Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment52  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 20.0
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 17.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 5.9
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 2.5
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 2.4
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 2.3
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.0
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.9
 LDTP02502  Thioredoxin (TXN) C32 1.9
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.8
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.8
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.7
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.7
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.6
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 1.5
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.5
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.5
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.4
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.4
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.4
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.4
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.4
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.4
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.3
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.3
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.3
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.3
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.3
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.3
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 1.3
 LDTP02672  Elongation factor 2 (EEF2) C136 1.3
 LDTP04689  Adenosine kinase (ADK) C353 1.2
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 1.2
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.2
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.2
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.2
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.2
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.2
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.2
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 1.2
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 1.2
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.2
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.1
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.1
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.1
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 2.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.4
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.4
 LDTP04801  Gasdermin-D (GSDMD) C268 1.3
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.2
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.0
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02016  Glucocorticoid receptor (NR3C1) C302 1.8
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.8
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.3
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 20.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 20.0
 LDTP05867  Treacle protein (TCOF1) C1298 17.8
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 12.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 3.6
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 3.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.8
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 2.5
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 2.3
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.3
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 2.1
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.8
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.8
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.7
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 1.7
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.6
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.5
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.5
 LDTP04092  Crk-like protein (CRKL) C249 1.5
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.5
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.5
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.4
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.4
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.4
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.4
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 1.3
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.3
 LDTP02205  Tubulin beta chain (TUBB) C354 1.3
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.3
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.3
 LDTP10864  Calponin-2 (CNN2) C215 1.3
 LDTP02205  Tubulin beta chain (TUBB) C239 1.3
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.3
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 1.3
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.2
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.2
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.2
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.1
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.1
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.1
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.0
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.9
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.8

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.