Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment41					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	7.9
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	7.8
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	4.5
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	4.4
LDTP01245	Enoyl-CoA delta isomerase 2 (ECI2)				C380	3.6
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	3.4
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	2.7
LDTP03400	Deoxycytidine kinase (DCK)				C45	2.4
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	2.0
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.8
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	1.7
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	1.6
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	1.5
LDTP04689	Adenosine kinase (ADK)				C353	1.4
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	1.4
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	1.4
LDTP02672	Elongation factor 2 (EEF2)				C41	1.3
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.3
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	1.2
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.1
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	1.1
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.1
LDTP02502	Thioredoxin (TXN)				C32	1.1
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.1
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.1
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.1
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.0
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.0
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.0
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.0
LDTP05992	Bleomycin hydrolase (BLMH)				C73	1.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	1.0
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.0
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.0
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.0
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.0
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.0
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.0
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.0
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	1.0
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C9	0.9
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	0.9
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	0.9
LDTP02672	Elongation factor 2 (EEF2)				C136	0.9
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	0.9
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	0.9
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	0.9
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	0.9
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	0.9
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	0.9
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	0.9
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	0.8
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.8
LDTP06211	Caspase-8 (CASP8)				C360	0.8
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	0.8
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	0.8
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	0.8
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	0.8
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.7
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	0.7
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	0.7
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	0.7
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	0.7
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	0.6
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.6
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	0.6
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	0.6
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.5
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	0.5
LDTP04251	Elongation factor Tu, mitochondrial (TUFM)				C147	0.4
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C170	0.2

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP01574	Importin-7 (IPO7)				C757	20.0
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	4.7
LDTP00501	Exportin-1 (XPO1)				C34	2.0
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.4
LDTP04801	Gasdermin-D (GSDMD)				C268	1.3
LDTP13661	Sorting nexin-6 (SNX6)				C264	1.3
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.2
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	1.2
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	0.9
LDTP04707	Protein SEC13 homolog (SEC13)				C187	0.9
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.8
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	0.7

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	12.2
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	6.1
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	2.8
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	2.0
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.1
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	20.0
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	7.4
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	3.4
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	2.5
LDTP13964	MOB-like protein phocein (MOB4)				C134	2.1
LDTP02205	Tubulin beta chain (TUBB)				C239	2.0
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	2.0
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.8
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.7
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	1.7
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.5
LDTP01532	ZW10 interactor (ZWINT)				C54	1.5
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	1.4
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	1.3
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.3
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.3
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.2
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	1.2
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.2
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	1.2
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.2
LDTP07755	Dynamin-binding protein (DNMBP)				C691	1.2
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.2
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.1
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	1.1
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	1.1
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.1
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.0
LDTP13580	Coronin-1C (CORO1C)				C420	1.0
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	1.0
LDTP00202	AH receptor-interacting protein (AIP)				C122	1.0
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.0
LDTP10864	Calponin-2 (CNN2)				C215	1.0
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	1.0
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	0.9
LDTP04092	Crk-like protein (CRKL)				C249	0.9
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	0.9
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	0.9
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	0.9
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	0.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	0.9
LDTP10864	Calponin-2 (CNN2)				C164	0.8
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	0.8
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	0.8
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	0.8
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	0.8
LDTP02205	Tubulin beta chain (TUBB)				C354	0.8
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.8
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	0.8
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	0.7
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.6
LDTP05259	Heterogeneous nuclear ribonucleoprotein U (HNRNPU)				C562	0.3

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.