Details of the Target

General Information of Target

Target ID LDTP06268
Target Name Condensin complex subunit 2 (NCAPH)
Gene Name NCAPH
Gene ID 23397
Synonyms
BRRN; BRRN1; CAPH; KIAA0074; Condensin complex subunit 2; Barren homolog protein 1; Chromosome-associated protein H; hCAP-H; Non-SMC condensin I complex subunit H; XCAP-H homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGPPGPALPATMNNSSSETRGHPHSASSPSERVFPMPLPRKAPLNIPGTPVLEDFPQNDD
EKERLQRRRSRVFDLQFSTDSPRLLASPSSRSIDISATIPKFTNTQITEHYSTCIKLSTE
NKITTKNAFGLHLIDFMSEILKQKDTEPTNFKVAAGTLDASTKIYAVRVDAVHADVYRVL
GGLGKDAPSLEEVEGHVADGSATEMGTTKKAVKPKKKHLHRTIEQNINNLNVSEADRKCE
IDPMFQKTAASFDECSTAGVFLSTLHCQDYRSELLFPSDVQTLSTGEPLELPELGCVEMT
DLKAPLQQCAEDRQICPSLAGFQFTQWDSETHNESVSALVDKFKKNDQVFDINAEVDESD
CGDFPDGSLGDDFDANDEPDHTAVGDHEEFRSWKEPCQVQSCQEEMISLGDGDIRTMCPL
LSMKPGEYSYFSPRTMSMWAGPDHWRFRPRRKQDAPSQSENKKKSTKKDFEIDFEDDIDF
DVYFRKTKAATILTKSTLENQNWRATTLPTDFNYNVDTLVQLHLKPGTRLLKMAQGHRVE
TEHYEEIEDYDYNNPNDTSNFCPGLQAADSDDEDLDDLFVGPVGNSDLSPYPCHPPKTAQ
QNGDTPEAQGLDITTYGESNLVAEPQKVNKIEIHYAKTAKKMDMKKLKQSMWSLLTALSG
KEADAEANHREAGKEAALAEVADEKMLSGLTKDLQRSLPPVMAQNLSIPLAFACLLHLAN
EKNLKLEGTEDLSDVLVRQGD
Target Bioclass
Other
Family
CND2 (condensin subunit 2) family
Subcellular location
Nucleus
Function
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
Uniprot ID
Q15003
Ensemble ID
ENST00000240423.9
HGNC ID
HGNC:1112

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH4 SNV: p.M642V DBIA    Probe Info 
MOLT4 SNV: p.A166V IA-alkyne    Probe Info 
NCIH1155 SNV: p.A249T DBIA    Probe Info 
NCIH23 SNV: p.N14K DBIA    Probe Info 
OVK18 SNV: p.H196Q DBIA    Probe Info 
RL952 Insertion: p.H24PfsTer36 DBIA    Probe Info 
SW1271 SNV: p.C114Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y111(20.00); Y635(8.53); Y428(8.51)  LDD0257  [3]
TH216
 Probe Info  		Y635(12.89)  LDD0259  [3]
STPyne
 Probe Info  		K495(10.00); K532(10.00); K630(1.15); K648(6.15)  LDD0277  [4]
BTD
 Probe Info  		C309(0.52)  LDD2089  [5]
Sulforaphane-probe2
 Probe Info  		2.02  LDD0160  [6]
DA-P3
 Probe Info  		4.11  LDD0179  [7]
AHL-Pu-1
 Probe Info  		C397(2.21); C296(5.82)  LDD0168  [8]
HHS-482
 Probe Info  		Y635(0.97)  LDD0285  [9]
HHS-475
 Probe Info  		Y430(0.86); Y428(0.88); Y635(0.88)  LDD0264  [10]
HHS-465
 Probe Info  		Y635(8.38)  LDD2237  [11]
DBIA
 Probe Info  		C397(1.02); C402(1.02)  LDD0078  [12]
5E-2FA
 Probe Info  		H669(0.00); H110(0.00); H24(0.00); H173(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K116(0.00); K637(0.00); K640(0.00); K692(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C309(0.00); C114(0.00); C296(0.00); C714(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C309(0.00); C239(0.00); C114(0.00); C316(0.00)  LDD0036  [15]
Lodoacetamide azide
 Probe Info  		C309(0.00); C114(0.00); C316(0.00); C296(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		C114(0.00); C239(0.00); C255(0.00); C296(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C114(0.00); C418(0.00)  LDD0027  [16]
WYneN
 Probe Info  		C239(0.00); C309(0.00)  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
1d-yne
 Probe Info  		K41(0.00); K692(0.00); K394(0.00)  LDD0356  [19]
Compound 10
 Probe Info  		C114(0.00); C239(0.00); C255(0.00); C418(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C239(0.00); C418(0.00)  LDD2213  [20]
IPM
 Probe Info  		C418(0.00); C239(0.00)  LDD0005  [18]
NPM
 Probe Info  		N.A.  LDD0016  [18]
SF
 Probe Info  		N.A.  LDD0028  [21]
VSF
 Probe Info  		C296(0.00); C239(0.00); C397(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		C418(0.00); C239(0.00); C402(0.00); C255(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K495(0.00); K725(0.00); K424(0.00); K661(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C114(0.00); C309(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		C239(0.00); C714(0.00); C114(0.00); C418(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C198
 Probe Info  		11.96  LDD1874  [26]
C264
 Probe Info  		16.56  LDD1935  [26]
FFF probe13
 Probe Info  		6.53  LDD0475  [27]
FFF probe14
 Probe Info  		12.95  LDD0477  [27]
FFF probe2
 Probe Info  		6.42  LDD0463  [27]
FFF probe3
 Probe Info  		20.00  LDD0464  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C418(0.95)  LDD2112  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C239(0.95)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C309(1.18)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C309(1.81)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C418(0.99)  LDD2103  [5]
 LDCM0025  4SU-RNA HEK-293T C397(2.21); C296(5.82)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C402(4.55); C397(4.89); C296(3.29)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C418(0.99); C239(1.04); C309(0.34); C397(1.05)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C418(1.12); C239(0.92); C309(0.76); C397(1.26)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C418(1.07); C239(1.33); C255(1.08); C267(1.08)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C418(1.01); C239(1.31); C255(1.05); C267(1.05)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C418(1.03); C239(1.18); C255(1.13); C267(1.13)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C418(1.15); C239(1.35); C255(0.70); C267(0.70)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C418(1.00); C239(1.11); C255(1.01); C267(1.01)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C418(1.01); C239(1.35); C255(1.19); C267(1.19)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C418(1.17); C239(1.52); C255(0.57); C267(0.57)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C418(0.96); C239(1.36); C255(0.79); C267(0.79)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C418(1.05); C239(1.27); C255(1.09); C267(1.09)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C418(0.95); C239(1.05); C255(0.88); C267(0.88)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C418(1.07); C239(0.91); C309(0.76); C397(1.39)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C418(1.01); C239(1.43); C255(0.76); C267(0.76)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C418(1.04); C239(1.39); C255(1.19); C267(1.19)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C418(1.00); C239(1.39); C255(0.50); C267(0.50)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C418(0.99); C239(1.01); C255(0.57); C267(0.57)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C418(1.02); C239(0.98); C255(0.50); C267(0.50)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C418(1.02); C239(1.03); C255(0.50); C267(0.50)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C418(1.03); C239(1.11); C255(0.52); C267(0.52)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C418(1.06); C239(1.11); C255(0.46); C267(0.46)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C418(0.96); C239(0.98); C255(0.56); C267(0.56)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C418(1.08); C239(1.26); C255(0.54); C267(0.54)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C418(1.06); C239(0.85); C309(0.82); C397(1.08)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C418(1.01); C239(1.07); C255(0.48); C267(0.48)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C418(0.85); C239(0.81); C255(0.50); C267(0.50)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C418(1.09); C239(1.06); C255(0.57); C267(0.57)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C418(0.96); C239(0.81); C255(0.70); C267(0.70)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C418(0.89); C239(0.85); C255(0.49); C267(0.49)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C418(0.90); C239(0.91); C255(0.58); C267(0.58)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C418(0.88); C239(0.82); C255(0.57); C267(0.57)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C418(1.02); C239(0.92); C255(0.65); C267(0.65)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C239(0.66); C255(1.29); C267(1.29); C309(0.57)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C239(0.74); C255(1.26); C267(1.26); C309(1.12)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C239(0.82); C255(1.33); C267(1.33); C309(0.71)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C239(0.67); C255(1.48); C267(1.48); C309(0.78)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C239(0.82); C255(1.32); C267(1.32); C309(0.56)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C239(0.79); C255(1.29); C267(1.29); C309(0.67)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C239(0.79); C255(1.30); C267(1.30); C309(0.63)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C239(0.77); C255(1.32); C267(1.32); C309(0.64)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C239(0.80); C255(1.25); C267(1.25); C309(0.46)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C239(0.79); C255(1.12); C267(1.12); C309(0.54)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C239(0.79); C255(1.33); C267(1.33); C309(0.62)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C239(0.95); C255(1.31); C267(1.31); C309(0.75)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C418(0.90); C239(0.81); C309(0.87); C397(1.24)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C239(0.93); C255(1.29); C267(1.29); C309(0.63)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C239(0.85); C255(1.33); C267(1.33); C309(0.66)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C239(0.82); C255(1.33); C267(1.33); C309(0.49)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C418(1.22); C309(0.76); C397(0.99); C402(0.99)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C309(0.62); C418(0.80); C239(1.01); C397(1.09)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C418(0.89); C309(1.07); C239(1.18); C397(1.24)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C309(0.69); C418(0.89); C239(1.19); C397(1.33)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C309(0.74); C418(0.84); C239(1.02); C397(1.25)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C418(0.84); C309(1.14); C397(1.52); C402(1.54)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C309(0.71); C418(0.95); C239(1.37); C397(1.48)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C418(0.88); C309(0.89); C239(0.90); C397(1.23)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C309(0.90); C418(0.96); C239(1.16); C397(1.28)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C309(0.60); C397(0.97); C418(1.00); C402(1.05)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C418(0.76); C309(0.94); C239(1.15); C397(1.45)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C418(0.70); C309(1.10); C397(1.55); C402(1.58)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C418(0.72); C239(1.25); C309(0.69); C397(1.15)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C418(0.85); C239(1.30); C309(0.83); C397(1.25)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C418(0.81); C239(1.28); C309(1.24); C397(1.28)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C418(0.73); C239(1.18); C309(0.79); C397(1.33)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C309(0.68); C418(0.90); C402(1.02); C397(1.02)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C309(0.67); C418(1.07); C397(1.25); C402(1.25)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C309(0.78); C418(0.94); C397(1.08); C402(1.10)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C309(0.76); C397(0.95); C402(0.95); C418(1.01)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C309(0.67); C418(0.89); C397(1.04); C239(1.08)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C309(0.62); C418(0.89); C239(1.24); C397(1.28)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C309(0.73); C418(0.90); C397(0.99); C402(1.01)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C309(0.60); C418(0.99); C239(1.01); C397(1.31)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C309(0.63); C418(0.74); C239(1.08); C397(1.13)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C418(0.96); C402(1.06); C397(1.14); C239(1.17)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C309(0.93); C418(1.00); C397(1.08); C402(1.11)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C309(0.92); C418(0.97); C402(1.08); C397(1.12)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C309(0.91); C418(0.98); C397(1.16); C402(1.18)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C309(0.78); C418(1.03); C402(1.24); C397(1.33)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C309(0.53); C418(0.94); C397(1.01); C402(1.01)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C309(0.81); C402(1.08); C418(1.08); C397(1.11)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C309(0.83); C418(0.88); C402(1.01); C397(1.04)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C309(0.59); C418(1.00); C397(1.33); C402(1.37)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C309(0.66); C418(0.94); C402(1.25); C397(1.26)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C309(0.63); C418(1.05); C402(1.26); C397(1.44)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C255(0.96); C267(0.96); C239(0.97); C397(1.03)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C397(0.91); C402(0.91); C309(1.05); C239(1.06)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C397(0.84); C402(0.84); C309(0.96); C239(1.02)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C309(0.91); C255(1.06); C267(1.06); C397(1.07)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C255(0.81); C267(0.81); C397(0.97); C402(0.97)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C309(0.39); C418(0.85); C397(1.06); C402(1.06)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C309(0.99); C397(0.99); C402(0.99); C255(1.00)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C397(0.94); C402(0.94); C255(0.94); C267(0.94)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C255(0.82); C267(0.82); C397(0.94); C402(0.94)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C255(0.86); C267(0.86); C309(0.87); C397(1.04)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C255(0.87); C267(0.87); C397(0.96); C402(0.96)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C255(0.87); C267(0.87); C239(0.97); C397(1.07)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C309(0.82); C397(0.96); C402(0.96); C418(1.19)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C397(1.00); C402(1.00); C239(1.07); C418(1.09)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C309(0.79); C397(0.99); C402(0.99); C418(1.02)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C309(0.96); C397(1.20); C402(1.20); C239(1.27)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C309(0.38); C418(0.87); C397(0.87); C402(0.87)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C309(0.84); C418(1.18); C397(1.24); C402(1.24)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C309(0.93); C397(1.05); C402(1.05); C239(1.18)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C309(0.82); C397(0.98); C402(0.98); C239(1.10)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C309(0.66); C239(1.02); C397(1.18); C402(1.18)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C309(0.68); C418(1.07); C397(1.13); C402(1.13)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C309(0.90); C239(1.08); C418(1.26); C397(1.41)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C309(0.94); C239(1.19); C418(1.31); C397(1.70)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C309(0.71); C418(1.01); C397(1.02); C402(1.02)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C309(0.67); C418(1.03); C397(1.18); C402(1.18)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C309(0.66); C418(1.00); C397(1.30); C402(1.30)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C309(0.78); C418(1.04); C239(1.08); C397(1.26)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C309(0.77); C397(1.10); C402(1.10); C418(1.17)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C309(0.53); C397(0.99); C402(0.99); C418(1.02)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C309(0.81); C397(1.20); C402(1.20); C418(1.28)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C309(0.67); C397(1.10); C402(1.10); C418(1.40)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C309(0.68); C418(1.15); C397(1.27); C402(1.27)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C309(0.67); C397(1.09); C402(1.09); C418(1.12)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C309(0.59); C397(0.97); C402(0.97); C418(1.14)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C309(0.75); C418(1.11); C397(1.15); C402(1.15)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C418(0.82); C239(0.88); C397(0.95); C402(0.95)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C239(0.83); C418(0.87); C309(0.90); C397(0.92)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C309(0.80); C239(0.93); C397(1.01); C402(1.01)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C309(0.76); C397(0.83); C402(0.83); C239(0.92)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C397(0.79); C402(0.79); C418(0.82); C309(0.82)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C397(0.83); C402(0.83); C309(0.90); C239(0.99)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C397(1.02); C402(1.02); C418(1.11); C309(1.14)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C418(0.89); C239(0.92); C397(0.98); C402(0.98)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C397(1.05); C402(1.05); C239(1.07); C418(1.08)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C397(0.89); C402(0.89); C309(0.90); C418(0.96)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C309(0.90); C418(0.93); C397(0.93); C402(0.93)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C309(0.84); C418(0.93); C397(0.95); C402(0.95)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C397(0.89); C402(0.89); C309(0.95); C418(0.96)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C309(0.67); C239(0.97); C418(1.10); C397(1.10)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C418(0.89); C397(0.94); C402(0.94); C309(1.20)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C397(0.88); C402(0.88); C418(0.89); C239(0.91)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C418(0.93); C239(1.02); C309(1.06); C397(1.09)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C309(0.74); C239(1.17); C418(1.35); C397(1.55)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C309(1.06); C239(1.11); C397(1.33); C402(1.34)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C309(0.88); C239(1.16); C402(1.35); C418(1.39)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C309(1.08); C239(1.13); C418(1.23); C402(1.25)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C309(0.66); C418(0.98); C239(1.01); C397(1.10)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C418(1.05); C239(1.13); C397(1.19); C402(1.27)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C309(1.05); C418(1.15); C239(1.23); C402(1.36)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C309(0.99); C402(1.04); C397(1.07); C418(1.09)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C309(0.65); C239(1.15); C418(1.43); C397(1.50)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C309(0.82); C239(1.14); C418(1.33); C397(1.49)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C309(0.87); C239(1.12); C397(1.28); C402(1.36)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C309(0.80); C397(1.28); C239(1.29); C402(1.37)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C309(1.00); C239(1.09); C397(1.16); C402(1.19)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C309(0.77); C239(1.11); C397(1.32); C402(1.35)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C309(0.93); C239(1.38); C402(1.52); C397(1.57)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C255(1.05); C267(1.05); C397(1.18); C402(1.18)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C397(0.81); C402(0.81); C255(1.03); C267(1.03)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C418(0.98); C239(0.99); C309(0.74); C397(1.02)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C309(0.74); C239(0.92); C418(1.00); C397(1.14)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C309(0.68); C239(1.02); C418(1.04); C397(1.47)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.39  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C397(1.02); C402(1.02)  LDD0078  [12]
 LDCM0087  Capsaicin HEK-293T 11.52  LDD0185  [7]
 LDCM0108  Chloroacetamide HeLa C309(0.00); H24(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C418(20.00); C114(1.48)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C309(0.88); C397(0.90); C402(0.90); C239(0.94)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C309(0.79); C418(1.08); C397(1.16); C402(1.16)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C309(0.52); C397(0.95); C402(0.95); C418(0.98)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C309(0.88); C239(0.94); C418(1.00); C397(1.35)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C239(0.75); C309(0.84); C397(1.11); C402(1.11)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C309(0.70); C239(0.80); C418(0.96); C397(1.19)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C239(0.87); C418(1.03); C309(1.07); C397(1.10)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C309(0.68); C418(1.02); C402(1.04); C397(1.05)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C309(0.84); C418(0.91); C402(1.21); C397(1.22)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C309(0.75); C418(1.00); C402(1.14); C397(1.15)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C309(0.78); C418(0.84); C402(1.06); C397(1.07)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C309(0.87); C402(1.03); C397(1.03); C418(1.28)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C309(0.76); C397(1.23); C402(1.23); C239(1.27)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C309(0.67); C418(0.88); C402(1.13); C397(1.21)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C309(0.89); C418(1.02); C397(1.10); C402(1.10)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C309(0.82); C418(0.99); C402(1.04); C397(1.09)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C309(0.90); C418(0.99); C402(1.19); C397(1.20)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C309(0.88); C397(1.00); C402(1.04); C418(1.24)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C309(0.91); C397(1.07); C418(1.12); C402(1.15)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C309(0.83); C402(1.01); C397(1.02); C418(1.14)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C255(0.91); C267(0.91); C309(1.09); C397(1.20)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C397(0.86); C402(0.86); C255(1.01); C267(1.01)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C397(0.96); C402(0.96); C255(0.97); C267(0.97)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C418(0.99); C309(1.13); C397(1.38); C402(1.38)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C255(0.88); C267(0.88); C397(0.93); C402(0.93)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C309(0.80); C239(1.12); C418(1.15); C397(2.56)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C309(0.79); C397(0.99); C402(0.99); C239(1.12)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C309(0.67); C397(1.18); C402(1.18); C239(1.21)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C309(0.84); C239(1.20); C397(1.21); C402(1.21)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C397(0.89); C402(0.89); C309(0.90); C418(1.22)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C309(0.69); C397(0.91); C402(0.91); C418(1.30)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C309(0.64); C397(0.92); C402(0.92); C418(1.21)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C309(0.65); C418(1.10); C397(1.12); C402(1.12)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C309(0.89); C418(1.00); C397(1.11); C402(1.11)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C309(0.78); C397(0.99); C402(0.99); C239(1.14)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C309(0.84); C397(1.06); C402(1.06); C239(1.16)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C309(0.72); C397(1.04); C402(1.04); C418(1.13)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C309(0.62); C397(0.92); C402(0.92); C239(1.11)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C309(0.67); C397(0.99); C402(0.99); C418(1.05)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C309(0.70); C418(0.97); C397(1.07); C402(1.07)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C239(0.91); C397(0.91); C402(0.91); C418(1.11)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C309(0.74); C418(1.09); C397(1.15); C402(1.15)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C309(0.62); C239(1.33); C397(1.38); C402(1.38)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C309(0.72); C418(1.02); C239(1.80); C397(1.83)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C309(0.67); C418(1.01); C239(1.13); C397(1.24)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C309(0.69); C418(0.98); C397(1.36); C402(1.36)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C418(1.13); C239(1.27); C309(0.57); C397(1.31)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C418(1.18); C239(1.16); C309(0.69); C397(1.07)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C418(0.97); C239(1.17); C309(0.69); C397(1.13)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C418(1.23); C239(1.42); C309(0.63); C397(1.06)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C418(1.04); C239(1.45); C309(0.72); C397(1.20)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C418(1.10); C239(0.97); C309(0.95); C397(0.88)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C418(1.22); C239(1.13); C309(0.67); C397(0.94)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C418(1.02); C239(1.17); C255(0.88); C267(0.88)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C418(1.08); C239(1.16); C255(0.90); C267(0.90)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C418(2.37); C239(1.33); C255(0.91); C267(0.91)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C418(1.18); C239(2.05); C255(1.02); C267(1.02)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C418(1.01); C239(1.66); C255(0.93); C267(0.93)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C418(1.11); C239(1.47); C255(1.19); C267(1.19)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C418(0.91); C239(1.91); C255(0.95); C267(0.95)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C418(1.04); C239(1.52); C255(0.99); C267(0.99)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C418(2.65); C239(1.10); C309(0.77); C397(0.96)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C418(1.08); C239(1.38); C255(0.81); C267(0.81)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C418(1.17); C239(1.39); C255(0.91); C267(0.91)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C418(0.95); C239(1.76); C255(0.73); C267(0.73)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C418(1.08); C239(1.63); C255(0.95); C267(0.95)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C418(1.05); C239(1.52); C255(0.87); C267(0.87)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C418(1.09); C239(1.76); C255(0.94); C267(0.94)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C418(1.60); C239(1.11); C255(0.65); C267(0.65)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C418(1.12); C239(1.05); C255(0.98); C267(0.98)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C418(1.08); C239(1.03); C255(1.60); C267(1.60)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C418(1.08); C239(1.04); C255(1.40); C267(1.40)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C418(0.99); C239(0.99); C309(0.90); C397(1.03)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C418(1.13); C239(0.92); C255(1.70); C267(1.70)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C418(1.36); C239(1.06); C255(2.26); C267(2.26)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C418(1.27); C239(1.14); C255(1.44); C267(1.44)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C418(1.27); C239(0.99); C255(1.52); C267(1.52)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C418(1.12); C239(1.00); C255(1.79); C267(1.79)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C418(1.06); C239(0.95); C255(1.05); C267(1.05)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C418(1.09); C239(0.96); C255(0.87); C267(0.87)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C418(1.44); C239(0.95); C255(1.85); C267(1.85)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C418(1.46); C239(1.04); C255(1.32); C267(1.32)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C418(0.94); C239(1.01); C255(1.20); C267(1.20)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C418(1.16); C239(1.04); C309(0.91); C397(1.06)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C418(1.17); C239(1.08); C255(1.14); C267(1.14)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C418(1.31); C239(1.12); C255(0.60); C267(0.60)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C418(1.33); C239(1.17); C255(0.76); C267(0.76)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C418(1.79); C239(1.16); C255(0.94); C267(0.94)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C418(1.37); C239(1.44); C255(0.62); C267(0.62)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C418(1.11); C239(1.03); C255(0.83); C267(0.83)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C418(1.46); C239(1.27); C255(0.62); C267(0.62)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C418(1.42); C239(1.30); C255(0.90); C267(0.90)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C418(1.10); C239(1.54); C255(0.70); C267(0.70)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C418(1.59); C239(1.32); C255(0.89); C267(0.89)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C418(0.90); C239(1.22); C309(0.90); C397(1.11)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C418(1.03); C239(1.15); C255(0.83); C267(0.83)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C418(1.34); C239(1.28); C255(0.76); C267(0.76)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C418(1.29); C239(1.38); C255(0.88); C267(0.88)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C418(1.46); C239(1.28); C255(0.80); C267(0.80)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C418(1.24); C239(1.30); C255(0.78); C267(0.78)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C418(0.94); C239(0.92); C309(1.24); C397(1.10)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C418(1.13); C239(0.86); C309(1.10); C397(0.88)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C418(1.16); C239(0.92); C309(0.98); C397(0.98)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C418(1.00); C239(0.96); C309(0.93); C397(1.21)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C418(6.38); C239(1.59); C309(0.84); C397(1.47)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C418(0.96); C239(0.88); C309(0.77); C397(1.05)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C418(0.93); C239(0.93); C309(0.92); C397(1.11)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C418(0.96); C239(0.87); C309(0.89); C397(1.39)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C418(1.03); C239(0.96); C309(0.91); C397(1.18)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C418(1.03); C239(0.84); C309(0.98); C397(1.51)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C418(0.97); C239(0.92); C309(0.85); C397(0.97)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C418(0.91); C239(0.84); C309(0.80); C397(0.83)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C418(1.19); C239(0.89); C309(0.92); C397(0.99)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C418(1.03); C239(0.85); C309(0.88); C397(1.37)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C418(0.84); C239(0.80); C309(1.06); C397(1.78)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C418(1.20); C239(1.25); C309(0.67); C397(1.01)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C418(2.20); C239(0.87); C309(0.77); C397(0.93)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C418(1.05); C239(1.24); C309(1.07); C397(1.18)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C418(1.05); C239(1.12); C309(1.03); C397(1.12)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C418(0.98); C239(1.05); C309(0.66); C397(0.99)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C418(0.99); C239(1.33); C309(0.76); C397(1.34)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C418(1.53); C239(1.23); C309(0.54); C397(1.20)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C418(0.99); C239(1.21); C309(0.55); C397(0.93)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C418(1.01); C239(1.15); C309(0.50); C397(1.14)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C418(1.06); C239(1.23); C309(0.75); C397(1.02)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C418(1.07); C239(1.20); C309(0.44); C397(1.03)  LDD0811  [12]
 LDCM0191  Compound 21 HEK-293T 11.30  LDD0508  [27]
 LDCM0190  Compound 34 HEK-293T 7.87  LDD0510  [27]
 LDCM0192  Compound 35 HEK-293T 6.58  LDD0509  [27]
 LDCM0193  Compound 36 HEK-293T 8.97  LDD0511  [27]
 LDCM0634  CY-0357 Hep-G2 C296(2.12); C309(1.93); C114(1.66)  LDD2228  [17]
 LDCM0028  Dobutamine HEK-293T 6.59  LDD0180  [7]
 LDCM0027  Dopamine HEK-293T 4.11  LDD0179  [7]
 LDCM0495  E2913 HEK-293T C309(1.13); C239(0.93); C418(1.20); C316(1.23)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C114(2.31); C239(1.60)  LDD1702  [5]
 LDCM0031  Epigallocatechin gallate HEK-293T 77.26  LDD0183  [7]
 LDCM0625  F8 Ramos C309(0.99); C114(1.42); C239(1.15); C418(1.33)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C309(0.58); C114(0.75); C239(1.66); C418(3.47)  LDD2189  [29]
 LDCM0573  Fragment11 MDA-MB-231 C418(1.63)  LDD1467  [30]
 LDCM0574  Fragment12 Ramos C418(2.60)  LDD1394  [30]
 LDCM0575  Fragment13 Ramos C418(0.92)  LDD1396  [30]
 LDCM0576  Fragment14 MDA-MB-231 C418(1.39)  LDD1397  [30]
 LDCM0579  Fragment20 Ramos C418(2.21)  LDD1403  [30]
 LDCM0580  Fragment21 MDA-MB-231 C418(1.20)  LDD1404  [30]
 LDCM0582  Fragment23 MDA-MB-231 C418(1.57)  LDD1408  [30]
 LDCM0583  Fragment24 Ramos C418(1.42)  LDD1410  [30]
 LDCM0584  Fragment25 MDA-MB-231 C418(0.86)  LDD1411  [30]
 LDCM0585  Fragment26 Ramos C418(1.12)  LDD1412  [30]
 LDCM0578  Fragment27 MDA-MB-231 C418(1.11)  LDD1401  [30]
 LDCM0586  Fragment28 MDA-MB-231 C418(1.54)  LDD1415  [30]
 LDCM0587  Fragment29 MDA-MB-231 C418(1.35)  LDD1417  [30]
 LDCM0588  Fragment30 MDA-MB-231 C418(1.62)  LDD1419  [30]
 LDCM0589  Fragment31 MDA-MB-231 C418(1.68)  LDD1421  [30]
 LDCM0590  Fragment32 MDA-MB-231 C418(13.08)  LDD1423  [30]
 LDCM0468  Fragment33 HCT 116 C418(1.17); C239(1.34); C255(0.79); C267(0.79)  LDD0785  [12]
 LDCM0596  Fragment38 MDA-MB-231 C418(1.14)  LDD1433  [30]
 LDCM0566  Fragment4 MDA-MB-231 C418(3.86)  LDD1378  [30]
 LDCM0598  Fragment40 Ramos C418(1.36)  LDD1437  [30]
 LDCM0599  Fragment41 MDA-MB-231 C418(1.23)  LDD1438  [30]
 LDCM0600  Fragment42 Ramos C418(0.99)  LDD1440  [30]
 LDCM0601  Fragment43 MDA-MB-231 C418(12.96)  LDD1441  [30]
 LDCM0602  Fragment44 MDA-MB-231 C418(0.78)  LDD1443  [30]
 LDCM0603  Fragment45 MDA-MB-231 C418(20.00)  LDD1482  [30]
 LDCM0427  Fragment51 HCT 116 C418(1.05); C239(1.97); C255(0.77); C267(0.77)  LDD0744  [12]
 LDCM0610  Fragment52 MDA-MB-231 C418(1.19)  LDD1452  [30]
 LDCM0614  Fragment56 MDA-MB-231 C418(1.29)  LDD1484  [30]
 LDCM0569  Fragment7 MDA-MB-231 C418(2.38)  LDD1383  [30]
 LDCM0570  Fragment8 MDA-MB-231 C418(4.42)  LDD1385  [30]
 LDCM0571  Fragment9 MDA-MB-231 C418(1.51)  LDD1387  [30]
 LDCM0116  HHS-0101 DM93 Y430(0.86); Y428(0.88); Y635(0.88)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y428(0.93); Y635(0.94); Y430(1.31)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y428(0.70); Y635(1.03); Y430(1.07)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y428(0.86); Y635(0.90); Y430(1.08)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y635(0.78); Y428(1.09); Y430(1.58)  LDD0268  [10]
 LDCM0107  IAA HeLa H110(0.00); H24(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y635(0.97)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y635(0.90)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y635(1.12)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y635(3.14)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y635(1.94)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y635(1.28)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y635(0.56)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y635(0.91)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C397(4.80); C402(4.80); C309(2.40)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C397(3.65); C402(3.65); C309(0.73)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C397(4.04); C402(4.04); C309(1.20)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 30.84  LDD0182  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C418(0.54)  LDD2121  [5]
 LDCM0109  NEM HeLa H173(0.00); H24(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C309(0.52)  LDD2089  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C418(0.60)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C309(0.88)  LDD2093  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C309(1.05)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C418(1.09)  LDD2099  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C418(0.93); C114(1.26)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C239(1.06); C309(1.22)  LDD2107  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C239(1.93)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C309(0.96)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C418(0.97); C309(0.85); C114(1.28)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C309(0.83)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C309(1.04)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C239(1.13); C418(0.91)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C309(0.99); C114(0.74)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C309(1.17)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C309(1.11)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C418(0.96); C309(1.01)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C418(2.06); C114(1.49)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C418(0.97); C309(0.93)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C418(0.54); C309(0.63); C114(0.77)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C114(1.15)  LDD2153  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C239(1.33)  LDD2206  [31]
 LDCM0032  Oleacein HEK-293T 8.09  LDD0184  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C114(0.61)  LDD2207  [31]
 LDCM0029  Quercetin HEK-293T 13.62  LDD0181  [7]
 LDCM0003  Sulforaphane MDA-MB-231 2.02  LDD0160  [6]
 LDCM0021  THZ1 HCT 116 C239(1.09); C255(1.38); C267(1.38); C397(0.95)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DDX3X (DDX3X) DEAD box helicase family O00571
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Condensin complex subunit 1 (NCAPD2) CND1 (condensin subunit 1) family Q15021
Condensin complex subunit 3 (NCAPG) CND3 (condensin subunit 3) family Q9BPX3
Structural maintenance of chromosomes protein 2 (SMC2) SMC family O95347
Structural maintenance of chromosomes protein 4 (SMC4) SMC family Q9NTJ3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.