Details of the Target

General Information of Target

Target ID LDTP08135
Target Name E3 ubiquitin-protein ligase HUWE1 (HUWE1)
Gene Name HUWE1
Gene ID 10075
Synonyms
KIAA0312; KIAA1578; UREB1; E3 ubiquitin-protein ligase HUWE1; EC 2.3.2.26; ARF-binding protein 1; ARF-BP1; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; Homologous to E6AP carboxyl terminus homologous protein 9; HectH9; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI
LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP
VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ
RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL
KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV
LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG
SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH
AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI
LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV
LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH
AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL
PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA
PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR
QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP
MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK
PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ
QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA
MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT
DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL
PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL
LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF
DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML
TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET
KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS
TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG
SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN
AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL
QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR
DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE
LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL
GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG
LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ
GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ
EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR
EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD
DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV
RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL
LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT
LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE
ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE
TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET
TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS
EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS
RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS
TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA
LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL
LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI
ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI
FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN
CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE
TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA
SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA
TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED
AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET
LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ
KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR
EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER
PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV
RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE
THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH
VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL
FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS
VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE
ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID
DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI
QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA
Target Bioclass
Enzyme
Family
UPL family, TOM1/PTR1 subfamily
Subcellular location
Cytoplasm
Function
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC. Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling.
Uniprot ID
Q7Z6Z7
Ensemble ID
ENST00000262854.11
HGNC ID
HGNC:30892
ChEMBL ID
CHEMBL4295881

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 Insertion: . DBIA    Probe Info 
AN3CA SNV: p.G2763D DBIA    Probe Info 
CCK81 Deletion: p.I261TfsTer8
SNV: p.M375I;p.I4259V		 DBIA    Probe Info 
COLO792 SNV: p.A4294V
Substitution: p.T3964L		 DBIA    Probe Info 
EFO27 SNV: p.R110Q DBIA    Probe Info 
HCC1187 SNV: p.R481K DBIA    Probe Info 
HCT116 SNV: p.R2162W DBIA    Probe Info 
HCT15 SNV: p.A3216T DBIA    Probe Info 
HEC1 SNV: p.T956A DBIA    Probe Info 
HEC1B SNV: p.T956A IA-alkyne    Probe Info 
HT29 SNV: p.Y3632S DBIA    Probe Info 
HT3 SNV: p.E4177K DBIA    Probe Info 
ICC9 SNV: p.P3423A DBIA    Probe Info 
IGROV1 SNV: p.D4N; p.K592E DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Y52H; p.A3120T DBIA    Probe Info 
JHH7 SNV: p.C3239Ter .
KARPAS422 SNV: p.T2252I DBIA    Probe Info 
KMS27 SNV: p.V1649M DBIA    Probe Info 
LOXIMVI SNV: p.D3612E DBIA    Probe Info 
LS180 SNV: p.E1289G; p.N1814S DBIA    Probe Info 
MCC13 SNV: p.P715S DBIA    Probe Info 
MCF7 SNV: p.L3620F .
MELHO SNV: p.D664N DBIA    Probe Info 
NCIH1299 SNV: p.A3959V m-APA    Probe Info 
NCIH1993 Insertion: p.S3159RfsTer13 .
NCIH23 SNV: p.T3541S DBIA    Probe Info 
NUGC3 SNV: p.R3044Ter DBIA    Probe Info 
OCIAML2 SNV: p.G1749D DBIA    Probe Info 
PF382 SNV: p.N2238S DBIA    Probe Info 
RKO SNV: p.D2285N DBIA    Probe Info 
RL952 SNV: p.R2605C DBIA    Probe Info 
RVH421 SNV: p.S1861R DBIA    Probe Info 
SKMEL30 SNV: p.E1910K DBIA    Probe Info 
SKNMC SNV: p.P2645H DBIA    Probe Info 
SNGM SNV: p.A279V DBIA    Probe Info 
SNU1 SNV: p.T1672R DBIA    Probe Info 
SUDHL6 SNV: p.D2486N DBIA    Probe Info 
SW1573 SNV: p.A1906T DBIA    Probe Info 
SW1783 SNV: p.G987R DBIA    Probe Info 
SW756 SNV: p.E2412Q; p.E2447D; p.E2469K DBIA    Probe Info 
SW948 SNV: p.G2544R DBIA    Probe Info 
TE1 SNV: p.T3506I DBIA    Probe Info 
TF1 SNV: p.Q4245K DBIA    Probe Info 
TOV21G SNV: p.W1489L DBIA    Probe Info 
WM2664 Insertion: p.N3201KfsTer3 DBIA    Probe Info 
YSCCC SNV: p.T655A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.38  LDD0402  [1]
A-EBA
 Probe Info  		2.77  LDD0215  [2]
DAyne
 Probe Info  		3.15  LDD0261  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y1988(11.75); Y697(7.36); Y1148(6.48)  LDD0257  [5]
TH216
 Probe Info  		Y3142(19.09); Y697(15.73)  LDD0259  [5]
Probe 1
 Probe Info  		Y147(74.11); Y3142(95.07); Y3648(95.92)  LDD3495  [6]
THZ1-DTB
 Probe Info  		C612(1.01)  LDD0460  [7]
AHL-Pu-1
 Probe Info  		C3259(2.04); C3658(4.48); C3361(2.29); C3239(2.37)  LDD0168  [8]
HHS-475
 Probe Info  		Y3424(0.61); Y1148(0.85); Y1988(2.48)  LDD0264  [9]
HHS-465
 Probe Info  		Y1148(8.93); Y1609(10.00); Y223(10.00); Y697(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C2721(1.13); C1832(1.05); C3361(1.03); C1891(0.96)  LDD0078  [11]
5E-2FA
 Probe Info  		H3115(0.00); H1085(0.00); H2677(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K2267(0.00); K2272(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1252(0.00); C1762(0.00); C1401(0.00); C3658(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C29(0.00); C19(0.00); C3296(0.00); C612(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		C1762(0.00); C1782(0.00)  LDD0030  [16]
IPIAA_L
 Probe Info  		C1447(0.00); C4341(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C1252(0.00); C1762(0.00); C3658(0.00); C471(0.00)  LDD0037  [14]
BTD
 Probe Info  		C471(0.00); C1421(0.00)  LDD0004  [17]
NAIA_4
 Probe Info  		C1401(0.00); C1832(0.00); C3296(0.00); C3658(0.00)  LDD2226  [18]
TFBX
 Probe Info  		C3658(0.00); C3213(0.00); C3239(0.00); C1832(0.00)  LDD0027  [19]
WYneN
 Probe Info  		C29(0.00); C471(0.00); C1832(0.00); C1879(0.00)  LDD0021  [17]
WYneO
 Probe Info  		C2721(0.00); C3658(0.00); C1401(0.00); C3239(0.00)  LDD0022  [17]
DA-P3
 Probe Info  		N.A.  LDD0178  [20]
1d-yne
 Probe Info  		K3409(0.00); K2248(0.00)  LDD0356  [21]
Compound 10
 Probe Info  		C1401(0.00); C1832(0.00); C2721(0.00); C3239(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		C1401(0.00); C2721(0.00); C3239(0.00)  LDD2213  [22]
ENE
 Probe Info  		C3658(0.00); C19(0.00); C2721(0.00); C3239(0.00)  LDD0006  [17]
IPM
 Probe Info  		C4341(0.00); C3239(0.00); C1832(0.00); C349(0.00)  LDD0005  [17]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
VSF
 Probe Info  		C1401(0.00); C3658(0.00); C1891(0.00); C471(0.00)  LDD0007  [17]
1c-yne
 Probe Info  		K1608(0.00); K1931(0.00); K2248(0.00); K3345(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C3658(0.00); C4341(0.00); C3239(0.00); C689(0.00)  LDD0217  [24]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [24]
Crotonaldehyde
 Probe Info  		H1085(0.00); C3213(0.00); C689(0.00); C2721(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C790(0.00); C3658(0.00); C3213(0.00); C624(0.00)  LDD0218  [24]
W1
 Probe Info  		C1832(0.00); C19(0.00); C1879(0.00); C1401(0.00)  LDD0236  [25]
AOyne
 Probe Info  		4.40  LDD0443  [26]
NAIA_5
 Probe Info  		C1401(0.00); C2721(0.00); C471(0.00); C1421(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y1148(0.94); Y3424(1.70); Y697(0.72)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		12.60  LDD0477  [27]
FFF probe2
 Probe Info  		20.00  LDD0463  [27]
FFF probe3
 Probe Info  		5.04  LDD0464  [27]
STS-1
 Probe Info  		N.A.  LDD0137  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C471(0.77); C19(0.70); C699(0.86); C3213(0.66)  LDD2142  [29]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C471(1.08); C19(0.87); C3213(0.90); C1401(1.01)  LDD2112  [29]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C471(0.85); C19(0.77); C699(0.68); C3213(0.58)  LDD2095  [29]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C471(1.18); C19(0.94); C3213(1.02); C1401(0.83)  LDD2130  [29]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C471(1.13); C19(1.06); C699(0.68); C3213(1.09)  LDD2117  [29]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C471(1.81); C19(1.24); C1879(1.31); C1252(0.75)  LDD2152  [29]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C471(0.60); C699(1.00); C2721(0.72)  LDD2103  [29]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C471(1.04); C3213(0.59)  LDD2132  [29]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C471(0.72); C19(0.69); C3213(0.65)  LDD2131  [29]
 LDCM0025  4SU-RNA HEK-293T C3259(2.04); C3658(4.48); C3361(2.29); C3239(2.37)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C3259(2.56); C1879(2.12); C3658(2.18); C3361(3.13)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C3385(1.12); C3372(1.12); C1832(0.91); C3375(1.12)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C3385(1.16); C3372(1.16); C1832(1.38); C3375(1.16)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C3385(1.06); C3372(1.06); C1832(1.17); C3375(1.02)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C3385(0.93); C3372(0.93); C1832(1.22); C3375(0.86)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C3385(0.99); C3372(0.99); C1832(1.11); C3375(0.94)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C3385(1.24); C3372(1.24); C1832(1.28); C3375(1.18)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C3385(1.21); C3372(1.21); C1832(1.07); C3375(1.01)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C3385(1.12); C3372(1.12); C1832(1.23); C3375(1.03)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C3385(1.13); C3372(1.13); C1832(1.30); C3375(1.01)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C3385(1.38); C3372(1.38); C1832(1.04); C3375(1.28)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C3385(0.84); C3372(0.84); C1832(1.33); C3375(0.78)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C3385(0.83); C3372(0.83); C1832(1.10); C3375(0.69)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C3385(0.99); C3372(0.99); C1832(1.39); C3375(0.99)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C3385(0.96); C3372(0.96); C1832(1.35); C3375(0.91)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C3385(0.97); C3372(0.97); C1832(1.41); C3375(0.91)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C3385(1.23); C3372(1.23); C1832(1.13); C3375(1.22)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C3385(1.15); C3372(1.15); C1832(1.01); C3375(1.15)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C3385(1.44); C3372(1.44); C1832(0.99); C3375(1.44)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C3385(1.36); C3372(1.36); C1832(1.16); C3375(1.36)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C3385(1.78); C3372(1.78); C1832(1.11); C3375(1.78)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C3385(1.29); C3372(1.29); C1832(0.94); C3375(1.29)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C3385(1.16); C3372(1.16); C1832(1.01); C3375(1.16)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C3385(1.67); C3372(1.67); C1832(1.02); C3375(1.67)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C3385(0.98); C3372(0.98); C1832(1.16); C3375(0.98)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C3385(1.57); C3372(1.57); C1832(1.02); C3375(1.57)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C3385(1.12); C3372(1.12); C1832(0.86); C3375(1.12)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C3385(1.39); C3372(1.39); C1832(1.08); C3375(1.39)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C3385(1.11); C3372(1.11); C1832(0.88); C3375(1.11)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C3385(1.26); C3372(1.26); C1832(0.87); C3375(1.26)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C3385(1.25); C3372(1.25); C1832(0.98); C3375(1.25)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C3385(1.65); C3372(1.65); C1832(1.05); C3375(1.65)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C3385(1.79); C3372(1.79); C1832(0.94); C3375(1.79)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C3385(1.58); C1832(1.05); C3375(1.58); C790(0.82)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C3385(0.86); C1832(1.32); C3375(0.86); C790(1.01)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C3385(1.41); C1832(1.34); C3375(1.41); C790(0.82)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C3385(0.97); C1832(1.23); C3375(0.97); C790(0.98)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C3385(0.91); C1832(1.47); C3375(0.91); C790(0.77)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C3385(1.00); C1832(1.38); C3375(1.00); C790(0.91)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C3385(1.19); C1832(1.77); C3375(1.19); C790(1.12)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C3385(1.26); C1832(1.42); C3375(1.26); C790(0.96)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C3385(1.29); C1832(1.36); C3375(1.29); C790(0.98)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C3385(1.00); C1832(1.52); C3375(1.00); C790(0.87)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C3385(1.16); C1832(2.06); C3375(1.16); C790(0.95)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C3385(1.17); C1832(1.82); C3375(1.17); C790(1.03)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C3385(0.91); C3372(0.91); C1832(1.23); C3375(0.91)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C3385(1.39); C1832(2.09); C3375(1.39); C790(0.91)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C3385(1.24); C1832(2.06); C3375(1.24); C790(1.11)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C3385(0.86); C1832(1.54); C3375(0.86); C790(1.01)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C3385(1.19); C3372(1.19); C1832(1.14); C3375(1.19)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C183(0.71); C182(0.74); C624(0.83); C4126(0.83)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C467(0.73); C182(0.77); C49(0.81); C4126(0.85)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C1252(0.58); C182(0.64); C183(0.67); C49(0.75)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C183(0.69); C182(0.72); C467(0.84); C4126(0.85)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C182(0.67); C183(0.72); C467(0.73); C624(0.86)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C1252(0.66); C182(0.68); C467(0.68); C49(0.69)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C183(0.76); C182(0.76); C1252(0.80); C624(0.84)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C1252(0.62); C182(0.73); C183(0.83); C467(0.85)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C1252(0.74); C182(0.77); C183(0.87); C4126(0.87)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C1252(0.56); C467(0.60); C49(0.65); C182(0.72)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C1252(0.64); C182(0.68); C624(0.78); C183(0.89)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C3385(1.81); C3372(1.81); C1832(1.28); C3375(1.81)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C3385(1.54); C3372(1.54); C1832(1.33); C3375(1.54)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C3385(1.11); C3372(1.11); C1832(1.17); C3375(1.11)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C3385(1.25); C3372(1.25); C1832(0.91); C3375(1.25)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C790(0.72); C3296(0.72); C3213(0.76); C49(0.85)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C49(0.41); C790(0.56); C3213(0.65); C689(0.68)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C790(0.51); C3296(0.60); C3213(0.72); C49(0.83)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C182(0.84); C183(0.84); C1628(0.88); C471(0.89)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C3296(0.64); C790(0.65); C3213(0.80); C183(0.86)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C790(0.61); C3296(0.71); C49(0.71); C3213(0.79)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C790(0.76); C3213(0.83); C1891(0.85); C1567(0.88)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C790(0.71); C3296(0.75); C3213(0.77); C1567(0.81)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C790(0.65); C3296(0.71); C3213(0.76); C1892(0.92)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C3296(0.86); C1628(0.86); C182(0.87); C183(0.87)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C4126(0.73); C182(0.75); C183(0.75); C624(0.84)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C4126(0.65); C624(0.72); C182(0.75); C183(0.75)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C4126(0.69); C624(0.74); C49(0.75); C182(0.75)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C19(0.53); C4126(0.59); C182(0.69); C183(0.69)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C1832(0.85); C3635(0.93); C1252(0.94); C182(0.95)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C4126(0.57); C19(0.57); C624(0.77); C182(0.78)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C4126(0.65); C624(0.65); C182(0.66); C183(0.66)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C4126(0.54); C182(0.64); C183(0.64); C19(0.66)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C182(0.72); C183(0.72); C624(0.74); C19(0.76)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C19(0.63); C471(0.67); C182(0.69); C183(0.69)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C2721(0.42); C49(0.76); C1892(0.86); C1891(0.87)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C2721(0.42); C19(0.78); C1892(0.87); C790(0.87)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C2721(0.49); C1892(0.86); C1891(0.87); C4126(0.88)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C2721(0.45); C471(0.84); C19(0.84); C1892(0.86)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C2721(0.73); C19(0.83); C4126(0.85); C49(0.93)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C182(0.73); C183(0.73); C1832(0.85); C49(0.89)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C2721(0.74); C790(0.84); C4126(0.89); C19(0.92)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C2721(0.40); C471(0.70); C19(0.79); C790(0.89)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C2721(0.63); C471(0.76); C4126(0.86); C19(0.86)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C2721(0.63); C19(0.66); C471(0.68); C3635(0.86)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C2721(0.56); C471(0.66); C19(0.94); C1891(0.95)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C2721(0.63); C471(0.66); C19(0.78); C3635(0.81)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C1252(0.69); C182(0.75); C624(0.82); C183(0.82)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C1252(0.73); C624(0.83); C3361(0.88); C4126(0.90)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C182(0.76); C624(0.82); C183(0.86); C3635(0.88)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C182(0.76); C183(0.84); C49(0.92); C624(0.96)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C182(0.84); C183(0.84); C1832(0.87); C1892(0.95)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C4126(0.82); C182(0.83); C183(0.91); C790(0.93)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C182(0.79); C3635(0.87); C790(0.89); C471(0.89)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C182(0.85); C4126(0.85); C183(0.85); C1252(0.90)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C1252(0.78); C624(0.83); C182(0.86); C3213(0.87)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C182(0.81); C183(0.83); C1252(0.83); C3213(0.89)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C1252(0.77); C182(0.90); C624(0.91); C183(0.93)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C182(0.74); C4126(0.83); C183(0.84); C624(0.97)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C2721(0.72); C183(0.82); C182(0.84); C4126(0.86)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C3361(0.60); C182(0.72); C183(0.73); C1892(0.79)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C182(0.72); C183(0.73); C2721(0.78); C4126(0.82)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C624(0.71); C183(0.77); C182(0.78); C4126(0.81)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C183(0.69); C182(0.71); C471(0.74); C467(0.76)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C183(0.77); C2721(0.79); C182(0.80); C4126(0.83)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C183(0.73); C182(0.73); C2721(0.75); C467(0.87)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C2721(0.65); C183(0.72); C182(0.73); C4126(0.79)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C2721(0.61); C183(0.83); C4126(0.86); C182(0.92)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C183(0.72); C182(0.74); C471(0.87); C1892(0.88)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C3361(0.69); C182(0.79); C183(0.80); C2721(0.87)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C183(0.74); C182(0.75); C4126(0.76); C2721(0.80)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C1401(0.65); C4126(0.82); C624(0.83); C3361(0.84)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C1401(0.72); C4126(0.82); C689(0.86); C790(0.89)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C182(0.88); C790(0.88); C1628(0.88); C183(0.89)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C4126(0.74); C1401(0.84); C182(0.84); C183(0.84)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C3361(0.78); C1401(0.80); C689(0.93); C182(0.96)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C624(0.87); C4126(0.88); C182(0.89); C183(0.89)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C182(0.78); C183(0.78); C4126(0.84); C790(0.93)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C1401(0.67); C182(0.95); C183(0.95); C624(0.97)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C1401(0.73); C4126(0.78); C182(0.84); C183(0.84)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C3361(0.83); C182(0.89); C183(0.89); C4126(0.92)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C471(0.84); C19(0.84); C4126(0.85); C790(0.86)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C471(0.85); C3361(0.86); C624(0.89); C182(0.90)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C790(0.88); C624(0.93); C182(0.95); C183(0.95)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C624(0.72); C1892(0.77); C183(0.79); C182(0.80)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C3361(0.78); C1401(0.86); C689(0.86); C19(0.89)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C3296(0.43); C1401(0.68); C4126(0.80); C1567(0.85)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C1401(0.81); C4126(0.90); C182(0.94); C183(0.94)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C1628(0.74); C19(0.75); C182(0.79); C183(0.79)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C1628(0.69); C19(0.72); C182(0.81); C183(0.81)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C1628(0.70); C19(0.73); C182(0.79); C183(0.79)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C1628(0.72); C4126(0.74); C19(0.75); C182(0.82)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C1628(0.76); C4126(0.92); C1252(0.93); C471(0.94)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C1628(0.68); C4126(0.79); C3658(0.82); C19(0.83)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C19(0.70); C1628(0.72); C4126(0.80); C182(0.82)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C1252(0.73); C3635(0.82); C1628(0.97); C1401(1.02)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C1628(0.76); C1252(0.76); C19(0.80); C182(0.83)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C1628(0.73); C19(0.75); C182(0.81); C183(0.81)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C1628(0.66); C19(0.74); C4126(0.80); C1892(0.84)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C1628(0.68); C3635(0.81); C1252(0.82); C19(0.87)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C1628(0.64); C689(0.77); C182(0.80); C183(0.80)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C1628(0.63); C1252(0.74); C3635(0.82); C19(0.85)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C19(0.67); C1628(0.74); C4126(0.77); C182(0.78)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C19(0.50); C689(0.50); C4126(0.51); C182(0.52)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C182(0.59); C183(0.59); C689(0.63); C19(0.63)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C471(0.30); C19(0.33); C3213(0.43); C1879(0.38)  LDD2138  [29]
 LDCM0520  AKOS000195272 MDA-MB-231 C19(0.67); C699(0.64); C1879(0.85); C1074(0.18)  LDD2113  [29]
 LDCM0248  AKOS034007472 HCT 116 C3385(0.87); C3372(0.87); C1832(1.10); C3375(0.87)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C3658(0.80); C19(0.86); C1628(0.87); C182(0.87)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C183(0.75); C1252(0.80); C182(0.80); C4126(0.82)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C2721(1.13); C1832(1.05); C3361(1.03); C1891(0.96)  LDD0078  [11]
 LDCM0102  BDHI 8 Jurkat C3863(8.27)  LDD0204  [30]
 LDCM0498  BS-3668 MDA-MB-231 C471(0.40); C699(0.34); C3213(0.91)  LDD2091  [29]
 LDCM0630  CCW28-3 231MFP C4341(1.34)  LDD2214  [31]
 LDCM0108  Chloroacetamide HeLa C4341(0.00); C2666(0.00); C3333(0.00); C3658(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C1401(20.00); C689(20.00); C3361(20.00); C2721(2.31)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C471(0.93); C467(0.98); C4126(1.01); C1252(1.04)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C4126(0.83); C471(0.88); C1567(0.89); C1252(0.89)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C182(0.80); C183(0.80); C49(0.84); C3635(0.89)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C4126(0.77); C183(0.79); C182(0.84); C1628(0.85)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C624(0.79); C3385(0.83); C3372(0.83); C3375(0.83)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C624(0.71); C1401(0.88); C3361(0.94); C1628(0.95)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C3361(0.84); C4126(0.98); C182(0.99); C183(1.00)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C49(0.76); C3361(0.81); C1891(0.81); C790(0.83)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C790(0.56); C49(0.60); C3658(0.70); C3296(0.77)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C3296(0.70); C49(0.77); C790(0.77); C3658(0.79)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C1401(0.69); C3361(0.71); C183(0.79); C182(0.80)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C790(0.58); C3296(0.61); C49(0.70); C1567(0.83)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C4126(0.76); C1401(0.79); C182(0.83); C183(0.83)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C49(0.77); C3361(0.85); C3213(0.85); C689(0.87)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C790(0.54); C3296(0.68); C3213(0.74); C49(0.80)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C19(0.68); C49(0.78); C182(0.87); C183(0.87)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C19(0.55); C4126(0.63); C182(0.68); C183(0.68)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C4126(0.67); C19(0.67); C624(0.75); C1628(0.77)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C182(0.75); C183(0.75); C19(0.76); C471(0.78)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C467(0.79); C182(0.80); C183(0.80); C471(0.82)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C471(0.77); C3635(0.88); C2721(0.90); C790(0.94)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C2721(0.61); C19(0.67); C4126(0.85); C1892(0.89)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C2721(0.61); C19(0.65); C1892(0.91); C471(0.94)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C182(0.81); C183(0.81); C4126(0.87); C1401(1.00)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C2721(0.45); C19(0.74); C471(0.88); C1628(0.93)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C3213(0.63); C1892(0.66); C49(0.66); C1252(0.66)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C182(0.67); C183(0.80); C1252(0.80); C471(0.87)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C3213(0.67); C182(0.72); C1252(0.87); C471(0.92)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C1252(0.79); C3213(0.84); C182(0.84); C183(0.90)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C183(0.85); C182(0.86); C1892(0.87); C624(0.88)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C3361(0.68); C183(0.84); C182(0.86); C471(0.88)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C471(0.78); C182(0.80); C183(0.82); C624(0.83)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C183(0.71); C182(0.72); C2721(0.82); C4126(0.82)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C4126(0.86); C182(0.88); C183(0.88); C1567(0.91)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C1401(0.81); C1567(0.87); C3361(0.92); C624(0.94)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C4126(0.78); C182(0.83); C183(0.83); C1252(0.90)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C3361(0.63); C182(0.76); C183(0.76); C624(0.81)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C182(0.77); C183(0.77); C4126(0.84); C467(0.86)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C467(0.50); C182(0.52); C183(0.52); C624(0.69)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C182(0.60); C183(0.60); C467(0.65); C624(0.80)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C3296(0.80); C4126(0.82); C182(0.87); C183(0.87)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C467(0.67); C182(0.68); C183(0.68); C624(0.74)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C182(0.70); C183(0.70); C467(0.74); C3635(0.82)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C3361(0.71); C182(0.76); C183(0.76); C624(0.83)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C182(0.68); C183(0.68); C624(0.71); C19(0.73)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C182(0.61); C183(0.61); C467(0.75); C624(0.79)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C3385(2.99); C3372(2.19); C1832(1.64); C3375(2.03)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C3385(1.33); C3372(1.18); C1832(1.11); C3375(1.34)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C3385(1.56); C3372(1.33); C1832(1.11); C3375(1.52)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C3385(1.89); C3372(1.53); C1832(1.19); C3375(1.85)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C3385(1.47); C3372(1.31); C1832(1.25); C3375(1.51)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C3385(1.27); C3372(1.27); C1832(0.99); C3375(1.29)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C3385(1.18); C3372(1.07); C1832(1.06); C3375(1.17)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C1832(1.38); C790(1.53); C1401(0.88); C1567(0.97)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C1832(1.26); C790(0.83); C1401(0.93); C1567(0.99)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C1832(1.99); C790(0.84); C1401(0.80); C1567(0.90)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C1832(1.52); C790(0.94); C1401(0.89); C1567(0.92)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C1832(1.41); C790(1.17); C1401(0.70); C1567(0.87)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C1832(1.33); C790(0.86); C1401(0.70); C1567(0.84)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C1832(1.59); C790(1.16); C1401(0.75); C1567(0.87)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C1832(1.70); C790(0.72); C1401(0.61); C1567(1.01)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C3385(1.25); C3372(1.25); C1832(1.03); C3375(1.20)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C1832(1.58); C790(0.84); C1401(0.41); C1567(0.82)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C1832(1.25); C790(0.87); C1401(0.69); C1567(0.81)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C1832(2.23); C790(1.01); C1401(0.49); C1567(1.10)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C1832(1.60); C790(0.65); C1401(0.60); C1567(0.95)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C1832(1.57); C790(0.98); C1401(0.65); C1567(0.97)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C1832(1.97); C790(0.94); C1401(0.59); C1567(1.06)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C1832(0.85); C790(0.74); C1401(0.85); C1628(1.24)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C1832(0.86); C790(0.70); C1401(0.82); C1628(1.14)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C1832(0.87); C790(0.96); C1401(0.79); C1628(1.40)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C1832(0.89); C790(0.88); C1401(0.87); C1628(1.05)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C3385(1.18); C3372(1.18); C1832(0.93); C3375(1.10)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C1832(0.88); C790(0.90); C1401(1.18); C1628(1.08)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C1832(1.01); C790(2.92); C1401(1.03); C1628(1.11)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C1832(0.85); C790(0.88); C1401(0.87); C1628(1.26)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C1832(0.88); C790(0.81); C1401(1.11); C1628(1.32)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C1832(0.82); C790(0.82); C1401(0.90); C1628(1.13)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C1832(0.87); C790(0.94); C1401(0.74); C1628(1.14)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C1832(1.01); C790(0.83); C1401(1.11); C1628(1.14)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C1832(0.89); C790(0.85); C1401(0.82); C1628(1.26)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C1832(0.81); C790(0.76); C1401(0.78); C1628(1.13)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C1832(0.90); C790(1.00); C1401(1.06); C1628(1.06)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C3385(2.14); C3372(2.14); C1832(1.24); C3375(2.07)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C1832(0.87); C790(0.83); C1401(0.91); C1628(1.30)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C1832(1.13); C790(0.75); C1401(0.93); C1628(0.91)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C1832(1.26); C790(0.84); C1401(0.87); C1628(0.90)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C1832(1.43); C790(1.13); C1401(0.93); C1628(0.86)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C1832(1.50); C790(0.92); C1401(0.97); C1628(0.82)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C1832(1.16); C790(0.88); C1401(0.84); C1628(0.97)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C1832(1.62); C790(0.88); C1401(0.92); C1628(1.00)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C1832(1.34); C790(0.84); C1401(0.87); C1628(1.05)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C1832(1.26); C790(0.76); C1401(0.82); C1628(1.03)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C1832(1.15); C790(0.81); C1401(1.02); C1628(1.02)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C3385(1.58); C3372(1.58); C1832(1.21); C3375(1.31)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C1832(1.30); C790(0.79); C1401(0.88); C1628(1.03)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C1832(1.36); C790(0.80); C1401(0.94); C1628(0.96)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C1832(1.18); C790(0.78); C1401(0.96); C1628(0.89)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C1832(1.40); C790(0.85); C1401(0.96); C1628(1.42)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C1832(1.39); C790(0.87); C1401(0.82); C1628(0.98)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C3385(1.03); C1832(1.12); C3375(1.03); C790(1.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C3385(2.01); C1832(1.29); C3375(2.01); C790(1.20)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C3385(1.04); C1832(1.30); C3375(1.04); C790(1.09)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C3385(1.59); C1832(1.39); C3375(1.59); C790(0.95)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C3385(5.57); C3372(5.57); C1832(2.25); C3375(3.72)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C3385(1.06); C1832(1.09); C3375(1.06); C790(1.09)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C3385(1.37); C1832(1.26); C3375(1.37); C790(1.01)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C3385(2.39); C1832(1.54); C3375(2.39); C790(1.14)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C3385(1.86); C1832(1.65); C3375(1.86); C790(1.25)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C3385(2.65); C1832(1.99); C3375(2.65); C790(1.80)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C3385(1.18); C1832(1.33); C3375(1.18); C790(0.92)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C3385(1.06); C1832(1.24); C3375(1.06); C790(0.94)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C3385(1.72); C1832(1.44); C3375(1.72); C790(0.93)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C3385(1.28); C1832(1.41); C3375(1.28); C790(1.09)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C3385(2.70); C1832(1.98); C3375(2.70); C790(1.28)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C3385(1.57); C3372(1.57); C1832(1.19); C3375(1.24)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C3385(1.97); C1832(4.78); C3375(1.97); C790(1.22)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C3385(1.25); C3372(1.25); C1832(1.09); C3375(1.25)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C3385(1.59); C3372(1.59); C1832(1.14); C3375(1.59)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C3385(1.12); C3372(1.12); C1832(1.01); C3375(1.12)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C3385(2.21); C3372(2.21); C1832(0.86); C3375(2.21)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C3385(2.08); C3372(2.08); C1832(1.28); C3375(2.08)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C3385(1.70); C3372(1.70); C1832(1.03); C3375(1.70)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C3385(1.73); C3372(1.73); C1832(1.08); C3375(1.73)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C3385(1.38); C3372(1.38); C1832(1.16); C3375(1.38)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C3385(1.26); C3372(1.26); C1832(0.94); C3375(1.26)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C467(0.95); C1832(0.91); C1401(0.81); C3239(0.75)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C3361(0.95); C2721(0.97); C19(1.17); C1879(1.01)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1252(4.50); C349(2.88); C1879(2.43); C1832(1.87)  LDD1702  [29]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.56  LDD0183  [20]
 LDCM0625  F8 Ramos C3213(0.96); C2721(1.54); C3239(1.44); C3658(1.16)  LDD2187  [33]
 LDCM0572  Fragment10 MDA-MB-231 C4367(0.90)  LDD1389  [34]
 LDCM0573  Fragment11 MDA-MB-231 C4367(1.48)  LDD1391  [34]
 LDCM0574  Fragment12 Ramos C3213(0.65); C2721(0.95); C3239(1.13); C3658(0.74)  LDD2191  [33]
 LDCM0575  Fragment13 MDA-MB-231 C4367(0.87)  LDD1395  [34]
 LDCM0576  Fragment14 MDA-MB-231 C4367(1.75)  LDD1397  [34]
 LDCM0577  Fragment15 MDA-MB-231 C4367(0.93)  LDD1399  [34]
 LDCM0579  Fragment20 Ramos C3213(0.65); C2721(0.84); C3239(1.73); C3658(0.69)  LDD2194  [33]
 LDCM0580  Fragment21 MDA-MB-231 C4367(20.00)  LDD1404  [34]
 LDCM0582  Fragment23 MDA-MB-231 C4367(0.91)  LDD1408  [34]
 LDCM0578  Fragment27 MDA-MB-231 C4367(0.63)  LDD1401  [34]
 LDCM0586  Fragment28 MDA-MB-231 C4367(0.78)  LDD1415  [34]
 LDCM0588  Fragment30 Ramos C3213(1.36); C2721(1.72); C3239(1.36); C3658(1.33)  LDD2199  [33]
 LDCM0589  Fragment31 MDA-MB-231 C4367(1.19)  LDD1421  [34]
 LDCM0590  Fragment32 MDA-MB-231 C4367(1.36)  LDD1423  [34]
 LDCM0468  Fragment33 HCT 116 C1832(1.18); C790(0.88); C1401(0.88); C1628(0.99)  LDD0785  [11]
 LDCM0596  Fragment38 MDA-MB-231 C4367(1.04)  LDD1433  [34]
 LDCM0597  Fragment39 MDA-MB-231 C4367(1.77)  LDD1435  [34]
 LDCM0566  Fragment4 Ramos C3213(0.72); C2721(0.72); C3239(1.12); C3658(0.89)  LDD2184  [33]
 LDCM0604  Fragment46 MDA-MB-231 C4367(1.21)  LDD1445  [34]
 LDCM0608  Fragment50 MDA-MB-231 C4367(1.14)  LDD1449  [34]
 LDCM0427  Fragment51 HCT 116 C1832(2.13); C790(1.61); C1401(0.45); C1567(0.93)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C3213(1.75); C2721(1.86); C3239(1.13); C3658(1.35)  LDD2204  [33]
 LDCM0614  Fragment56 MDA-MB-231 C4367(1.30)  LDD1458  [34]
 LDCM0569  Fragment7 MDA-MB-231 C4367(1.38)  LDD1383  [34]
 LDCM0571  Fragment9 MDA-MB-231 C4367(0.89)  LDD1387  [34]
 LDCM0116  HHS-0101 DM93 Y3424(0.61); Y1148(0.85); Y1988(2.48)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y1988(0.20); Y1148(0.75)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y1148(0.62)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y1988(0.36); Y1148(0.81); Y3424(2.73)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y1988(0.33); Y3424(0.82); Y1148(0.92)  LDD0268  [9]
 LDCM0107  IAA HeLa H1085(0.00); H3315(0.00); H336(0.00); C689(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C1891(3.54); C1892(3.54); C19(1.32); C3239(1.94)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C1891(6.40); C1892(6.40); C19(1.78); C3239(1.72)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C1891(4.66); C1892(4.66); C19(2.61); C3239(1.97)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C471(0.54); C699(0.87); C3213(0.93); C1401(1.13)  LDD2102  [29]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C19(0.49); C3213(0.65); C1879(0.60); C2721(0.37)  LDD2121  [29]
 LDCM0109  NEM HeLa H1085(0.00); H165(0.00); H4025(0.00); H336(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C471(0.78); C19(0.68); C699(0.29)  LDD2089  [29]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C471(0.88); C699(1.08); C1401(1.16); C1879(1.58)  LDD2090  [29]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C471(0.51); C699(0.82); C3213(0.90); C1401(1.00)  LDD2092  [29]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C471(1.05); C19(0.88); C699(0.90); C1074(0.55)  LDD2093  [29]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C471(0.58); C699(0.83); C3213(0.95); C1832(1.64)  LDD2094  [29]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C471(1.07)  LDD2096  [29]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C3213(0.99)  LDD2097  [29]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C471(1.00); C699(0.86); C3213(0.98); C1401(0.82)  LDD2098  [29]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C471(0.88); C19(1.08); C699(0.64); C3213(1.29)  LDD2099  [29]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C471(1.38); C19(0.69); C699(0.72); C3213(1.00)  LDD2100  [29]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C471(0.57); C19(0.77); C699(1.02); C3213(1.17)  LDD2101  [29]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C471(1.04); C19(0.62); C699(0.57); C1401(0.94)  LDD2104  [29]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C471(1.02); C699(1.11); C3213(1.19); C1401(1.04)  LDD2105  [29]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C19(0.63); C1401(1.03); C1421(0.48); C689(1.10)  LDD2106  [29]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C19(0.91); C699(1.13); C3213(0.83); C1401(1.10)  LDD2107  [29]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C471(1.03); C3213(0.86); C1401(1.07); C2721(1.11)  LDD2108  [29]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C471(0.97); C19(0.79); C3213(0.88); C1401(0.79)  LDD2109  [29]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C19(0.99); C1401(1.92); C2721(1.74)  LDD2110  [29]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C471(1.04); C19(1.09); C699(0.88); C3213(1.26)  LDD2111  [29]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C471(0.78); C19(0.58); C1401(0.98); C2721(0.94)  LDD2114  [29]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C19(0.50)  LDD2115  [29]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C471(1.04); C1401(0.91); C2721(1.02)  LDD2116  [29]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C471(1.01); C1401(0.80); C624(0.44); C689(1.23)  LDD2118  [29]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1879(3.22); C1832(1.54); C1074(0.71); C1252(0.81)  LDD2119  [29]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C471(0.84); C699(0.84); C1401(1.21); C1879(1.08)  LDD2120  [29]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C471(0.94); C19(0.98); C699(0.64); C3213(0.97)  LDD2123  [29]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C19(1.09); C1401(0.68)  LDD2124  [29]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C471(0.84); C19(1.00); C699(0.70); C3213(1.02)  LDD2125  [29]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C19(1.04); C1401(0.54)  LDD2126  [29]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C471(1.15); C19(1.01); C699(0.86); C3213(1.37)  LDD2127  [29]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C699(0.87); C1879(1.15); C1421(0.97)  LDD2128  [29]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C19(0.92); C699(0.70); C1401(1.34); C29(1.29)  LDD2129  [29]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C19(0.55); C1252(0.40)  LDD2133  [29]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C19(0.41); C699(0.95); C3213(0.53)  LDD2134  [29]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C471(0.56); C19(1.02); C699(0.68); C3213(1.71)  LDD2135  [29]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C471(0.86); C19(1.19); C699(0.63); C3213(1.45)  LDD2136  [29]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C19(1.01); C699(0.90); C3213(0.99); C1401(1.00)  LDD2137  [29]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C19(2.41); C1879(2.12); C1074(1.40); C1401(1.21)  LDD1700  [29]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C471(0.94); C19(1.01); C699(0.53); C3213(0.88)  LDD2140  [29]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C471(0.75); C19(0.93); C699(0.75); C3213(0.68)  LDD2141  [29]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C699(1.18); C1879(1.02)  LDD2143  [29]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C19(1.81); C1832(1.60)  LDD2144  [29]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C471(0.95); C19(1.14); C699(0.73); C3213(1.67)  LDD2146  [29]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C699(4.99)  LDD2147  [29]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C19(0.55); C3213(0.47); C1879(0.59)  LDD2148  [29]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C471(0.42); C19(0.35); C699(0.36); C3213(0.66)  LDD2150  [29]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C699(1.55); C1401(1.37); C1879(1.21); C2721(1.30)  LDD2153  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C790(0.91)  LDD2207  [35]
 LDCM0021  THZ1 HeLa S3 C612(1.01)  LDD0460  [7]
 LDCM0111  W14 Hep-G2 C1832(1.10)  LDD0238  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Ubiquitin carboxyl-terminal hydrolase 4 (USP4) Peptidase C19 family Q13107
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Cellular tumor antigen p53 (TP53) P53 family P04637
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 1 group D member 1 (NR1D1) Nuclear hormone receptor family P20393
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Bcl-2 family Q07820
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Tumor suppressor ARF (CDKN2A) . Q8N726

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
30 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
31 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.