Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment53					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	1.6
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	1.6
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	1.5
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.4
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.3
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.3
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	1.2
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.2
LDTP02502	Thioredoxin (TXN)				C32	1.2
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.2
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	1.2
LDTP12190	NmrA-like family domain-containing protein 1 (NMRAL1)				C154	1.2
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	1.2
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.2
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.1
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.1
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.1
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.1
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.1
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.1
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.1
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	1.1
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C377	1.1
LDTP05289	AMP deaminase 2 (AMPD2)				C107	1.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.1
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.0
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.0
LDTP13147	Cathepsin Z (CTSZ)				C92	1.0
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.0
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.0
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.0
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	1.0
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.0
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.0
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.0
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.0
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.0
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.0
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	0.9
LDTP02672	Elongation factor 2 (EEF2)				C41	0.9
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.9
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	0.9
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	0.9
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	0.9
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C9	0.9
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	0.9
LDTP04689	Adenosine kinase (ADK)				C353	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.9
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	0.9
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	0.9
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.9
LDTP04424	Galactokinase (GALK1)				C182	0.9
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	0.9
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	0.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.8
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.8
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	0.8
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	0.8
LDTP02672	Elongation factor 2 (EEF2)				C136	0.8
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	0.8
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	0.8
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.8
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.7
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	0.7
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C358	0.6
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	0.6
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.4
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	1.3
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.1
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.0
LDTP00501	Exportin-1 (XPO1)				C34	1.0
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	0.9
LDTP04801	Gasdermin-D (GSDMD)				C268	0.9
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	0.8
LDTP00501	Exportin-1 (XPO1)				C528	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.2
LDTP05485	Recombining binding protein suppressor of hairless (RBPJ)				C313	1.0
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.0
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP14337	Protein strawberry notch homolog 1 (SBNO1)				C445	20.0
LDTP03244	Cofilin-1 (CFL1)				C80	1.4
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	1.2
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.2
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.2
LDTP05867	Treacle protein (TCOF1)				C38	1.2
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.2
LDTP04092	Crk-like protein (CRKL)				C249	1.1
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	1.1
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	1.1
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.1
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.1
LDTP05259	Heterogeneous nuclear ribonucleoprotein U (HNRNPU)				C562	1.1
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.1
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	1.1
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.1
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.0
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.0
LDTP13964	MOB-like protein phocein (MOB4)				C134	1.0
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.0
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	1.0
LDTP10864	Calponin-2 (CNN2)				C164	1.0
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	1.0
LDTP02205	Tubulin beta chain (TUBB)				C239	1.0
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.0
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.0
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	0.9
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	0.9
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	0.9
LDTP00202	AH receptor-interacting protein (AIP)				C122	0.9
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	0.9
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	0.9
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	0.9
LDTP10864	Calponin-2 (CNN2)				C215	0.9
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	0.9
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	0.9
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	0.9
LDTP13580	Coronin-1C (CORO1C)				C420	0.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	0.8
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	0.8
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	0.8
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.8
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	0.8
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	0.8
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	0.8
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	0.8
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	0.8
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.8
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	0.7
LDTP02205	Tubulin beta chain (TUBB)				C354	0.7
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	0.6

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.