Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment15  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 52 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 5.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 4.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 4.1
 LDTP04689  Adenosine kinase (ADK) C353 3.7
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 2.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.6
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.5
 LDTP03496  Protein PML (PML) C389 2.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 2.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 2.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.2
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.6
 LDTP02223  Cathepsin B (CTSB) C319 1.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.4
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.3
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.2
 LDTP02198  Cathepsin D (CTSD) C117 1.2
 LDTP03642  Cytidine deaminase (CDA) C14 1.2
 LDTP13147  Cathepsin Z (CTSZ) C92 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.1
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.1
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C358 1.1
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.0
 LDTP02502  Thioredoxin (TXN) C32 1.0
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.0
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C4367 0.9
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.9
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.9
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.8
 LDTP14155  Serine/threonine-protein kinase MRCK beta (CDC42BPB) C1517 0.8
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.8
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.8
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.8
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.7
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 0.7
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.5
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.1
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.9
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.8
 LDTP00501  Exportin-1 (XPO1) C528 0.8
 LDTP01574  Importin-7 (IPO7) C757 0.5
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.8
Other
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 7.4
 LDTP13964  MOB-like protein phocein (MOB4) C134 4.4
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 3.9
 LDTP06681  Inverted formin-2 (INF2) C332 3.2
 LDTP02205  Tubulin beta chain (TUBB) C239 2.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 2.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 2.3
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 2.3
 LDTP02692  Plastin-3 (PLS3) C33 1.6
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.6
 LDTP05867  Treacle protein (TCOF1) C38 1.6
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 1.4
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.4
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.4
 LDTP03620  Protein S100-A11 (S100A11) C91 1.4
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.3
 LDTP08238  Kinectin (KTN1) C303 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.3
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.2
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 1.2
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.1
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 1.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.1
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.1
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 0.9
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.8
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.7
 LDTP11235  Protein PAXX (PAXX) C180 0.7
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.