Details of the Target

General Information of Target

Target ID LDTP00089
Target Name Glycerol-3-phosphate phosphatase (PGP)
Gene Name PGP
Gene ID 283871
Synonyms
Glycerol-3-phosphate phosphatase; G3PP; EC 3.1.3.21; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; EC 3.1.3.48; Phosphoglycolate phosphatase; PGP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARG
KRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPK
AYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMK
LTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFI
FDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSK
KKMVPDFYVDSIADLLPALQG
Target Bioclass
Enzyme
Family
HAD-like hydrolase superfamily, CbbY/CbbZ/Gph/YieH family
Function
Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.
Uniprot ID
A6NDG6
Ensemble ID
ENST00000333503.8
HGNC ID
HGNC:8909

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		6.66  LDD0348  [2]
HRP
 Probe Info  		4.51  LDD0347  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K72(5.68); K80(10.00)  LDD0277  [4]
BTD
 Probe Info  		C297(7.64)  LDD1699  [5]
ONAyne
 Probe Info  		K80(0.00); K235(0.00)  LDD0273  [4]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [6]
DBIA
 Probe Info  		C297(5.85)  LDD0209  [7]
AMP probe
 Probe Info  		N.A.  LDD0200  [8]
ATP probe
 Probe Info  		K72(0.00); K300(0.00); K301(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C35(0.00); C217(0.00); C243(0.00); C297(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C297(0.00); C243(0.00)  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		C297(0.00); C243(0.00); C193(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C35(0.00); C243(0.00); C193(0.00); C217(0.00)  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		C217(0.00); C297(0.00)  LDD2226  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
DA-P3
 Probe Info  		N.A.  LDD0178  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
ENE
 Probe Info  		N.A.  LDD0006  [14]
TFBX
 Probe Info  		C217(0.00); C297(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C297(0.00); C272(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		C297(0.00); C243(0.00)  LDD0236  [18]
AOyne
 Probe Info  		13.30  LDD0443  [19]
NAIA_5
 Probe Info  		C35(0.00); C217(0.00); C243(0.00); C272(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [20]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		7.84  LDD1937  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C297(1.00)  LDD2117  [5]
 LDCM0214  AC1 HCT 116 C297(0.98)  LDD0531  [24]
 LDCM0215  AC10 HCT 116 C297(1.86)  LDD0532  [24]
 LDCM0216  AC100 HCT 116 C297(1.39)  LDD0533  [24]
 LDCM0217  AC101 HCT 116 C297(1.15)  LDD0534  [24]
 LDCM0218  AC102 HCT 116 C297(1.13)  LDD0535  [24]
 LDCM0219  AC103 HCT 116 C297(1.65)  LDD0536  [24]
 LDCM0220  AC104 HCT 116 C297(1.36)  LDD0537  [24]
 LDCM0221  AC105 HCT 116 C297(1.22)  LDD0538  [24]
 LDCM0222  AC106 HCT 116 C297(1.61)  LDD0539  [24]
 LDCM0223  AC107 HCT 116 C297(1.21)  LDD0540  [24]
 LDCM0224  AC108 HCT 116 C297(1.07)  LDD0541  [24]
 LDCM0225  AC109 HCT 116 C297(1.08)  LDD0542  [24]
 LDCM0226  AC11 HCT 116 C297(1.54)  LDD0543  [24]
 LDCM0227  AC110 HCT 116 C297(1.37)  LDD0544  [24]
 LDCM0228  AC111 HCT 116 C297(1.29)  LDD0545  [24]
 LDCM0229  AC112 HCT 116 C297(1.19)  LDD0546  [24]
 LDCM0230  AC113 HCT 116 C297(0.95)  LDD0547  [24]
 LDCM0231  AC114 HCT 116 C297(1.21)  LDD0548  [24]
 LDCM0232  AC115 HCT 116 C297(1.22)  LDD0549  [24]
 LDCM0233  AC116 HCT 116 C297(1.42)  LDD0550  [24]
 LDCM0234  AC117 HCT 116 C297(1.31)  LDD0551  [24]
 LDCM0235  AC118 HCT 116 C297(1.04)  LDD0552  [24]
 LDCM0236  AC119 HCT 116 C297(1.09)  LDD0553  [24]
 LDCM0237  AC12 HCT 116 C297(1.53)  LDD0554  [24]
 LDCM0238  AC120 HCT 116 C297(1.10)  LDD0555  [24]
 LDCM0239  AC121 HCT 116 C297(1.17)  LDD0556  [24]
 LDCM0240  AC122 HCT 116 C297(1.07)  LDD0557  [24]
 LDCM0241  AC123 HCT 116 C297(0.90)  LDD0558  [24]
 LDCM0242  AC124 HCT 116 C297(1.05)  LDD0559  [24]
 LDCM0243  AC125 HCT 116 C297(1.06)  LDD0560  [24]
 LDCM0244  AC126 HCT 116 C297(1.17)  LDD0561  [24]
 LDCM0245  AC127 HCT 116 C297(1.37)  LDD0562  [24]
 LDCM0246  AC128 HCT 116 C297(1.38)  LDD0563  [24]
 LDCM0247  AC129 HCT 116 C297(1.50)  LDD0564  [24]
 LDCM0249  AC130 HCT 116 C297(1.56)  LDD0566  [24]
 LDCM0250  AC131 HCT 116 C297(1.12)  LDD0567  [24]
 LDCM0251  AC132 HCT 116 C297(1.39)  LDD0568  [24]
 LDCM0252  AC133 HCT 116 C297(1.33)  LDD0569  [24]
 LDCM0253  AC134 HCT 116 C297(2.05)  LDD0570  [24]
 LDCM0254  AC135 HCT 116 C297(1.70)  LDD0571  [24]
 LDCM0255  AC136 HCT 116 C297(1.49)  LDD0572  [24]
 LDCM0256  AC137 HCT 116 C297(1.68)  LDD0573  [24]
 LDCM0257  AC138 HCT 116 C297(1.79)  LDD0574  [24]
 LDCM0258  AC139 HCT 116 C297(1.23)  LDD0575  [24]
 LDCM0259  AC14 HCT 116 C297(1.11)  LDD0576  [24]
 LDCM0260  AC140 HCT 116 C297(1.70)  LDD0577  [24]
 LDCM0261  AC141 HCT 116 C297(1.93)  LDD0578  [24]
 LDCM0262  AC142 HCT 116 C297(1.75)  LDD0579  [24]
 LDCM0263  AC143 HEK-293T C217(0.92); C297(0.82)  LDD0861  [24]
 LDCM0264  AC144 HEK-293T C217(1.06); C297(0.99)  LDD0862  [24]
 LDCM0265  AC145 HEK-293T C217(1.00); C297(1.19)  LDD0863  [24]
 LDCM0266  AC146 HEK-293T C217(1.07); C297(1.09)  LDD0864  [24]
 LDCM0267  AC147 HEK-293T C217(1.06); C297(0.86)  LDD0865  [24]
 LDCM0268  AC148 HEK-293T C217(1.02); C297(0.79)  LDD0866  [24]
 LDCM0269  AC149 HEK-293T C217(0.84); C297(0.89)  LDD0867  [24]
 LDCM0270  AC15 HCT 116 C297(1.20)  LDD0587  [24]
 LDCM0271  AC150 HEK-293T C217(0.92); C297(0.80)  LDD0869  [24]
 LDCM0272  AC151 HEK-293T C217(1.03); C297(1.08)  LDD0870  [24]
 LDCM0273  AC152 HEK-293T C217(0.87); C297(1.03)  LDD0871  [24]
 LDCM0274  AC153 HEK-293T C217(0.94); C297(0.95)  LDD0872  [24]
 LDCM0621  AC154 HEK-293T C217(0.86); C297(0.99)  LDD2162  [24]
 LDCM0622  AC155 HEK-293T C217(0.83); C297(1.01)  LDD2163  [24]
 LDCM0623  AC156 HEK-293T C217(1.09); C297(0.89)  LDD2164  [24]
 LDCM0624  AC157 HEK-293T C217(1.16); C297(0.93)  LDD2165  [24]
 LDCM0276  AC17 HCT 116 C297(1.15); C217(1.31)  LDD0593  [24]
 LDCM0277  AC18 HCT 116 C217(1.08); C297(1.31)  LDD0594  [24]
 LDCM0278  AC19 HCT 116 C217(1.15); C297(1.20)  LDD0595  [24]
 LDCM0279  AC2 HCT 116 C297(0.86)  LDD0596  [24]
 LDCM0280  AC20 HCT 116 C217(1.03); C297(1.33)  LDD0597  [24]
 LDCM0281  AC21 HCT 116 C217(1.18); C297(1.39)  LDD0598  [24]
 LDCM0282  AC22 HCT 116 C217(1.12); C297(1.15)  LDD0599  [24]
 LDCM0283  AC23 HCT 116 C217(1.13); C297(1.97)  LDD0600  [24]
 LDCM0284  AC24 HCT 116 C297(1.01); C217(1.30)  LDD0601  [24]
 LDCM0285  AC25 HCT 116 C297(1.06)  LDD0602  [24]
 LDCM0286  AC26 HCT 116 C297(1.15)  LDD0603  [24]
 LDCM0287  AC27 HCT 116 C297(1.35)  LDD0604  [24]
 LDCM0288  AC28 HCT 116 C297(1.28)  LDD0605  [24]
 LDCM0289  AC29 HCT 116 C297(1.37)  LDD0606  [24]
 LDCM0290  AC3 HCT 116 C297(0.94)  LDD0607  [24]
 LDCM0291  AC30 HCT 116 C297(1.25)  LDD0608  [24]
 LDCM0292  AC31 HCT 116 C297(1.17)  LDD0609  [24]
 LDCM0293  AC32 HCT 116 C297(1.51)  LDD0610  [24]
 LDCM0294  AC33 HCT 116 C297(1.29)  LDD0611  [24]
 LDCM0295  AC34 HCT 116 C297(1.45)  LDD0612  [24]
 LDCM0296  AC35 HCT 116 C297(0.85); C217(1.08)  LDD0613  [24]
 LDCM0297  AC36 HCT 116 C217(0.89); C297(1.01)  LDD0614  [24]
 LDCM0298  AC37 HCT 116 C217(1.13); C297(1.17)  LDD0615  [24]
 LDCM0299  AC38 HCT 116 C297(1.06); C217(1.11)  LDD0616  [24]
 LDCM0300  AC39 HCT 116 C217(1.04); C297(1.29)  LDD0617  [24]
 LDCM0301  AC4 HCT 116 C297(0.92)  LDD0618  [24]
 LDCM0302  AC40 HCT 116 C217(1.06); C297(1.29)  LDD0619  [24]
 LDCM0303  AC41 HCT 116 C217(1.15); C297(1.34)  LDD0620  [24]
 LDCM0304  AC42 HCT 116 C297(1.15); C217(1.35)  LDD0621  [24]
 LDCM0305  AC43 HCT 116 C297(1.14); C217(1.18)  LDD0622  [24]
 LDCM0306  AC44 HCT 116 C217(1.04); C297(1.16)  LDD0623  [24]
 LDCM0307  AC45 HCT 116 C217(1.13); C297(1.39)  LDD0624  [24]
 LDCM0308  AC46 HCT 116 C297(1.09)  LDD0625  [24]
 LDCM0309  AC47 HCT 116 C297(1.11)  LDD0626  [24]
 LDCM0310  AC48 HCT 116 C297(1.36)  LDD0627  [24]
 LDCM0311  AC49 HCT 116 C297(1.39)  LDD0628  [24]
 LDCM0312  AC5 HCT 116 C297(0.92)  LDD0629  [24]
 LDCM0313  AC50 HCT 116 C297(1.87)  LDD0630  [24]
 LDCM0314  AC51 HCT 116 C297(1.13)  LDD0631  [24]
 LDCM0315  AC52 HCT 116 C297(1.18)  LDD0632  [24]
 LDCM0316  AC53 HCT 116 C297(1.37)  LDD0633  [24]
 LDCM0317  AC54 HCT 116 C297(1.29)  LDD0634  [24]
 LDCM0318  AC55 HCT 116 C297(1.23)  LDD0635  [24]
 LDCM0319  AC56 HCT 116 C297(1.61)  LDD0636  [24]
 LDCM0320  AC57 HCT 116 C297(1.39)  LDD0637  [24]
 LDCM0321  AC58 HCT 116 C297(1.49)  LDD0638  [24]
 LDCM0322  AC59 HCT 116 C297(1.44)  LDD0639  [24]
 LDCM0323  AC6 HCT 116 C297(1.42)  LDD0640  [24]
 LDCM0324  AC60 HCT 116 C297(1.45)  LDD0641  [24]
 LDCM0325  AC61 HCT 116 C297(1.57)  LDD0642  [24]
 LDCM0326  AC62 HCT 116 C297(1.49)  LDD0643  [24]
 LDCM0327  AC63 HCT 116 C297(1.39)  LDD0644  [24]
 LDCM0328  AC64 HCT 116 C297(1.56)  LDD0645  [24]
 LDCM0329  AC65 HCT 116 C297(1.74)  LDD0646  [24]
 LDCM0330  AC66 HCT 116 C297(1.50)  LDD0647  [24]
 LDCM0331  AC67 HCT 116 C297(1.85)  LDD0648  [24]
 LDCM0332  AC68 HCT 116 C217(0.83); C297(1.27)  LDD0649  [24]
 LDCM0333  AC69 HCT 116 C217(0.75); C297(1.23)  LDD0650  [24]
 LDCM0334  AC7 HCT 116 C297(1.25)  LDD0651  [24]
 LDCM0335  AC70 HCT 116 C217(0.83); C297(1.42)  LDD0652  [24]
 LDCM0336  AC71 HCT 116 C217(0.91); C297(1.07)  LDD0653  [24]
 LDCM0337  AC72 HCT 116 C217(0.81); C297(1.28)  LDD0654  [24]
 LDCM0338  AC73 HCT 116 C217(0.98); C297(1.49)  LDD0655  [24]
 LDCM0339  AC74 HCT 116 C217(0.98); C297(1.71)  LDD0656  [24]
 LDCM0340  AC75 HCT 116 C217(0.82); C297(1.74)  LDD0657  [24]
 LDCM0341  AC76 HCT 116 C217(1.02); C297(1.34)  LDD0658  [24]
 LDCM0342  AC77 HCT 116 C217(0.75); C297(1.37)  LDD0659  [24]
 LDCM0343  AC78 HCT 116 C217(0.83); C297(1.19)  LDD0660  [24]
 LDCM0344  AC79 HCT 116 C217(0.76); C297(1.14)  LDD0661  [24]
 LDCM0345  AC8 HCT 116 C297(1.38)  LDD0662  [24]
 LDCM0346  AC80 HCT 116 C217(0.87); C297(1.24)  LDD0663  [24]
 LDCM0347  AC81 HCT 116 C217(0.84); C297(0.89)  LDD0664  [24]
 LDCM0348  AC82 HCT 116 C217(0.85); C297(2.02)  LDD0665  [24]
 LDCM0349  AC83 HCT 116 C217(1.21); C297(2.19)  LDD0666  [24]
 LDCM0350  AC84 HCT 116 C217(1.32); C297(1.74)  LDD0667  [24]
 LDCM0351  AC85 HCT 116 C217(1.21); C297(1.53)  LDD0668  [24]
 LDCM0352  AC86 HCT 116 C217(1.01); C297(1.21)  LDD0669  [24]
 LDCM0353  AC87 HCT 116 C217(1.20); C297(1.33)  LDD0670  [24]
 LDCM0354  AC88 HCT 116 C217(1.05); C297(1.62)  LDD0671  [24]
 LDCM0355  AC89 HCT 116 C217(1.17); C297(1.36)  LDD0672  [24]
 LDCM0357  AC90 HCT 116 C217(1.22); C297(1.45)  LDD0674  [24]
 LDCM0358  AC91 HCT 116 C217(1.16); C297(2.02)  LDD0675  [24]
 LDCM0359  AC92 HCT 116 C217(1.18); C297(1.81)  LDD0676  [24]
 LDCM0360  AC93 HCT 116 C217(1.15); C297(1.52)  LDD0677  [24]
 LDCM0361  AC94 HCT 116 C217(1.25); C297(1.34)  LDD0678  [24]
 LDCM0362  AC95 HCT 116 C217(1.17); C297(1.28)  LDD0679  [24]
 LDCM0363  AC96 HCT 116 C217(1.10); C297(1.77)  LDD0680  [24]
 LDCM0364  AC97 HCT 116 C217(1.30); C297(1.82)  LDD0681  [24]
 LDCM0365  AC98 HCT 116 C297(1.45)  LDD0682  [24]
 LDCM0366  AC99 HCT 116 C297(1.08)  LDD0683  [24]
 LDCM0520  AKOS000195272 MDA-MB-231 C217(0.80)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C297(1.02)  LDD0565  [24]
 LDCM0356  AKOS034007680 HCT 116 C297(1.09)  LDD0673  [24]
 LDCM0275  AKOS034007705 HCT 116 C297(1.44)  LDD0592  [24]
 LDCM0156  Aniline NCI-H1299 13.03  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C297(1.21); C243(0.73)  LDD2171  [24]
 LDCM0108  Chloroacetamide HeLa C217(0.00); C297(0.00); C272(0.00); C193(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C297(2.08); C297(1.53); C297(0.86)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C297(1.32)  LDD0684  [24]
 LDCM0368  CL10 HCT 116 C297(1.12)  LDD0685  [24]
 LDCM0369  CL100 HCT 116 C297(1.10)  LDD0686  [24]
 LDCM0370  CL101 HCT 116 C297(1.40)  LDD0687  [24]
 LDCM0371  CL102 HCT 116 C297(1.60)  LDD0688  [24]
 LDCM0372  CL103 HCT 116 C297(1.07)  LDD0689  [24]
 LDCM0373  CL104 HCT 116 C297(1.15)  LDD0690  [24]
 LDCM0374  CL105 HCT 116 C217(1.31); C297(1.48)  LDD0691  [24]
 LDCM0375  CL106 HCT 116 C217(0.89); C297(1.76)  LDD0692  [24]
 LDCM0376  CL107 HCT 116 C217(0.93); C297(1.66)  LDD0693  [24]
 LDCM0377  CL108 HCT 116 C217(1.29); C297(1.58)  LDD0694  [24]
 LDCM0378  CL109 HCT 116 C217(1.40); C297(1.48)  LDD0695  [24]
 LDCM0379  CL11 HCT 116 C297(1.67)  LDD0696  [24]
 LDCM0380  CL110 HCT 116 C217(0.95); C297(1.61)  LDD0697  [24]
 LDCM0381  CL111 HCT 116 C217(0.93); C297(1.88)  LDD0698  [24]
 LDCM0382  CL112 HCT 116 C297(1.38)  LDD0699  [24]
 LDCM0383  CL113 HCT 116 C297(1.27)  LDD0700  [24]
 LDCM0384  CL114 HCT 116 C297(1.66)  LDD0701  [24]
 LDCM0385  CL115 HCT 116 C297(1.50)  LDD0702  [24]
 LDCM0386  CL116 HCT 116 C297(1.42)  LDD0703  [24]
 LDCM0387  CL117 HCT 116 C217(0.92); C297(1.67)  LDD0704  [24]
 LDCM0388  CL118 HCT 116 C217(1.13); C297(1.23)  LDD0705  [24]
 LDCM0389  CL119 HCT 116 C217(1.13); C297(1.44)  LDD0706  [24]
 LDCM0390  CL12 HCT 116 C297(1.21)  LDD0707  [24]
 LDCM0391  CL120 HCT 116 C217(1.14); C297(1.43)  LDD0708  [24]
 LDCM0392  CL121 HCT 116 C297(0.62)  LDD0709  [24]
 LDCM0393  CL122 HCT 116 C297(1.43)  LDD0710  [24]
 LDCM0394  CL123 HCT 116 C297(1.34)  LDD0711  [24]
 LDCM0395  CL124 HCT 116 C297(1.36)  LDD0712  [24]
 LDCM0396  CL125 HCT 116 C297(1.27)  LDD0713  [24]
 LDCM0397  CL126 HCT 116 C297(1.11)  LDD0714  [24]
 LDCM0398  CL127 HCT 116 C297(1.42)  LDD0715  [24]
 LDCM0399  CL128 HCT 116 C297(1.21)  LDD0716  [24]
 LDCM0400  CL13 HCT 116 C297(1.26)  LDD0717  [24]
 LDCM0401  CL14 HCT 116 C297(1.24)  LDD0718  [24]
 LDCM0402  CL15 HCT 116 C297(1.72)  LDD0719  [24]
 LDCM0403  CL16 HCT 116 C297(0.94); C217(1.10)  LDD0720  [24]
 LDCM0404  CL17 HCT 116 C297(1.38)  LDD0721  [24]
 LDCM0405  CL18 HCT 116 C297(0.94)  LDD0722  [24]
 LDCM0406  CL19 HCT 116 C297(0.89)  LDD0723  [24]
 LDCM0407  CL2 HCT 116 C297(1.25)  LDD0724  [24]
 LDCM0408  CL20 HCT 116 C297(1.20)  LDD0725  [24]
 LDCM0409  CL21 HCT 116 C297(1.86)  LDD0726  [24]
 LDCM0410  CL22 HCT 116 C297(1.60)  LDD0727  [24]
 LDCM0411  CL23 HCT 116 C297(0.96)  LDD0728  [24]
 LDCM0412  CL24 HCT 116 C297(1.21)  LDD0729  [24]
 LDCM0413  CL25 HCT 116 C297(1.21)  LDD0730  [24]
 LDCM0414  CL26 HCT 116 C297(1.20)  LDD0731  [24]
 LDCM0415  CL27 HCT 116 C297(1.07)  LDD0732  [24]
 LDCM0416  CL28 HCT 116 C297(1.01)  LDD0733  [24]
 LDCM0417  CL29 HCT 116 C297(1.12)  LDD0734  [24]
 LDCM0418  CL3 HCT 116 C297(1.10)  LDD0735  [24]
 LDCM0419  CL30 HCT 116 C297(0.94)  LDD0736  [24]
 LDCM0420  CL31 HCT 116 C297(1.37)  LDD0737  [24]
 LDCM0421  CL32 HCT 116 C217(1.45); C297(1.18)  LDD0738  [24]
 LDCM0422  CL33 HCT 116 C217(1.44); C297(1.68)  LDD0739  [24]
 LDCM0423  CL34 HCT 116 C217(1.88); C297(1.39)  LDD0740  [24]
 LDCM0424  CL35 HCT 116 C217(2.24); C297(1.70)  LDD0741  [24]
 LDCM0425  CL36 HCT 116 C217(2.12); C297(1.66)  LDD0742  [24]
 LDCM0426  CL37 HCT 116 C217(2.38); C297(1.34)  LDD0743  [24]
 LDCM0428  CL39 HCT 116 C217(1.54); C297(1.86)  LDD0745  [24]
 LDCM0429  CL4 HCT 116 C297(1.54)  LDD0746  [24]
 LDCM0430  CL40 HCT 116 C217(1.32); C297(1.98)  LDD0747  [24]
 LDCM0431  CL41 HCT 116 C217(1.81); C297(1.58)  LDD0748  [24]
 LDCM0432  CL42 HCT 116 C217(2.02); C297(1.96)  LDD0749  [24]
 LDCM0433  CL43 HCT 116 C217(1.81); C297(1.32)  LDD0750  [24]
 LDCM0434  CL44 HCT 116 C217(2.07); C297(1.38)  LDD0751  [24]
 LDCM0435  CL45 HCT 116 C217(2.38); C297(1.66)  LDD0752  [24]
 LDCM0436  CL46 HCT 116 C297(1.22)  LDD0753  [24]
 LDCM0437  CL47 HCT 116 C297(1.04)  LDD0754  [24]
 LDCM0438  CL48 HCT 116 C297(0.93)  LDD0755  [24]
 LDCM0439  CL49 HCT 116 C297(0.99)  LDD0756  [24]
 LDCM0440  CL5 HCT 116 C297(1.01)  LDD0757  [24]
 LDCM0441  CL50 HCT 116 C297(1.21)  LDD0758  [24]
 LDCM0442  CL51 HCT 116 C297(1.14)  LDD0759  [24]
 LDCM0443  CL52 HCT 116 C297(1.10)  LDD0760  [24]
 LDCM0444  CL53 HCT 116 C297(1.18)  LDD0761  [24]
 LDCM0445  CL54 HCT 116 C297(0.99)  LDD0762  [24]
 LDCM0446  CL55 HCT 116 C297(0.98)  LDD0763  [24]
 LDCM0447  CL56 HCT 116 C297(1.09)  LDD0764  [24]
 LDCM0448  CL57 HCT 116 C297(1.07)  LDD0765  [24]
 LDCM0449  CL58 HCT 116 C297(0.92)  LDD0766  [24]
 LDCM0450  CL59 HCT 116 C297(0.97)  LDD0767  [24]
 LDCM0451  CL6 HCT 116 C297(1.17)  LDD0768  [24]
 LDCM0452  CL60 HCT 116 C297(0.98)  LDD0769  [24]
 LDCM0453  CL61 HCT 116 C297(1.25)  LDD0770  [24]
 LDCM0454  CL62 HCT 116 C297(1.27)  LDD0771  [24]
 LDCM0455  CL63 HCT 116 C297(1.35)  LDD0772  [24]
 LDCM0456  CL64 HCT 116 C297(1.34)  LDD0773  [24]
 LDCM0457  CL65 HCT 116 C297(1.10)  LDD0774  [24]
 LDCM0458  CL66 HCT 116 C297(2.05)  LDD0775  [24]
 LDCM0459  CL67 HCT 116 C297(1.36)  LDD0776  [24]
 LDCM0460  CL68 HCT 116 C297(1.37)  LDD0777  [24]
 LDCM0461  CL69 HCT 116 C297(1.28)  LDD0778  [24]
 LDCM0462  CL7 HCT 116 C297(1.05)  LDD0779  [24]
 LDCM0463  CL70 HCT 116 C297(1.14)  LDD0780  [24]
 LDCM0464  CL71 HCT 116 C297(1.36)  LDD0781  [24]
 LDCM0465  CL72 HCT 116 C297(1.02)  LDD0782  [24]
 LDCM0466  CL73 HCT 116 C297(1.33)  LDD0783  [24]
 LDCM0467  CL74 HCT 116 C297(1.56)  LDD0784  [24]
 LDCM0469  CL76 HCT 116 C297(1.08)  LDD0786  [24]
 LDCM0470  CL77 HCT 116 C297(1.46)  LDD0787  [24]
 LDCM0471  CL78 HCT 116 C297(1.20)  LDD0788  [24]
 LDCM0472  CL79 HCT 116 C297(1.16)  LDD0789  [24]
 LDCM0473  CL8 HCT 116 C297(2.14)  LDD0790  [24]
 LDCM0474  CL80 HCT 116 C297(1.07)  LDD0791  [24]
 LDCM0475  CL81 HCT 116 C297(1.02)  LDD0792  [24]
 LDCM0476  CL82 HCT 116 C297(0.84)  LDD0793  [24]
 LDCM0477  CL83 HCT 116 C297(0.98)  LDD0794  [24]
 LDCM0478  CL84 HCT 116 C297(1.17)  LDD0795  [24]
 LDCM0479  CL85 HCT 116 C297(1.17)  LDD0796  [24]
 LDCM0480  CL86 HCT 116 C297(1.00)  LDD0797  [24]
 LDCM0481  CL87 HCT 116 C297(1.04)  LDD0798  [24]
 LDCM0482  CL88 HCT 116 C297(1.12)  LDD0799  [24]
 LDCM0483  CL89 HCT 116 C297(1.01)  LDD0800  [24]
 LDCM0484  CL9 HCT 116 C297(1.38)  LDD0801  [24]
 LDCM0485  CL90 HCT 116 C297(1.78)  LDD0802  [24]
 LDCM0486  CL91 HCT 116 C297(1.08)  LDD0803  [24]
 LDCM0487  CL92 HCT 116 C297(1.14)  LDD0804  [24]
 LDCM0488  CL93 HCT 116 C297(1.06)  LDD0805  [24]
 LDCM0489  CL94 HCT 116 C297(1.05)  LDD0806  [24]
 LDCM0490  CL95 HCT 116 C297(1.28)  LDD0807  [24]
 LDCM0491  CL96 HCT 116 C297(0.96)  LDD0808  [24]
 LDCM0492  CL97 HCT 116 C297(1.09)  LDD0809  [24]
 LDCM0493  CL98 HCT 116 C297(1.05)  LDD0810  [24]
 LDCM0494  CL99 HCT 116 C297(1.23)  LDD0811  [24]
 LDCM0634  CY-0357 Hep-G2 C297(1.09)  LDD2228  [13]
 LDCM0027  Dopamine HEK-293T 8.31  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C297(1.15); C217(0.77); C35(0.98); C272(1.09)  LDD1698  [25]
 LDCM0031  Epigallocatechin gallate HEK-293T 16.78  LDD0183  [2]
 LDCM0625  F8 Ramos C297(1.51); C193(0.77); C243(0.38)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C297(1.57)  LDD1390  [27]
 LDCM0573  Fragment11 Ramos C297(12.55)  LDD1392  [27]
 LDCM0574  Fragment12 MDA-MB-231 C297(1.99)  LDD1393  [27]
 LDCM0575  Fragment13 MDA-MB-231 C297(1.47)  LDD1395  [27]
 LDCM0576  Fragment14 MDA-MB-231 C297(1.68)  LDD1397  [27]
 LDCM0577  Fragment15 MDA-MB-231 C297(0.92)  LDD1399  [27]
 LDCM0579  Fragment20 MDA-MB-231 C297(1.37)  LDD1402  [27]
 LDCM0580  Fragment21 MDA-MB-231 C297(1.21)  LDD1404  [27]
 LDCM0581  Fragment22 MDA-MB-231 C297(2.25)  LDD1406  [27]
 LDCM0582  Fragment23 MDA-MB-231 C297(0.57)  LDD1408  [27]
 LDCM0583  Fragment24 Ramos C297(1.12)  LDD1410  [27]
 LDCM0585  Fragment26 Ramos C297(0.99)  LDD1412  [27]
 LDCM0578  Fragment27 MDA-MB-231 C297(0.83)  LDD1401  [27]
 LDCM0586  Fragment28 Ramos C297(0.97)  LDD1416  [27]
 LDCM0587  Fragment29 MDA-MB-231 C297(1.49)  LDD1417  [27]
 LDCM0588  Fragment30 MDA-MB-231 C297(0.92)  LDD1419  [27]
 LDCM0589  Fragment31 Ramos C297(1.35)  LDD1422  [27]
 LDCM0590  Fragment32 MDA-MB-231 C297(5.72)  LDD1423  [27]
 LDCM0468  Fragment33 HCT 116 C297(1.20)  LDD0785  [24]
 LDCM0592  Fragment34 MDA-MB-231 C297(0.71)  LDD1427  [27]
 LDCM0593  Fragment35 Ramos C297(0.96)  LDD1430  [27]
 LDCM0595  Fragment37 Ramos C297(0.97)  LDD1432  [27]
 LDCM0596  Fragment38 MDA-MB-231 C297(1.06)  LDD1433  [27]
 LDCM0566  Fragment4 MDA-MB-231 C297(1.64)  LDD1378  [27]
 LDCM0598  Fragment40 MDA-MB-231 C297(0.98)  LDD1436  [27]
 LDCM0599  Fragment41 MDA-MB-231 C297(1.01)  LDD1438  [27]
 LDCM0600  Fragment42 Ramos C297(0.82)  LDD1440  [27]
 LDCM0601  Fragment43 Ramos C297(3.71)  LDD1442  [27]
 LDCM0602  Fragment44 MDA-MB-231 C297(0.80)  LDD1443  [27]
 LDCM0605  Fragment47 MDA-MB-231 C297(1.06)  LDD1446  [27]
 LDCM0608  Fragment50 MDA-MB-231 C297(1.59)  LDD1449  [27]
 LDCM0427  Fragment51 HCT 116 C217(1.61); C297(2.01)  LDD0744  [24]
 LDCM0610  Fragment52 Ramos C297(1.33)  LDD1453  [27]
 LDCM0612  Fragment54 MDA-MB-231 C297(1.19)  LDD1456  [27]
 LDCM0613  Fragment55 MDA-MB-231 C297(1.00)  LDD1457  [27]
 LDCM0614  Fragment56 Ramos C297(1.05)  LDD1459  [27]
 LDCM0569  Fragment7 Ramos C297(1.47)  LDD1384  [27]
 LDCM0570  Fragment8 MDA-MB-231 C297(1.45)  LDD1385  [27]
 LDCM0571  Fragment9 MDA-MB-231 C297(1.77)  LDD1387  [27]
 LDCM0107  IAA HeLa C217(0.00); C272(0.00); C193(0.00)  LDD0221  [17]
 LDCM0022  KB02 MDA-MB-231 C297(20.00)  LDD1374  [27]
 LDCM0023  KB03 Jurkat C297(5.85)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C217(1.53)  LDD3310  [28]
 LDCM0030  Luteolin HEK-293T 9.66  LDD0182  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C297(0.95)  LDD2090  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C217(0.61)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C297(0.95); C217(1.45)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C297(1.37)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C217(0.84)  LDD2101  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C297(0.91); C217(0.87)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C297(0.79); C217(1.45)  LDD2109  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C297(1.00)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C297(0.81)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C217(0.21)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C297(0.94)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C297(0.86)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C217(1.39)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C217(0.45)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C297(0.54)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C297(1.01)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C297(1.10); C217(1.30)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C297(0.86)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C297(0.85)  LDD2141  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C217(0.49)  LDD2148  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C297(0.64)  LDD2206  [29]
 LDCM0032  Oleacein HEK-293T 4.28  LDD0184  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C297(0.64)  LDD2207  [29]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0390  [6]
 LDCM0029  Quercetin HEK-293T 5.01  LDD0181  [2]
 LDCM0131  RA190 MM1.R C297(1.10)  LDD0304  [30]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [23]
 LDCM0170  Structure8 Ramos 15.58  LDD0433  [31]
 LDCM0021  THZ1 HCT 116 C297(1.21); C243(0.73)  LDD2173  [24]
 LDCM0110  W12 Hep-G2 C297(19.66)  LDD0237  [18]
 LDCM0111  W14 Hep-G2 C297(17.39)  LDD0238  [18]
 LDCM0112  W16 Hep-G2 C297(1.34)  LDD0239  [18]

References

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Mass spectrometry data entry: PXD043348
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD038010
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
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