Details of the Target

General Information of Target

Target ID LDTP10700
Target Name KH domain-containing RNA-binding protein QKI (QKI)
Gene Name QKI
Gene ID 9444
Synonyms
HKQ; KH domain-containing RNA-binding protein QKI; Protein quaking; Hqk; HqkI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL
VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP
TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI
NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS
RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPA
GRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP
QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT
SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK
YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY
GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA
VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE
NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI
KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ
FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK
LLMAVENAQGFEGVD
Target Bioclass
Other
Subcellular location
Nucleus
Function
RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation . Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms. First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway. Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes. Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development. May also play a role in smooth muscle development. In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2.; [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing. Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing. Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA. Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression. Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1. Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation. In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis. SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency.; [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation. Acts as a translational repressor for HNRNPA1 and GLI1. Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing. Involved in astrocyte differentiation by regulating translation of target mRNAs.; [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation. Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation. Can also induce apoptosis in the cytoplasm. Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis. Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122.
Uniprot ID
Q96PU8
Ensemble ID
ENST00000275262.11
HGNC ID
HGNC:21100

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R324S .
HUCCT1 SNV: p.Q329E .
JURKAT SNV: p.P237L Compound 10    Probe Info 
P31FUJ SNV: p.R43Q DBIA    Probe Info 
SNGM Deletion: p.N138IfsTer10 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y204(14.37); Y17(12.57)  LDD0257  [2]
TH216
 Probe Info  		Y328(14.75)  LDD0259  [2]
Probe 1
 Probe Info  		Y57(6.91); Y93(32.74)  LDD3495  [3]
BTD
 Probe Info  		C119(2.52)  LDD1700  [4]
HPAP
 Probe Info  		4.45  LDD0063  [5]
Alkyne-RA190
 Probe Info  		2.53  LDD0299  [6]
HHS-475
 Probe Info  		Y93(0.82)  LDD0264  [7]
HHS-465
 Probe Info  		Y204(10.00); Y57(5.69); Y93(3.55)  LDD2237  [8]
DBIA
 Probe Info  		C35(0.89)  LDD0078  [9]
ATP probe
 Probe Info  		K111(0.00); K190(0.00); K191(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		C119(0.00); C35(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C119(0.00); C35(0.00)  LDD0037  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
IPM
 Probe Info  		N.A.  LDD0005  [14]
SF
 Probe Info  		K91(0.00); Y93(0.00); Y328(0.00)  LDD0028  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
1c-yne
 Probe Info  		K91(0.00); K210(0.00); K191(0.00)  LDD0228  [18]
1d-yne
 Probe Info  		N.A.  LDD0357  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
W1
 Probe Info  		N.A.  LDD0236  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C284
 Probe Info  		24.08  LDD1954  [23]
C293
 Probe Info  		17.75  LDD1963  [23]
C346
 Probe Info  		11.55  LDD2007  [23]
C403
 Probe Info  		13.93  LDD2061  [23]
FFF probe11
 Probe Info  		13.54  LDD0472  [24]
FFF probe13
 Probe Info  		12.87  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
FFF probe9
 Probe Info  		12.38  LDD0470  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C119(0.21)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C119(0.46)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C119(0.95)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C119(1.17)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C35(1.12)  LDD1507  [25]
 LDCM0215  AC10 HCT 116 C35(1.44)  LDD0532  [9]
 LDCM0216  AC100 HEK-293T C35(0.78)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C35(0.92)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C35(0.76)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C35(0.64)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C35(0.75)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C35(1.96)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C35(5.49)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C35(0.87)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C35(2.92)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C35(1.71)  LDD0823  [9]
 LDCM0226  AC11 HCT 116 C35(1.82)  LDD0543  [9]
 LDCM0227  AC110 HEK-293T C35(0.91)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C35(1.01)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C35(0.85)  LDD0827  [9]
 LDCM0230  AC113 PaTu 8988t C35(0.85)  LDD1109  [9]
 LDCM0231  AC114 PaTu 8988t C35(0.89)  LDD1110  [9]
 LDCM0232  AC115 PaTu 8988t C35(1.12)  LDD1111  [9]
 LDCM0233  AC116 PaTu 8988t C35(1.01)  LDD1112  [9]
 LDCM0234  AC117 PaTu 8988t C35(0.86)  LDD1113  [9]
 LDCM0235  AC118 PaTu 8988t C35(1.06)  LDD1114  [9]
 LDCM0236  AC119 PaTu 8988t C35(1.14)  LDD1115  [9]
 LDCM0237  AC12 HCT 116 C35(1.35)  LDD0554  [9]
 LDCM0238  AC120 PaTu 8988t C35(1.21)  LDD1117  [9]
 LDCM0239  AC121 PaTu 8988t C35(0.96)  LDD1118  [9]
 LDCM0240  AC122 PaTu 8988t C35(1.34)  LDD1119  [9]
 LDCM0241  AC123 PaTu 8988t C35(1.43)  LDD1120  [9]
 LDCM0242  AC124 PaTu 8988t C35(1.79)  LDD1121  [9]
 LDCM0243  AC125 PaTu 8988t C35(1.45)  LDD1122  [9]
 LDCM0244  AC126 PaTu 8988t C35(1.15)  LDD1123  [9]
 LDCM0245  AC127 PaTu 8988t C35(1.33)  LDD1124  [9]
 LDCM0246  AC128 HCT 116 C35(0.97)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C35(0.83)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C35(0.97)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C35(0.73)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C35(0.67)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C35(0.90)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C35(1.19)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C35(1.68)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C35(0.77)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C35(0.85)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C35(1.02)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C35(0.98)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C35(1.49)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C35(0.74)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C35(1.01)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C35(0.74)  LDD0579  [9]
 LDCM0263  AC143 HEK-293T C35(2.88)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C35(0.53)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C35(0.61)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C35(0.63)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C35(0.93)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C35(1.71)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C35(0.67)  LDD0867  [9]
 LDCM0270  AC15 HCT 116 C35(1.38)  LDD0587  [9]
 LDCM0271  AC150 HEK-293T C35(0.94)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C35(0.60)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C35(0.52)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C35(0.57)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C35(0.77)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C35(0.96)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C35(0.98)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C35(0.82)  LDD2165  [9]
 LDCM0276  AC17 PaTu 8988t C119(1.07)  LDD1155  [9]
 LDCM0277  AC18 PaTu 8988t C119(0.77)  LDD1156  [9]
 LDCM0278  AC19 PaTu 8988t C119(0.98)  LDD1157  [9]
 LDCM0279  AC2 HEK-293T C119(1.09); C35(1.00)  LDD1518  [25]
 LDCM0280  AC20 PaTu 8988t C119(0.98)  LDD1159  [9]
 LDCM0281  AC21 PaTu 8988t C119(1.07)  LDD1160  [9]
 LDCM0282  AC22 PaTu 8988t C119(1.04)  LDD1161  [9]
 LDCM0283  AC23 PaTu 8988t C119(0.93)  LDD1162  [9]
 LDCM0284  AC24 PaTu 8988t C119(0.86)  LDD1163  [9]
 LDCM0285  AC25 PaTu 8988t C35(0.89); C119(1.05)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C35(0.93); C119(1.09)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C35(1.20); C119(0.67)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C35(1.29); C119(0.86)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C35(1.04); C119(0.73)  LDD1168  [9]
 LDCM0290  AC3 HEK-293T C35(1.04)  LDD1529  [25]
 LDCM0291  AC30 PaTu 8988t C35(1.17); C119(1.00)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C35(0.98); C119(0.84)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C35(0.87); C119(0.69)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C35(1.04); C119(0.84)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C35(0.92); C119(0.97)  LDD1174  [9]
 LDCM0296  AC35 HCT 116 C35(0.69)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C35(0.62)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C35(1.09)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C35(1.23)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C35(0.87)  LDD0617  [9]
 LDCM0301  AC4 HEK-293T C35(1.00)  LDD1540  [25]
 LDCM0302  AC40 HCT 116 C35(0.90)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C35(0.93)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C35(1.23)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C35(1.02)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C35(1.01)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C35(1.13)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C35(1.01)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C35(1.13)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C35(1.07)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C35(1.23)  LDD0628  [9]
 LDCM0312  AC5 HEK-293T C119(1.11); C35(0.94)  LDD1551  [25]
 LDCM0313  AC50 HCT 116 C35(1.13)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C35(0.88)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C35(1.04)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C35(1.10)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C35(1.17)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C35(1.25)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C35(1.56)  LDD0636  [9]
 LDCM0320  AC57 PaTu 8988t C35(0.95)  LDD1199  [9]
 LDCM0321  AC58 PaTu 8988t C35(1.03)  LDD1200  [9]
 LDCM0322  AC59 PaTu 8988t C35(1.16)  LDD1201  [9]
 LDCM0323  AC6 HCT 116 C35(1.28)  LDD0640  [9]
 LDCM0324  AC60 PaTu 8988t C35(1.03)  LDD1203  [9]
 LDCM0325  AC61 PaTu 8988t C35(0.92)  LDD1204  [9]
 LDCM0326  AC62 PaTu 8988t C35(1.16)  LDD1205  [9]
 LDCM0327  AC63 PaTu 8988t C35(0.90)  LDD1206  [9]
 LDCM0328  AC64 PaTu 8988t C35(1.10)  LDD1207  [9]
 LDCM0329  AC65 PaTu 8988t C35(1.14)  LDD1208  [9]
 LDCM0330  AC66 PaTu 8988t C35(1.11)  LDD1209  [9]
 LDCM0331  AC67 PaTu 8988t C35(0.99)  LDD1210  [9]
 LDCM0332  AC68 PaTu 8988t C35(1.02)  LDD1211  [9]
 LDCM0333  AC69 PaTu 8988t C35(1.16)  LDD1212  [9]
 LDCM0334  AC7 HCT 116 C35(1.50)  LDD0651  [9]
 LDCM0335  AC70 PaTu 8988t C35(1.10)  LDD1214  [9]
 LDCM0336  AC71 PaTu 8988t C35(0.93)  LDD1215  [9]
 LDCM0337  AC72 PaTu 8988t C35(0.77)  LDD1216  [9]
 LDCM0338  AC73 PaTu 8988t C35(0.87)  LDD1217  [9]
 LDCM0339  AC74 PaTu 8988t C35(1.18)  LDD1218  [9]
 LDCM0340  AC75 PaTu 8988t C35(1.24)  LDD1219  [9]
 LDCM0341  AC76 PaTu 8988t C35(0.90)  LDD1220  [9]
 LDCM0342  AC77 PaTu 8988t C35(0.95)  LDD1221  [9]
 LDCM0343  AC78 PaTu 8988t C35(1.02)  LDD1222  [9]
 LDCM0344  AC79 PaTu 8988t C35(1.06)  LDD1223  [9]
 LDCM0345  AC8 HCT 116 C35(1.69)  LDD0662  [9]
 LDCM0346  AC80 PaTu 8988t C35(1.16)  LDD1225  [9]
 LDCM0347  AC81 PaTu 8988t C35(0.99)  LDD1226  [9]
 LDCM0348  AC82 PaTu 8988t C35(0.92)  LDD1227  [9]
 LDCM0365  AC98 HEK-293T C35(1.21)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C35(1.48)  LDD0964  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C119(0.57)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C35(1.21)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C35(1.42)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C35(1.89)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C35(0.89)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C35(0.72)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C35(1.59)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C35(1.12)  LDD0685  [9]
 LDCM0369  CL100 HEK-293T C119(1.02); C35(1.02)  LDD1573  [25]
 LDCM0370  CL101 HCT 116 C35(1.46)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C35(1.18)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C35(1.16)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C35(1.48)  LDD0690  [9]
 LDCM0374  CL105 PaTu 8988t C119(0.93)  LDD1253  [9]
 LDCM0375  CL106 PaTu 8988t C119(1.03)  LDD1254  [9]
 LDCM0376  CL107 PaTu 8988t C119(0.98)  LDD1255  [9]
 LDCM0377  CL108 PaTu 8988t C119(0.93)  LDD1256  [9]
 LDCM0378  CL109 PaTu 8988t C119(1.01)  LDD1257  [9]
 LDCM0379  CL11 HCT 116 C35(1.30)  LDD0696  [9]
 LDCM0380  CL110 PaTu 8988t C119(0.80)  LDD1259  [9]
 LDCM0381  CL111 PaTu 8988t C119(0.82)  LDD1260  [9]
 LDCM0382  CL112 PaTu 8988t C35(0.98); C119(0.82)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C35(0.96); C119(1.09)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C35(1.22); C119(0.88)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C35(1.18); C119(0.79)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C35(0.96); C119(0.86)  LDD1265  [9]
 LDCM0387  CL117 HCT 116 C35(1.81)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C35(0.97)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C35(0.91)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C35(1.38)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C35(0.84)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C35(0.88)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C35(1.10)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C35(1.33)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C35(1.57)  LDD0712  [9]
 LDCM0396  CL125 PaTu 8988t C35(0.89)  LDD1275  [9]
 LDCM0397  CL126 PaTu 8988t C35(1.43)  LDD1276  [9]
 LDCM0398  CL127 PaTu 8988t C35(1.23)  LDD1277  [9]
 LDCM0399  CL128 PaTu 8988t C35(1.04)  LDD1278  [9]
 LDCM0400  CL13 HCT 116 C35(2.27)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C35(1.57)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C35(1.70)  LDD0719  [9]
 LDCM0403  CL16 PaTu 8988t C35(0.88); C119(0.71)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C35(1.11); C119(0.74)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C35(1.41); C119(0.78)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C35(1.18); C119(0.64)  LDD1285  [9]
 LDCM0407  CL2 HCT 116 C35(0.92)  LDD0724  [9]
 LDCM0408  CL20 PaTu 8988t C35(1.34); C119(0.64)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C35(1.34); C119(0.46)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C35(1.24); C119(0.52)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C35(1.07); C119(0.49)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C35(1.41); C119(0.62)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C35(1.33); C119(0.60)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C35(1.52); C119(0.69)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C35(1.47); C119(0.63)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C35(1.19); C119(0.46)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C35(1.24); C119(0.41)  LDD1296  [9]
 LDCM0418  CL3 HCT 116 C35(0.80)  LDD0735  [9]
 LDCM0419  CL30 PaTu 8988t C35(1.32); C119(0.51)  LDD1298  [9]
 LDCM0420  CL31 HCT 116 C35(1.00)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C35(1.43)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C35(1.27)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C35(1.48)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C35(1.75)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C35(1.33)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C35(1.64)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C35(1.06)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C35(0.97)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C35(1.41)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C35(1.39)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C35(2.03)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C35(1.67)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C35(1.27)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C35(1.21)  LDD0752  [9]
 LDCM0436  CL46 HEK-293T C35(0.41)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C35(1.14)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C35(0.71)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C35(0.55)  LDD1037  [9]
 LDCM0440  CL5 HCT 116 C35(1.01)  LDD0757  [9]
 LDCM0441  CL50 HEK-293T C35(0.26)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C35(0.44)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C35(20.00)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C35(1.71)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C35(0.70)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C35(0.49)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C35(2.18)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C35(1.13)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C35(0.83)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C35(0.35)  LDD1048  [9]
 LDCM0451  CL6 HCT 116 C35(1.17)  LDD0768  [9]
 LDCM0452  CL60 HEK-293T C35(0.32)  LDD1050  [9]
 LDCM0453  CL61 HEK-293T C35(1.12)  LDD1051  [9]
 LDCM0454  CL62 HEK-293T C35(0.76)  LDD1052  [9]
 LDCM0455  CL63 HEK-293T C35(0.56)  LDD1053  [9]
 LDCM0456  CL64 HEK-293T C35(1.76)  LDD1054  [9]
 LDCM0457  CL65 HEK-293T C35(1.24)  LDD1055  [9]
 LDCM0458  CL66 HEK-293T C35(0.84)  LDD1056  [9]
 LDCM0459  CL67 HEK-293T C35(0.57)  LDD1057  [9]
 LDCM0460  CL68 HEK-293T C35(0.56)  LDD1058  [9]
 LDCM0461  CL69 HEK-293T C35(0.69)  LDD1059  [9]
 LDCM0462  CL7 HCT 116 C35(1.45)  LDD0779  [9]
 LDCM0463  CL70 HEK-293T C35(0.96)  LDD1061  [9]
 LDCM0464  CL71 HEK-293T C35(0.69)  LDD1062  [9]
 LDCM0465  CL72 HEK-293T C35(0.87)  LDD1063  [9]
 LDCM0466  CL73 HEK-293T C35(0.55)  LDD1064  [9]
 LDCM0467  CL74 HEK-293T C35(0.25)  LDD1065  [9]
 LDCM0469  CL76 PaTu 8988t C35(1.32); C119(1.25)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C35(1.61); C119(1.05)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C35(1.62); C119(0.77)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C35(1.81); C119(0.82)  LDD1351  [9]
 LDCM0473  CL8 HCT 116 C35(1.88)  LDD0790  [9]
 LDCM0474  CL80 PaTu 8988t C35(1.54); C119(0.77)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C35(1.62); C119(0.98)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C35(1.32); C119(1.34)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C35(1.63); C119(0.85)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C35(1.70); C119(0.85)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C35(1.69); C119(0.79)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C35(1.84); C119(0.71)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C35(1.47); C119(1.03)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C35(1.58); C119(1.12)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C35(1.51); C119(0.94)  LDD1362  [9]
 LDCM0484  CL9 HCT 116 C35(1.26)  LDD0801  [9]
 LDCM0485  CL90 PaTu 8988t C35(2.05); C119(0.65)  LDD1364  [9]
 LDCM0486  CL91 HEK-293T C35(0.97)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C35(0.93)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C119(1.07); C35(0.95)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C35(0.91)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C35(2.09)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C119(0.98); C35(1.04)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C35(1.09)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C119(1.09); C35(0.95)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C119(1.03); C35(1.04)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C119(1.04); C35(0.98)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C35(9.43)  LDD1702  [4]
 LDCM0625  F8 Ramos C35(0.82)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C35(2.38)  LDD2189  [26]
 LDCM0573  Fragment11 MDA-MB-231 C35(1.34)  LDD1391  [27]
 LDCM0574  Fragment12 Ramos C35(0.71)  LDD1394  [27]
 LDCM0575  Fragment13 Ramos C35(0.85)  LDD2192  [26]
 LDCM0576  Fragment14 MDA-MB-231 C35(1.06)  LDD1397  [27]
 LDCM0579  Fragment20 MDA-MB-231 C35(1.62)  LDD1402  [27]
 LDCM0580  Fragment21 MDA-MB-231 C35(0.82)  LDD1404  [27]
 LDCM0582  Fragment23 Ramos C35(0.91)  LDD2196  [26]
 LDCM0583  Fragment24 Ramos C35(1.55)  LDD1410  [27]
 LDCM0584  Fragment25 MDA-MB-231 C35(0.66)  LDD1411  [27]
 LDCM0585  Fragment26 Ramos C35(0.70)  LDD1412  [27]
 LDCM0578  Fragment27 MDA-MB-231 C35(0.82)  LDD1401  [27]
 LDCM0586  Fragment28 MDA-MB-231 C35(0.67)  LDD1415  [27]
 LDCM0587  Fragment29 MDA-MB-231 C35(1.19)  LDD1417  [27]
 LDCM0588  Fragment30 Ramos C35(0.79)  LDD2199  [26]
 LDCM0589  Fragment31 MDA-MB-231 C35(1.44)  LDD1421  [27]
 LDCM0590  Fragment32 MDA-MB-231 C35(1.10)  LDD1423  [27]
 LDCM0468  Fragment33 HEK-293T C35(0.62)  LDD1066  [9]
 LDCM0592  Fragment34 MDA-MB-231 C35(0.99)  LDD1427  [27]
 LDCM0596  Fragment38 Ramos C35(2.59)  LDD2203  [26]
 LDCM0566  Fragment4 MDA-MB-231 C35(1.33)  LDD1378  [27]
 LDCM0598  Fragment40 MDA-MB-231 C35(0.73)  LDD1436  [27]
 LDCM0600  Fragment42 Ramos C35(0.97)  LDD1440  [27]
 LDCM0601  Fragment43 MDA-MB-231 C35(1.25)  LDD1441  [27]
 LDCM0608  Fragment50 MDA-MB-231 C35(1.30)  LDD1449  [27]
 LDCM0427  Fragment51 HCT 116 C35(1.90)  LDD0744  [9]
 LDCM0610  Fragment52 MDA-MB-231 C35(1.47)  LDD1452  [27]
 LDCM0614  Fragment56 Ramos C35(0.89)  LDD2205  [26]
 LDCM0568  Fragment6 MDA-MB-231 C35(1.02)  LDD1382  [27]
 LDCM0569  Fragment7 MDA-MB-231 C35(1.51)  LDD1383  [27]
 LDCM0570  Fragment8 MDA-MB-231 C35(1.20)  LDD1385  [27]
 LDCM0571  Fragment9 MDA-MB-231 C35(1.02)  LDD1387  [27]
 LDCM0116  HHS-0101 DM93 Y93(0.82)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y93(0.53)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y93(0.66)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y93(0.80)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y93(0.98)  LDD0268  [7]
 LDCM0015  HNE MDA-MB-231 C35(1.09)  LDD0346  [26]
 LDCM0022  KB02 HCT 116 C119(2.34); C35(1.98)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C119(2.75); C35(3.07)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C119(2.96); C35(1.86)  LDD0082  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C119(0.92)  LDD2090  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C119(0.59)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C119(1.03)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C119(0.32)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C119(0.70)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C119(0.43)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C119(0.95)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C119(0.55)  LDD2108  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C119(0.45)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C119(1.05)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C119(0.38)  LDD2114  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C119(1.01)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C119(1.32)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C119(0.54)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C119(1.03)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C119(1.87)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C119(0.76)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C119(1.02)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C119(1.13)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C119(0.41)  LDD2133  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C119(1.29)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C119(1.10)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C119(1.00)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C119(2.52)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C119(0.86)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C119(0.61)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C119(2.60)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C119(0.16)  LDD2145  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C119(0.71)  LDD2147  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C35(0.75)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C35(1.11)  LDD2207  [28]
 LDCM0014  Panhematin K562 4.45  LDD0063  [5]
 LDCM0131  RA190 MM1.R 2.53  LDD0299  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Histone-arginine methyltransferase CARM1 (CARM1) Protein arginine N-methyltransferase family Q86X55
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) Peptidase C14B family Q9UDY8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
SOSS complex subunit B2 (NABP1) SOSS-B family Q96AH0
Far upstream element-binding protein 3 (FUBP3) . Q96I24
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) . Q8WVV9
Poly(rC)-binding protein 1 (PCBP1) . Q15365
Polypyrimidine tract-binding protein 1 (PTBP1) . P26599
RNA binding protein fox-1 homolog 1 (RBFOX1) . Q9NWB1
RNA binding protein fox-1 homolog 2 (RBFOX2) . O43251
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Splicing regulator RBM11 (RBM11) . P57052

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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