Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment7  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 92 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 20.0
 LDTP03681  DNA replication licensing factor MCM5 (MCM5) C482 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 20.0
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 20.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 6.2
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 4.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 4.2
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 4.2
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 4.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 3.7
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 3.7
 LDTP02198  Cathepsin D (CTSD) C117 3.5
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 3.3
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 3.1
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 3.0
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 2.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 2.7
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 2.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 2.4
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 2.4
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 2.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.3
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 2.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 2.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 2.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.2
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 2.1
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.1
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 2.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.9
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.9
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 1.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 1.8
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.7
 LDTP03496  Protein PML (PML) C389 1.7
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.7
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.7
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 1.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.7
 LDTP02223  Cathepsin B (CTSB) C319 1.6
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.6
 LDTP03642  Cytidine deaminase (CDA) C14 1.6
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.5
 LDTP04424  Galactokinase (GALK1) C182 1.5
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.5
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.5
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.4
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 1.4
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.4
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C4367 1.4
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 1.4
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 1.3
 LDTP02672  Elongation factor 2 (EEF2) C41 1.3
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.3
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.2
 LDTP04374  Dynamin-2 (DNM2) C27 1.1
 LDTP13147  Cathepsin Z (CTSZ) C92 1.1
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.1
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.1
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.1
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 1.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 1.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.0
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.9
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.9
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.9
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.8
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.8
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 0.8
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.7
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 2.4
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 2.0
 LDTP00501  Exportin-1 (XPO1) C34 1.7
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.5
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.5
 LDTP14808  Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) C45 1.4
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.4
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.3
 LDTP01574  Importin-7 (IPO7) C757 1.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.0
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.9
 LDTP00501  Exportin-1 (XPO1) C528 0.7
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.3
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.1
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.1
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.0
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.0
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 0.9
Other
Click to Show/Hide to Show 70 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06681  Inverted formin-2 (INF2) C971 12.4
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 3.6
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 3.0
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 3.0
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 3.0
 LDTP13925  Nucleolar protein 58 (NOP58) C106 2.9
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 2.8
 LDTP05867  Treacle protein (TCOF1) C38 2.5
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.5
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.4
 LDTP06330  Plectin (PLEC) C4071 2.4
 LDTP02205  Tubulin beta chain (TUBB) C354 2.2
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.2
 LDTP05867  Treacle protein (TCOF1) C1298 2.1
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 2.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 2.0
 LDTP10864  Calponin-2 (CNN2) C164 2.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.9
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.8
 LDTP00727  U4/U6.U5 tri-snRNP-associated protein 1 (SART1) C645 1.8
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.8
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) C903 1.8
 LDTP13580  Coronin-1C (CORO1C) C420 1.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.7
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.7
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.7
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.7
 LDTP06681  Inverted formin-2 (INF2) C332 1.7
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.6
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.6
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.6
 LDTP12443  Anillin (ANLN) C712 1.6
 LDTP01532  ZW10 interactor (ZWINT) C54 1.6
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 1.5
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 1.5
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.5
 LDTP02205  Tubulin beta chain (TUBB) C239 1.5
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 1.4
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.4
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 1.4
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.3
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.3
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.3
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.3
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.2
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.2
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.2
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.2
 LDTP08238  Kinectin (KTN1) C303 1.1
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.1
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.1
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C1117 1.1
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP02692  Plastin-3 (PLS3) C33 0.9
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 0.9
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 0.9
 LDTP04902  Actin-related protein 3 (ACTR3) C235 0.9
 LDTP03620  Protein S100-A11 (S100A11) C91 0.9
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 0.9
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 0.9
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 0.9
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.7
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 0.7
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 0.7
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.5

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.