Details of the Target

General Information of Target

Target ID LDTP03395
Target Name Large ribosomal subunit protein uL16 (RPL10)
Gene Name RPL10
Gene ID 6134
Synonyms
DXS648E; QM; Large ribosomal subunit protein uL16; 60S ribosomal protein L10; Laminin receptor homolog; Protein QM; Ribosomal protein L10; Tumor suppressor QM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQL
SSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAEKRLIPDGCGVKYIPSRGPLDKWRALHS
Target Bioclass
Other
Family
Universal ribosomal protein uL16 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
Uniprot ID
P27635
Ensemble ID
ENST00000344746.8
HGNC ID
HGNC:10298

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		1.56  LDD0453  [2]
P3
 Probe Info  		1.84  LDD0450  [2]
P8
 Probe Info  		2.47  LDD0455  [2]
A-EBA
 Probe Info  		3.82  LDD0215  [3]
CHEMBL5175495
 Probe Info  		6.51  LDD0196  [4]
CY-1
 Probe Info  		3.06  LDD0243  [5]
CY4
 Probe Info  		4.62  LDD0244  [5]
N1
 Probe Info  		3.32  LDD0242  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
AZ-9
 Probe Info  		E182(0.94)  LDD2208  [7]
ONAyne
 Probe Info  		K30(0.00); K121(0.00); K101(0.00); K208(0.00)  LDD0273  [8]
Probe 1
 Probe Info  		Y17(54.70)  LDD3495  [9]
JZ128-DTB
 Probe Info  		C49(0.00); C195(0.00)  LDD0462  [10]
THZ1-DTB
 Probe Info  		C49(0.98)  LDD0460  [10]
BTD
 Probe Info  		C105(1.49); C195(1.03)  LDD1700  [11]
AHL-Pu-1
 Probe Info  		C105(2.11)  LDD0168  [12]
EA-probe
 Probe Info  		C49(1.07)  LDD2210  [13]
HHS-482
 Probe Info  		Y57(0.62)  LDD0285  [14]
HHS-465
 Probe Info  		Y57(6.23)  LDD2237  [15]
DBIA
 Probe Info  		C105(1.77); C49(1.34); C195(1.04)  LDD0078  [16]
AMP probe
 Probe Info  		N.A.  LDD0200  [17]
ATP probe
 Probe Info  		K188(0.00); K121(0.00); K101(0.00); K82(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C49(0.00); C195(0.00); C105(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C49(0.00); C105(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		C49(0.00); C105(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C49(0.00); C195(0.00); C105(0.00)  LDD0037  [18]
JW-RF-010
 Probe Info  		C195(0.00); C105(0.00); C49(0.00); C80(0.00)  LDD0026  [21]
NAIA_4
 Probe Info  		C71(0.00); C105(0.00); C49(0.00)  LDD2226  [22]
TFBX
 Probe Info  		C49(0.00); C80(0.00); C105(0.00); C195(0.00)  LDD0027  [21]
WYneN
 Probe Info  		C195(0.00); C105(0.00)  LDD0021  [23]
WYneO
 Probe Info  		C195(0.00); C105(0.00)  LDD0022  [23]
1d-yne
 Probe Info  		K42(0.00); K175(0.00)  LDD0356  [24]
Compound 10
 Probe Info  		C105(0.00); C49(0.00)  LDD2216  [25]
Compound 11
 Probe Info  		N.A.  LDD2213  [25]
ENE
 Probe Info  		C195(0.00); C105(0.00)  LDD0006  [23]
IPM
 Probe Info  		C195(0.00); C49(0.00); C105(0.00)  LDD0005  [23]
NHS
 Probe Info  		K188(0.00); K145(0.00)  LDD0010  [23]
SF
 Probe Info  		K169(0.00); K121(0.00); K158(0.00)  LDD0028  [26]
STPyne
 Probe Info  		K145(0.00); K101(0.00); K82(0.00)  LDD0009  [23]
Phosphinate-6
 Probe Info  		C49(0.00); C80(0.00); C23(0.00); C105(0.00)  LDD0018  [27]
1c-yne
 Probe Info  		K175(0.00); K42(0.00); C49(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		C49(0.00); H51(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [28]
Methacrolein
 Probe Info  		C195(0.00); C80(0.00)  LDD0218  [28]
W1
 Probe Info  		C105(0.00); C195(0.00)  LDD0236  [29]
AOyne
 Probe Info  		15.00  LDD0443  [30]
NAIA_5
 Probe Info  		C49(0.00); C23(0.00); C71(0.00); C105(0.00)  LDD2223  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C105(0.81); C195(0.81)  LDD2112  [11]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C105(1.25); C195(0.84)  LDD2117  [11]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C105(0.88); C195(0.79)  LDD2103  [11]
 LDCM0025  4SU-RNA HEK-293T C105(2.11)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA DM93 C49(4.46); C105(2.38)  LDD0171  [12]
 LDCM0214  AC1 HCT 116 C105(1.12); C195(1.03); C49(1.08)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C105(1.38); C195(1.01); C49(0.87)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C105(1.11); C195(1.03); C49(0.72); C80(0.78)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C105(1.17); C195(0.99); C49(0.73); C80(0.70)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C105(1.08); C195(0.97); C49(0.65); C80(0.83)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C105(1.29); C195(1.19); C49(0.89); C80(1.11)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C105(0.96); C195(1.03); C49(0.68); C80(0.86)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C105(1.24); C195(1.08); C49(0.79); C80(1.07)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C105(1.25); C195(1.16); C49(0.65); C80(0.26)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C105(1.17); C195(1.22); C49(0.69); C80(0.60)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C105(1.19); C195(1.04); C49(0.65); C80(1.69)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C105(0.96); C195(0.86); C49(0.90); C80(1.18)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C105(1.30); C195(0.98); C49(0.88)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C105(1.27); C195(0.95); C49(0.72); C80(1.42)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C105(1.26); C195(0.96); C49(0.87); C80(1.28)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C105(1.09); C195(1.16); C49(0.67); C80(0.79)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C105(0.94); C195(0.98); C49(0.94); C71(1.07)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C105(1.13); C195(1.12); C49(0.97); C71(1.40)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C105(1.23); C195(1.15); C49(1.02); C71(0.91)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C105(1.15); C195(1.13); C49(1.04); C71(1.23)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C105(0.89); C195(1.03); C49(0.99); C71(1.03)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C105(1.00); C195(1.02); C49(1.16); C71(1.06)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C105(1.04); C195(1.09); C49(0.80); C71(1.36)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C105(1.18); C195(0.88); C49(0.79)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C105(1.03); C195(1.10); C49(0.80); C71(0.52)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C105(0.76); C195(0.98); C49(0.82); C71(1.18)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C105(0.94); C195(1.10); C49(0.98); C71(1.15)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C105(0.83); C195(1.01); C49(0.85); C71(0.87)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C105(0.87); C195(0.96); C49(1.15); C71(0.80)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C105(0.99); C195(1.03); C49(0.80); C71(0.59)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C105(0.98); C195(1.12); C49(0.81); C71(1.22)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C105(0.90); C195(1.14); C49(0.91); C71(0.91)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C105(1.05); C195(1.00); C49(1.04); C80(1.66)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C105(0.82); C195(0.77); C49(1.22); C80(0.91)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C105(1.11); C195(0.93); C49(1.21); C80(1.17)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C105(0.86); C195(0.78); C49(1.30); C80(0.99)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C105(1.08); C195(0.83); C49(0.93); C80(1.03)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C105(0.90); C195(0.90); C49(1.06); C80(1.37)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C105(1.08); C195(0.95); C49(1.37); C80(1.11)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C105(1.20); C195(0.95); C49(1.30); C80(1.46)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C105(1.10); C195(0.97); C49(1.15); C80(1.23)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C105(0.96); C195(0.89); C49(1.01); C80(1.53)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C105(1.19); C195(0.97); C49(1.27); C80(1.23)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C105(1.19); C195(0.93); C49(1.06); C80(1.31)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C105(1.20); C195(0.89); C49(0.99)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C105(1.37); C195(0.98); C49(1.08); C80(1.52)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C105(1.25); C195(0.96); C49(1.23); C80(1.23)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C105(1.01); C195(0.84); C49(1.21); C80(1.32)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C49(1.01); C105(1.12); C195(1.14)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C105(0.74); C49(1.06); C195(1.26)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C105(0.86); C49(1.01); C195(1.04)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C105(0.92); C49(1.14); C195(1.18)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C105(0.88); C49(1.14); C195(1.21)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C105(0.77); C49(1.40); C195(1.56)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C105(0.77); C49(1.21); C195(1.27)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C195(0.97); C49(0.99); C105(1.12)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C105(0.82); C195(1.03); C49(1.32)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C49(1.00); C105(1.03); C195(1.09)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C105(0.74); C49(0.96); C195(1.29)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C105(0.95); C49(1.35); C195(1.73)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C105(0.89); C195(1.18); C49(1.32)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C105(1.13); C195(1.24); C49(0.93)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C105(0.96); C195(1.03); C49(1.14)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C105(0.86); C195(1.00); C49(1.22)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C80(0.77); C71(0.79); C49(0.80); C195(1.00)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C71(0.65); C49(0.95); C195(1.08); C80(1.10)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C71(0.72); C80(0.78); C49(0.81); C195(0.95)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C49(0.90); C195(0.99); C105(1.09)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C71(0.96); C49(1.01); C80(1.04); C195(1.04)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C80(0.69); C71(0.80); C49(1.06); C195(1.21)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C71(0.54); C49(0.98); C80(1.07); C105(1.13)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C71(0.81); C49(0.86); C80(0.95); C195(0.96)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C71(0.67); C80(0.81); C49(0.87); C105(0.97)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C49(0.84); C195(1.01); C105(1.12)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C195(1.12); C49(1.12); C105(1.17)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C49(1.09); C195(1.14); C105(1.20)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C49(0.89); C105(1.15); C195(1.20)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C49(1.09); C105(1.26); C195(1.31)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C49(0.84); C195(0.98); C105(1.08)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C49(1.04); C195(1.28); C105(1.34)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C49(1.15); C195(1.17); C105(1.26)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C49(0.97); C195(1.26); C105(1.59)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C49(1.06); C195(1.31); C105(1.32)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C49(1.16); C195(1.25); C105(1.45)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C49(0.81); C105(0.89); C195(0.95); C71(0.99)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C49(0.87); C105(1.02); C195(1.05); C71(1.24)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C71(0.90); C80(1.02); C195(1.02); C49(1.03)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C49(0.63); C195(0.99); C80(1.04); C71(1.08)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C49(0.59); C105(1.03); C195(1.14); C71(1.36)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C49(1.05); C195(1.05); C105(1.21)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C49(0.87); C105(1.03); C195(1.15); C71(1.32)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C49(0.63); C71(0.98); C105(1.01); C195(1.20)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C49(0.86); C105(0.97); C195(1.05); C71(1.10)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C49(0.98); C105(1.06); C195(1.18); C71(1.38)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C105(0.98); C49(1.04); C195(1.08); C71(1.14)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C49(0.73); C71(1.00); C105(1.01); C195(1.19)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C80(1.03); C49(1.07); C105(1.25); C195(1.58)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C49(0.86); C80(1.03); C105(1.18); C195(1.29)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C49(0.77); C80(1.10); C105(1.23); C195(1.38)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C49(1.23); C105(1.25); C195(1.29); C80(1.55)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C49(1.01); C195(1.01); C105(1.20)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C105(1.13); C80(1.19); C49(1.21); C195(1.35)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C49(1.00); C80(1.21); C105(1.25); C195(1.38)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C80(1.07); C105(1.08); C49(1.10); C195(1.57)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C105(0.99); C49(1.13); C80(1.29); C195(1.31)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C80(1.06); C49(1.09); C105(1.09); C195(1.49)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C105(1.12); C49(1.27); C80(1.40); C195(1.66)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C105(1.11); C49(1.36); C80(1.55); C195(1.76)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C195(1.05); C105(1.13); C49(1.40)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C195(1.14); C105(1.18); C49(1.41)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C195(1.00); C105(1.21); C49(1.27)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C195(1.08); C49(1.10); C105(1.16)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C195(1.13); C105(1.28); C49(1.31)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C105(1.13); C195(1.18); C49(2.00)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C195(1.05); C49(1.30); C105(1.32)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C195(1.09); C105(1.14); C49(1.28)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C195(1.07); C105(1.23); C49(1.25)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C195(0.96); C49(1.19); C105(1.36)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C195(0.88); C49(1.24); C105(1.32)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C195(1.03); C49(1.18); C105(1.40)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C105(0.88); C49(1.06); C80(1.19); C195(1.26)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C105(0.93); C49(1.05); C80(1.08); C195(1.34)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C195(0.95); C49(1.14); C105(1.23)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C49(1.03); C105(1.09); C80(1.16); C195(1.47)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C105(0.91); C49(1.00); C80(1.10); C195(1.19)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C80(1.04); C49(1.05); C105(1.11); C195(1.42)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C105(1.16); C49(1.39); C80(1.47); C195(1.65)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C105(0.97); C49(1.32); C195(1.48); C80(1.50)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C105(1.08); C80(1.34); C49(1.65); C195(1.68)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C105(0.92); C80(1.00); C49(1.07); C195(1.28)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C105(0.98); C80(1.11); C49(1.18); C195(1.38)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C80(0.94); C105(1.01); C49(1.14); C195(1.47)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C80(0.95); C105(0.98); C49(1.03); C195(1.35)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C195(0.96); C49(0.98); C105(1.30)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C105(0.93); C80(1.01); C49(1.04); C195(1.23)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C80(0.66); C105(0.93); C49(1.09); C195(1.34)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C105(0.90); C80(1.50); C49(1.56); C195(1.80)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C71(0.71); C49(1.42); C105(1.56); C195(1.57)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C71(1.00); C49(1.11); C80(1.46); C195(1.50)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C49(1.12); C80(1.28); C71(1.35); C195(1.37)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C80(0.93); C49(1.08); C195(1.21); C71(1.26)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C49(0.83); C80(0.94); C71(0.98); C105(1.11)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C49(0.85); C80(1.04); C195(1.18); C105(1.29)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C80(0.85); C49(1.06); C71(1.18); C195(1.25)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C49(0.82); C80(1.08); C105(1.12); C195(1.12)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C71(1.10); C49(1.30); C80(1.34); C195(1.51)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C71(1.03); C49(1.06); C80(1.23); C195(1.48)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C49(0.86); C80(1.08); C71(1.09); C105(1.29)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C71(0.90); C49(1.04); C195(1.20); C105(1.22)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C80(0.97); C49(1.08); C71(1.15); C105(1.15)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C80(0.98); C71(1.03); C49(1.06); C105(1.26)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C71(0.96); C80(1.15); C49(1.18); C195(1.47)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C49(0.81); C80(1.14); C195(1.34); C105(1.38)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C80(0.76); C49(0.81); C195(1.03); C105(1.21)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C105(1.12); C195(1.07); C49(0.81)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C49(0.95); C195(1.01); C105(1.30)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C195(1.16); C49(1.31); C105(1.54)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C105(1.77); C49(1.34); C195(1.04)  LDD0078  [16]
 LDCM0498  BS-3668 MDA-MB-231 C105(0.61); C195(0.81)  LDD2091  [11]
 LDCM0108  Chloroacetamide HeLa C49(0.00); H51(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C80(2.03); C71(0.71); C105(0.65); C195(0.57)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C105(0.91); C195(0.95); C49(1.09); C71(1.26)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C105(0.84); C49(0.96); C195(1.02); C71(1.90)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C49(0.87); C195(1.00); C105(1.14)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C49(1.00); C195(1.03); C105(1.23)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C195(0.84); C49(0.85); C105(1.11)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C195(0.89); C49(0.93); C105(0.95)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C195(0.94); C49(1.06); C105(1.07)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C49(0.87); C71(1.00); C105(1.09); C195(1.10)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C71(0.80); C49(1.05); C195(1.25); C105(1.34)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C49(0.95); C71(1.10); C195(1.13); C80(1.29)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C71(0.85); C49(0.89); C80(1.13); C195(1.15)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C49(0.90); C71(0.91); C195(1.06); C80(1.06)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C105(0.80); C49(1.06); C195(1.07); C71(1.18)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C80(0.82); C49(0.89); C71(0.92); C195(1.04)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C71(0.81); C49(0.91); C195(0.96); C80(1.05)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C195(0.89); C49(0.99); C105(1.00)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C195(1.19); C105(1.24); C49(1.25)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C49(1.15); C195(1.16); C105(1.23)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C49(1.15); C105(1.27); C195(1.32)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C49(1.02); C105(1.21); C195(1.32)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C49(1.04); C105(1.13); C195(1.26); C71(1.54)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C49(0.97); C195(1.02); C105(1.04); C71(1.14)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C49(0.86); C105(1.01); C195(1.08); C71(1.33)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C105(0.86); C195(1.12); C71(1.68); C49(1.70)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C49(0.70); C105(1.04); C195(1.13); C71(1.21)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C49(0.88); C80(0.88); C105(1.10); C195(1.48)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C105(1.18); C49(1.30); C80(1.31); C195(1.58)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C49(0.95); C105(0.99); C80(1.17); C195(1.21)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C49(1.08); C105(1.22); C80(1.35); C195(1.58)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C195(0.90); C105(1.05); C49(1.24)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C105(1.07); C195(1.08); C49(1.20)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C195(1.03); C105(1.08); C49(1.65)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C195(0.97); C49(1.03); C105(1.09)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C105(0.90); C49(1.03); C195(1.08); C71(1.73)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C71(0.48); C105(0.87); C49(0.88); C195(0.97)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C105(0.85); C195(0.99); C71(1.16); C49(1.31)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C71(0.91); C80(0.95); C195(0.99); C49(1.10)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C71(0.94); C195(0.94); C105(0.97); C80(1.08)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C71(1.03); C80(1.09); C195(1.25); C49(1.26)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C71(1.03); C49(1.05); C195(1.07); C80(1.09)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C49(0.90); C105(0.91); C195(0.96); C71(1.15)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C195(0.98); C71(0.98); C80(1.07); C49(1.27)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C71(0.96); C49(1.01); C80(1.01); C195(1.08)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C80(0.85); C71(0.94); C195(1.18); C49(1.27)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C71(0.64); C49(0.95); C80(0.98); C105(1.01)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C105(1.40); C195(1.18); C49(1.09); C71(1.20)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C105(1.42); C195(1.09); C49(0.84); C71(0.95)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C105(1.58); C195(1.04); C49(0.87); C71(1.04)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C105(1.35); C195(1.06); C49(0.94); C71(1.03)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C105(1.34); C195(1.00); C49(0.88); C71(1.08)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C105(1.34); C195(1.09); C49(1.03); C71(0.54)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C105(0.86); C195(0.90); C49(0.74); C71(1.44)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C105(1.27); C195(1.00); C49(0.93); C71(0.33)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C105(0.95); C195(0.93); C49(1.25); C71(0.99)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C105(1.15); C195(1.06); C49(1.53); C71(0.98)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C105(1.09); C195(1.00); C49(1.28); C71(0.23)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C105(1.15); C195(1.08); C49(1.50); C71(1.20)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C105(1.06); C195(1.13); C49(1.76); C71(1.41)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C105(0.82); C195(1.02); C49(1.40); C71(0.93)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C105(1.06); C195(1.22); C49(1.56); C71(1.27)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C105(1.24); C195(1.05); C49(1.18); C71(0.32)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C105(0.79); C195(0.83); C49(0.77); C71(1.32)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C105(0.89); C195(0.86); C49(1.38); C71(0.92)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C105(0.91); C195(0.95); C49(1.43); C71(1.13)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C105(0.75); C195(0.92); C49(1.97); C71(0.31)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C105(1.09); C195(1.03); C49(1.57); C71(1.16)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C105(0.93); C195(1.04); C49(1.37); C71(1.28)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C105(0.87); C195(0.98); C49(1.21); C71(1.28)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C105(1.04); C195(0.83); C49(0.78); C71(1.09)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C105(1.10); C195(1.03); C49(0.90); C71(0.95)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C105(1.05); C195(0.84); C49(1.00); C71(0.47)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C105(1.04); C195(0.80); C49(0.72); C71(0.88)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C105(0.78); C195(0.94); C49(0.90); C71(0.99)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C105(1.04); C195(0.90); C49(0.93); C71(1.05)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C105(1.08); C195(0.83); C49(0.94); C71(1.07)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C105(1.07); C195(0.92); C49(0.91); C71(1.35)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C105(1.05); C195(0.81); C49(1.49); C71(0.92)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C105(1.07); C195(0.76); C49(0.92); C71(1.06)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C105(0.96); C195(0.80); C49(0.91); C71(0.97)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C105(1.07); C195(0.91); C49(1.14); C71(1.05)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C105(0.92); C195(0.84); C49(1.36); C71(1.04)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C105(1.13); C195(0.90); C49(0.89); C71(0.99)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C105(1.06); C195(0.97); C49(0.99); C71(1.06)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C105(0.86); C195(1.12); C49(1.47); C71(1.13)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C105(1.11); C195(0.99); C49(1.04); C71(0.98)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C105(1.13); C195(0.95); C49(0.85); C80(0.87)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C105(1.17); C195(0.93); C49(0.81); C80(1.09)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C105(1.26); C195(1.25); C49(0.90); C80(1.16)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C105(1.25); C195(1.01); C49(0.97); C80(1.05)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C105(1.13); C195(1.05); C49(1.13); C80(1.08)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C105(1.38); C195(1.07); C49(0.97); C80(1.07)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C105(1.21); C195(1.17); C49(1.09); C80(1.07)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C105(1.20); C195(1.03); C49(1.16); C80(1.17)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C105(1.17); C195(0.98); C49(1.28); C80(0.99)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C105(0.83); C195(1.07); C49(0.94); C71(1.81)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C105(1.12); C195(1.19); C49(1.27); C80(0.99)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C105(1.21); C195(1.06); C49(0.99); C80(1.09)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C105(1.14); C195(1.02); C49(0.95); C80(1.06)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C105(1.14); C195(0.91); C49(1.00); C80(1.02)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C105(1.11); C195(1.03); C49(1.04); C80(1.07)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C105(1.13); C195(1.09); C49(1.25); C80(1.14)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C105(1.16); C195(1.03); C49(1.16); C80(1.32)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C105(1.20); C195(1.06); C49(1.02); C80(0.98)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C105(1.25); C195(1.10); C49(1.10); C80(1.03)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C105(0.90); C195(1.06); C49(1.33); C71(1.38)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C105(1.11); C195(1.14); C49(1.41); C80(0.66)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C105(1.18); C195(1.05); C49(1.09); C80(1.14)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C105(1.42); C195(1.25); C49(1.36); C80(0.83)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C105(1.39); C195(1.28); C49(1.29); C80(1.01)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C105(1.79); C195(1.36); C49(1.33); C80(1.04)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C105(1.18); C195(1.26); C49(1.30); C80(1.15)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C105(1.28); C195(1.20); C49(1.19); C80(1.10)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C105(1.26); C195(1.20); C49(1.18); C80(1.07)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C105(1.39); C195(1.34); C49(1.25); C80(1.10)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C105(1.80); C195(1.44); C49(1.50); C80(0.91)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C105(1.02); C195(1.08); C49(1.18); C71(0.62)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C105(0.98); C195(0.84); C49(1.05); C80(0.53)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C105(1.07); C195(1.13); C49(0.92)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C105(1.22); C195(1.09); C49(0.92)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C105(1.08); C195(1.04); C49(0.93)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C105(1.13); C195(1.02); C49(0.97)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C105(1.12); C195(1.09); C49(0.94)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C105(1.06); C195(1.07); C49(1.01)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C105(1.11); C195(0.93); C49(1.00)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C105(1.19); C195(0.98); C49(0.93)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C105(1.17); C195(0.93); C49(0.85)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C105(0.89); C195(1.00); C49(0.99); C80(0.86)  LDD1698  [31]
 LDCM0175  Ethacrynic acid HeLa C49(1.07)  LDD2210  [13]
 LDCM0625  F8 Ramos C105(1.24); C195(1.72); C71(1.24); C49(1.02)  LDD2187  [32]
 LDCM0572  Fragment10 MDA-MB-231 C105(2.59)  LDD1389  [33]
 LDCM0573  Fragment11 MDA-MB-231 C105(1.96)  LDD1391  [33]
 LDCM0574  Fragment12 Ramos C105(1.92); C195(1.35); C71(0.93); C49(1.32)  LDD2191  [32]
 LDCM0575  Fragment13 MDA-MB-231 C105(1.41)  LDD1395  [33]
 LDCM0576  Fragment14 MDA-MB-231 C105(2.32)  LDD1397  [33]
 LDCM0577  Fragment15 Ramos C105(1.99)  LDD1400  [33]
 LDCM0579  Fragment20 MDA-MB-231 C105(1.17)  LDD1402  [33]
 LDCM0580  Fragment21 MDA-MB-231 C105(1.56)  LDD1404  [33]
 LDCM0581  Fragment22 MDA-MB-231 C105(1.44)  LDD1406  [33]
 LDCM0582  Fragment23 MDA-MB-231 C105(1.92)  LDD1408  [33]
 LDCM0584  Fragment25 MDA-MB-231 C105(0.92)  LDD1411  [33]
 LDCM0578  Fragment27 MDA-MB-231 C105(0.87)  LDD1401  [33]
 LDCM0586  Fragment28 MDA-MB-231 C105(0.93)  LDD1415  [33]
 LDCM0587  Fragment29 MDA-MB-231 C105(1.48)  LDD1417  [33]
 LDCM0588  Fragment30 MDA-MB-231 C105(1.12)  LDD1419  [33]
 LDCM0589  Fragment31 MDA-MB-231 C105(2.26)  LDD1421  [33]
 LDCM0590  Fragment32 MDA-MB-231 C105(2.94)  LDD1423  [33]
 LDCM0468  Fragment33 HCT 116 C105(1.18); C195(0.97); C49(1.00); C80(0.87)  LDD0785  [16]
 LDCM0592  Fragment34 Ramos C105(1.04)  LDD1428  [33]
 LDCM0593  Fragment35 Ramos C105(0.85)  LDD1430  [33]
 LDCM0594  Fragment36 MDA-MB-231 C105(1.38)  LDD1431  [33]
 LDCM0595  Fragment37 Ramos C105(0.86)  LDD1432  [33]
 LDCM0596  Fragment38 MDA-MB-231 C105(1.09)  LDD1433  [33]
 LDCM0566  Fragment4 MDA-MB-231 C105(2.71)  LDD1378  [33]
 LDCM0599  Fragment41 Ramos C105(0.95)  LDD1439  [33]
 LDCM0600  Fragment42 Ramos C105(1.04)  LDD1440  [33]
 LDCM0601  Fragment43 MDA-MB-231 C105(2.21)  LDD1441  [33]
 LDCM0603  Fragment45 MDA-MB-231 C105(5.63)  LDD1444  [33]
 LDCM0605  Fragment47 MDA-MB-231 C105(1.12)  LDD1446  [33]
 LDCM0606  Fragment48 MDA-MB-231 C105(1.15)  LDD1447  [33]
 LDCM0427  Fragment51 HCT 116 C105(0.64); C195(1.07); C49(1.52); C71(1.09)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C105(1.36)  LDD1453  [33]
 LDCM0611  Fragment53 MDA-MB-231 C105(1.12)  LDD1454  [33]
 LDCM0614  Fragment56 MDA-MB-231 C105(1.21)  LDD1458  [33]
 LDCM0569  Fragment7 Ramos C105(1.99)  LDD1384  [33]
 LDCM0570  Fragment8 MDA-MB-231 C105(2.31)  LDD1385  [33]
 LDCM0571  Fragment9 MDA-MB-231 C105(2.12)  LDD1387  [33]
 LDCM0015  HNE MDA-MB-231 C195(0.95); C49(1.00); C80(1.52)  LDD0346  [32]
 LDCM0107  IAA HeLa N.A.  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y57(0.62)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y57(0.40)  LDD0286  [14]
 LDCM0126  JWB150 DM93 Y57(2.75)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y57(1.69)  LDD0289  [14]
 LDCM0129  JWB202 DM93 Y57(0.22)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y57(0.52)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 C49(0.00); C195(0.00)  LDD0462  [10]
 LDCM0022  KB02 HCT 116 C195(2.94); C105(3.75); C49(1.95)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C195(3.08); C105(4.36); C49(3.85)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C195(4.40); C105(3.92); C49(3.71)  LDD0082  [16]
 LDCM0109  NEM HeLa N.A.  LDD0223  [28]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C105(1.34); C195(1.20)  LDD2090  [11]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C105(0.56); C195(0.67)  LDD2108  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C105(0.91); C195(0.64)  LDD2123  [11]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C105(0.82)  LDD2128  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C105(1.13); C195(0.75)  LDD2129  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C105(1.16); C195(0.74)  LDD2135  [11]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C105(1.49); C195(1.03)  LDD1700  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C105(0.78); C195(0.76)  LDD2140  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C105(0.95); C195(0.72)  LDD2146  [11]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C105(0.43)  LDD2150  [11]
 LDCM0627  NUDT7-COV-1 HEK-293T C49(2.09); C105(1.09); C49(1.05); C105(0.96)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C195(1.06); C80(0.93); C49(0.87); C195(0.86)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C49(1.52); C195(1.28)  LDD0304  [35]
 LDCM0021  THZ1 HeLa S3 C49(0.98)  LDD0460  [10]
 LDCM0110  W12 Hep-G2 C105(1.67)  LDD0237  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.