Details of the Target

General Information of Target

Target ID LDTP12166
Target Name Ras-related GTP-binding protein C (RRAGC)
Gene Name RRAGC
Gene ID 64121
Synonyms
Ras-related GTP-binding protein C; Rag C; RagC; EC 3.6.5.-; GTPase-interacting protein 2; TIB929
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELF
MPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYE
MWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRR
VLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFF
CLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLF
VLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMS
SRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQ
QETDPS
Target Bioclass
Enzyme
Family
GTR/RAG GTP-binding protein family
Subcellular location
Cytoplasm
Function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . This is a crucial step in the activation of the MTOR signaling cascade by amino acids. Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3.
Uniprot ID
Q9HB90
Ensemble ID
ENST00000373001.4
HGNC ID
HGNC:19902

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K361(5.56); K79(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y310(81.15)  LDD3495  [3]
DBIA
 Probe Info  		C377(1.95)  LDD3311  [4]
BTD
 Probe Info  		C377(0.79)  LDD2089  [5]
AHL-Pu-1
 Probe Info  		C52(2.24)  LDD0168  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C358(0.00); C377(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C358(0.00); C377(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C358(0.00); C377(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C52(0.00); C358(0.00); C377(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		C358(0.00); C377(0.00)  LDD0005  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		13.10  LDD0443  [15]
NAIA_5
 Probe Info  		C358(0.00); C377(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		8.17  LDD1977  [16]
FFF probe13
 Probe Info  		13.95  LDD0475  [17]
FFF probe9
 Probe Info  		7.71  LDD0470  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C377(0.87)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C377(0.63)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C377(0.98)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C377(1.51)  LDD2152  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C377(0.49)  LDD2131  [5]
 LDCM0025  4SU-RNA HEK-293T C52(2.24)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C358(2.71)  LDD0169  [6]
 LDCM0214  AC1 PaTu 8988t C339(0.49)  LDD1093  [19]
 LDCM0215  AC10 PaTu 8988t C339(0.61)  LDD1094  [19]
 LDCM0216  AC100 PaTu 8988t C339(0.77)  LDD1095  [19]
 LDCM0217  AC101 PaTu 8988t C339(0.82)  LDD1096  [19]
 LDCM0218  AC102 PaTu 8988t C339(0.35)  LDD1097  [19]
 LDCM0219  AC103 PaTu 8988t C339(0.68)  LDD1098  [19]
 LDCM0220  AC104 PaTu 8988t C339(0.57)  LDD1099  [19]
 LDCM0221  AC105 PaTu 8988t C339(0.75)  LDD1100  [19]
 LDCM0222  AC106 PaTu 8988t C339(0.63)  LDD1101  [19]
 LDCM0223  AC107 PaTu 8988t C339(0.74)  LDD1102  [19]
 LDCM0224  AC108 PaTu 8988t C339(0.54)  LDD1103  [19]
 LDCM0225  AC109 PaTu 8988t C339(0.40)  LDD1104  [19]
 LDCM0226  AC11 PaTu 8988t C339(0.94)  LDD1105  [19]
 LDCM0227  AC110 PaTu 8988t C339(0.32)  LDD1106  [19]
 LDCM0228  AC111 PaTu 8988t C339(0.55)  LDD1107  [19]
 LDCM0229  AC112 PaTu 8988t C339(0.66)  LDD1108  [19]
 LDCM0230  AC113 PaTu 8988t C339(1.70)  LDD1109  [19]
 LDCM0231  AC114 PaTu 8988t C339(0.78)  LDD1110  [19]
 LDCM0232  AC115 PaTu 8988t C339(1.70)  LDD1111  [19]
 LDCM0233  AC116 PaTu 8988t C339(1.82)  LDD1112  [19]
 LDCM0234  AC117 PaTu 8988t C339(1.45)  LDD1113  [19]
 LDCM0235  AC118 PaTu 8988t C339(0.66)  LDD1114  [19]
 LDCM0236  AC119 PaTu 8988t C339(1.42)  LDD1115  [19]
 LDCM0237  AC12 PaTu 8988t C339(0.78)  LDD1116  [19]
 LDCM0238  AC120 PaTu 8988t C339(1.18)  LDD1117  [19]
 LDCM0239  AC121 PaTu 8988t C339(1.56)  LDD1118  [19]
 LDCM0240  AC122 PaTu 8988t C339(0.82)  LDD1119  [19]
 LDCM0241  AC123 PaTu 8988t C339(1.42)  LDD1120  [19]
 LDCM0242  AC124 PaTu 8988t C339(1.41)  LDD1121  [19]
 LDCM0243  AC125 PaTu 8988t C339(0.82)  LDD1122  [19]
 LDCM0244  AC126 PaTu 8988t C339(1.09)  LDD1123  [19]
 LDCM0245  AC127 PaTu 8988t C339(1.40)  LDD1124  [19]
 LDCM0259  AC14 PaTu 8988t C339(0.84)  LDD1138  [19]
 LDCM0270  AC15 PaTu 8988t C339(0.55)  LDD1149  [19]
 LDCM0276  AC17 HEK-293T C377(1.04); C339(0.96)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C52(1.29); C377(0.91); C339(0.99)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C52(1.25); C377(0.97)  LDD1517  [20]
 LDCM0279  AC2 PaTu 8988t C339(0.60)  LDD1158  [19]
 LDCM0280  AC20 HEK-293T C377(1.00); C339(1.00)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C377(0.98); C339(0.97)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C52(1.44); C377(1.07); C339(0.90)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C52(1.12); C377(0.96); C339(0.83)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C377(1.00); C339(0.96)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C377(0.91); C339(1.02)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C52(1.22); C377(1.00); C339(0.93)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C52(0.98); C377(0.90)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C377(0.97); C339(1.04)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C377(0.95); C339(1.00)  LDD1528  [20]
 LDCM0290  AC3 PaTu 8988t C339(0.53)  LDD1169  [19]
 LDCM0291  AC30 HEK-293T C52(1.26); C377(0.94); C339(0.85)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C52(1.19); C377(0.94); C339(0.92)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C377(1.02); C339(0.87)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C377(1.03); C339(1.03)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C52(1.32); C377(0.98); C339(1.01)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C52(1.44); C377(0.98)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C377(1.04); C339(1.09)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C377(1.14); C339(1.05)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C52(1.17); C377(0.86); C339(0.89)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C52(1.26); C377(0.95); C339(0.97)  LDD1539  [20]
 LDCM0301  AC4 PaTu 8988t C339(0.55)  LDD1180  [19]
 LDCM0302  AC40 HEK-293T C377(1.11); C339(0.95)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C377(0.97); C339(0.99)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C52(1.26); C377(0.99); C339(0.94)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C52(1.03); C377(0.89)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C377(0.88); C339(0.98)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C377(1.03); C339(1.02)  LDD1546  [20]
 LDCM0308  AC46 PaTu 8988t C339(0.89)  LDD1187  [19]
 LDCM0309  AC47 PaTu 8988t C339(0.82)  LDD1188  [19]
 LDCM0310  AC48 PaTu 8988t C339(0.71)  LDD1189  [19]
 LDCM0311  AC49 PaTu 8988t C339(0.63)  LDD1190  [19]
 LDCM0312  AC5 PaTu 8988t C339(0.51)  LDD1191  [19]
 LDCM0313  AC50 PaTu 8988t C339(0.52)  LDD1192  [19]
 LDCM0314  AC51 PaTu 8988t C339(0.44)  LDD1193  [19]
 LDCM0315  AC52 PaTu 8988t C339(0.73)  LDD1194  [19]
 LDCM0316  AC53 PaTu 8988t C339(0.61)  LDD1195  [19]
 LDCM0317  AC54 PaTu 8988t C339(0.59)  LDD1196  [19]
 LDCM0318  AC55 PaTu 8988t C339(0.30)  LDD1197  [19]
 LDCM0319  AC56 PaTu 8988t C339(0.33)  LDD1198  [19]
 LDCM0320  AC57 PaTu 8988t C339(0.73)  LDD1199  [19]
 LDCM0321  AC58 PaTu 8988t C339(0.72)  LDD1200  [19]
 LDCM0322  AC59 PaTu 8988t C339(0.73)  LDD1201  [19]
 LDCM0323  AC6 PaTu 8988t C339(1.03)  LDD1202  [19]
 LDCM0324  AC60 PaTu 8988t C339(0.69)  LDD1203  [19]
 LDCM0325  AC61 PaTu 8988t C339(0.76)  LDD1204  [19]
 LDCM0326  AC62 PaTu 8988t C339(0.65)  LDD1205  [19]
 LDCM0327  AC63 PaTu 8988t C339(0.70)  LDD1206  [19]
 LDCM0328  AC64 PaTu 8988t C339(0.75)  LDD1207  [19]
 LDCM0329  AC65 PaTu 8988t C339(0.77)  LDD1208  [19]
 LDCM0330  AC66 PaTu 8988t C339(0.61)  LDD1209  [19]
 LDCM0331  AC67 PaTu 8988t C339(0.81)  LDD1210  [19]
 LDCM0334  AC7 PaTu 8988t C339(1.23)  LDD1213  [19]
 LDCM0345  AC8 PaTu 8988t C339(0.65)  LDD1224  [19]
 LDCM0365  AC98 PaTu 8988t C339(0.32)  LDD1244  [19]
 LDCM0366  AC99 PaTu 8988t C339(0.66)  LDD1245  [19]
 LDCM0545  Acetamide MDA-MB-231 C377(0.39)  LDD2138  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C339(0.75)  LDD1127  [19]
 LDCM0356  AKOS034007680 PaTu 8988t C339(0.67)  LDD1235  [19]
 LDCM0275  AKOS034007705 PaTu 8988t C339(0.55)  LDD1154  [19]
 LDCM0156  Aniline NCI-H1299 12.35  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C377(0.54)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C358(1.36)  LDD2214  [21]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C358(1.61); C358(0.94); C377(0.90); C52(0.42)  LDD2227  [10]
 LDCM0367  CL1 PaTu 8988t C339(0.99)  LDD1246  [19]
 LDCM0368  CL10 PaTu 8988t C339(0.84)  LDD1247  [19]
 LDCM0369  CL100 PaTu 8988t C339(0.35)  LDD1248  [19]
 LDCM0370  CL101 PaTu 8988t C339(0.91)  LDD1249  [19]
 LDCM0371  CL102 PaTu 8988t C339(1.10)  LDD1250  [19]
 LDCM0372  CL103 PaTu 8988t C339(0.84)  LDD1251  [19]
 LDCM0373  CL104 PaTu 8988t C339(1.08)  LDD1252  [19]
 LDCM0374  CL105 HEK-293T C52(1.12); C377(0.98); C339(0.99)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C52(0.96); C377(0.92); C339(0.80)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C52(1.34); C377(0.91); C339(0.92)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C52(1.00); C377(0.76)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C52(1.05); C377(0.91); C339(0.92)  LDD1582  [20]
 LDCM0379  CL11 PaTu 8988t C339(0.85)  LDD1258  [19]
 LDCM0380  CL110 HEK-293T C52(0.41); C377(1.00); C339(1.01)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C52(1.10); C377(0.96); C339(0.83)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C52(0.89); C377(0.83)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C52(1.27); C377(0.98); C339(0.96)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C52(1.13); C377(0.99); C339(0.90)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C52(1.02); C377(1.03); C339(1.08)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C52(0.98); C377(0.88)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C52(1.28); C377(1.03); C339(0.97)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C52(1.07); C377(0.86); C339(0.77)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C52(1.08); C377(0.97); C339(0.98)  LDD1593  [20]
 LDCM0390  CL12 PaTu 8988t C339(0.77)  LDD1269  [19]
 LDCM0391  CL120 HEK-293T C52(1.19); C377(0.98)  LDD1595  [20]
 LDCM0392  CL121 PaTu 8988t C339(0.67)  LDD1271  [19]
 LDCM0393  CL122 PaTu 8988t C339(0.68)  LDD1272  [19]
 LDCM0394  CL123 PaTu 8988t C339(0.59)  LDD1273  [19]
 LDCM0395  CL124 PaTu 8988t C339(0.59)  LDD1274  [19]
 LDCM0396  CL125 PaTu 8988t C339(0.79)  LDD1275  [19]
 LDCM0397  CL126 PaTu 8988t C339(0.83)  LDD1276  [19]
 LDCM0398  CL127 PaTu 8988t C339(0.74)  LDD1277  [19]
 LDCM0399  CL128 PaTu 8988t C339(0.87)  LDD1278  [19]
 LDCM0400  CL13 PaTu 8988t C339(0.93)  LDD1279  [19]
 LDCM0401  CL14 PaTu 8988t C339(0.80)  LDD1280  [19]
 LDCM0402  CL15 PaTu 8988t C339(0.85)  LDD1281  [19]
 LDCM0403  CL16 HEK-293T C52(1.02); C377(0.76)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C377(1.00); C339(1.13)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C52(0.91); C377(0.75); C339(0.96)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C52(0.85); C377(0.80)  LDD1610  [20]
 LDCM0407  CL2 PaTu 8988t C339(0.85)  LDD1286  [19]
 LDCM0408  CL20 HEK-293T C377(0.80); C339(0.97)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C377(0.97); C339(1.07)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C52(0.75); C377(1.02); C339(0.83)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C52(0.56); C377(0.98); C339(0.97)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C377(1.06); C339(1.03)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C52(1.69); C377(0.80); C339(1.12)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C52(0.98); C377(0.95); C339(0.85)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C52(1.16); C377(0.99); C339(0.92)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C52(0.96); C377(0.75)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C377(0.94); C339(1.09)  LDD1621  [20]
 LDCM0418  CL3 PaTu 8988t C339(0.46)  LDD1297  [19]
 LDCM0419  CL30 HEK-293T C52(1.02); C377(0.92); C339(0.95)  LDD1623  [20]
 LDCM0420  CL31 PaTu 8988t C339(0.98)  LDD1299  [19]
 LDCM0421  CL32 PaTu 8988t C339(0.70)  LDD1300  [19]
 LDCM0422  CL33 PaTu 8988t C339(0.61)  LDD1301  [19]
 LDCM0423  CL34 PaTu 8988t C339(0.82)  LDD1302  [19]
 LDCM0424  CL35 PaTu 8988t C339(0.75)  LDD1303  [19]
 LDCM0425  CL36 PaTu 8988t C339(0.17)  LDD1304  [19]
 LDCM0426  CL37 PaTu 8988t C339(0.65)  LDD1305  [19]
 LDCM0428  CL39 PaTu 8988t C339(0.63)  LDD1307  [19]
 LDCM0429  CL4 PaTu 8988t C339(0.38)  LDD1308  [19]
 LDCM0430  CL40 PaTu 8988t C339(0.83)  LDD1309  [19]
 LDCM0431  CL41 PaTu 8988t C339(0.84)  LDD1310  [19]
 LDCM0432  CL42 PaTu 8988t C339(0.68)  LDD1311  [19]
 LDCM0433  CL43 PaTu 8988t C339(0.71)  LDD1312  [19]
 LDCM0434  CL44 PaTu 8988t C339(0.43)  LDD1313  [19]
 LDCM0435  CL45 PaTu 8988t C339(0.62)  LDD1314  [19]
 LDCM0436  CL46 HEK-293T C52(0.55); C377(1.02); C339(0.88)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C52(0.57); C377(1.09); C339(1.05)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C377(1.00); C339(1.39)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C52(1.35); C377(0.84); C339(1.05)  LDD1643  [20]
 LDCM0440  CL5 PaTu 8988t C339(0.89)  LDD1319  [19]
 LDCM0441  CL50 HEK-293T C52(1.12); C377(0.94); C339(0.88)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C52(0.98); C377(1.05)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C377(1.10); C339(1.20)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C52(0.85); C377(0.68); C339(1.10)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C52(0.78); C377(0.99)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C377(0.88); C339(0.98)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C377(1.20); C339(1.11)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C52(0.63); C377(0.73); C339(1.17)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C52(0.54); C377(0.90); C339(0.98)  LDD1653  [20]
 LDCM0451  CL6 PaTu 8988t C339(0.78)  LDD1330  [19]
 LDCM0452  CL60 HEK-293T C377(1.15); C339(1.08)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C52(1.28); C377(0.92); C339(1.10)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C52(1.05); C377(0.94); C339(0.72)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C52(1.06); C377(1.04); C339(1.00)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C52(1.01); C377(0.96)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C377(0.96); C339(1.05)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C52(0.90); C377(0.86); C339(1.03)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C52(0.71); C377(0.94)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C377(0.81); C339(1.01)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C377(0.91); C339(1.04)  LDD1664  [20]
 LDCM0462  CL7 PaTu 8988t C339(0.85)  LDD1341  [19]
 LDCM0463  CL70 HEK-293T C52(0.71); C377(0.95); C339(0.94)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C52(0.61); C377(0.81); C339(1.01)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C377(1.07); C339(1.02)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C52(1.67); C377(0.92); C339(0.96)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C52(0.99); C377(0.84); C339(0.99)  LDD1670  [20]
 LDCM0469  CL76 PaTu 8988t C339(0.64)  LDD1348  [19]
 LDCM0470  CL77 PaTu 8988t C339(0.67)  LDD1349  [19]
 LDCM0471  CL78 PaTu 8988t C339(0.70)  LDD1350  [19]
 LDCM0472  CL79 PaTu 8988t C339(0.83)  LDD1351  [19]
 LDCM0473  CL8 PaTu 8988t C339(0.52)  LDD1352  [19]
 LDCM0474  CL80 PaTu 8988t C339(0.73)  LDD1353  [19]
 LDCM0475  CL81 PaTu 8988t C339(1.29)  LDD1354  [19]
 LDCM0476  CL82 PaTu 8988t C339(0.67)  LDD1355  [19]
 LDCM0477  CL83 PaTu 8988t C339(1.06)  LDD1356  [19]
 LDCM0478  CL84 PaTu 8988t C339(0.93)  LDD1357  [19]
 LDCM0479  CL85 PaTu 8988t C339(1.10)  LDD1358  [19]
 LDCM0480  CL86 PaTu 8988t C339(0.90)  LDD1359  [19]
 LDCM0481  CL87 PaTu 8988t C339(0.77)  LDD1360  [19]
 LDCM0482  CL88 PaTu 8988t C339(0.84)  LDD1361  [19]
 LDCM0483  CL89 PaTu 8988t C339(1.40)  LDD1362  [19]
 LDCM0484  CL9 PaTu 8988t C339(0.80)  LDD1363  [19]
 LDCM0485  CL90 PaTu 8988t C339(0.79)  LDD1364  [19]
 LDCM0486  CL91 PaTu 8988t C339(0.66)  LDD1365  [19]
 LDCM0487  CL92 PaTu 8988t C339(0.62)  LDD1366  [19]
 LDCM0488  CL93 PaTu 8988t C339(0.59)  LDD1367  [19]
 LDCM0489  CL94 PaTu 8988t C339(0.63)  LDD1368  [19]
 LDCM0490  CL95 PaTu 8988t C339(0.46)  LDD1369  [19]
 LDCM0491  CL96 PaTu 8988t C339(0.57)  LDD1370  [19]
 LDCM0492  CL97 PaTu 8988t C339(0.57)  LDD1371  [19]
 LDCM0493  CL98 PaTu 8988t C339(0.51)  LDD1372  [19]
 LDCM0494  CL99 PaTu 8988t C339(0.60)  LDD1373  [19]
 LDCM0495  E2913 HEK-293T C52(1.07); C377(0.97); C339(0.84)  LDD1698  [20]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0625  F8 Ramos C358(1.71); C377(0.64)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C377(0.09)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C377(1.64)  LDD1392  [23]
 LDCM0574  Fragment12 Ramos C358(0.73); C377(0.07)  LDD2191  [22]
 LDCM0575  Fragment13 MDA-MB-231 C377(2.06); C358(1.45)  LDD1395  [23]
 LDCM0576  Fragment14 MDA-MB-231 C358(0.89)  LDD1397  [23]
 LDCM0577  Fragment15 MDA-MB-231 C358(1.08)  LDD1399  [23]
 LDCM0579  Fragment20 Ramos C377(0.09)  LDD2194  [22]
 LDCM0580  Fragment21 MDA-MB-231 C377(1.42); C358(1.24)  LDD1404  [23]
 LDCM0581  Fragment22 MDA-MB-231 C377(1.71); C358(1.72)  LDD1406  [23]
 LDCM0582  Fragment23 MDA-MB-231 C377(1.54)  LDD1408  [23]
 LDCM0583  Fragment24 Ramos C377(1.45); C358(0.91)  LDD1410  [23]
 LDCM0584  Fragment25 MDA-MB-231 C377(0.98); C358(0.90)  LDD1411  [23]
 LDCM0578  Fragment27 MDA-MB-231 C377(0.96); C358(0.32)  LDD1401  [23]
 LDCM0586  Fragment28 MDA-MB-231 C377(1.27); C358(1.05)  LDD1415  [23]
 LDCM0587  Fragment29 MDA-MB-231 C377(1.32)  LDD1417  [23]
 LDCM0588  Fragment30 MDA-MB-231 C377(1.42); C358(0.98)  LDD1419  [23]
 LDCM0589  Fragment31 MDA-MB-231 C377(2.21); C358(2.31)  LDD1421  [23]
 LDCM0590  Fragment32 MDA-MB-231 C358(1.90)  LDD1423  [23]
 LDCM0468  Fragment33 MDA-MB-231 C377(1.07)  LDD1425  [23]
 LDCM0596  Fragment38 MDA-MB-231 C377(1.00); C358(1.14)  LDD1433  [23]
 LDCM0566  Fragment4 MDA-MB-231 C377(3.53); C358(1.52)  LDD1378  [23]
 LDCM0599  Fragment41 MDA-MB-231 C377(1.11); C358(1.31)  LDD1438  [23]
 LDCM0602  Fragment44 MDA-MB-231 C377(0.69)  LDD1443  [23]
 LDCM0604  Fragment46 MDA-MB-231 C358(1.08)  LDD1445  [23]
 LDCM0605  Fragment47 MDA-MB-231 C377(1.64)  LDD1446  [23]
 LDCM0606  Fragment48 MDA-MB-231 C377(1.42)  LDD1447  [23]
 LDCM0427  Fragment51 PaTu 8988t C339(0.67)  LDD1306  [19]
 LDCM0610  Fragment52 Ramos C358(0.92); C377(0.52)  LDD2204  [22]
 LDCM0611  Fragment53 Ramos C377(1.09); C358(0.62)  LDD1455  [23]
 LDCM0614  Fragment56 MDA-MB-231 C377(1.16); C358(1.04)  LDD1458  [23]
 LDCM0568  Fragment6 MDA-MB-231 C358(1.21)  LDD1382  [23]
 LDCM0569  Fragment7 Ramos C358(0.83); C377(0.15)  LDD2186  [22]
 LDCM0570  Fragment8 MDA-MB-231 C377(5.14)  LDD1385  [23]
 LDCM0571  Fragment9 MDA-MB-231 C377(1.85); C358(1.92)  LDD1387  [23]
 LDCM0022  KB02 MDA-MB-231 C377(20.00); C358(20.00)  LDD1374  [23]
 LDCM0023  KB03 MDA-MB-231 C377(3.71); C358(1.21)  LDD1376  [23]
 LDCM0024  KB05 G361 C377(1.95)  LDD3311  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C377(0.72)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C377(0.79)  LDD2089  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C377(1.12)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C377(0.91)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C377(0.93)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C377(1.10)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C377(0.72)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C377(0.75)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C377(1.04)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C377(1.05)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C377(0.84)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C377(0.84)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C377(0.72)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C377(1.12)  LDD2116  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C377(2.31)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C377(0.77)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C377(1.18)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C377(0.95)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C377(0.95)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C377(0.97)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C377(0.70)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C377(1.04)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C377(1.04)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C377(1.36)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C377(0.97)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C377(0.97)  LDD2140  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C377(1.02)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C377(1.82)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C377(0.85)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C377(0.39)  LDD2150  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C377(1.13)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C377(0.62)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C52(1.10)  LDD0304  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related GTP-binding protein A (RRAGA) GTR/RAG GTP-binding protein family Q7L523
Ras-related GTP-binding protein B (RRAGB) GTR/RAG GTP-binding protein family Q5VZM2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutral amino acid transporter 9 (SLC38A9) Amino acid/polyamine transporter 2 family Q8NBW4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.