Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment28  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 83 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13147  Cathepsin Z (CTSZ) C92 12.6
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 7.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 6.2
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 2.4
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 2.3
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 2.0
 LDTP02502  Thioredoxin (TXN) C32 1.8
 LDTP05992  Bleomycin hydrolase (BLMH) C73 1.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.7
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.7
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 1.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.6
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 1.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.5
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.5
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.5
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.5
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.4
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.4
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.4
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.4
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.4
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.3
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.3
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.3
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.3
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.2
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 1.2
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.2
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.2
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.2
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.2
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.1
 LDTP04689  Adenosine kinase (ADK) C353 1.1
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.1
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.1
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.1
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 1.1
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.1
 LDTP12190  NmrA-like family domain-containing protein 1 (NMRAL1) C154 1.0
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.0
 LDTP02672  Elongation factor 2 (EEF2) C41 1.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.0
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.0
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.0
 LDTP04424  Galactokinase (GALK1) C182 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 0.9
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.9
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.9
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.9
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 0.8
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 0.8
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 0.8
 LDTP02672  Elongation factor 2 (EEF2) C136 0.8
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.6
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.4
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.3
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.2
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.2
 LDTP04801  Gasdermin-D (GSDMD) C268 1.2
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.2
 LDTP04662  Exportin-2 (CSE1L) C842 1.1
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.1
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.1
 LDTP00501  Exportin-1 (XPO1) C34 0.9
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 0.9
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.2
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.2
 LDTP05284  Transcription factor RelB (RELB) C109 1.1
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.0
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.9
Other
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03244  Cofilin-1 (CFL1) C80 1.5
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.5
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.4
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C660 1.3
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 1.3
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.3
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.3
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.2
 LDTP02205  Tubulin beta chain (TUBB) C239 1.2
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.2
 LDTP04092  Crk-like protein (CRKL) C249 1.2
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.2
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.2
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.1
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.1
 LDTP10864  Calponin-2 (CNN2) C215 1.1
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.1
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.1
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.1
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 1.1
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.1
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.1
 LDTP01532  ZW10 interactor (ZWINT) C54 1.1
 LDTP10864  Calponin-2 (CNN2) C164 1.1
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.1
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.1
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.1
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.1
 LDTP02205  Tubulin beta chain (TUBB) C354 1.1
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.1
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.0
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.0
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.0
 LDTP05867  Treacle protein (TCOF1) C1298 1.0
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.0
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.9
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 0.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 0.9
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 0.9
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.9
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 0.9
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.9
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 0.9
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.8

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.