.32)  LDD1281  [5]
 LDCM0403  CL16 HCT 116 C674(1.42)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C674(1.18)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C674(1.15)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C674(1.07)  LDD0723  [5]
 LDCM0407  CL2 PaTu 8988t C133(0.90); C341(1.06)  LDD1286  [5]
 LDCM0408  CL20 HCT 116 C674(1.25)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C674(0.94)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C674(0.87)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C674(1.20)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C674(1.65)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C674(1.25)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C674(1.67)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C674(1.03)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C674(1.23)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C674(1.21)  LDD0734  [5]
 LDCM0418  CL3 PaTu 8988t C133(0.94); C341(1.54)  LDD1297  [5]
 LDCM0419  CL30 HCT 116 C674(1.23)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C674(1.08); C218(0.78); C221(0.78); C310(1.22)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C674(1.77); C218(0.81); C221(0.81); C310(1.40)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C674(1.10); C218(0.76); C221(0.76); C310(1.43)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C674(1.63); C218(0.82); C221(0.82); C310(1.88)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C674(1.70); C218(0.84); C221(0.84); C310(1.53)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C674(1.70); C218(0.86); C221(0.86); C310(1.14)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C674(1.49); C218(0.85); C221(0.85); C310(2.02)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C674(1.81); C218(0.88); C221(0.88); C310(1.28)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C133(1.03); C341(1.27)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C674(1.39); C218(0.88); C221(0.88); C310(1.33)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C674(1.57); C218(0.86); C221(0.86); C310(1.46)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C674(2.28); C218(0.83); C221(0.83); C310(1.82)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C674(2.37); C218(0.63); C221(0.63); C310(2.19)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C674(1.84); C218(0.81); C221(0.81); C310(1.80)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C674(1.36); C218(0.96); C221(0.96); C310(1.63)  LDD1314  [5]
 LDCM0436  CL46 HCT 116 C674(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C674(1.21)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C674(1.18)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C674(0.88)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C133(1.07); C341(1.97)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C674(1.42)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C674(1.10)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C674(1.53)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C674(0.99)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C674(1.97)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C674(1.87)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C674(0.96)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C674(1.40)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C674(1.18)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C674(0.87)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C133(0.85); C341(1.44)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C674(1.05)  LDD0769  [5]
 LDCM0453  CL61 PaTu 8988t C310(1.08); C133(0.84); C712(0.88); C715(0.88)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C310(1.19); C133(0.74); C712(1.09); C715(1.09)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C310(1.01); C133(0.98); C712(0.92); C715(0.92)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C310(1.12); C133(0.84); C712(0.78); C715(0.78)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C310(1.13); C133(0.76); C712(1.06); C715(1.06)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C310(1.12); C133(0.80); C712(0.72); C715(0.72)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C310(1.46); C133(0.98); C712(1.03); C715(1.03)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C310(1.90); C133(1.19); C712(0.86); C715(0.86)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C310(1.38); C133(0.91); C712(0.77); C715(0.77)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C133(0.96); C341(1.57)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C310(1.15); C133(0.94); C712(0.60); C715(0.60)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C310(1.02); C133(0.69); C712(0.99); C715(0.99)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C310(1.08); C133(0.76); C712(1.06); C715(1.06)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C310(1.61); C133(1.06); C712(0.91); C715(0.91)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C310(1.20); C133(0.86); C712(0.92); C715(0.92)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C674(2.25); C218(0.92); C221(0.92); C341(1.20)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C674(1.37); C218(0.79); C221(0.79); C341(1.09)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C674(1.64); C218(0.86); C221(0.86); C341(1.54)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C674(1.15); C218(0.96); C221(0.96); C341(1.23)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C133(0.90); C341(1.17)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C674(1.20); C218(0.87); C221(0.87); C341(1.33)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C674(1.35); C218(0.67); C221(0.67); C341(1.47)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C674(1.48); C218(0.79); C221(0.79); C341(1.35)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C674(1.41); C218(0.80); C221(0.80); C341(1.37)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C674(1.78); C218(0.80); C221(0.80); C341(1.61)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C674(1.14); C218(0.91); C221(0.91); C341(1.24)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C674(1.18); C218(0.83); C221(0.83); C341(1.28)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C674(1.50); C218(0.79); C221(0.79); C341(1.54)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C674(2.02); C218(0.99); C221(0.99); C341(1.54)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C674(1.39); C218(0.95); C221(0.95); C341(1.41)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C133(0.84); C341(1.79)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C674(1.18); C218(0.82); C221(0.82); C341(1.72)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C674(1.70); C218(0.72); C221(0.72); C712(0.81)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C674(1.40); C218(0.75); C221(0.75); C712(0.86)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C674(1.30); C218(0.73); C221(0.73); C712(0.87)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C674(1.85); C218(0.75); C221(0.75); C712(0.96)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C674(1.53); C218(0.82); C221(0.82); C712(0.79)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C674(1.38); C218(0.91); C221(0.91); C712(0.85)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C674(1.93); C218(0.80); C221(0.80); C712(0.76)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C674(2.06); C218(0.87); C221(0.87); C712(0.87)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C674(2.28); C218(0.78); C221(0.78); C712(0.99)  LDD1373  [5]
 LDCM0634  CY-0357 Hep-G2 C674(1.03); C341(0.74); C641(0.54)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C310(1.14)  LDD1698  [12]
 LDCM0572  Fragment10 MDA-MB-231 C286(1.10)  LDD1389  [13]
 LDCM0573  Fragment11 MDA-MB-231 C286(1.20)  LDD1391  [13]
 LDCM0574  Fragment12 MDA-MB-231 C286(1.03)  LDD1393  [13]
 LDCM0575  Fragment13 MDA-MB-231 C286(0.91)  LDD1395  [13]
 LDCM0576  Fragment14 MDA-MB-231 C286(0.89)  LDD1397  [13]
 LDCM0579  Fragment20 MDA-MB-231 C286(1.31)  LDD1402  [13]
 LDCM0580  Fragment21 MDA-MB-231 C286(0.87)  LDD1404  [13]
 LDCM0582  Fragment23 MDA-MB-231 C286(20.00)  LDD1408  [13]
 LDCM0584  Fragment25 MDA-MB-231 C286(20.00)  LDD1411  [13]
 LDCM0578  Fragment27 MDA-MB-231 C286(20.00)  LDD1401  [13]
 LDCM0586  Fragment28 MDA-MB-231 C286(0.99)  LDD1415  [13]
 LDCM0587  Fragment29 MDA-MB-231 C286(0.92)  LDD1417  [13]
 LDCM0588  Fragment30 Ramos C286(2.07)  LDD1420  [13]
 LDCM0468  Fragment33 PaTu 8988t C310(1.32); C133(0.71); C712(0.92); C715(0.92)  LDD1347  [5]
 LDCM0595  Fragment37 Ramos C286(0.90)  LDD1432  [13]
 LDCM0596  Fragment38 MDA-MB-231 C286(0.89)  LDD1433  [13]
 LDCM0597  Fragment39 MDA-MB-231 C286(20.00)  LDD1435  [13]
 LDCM0566  Fragment4 MDA-MB-231 C286(1.69)  LDD1378  [13]
 LDCM0599  Fragment41 Ramos C286(0.57)  LDD1439  [13]
 LDCM0600  Fragment42 Ramos C286(0.98)  LDD1440  [13]
 LDCM0601  Fragment43 MDA-MB-231 C286(1.85)  LDD1441  [13]
 LDCM0603  Fragment45 MDA-MB-231 C286(20.00)  LDD1444  [13]
 LDCM0604  Fragment46 MDA-MB-231 C286(0.88)  LDD1445  [13]
 LDCM0607  Fragment49 MDA-MB-231 C286(0.99)  LDD1448  [13]
 LDCM0427  Fragment51 PaTu 8988t C674(1.84); C218(0.96); C221(0.96); C310(1.71)  LDD1306  [5]
 LDCM0610  Fragment52 MDA-MB-231 C286(1.01)  LDD1452  [13]
 LDCM0611  Fragment53 MDA-MB-231 C286(1.05)  LDD1454  [13]
 LDCM0614  Fragment56 MDA-MB-231 C286(0.99)  LDD1458  [13]
 LDCM0568  Fragment6 MDA-MB-231 C286(0.91)  LDD1382  [13]
 LDCM0569  Fragment7 MDA-MB-231 C286(1.25)  LDD1383  [13]
 LDCM0570  Fragment8 MDA-MB-231 C286(1.75)  LDD1385  [13]
 LDCM0571  Fragment9 MDA-MB-231 C286(1.19)  LDD1387  [13]
 LDCM0022  KB02 MDA-MB-231 C286(20.00)  LDD1374  [13]
 LDCM0023  KB03 Jurkat C674(145.66)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C756(2.51)  LDD3310  [15]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C93(0.96)  LDD2107  [2]
 LDCM0014  Panhematin HEK-293T 7.02  LDD0062  [4]
 LDCM0003  Sulforaphane MCF-7 2.92  LDD0042  [3]
 LDCM0021  THZ1 HCT 116 C674(0.88)  LDD2173  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 114527 Antisense drug D0AJ0H
Isis 114530 Antisense drug D0N5CF
Isis 114531 Antisense drug D08WJY
Isis 114532 Antisense drug D0LY0E
Isis 114537 Antisense drug D0E5FG
Isis 114559 Antisense drug D03NEA
Isis 114563 Antisense drug D01KCM
Isis 14548 Antisense drug D0L3NU

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840