Details of the Target

General Information of Target

Target ID LDTP17082
Target Name Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)
Gene Name IAH1
Gene ID 285148
Synonyms
Isoamyl acetate-hydrolyzing esterase 1 homolog; EC 3.1.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGCKIGPSILNSDLANLGAKCLQMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQ
LGQDPFFDMHMMVSKPEQWVKPMAVAEANQYTFHLEATENPGTLIKDIRENGMKVGLAIK
PGTSVEYLAPWANQIDMALVMTVEPGFGEQKFMEDMMPKVHWLRTQFPSLDIEGDGGVGS
DTVHKCAEAGANMTVSGSAIMRSEDPRSVINLLRNICSEAAQKRSLDR
Target Bioclass
Enzyme
Family
'GDSL' lipolytic enzyme family, IAH1 subfamily
Function Probable lipase.
Uniprot ID
Q2TAA2
Ensemble ID
ENST00000470914.5
HGNC ID
HGNC:27696

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 Deletion: p.I78PfsTer12 .
HDQP1 SNV: p.R17C .
HT SNV: p.Y117C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K46(2.94); K63(10.00)  LDD0277  [2]
BTD
 Probe Info  		C47(1.17)  LDD1700  [3]
HHS-475
 Probe Info  		Y229(1.04)  LDD0264  [4]
IPM
 Probe Info  		C137(0.97)  LDD1702  [3]
HHS-465
 Probe Info  		Y229(2.41)  LDD2237  [5]
DBIA
 Probe Info  		C137(0.84); C150(0.84)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C47(0.00); C137(0.00); C145(0.00); C150(0.00)  LDD0037  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
1d-yne
 Probe Info  		N.A.  LDD0356  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		C47(0.00); C9(0.00)  LDD2223  [11]
HHS-482
 Probe Info  		Y229(0.68)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C47(0.68)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C47(1.00)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C47(0.81)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C47(0.98)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C47(0.80)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C47(1.13)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C47(0.43)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C47(0.89)  LDD2131  [3]
 LDCM0214  AC1 HEK-293T C137(0.99)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C137(1.09)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C137(0.80); C150(0.80)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C137(0.99); C150(0.99)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C137(1.06); C150(1.06)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C137(0.98); C150(0.98)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C137(1.54); C150(1.54)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C137(1.30); C150(1.30)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C137(1.04); C150(1.04)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C137(1.32); C150(1.32)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C137(0.65); C150(0.65)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C137(0.79); C150(0.79)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C137(1.00)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C137(0.90); C150(0.90)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C137(1.03); C150(1.03)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C137(1.09); C150(1.09)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C137(1.09)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C137(1.17)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C137(1.22)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C137(1.11)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C137(1.15)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C137(1.22)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C137(1.32)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C137(1.05)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C137(1.30)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C137(1.35)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C137(1.48)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C137(1.62)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C137(1.39)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C137(1.31)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C137(1.66)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C137(1.62)  LDD0843  [6]
 LDCM0246  AC128 PaTu 8988t C145(0.52); C137(0.61); C150(0.61)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C145(0.84); C137(0.76); C150(0.76)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C145(0.90); C137(0.82); C150(0.82)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C145(0.73); C137(0.74); C150(0.74)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C145(1.04); C137(0.95); C150(0.95)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C145(0.78); C137(0.62); C150(0.62)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C145(0.74); C137(0.79); C150(0.79)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C145(0.46); C137(0.62); C150(0.62)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C145(0.75); C137(0.75); C150(0.75)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C145(0.90); C137(0.77); C150(0.77)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C145(0.64); C137(0.75); C150(0.75)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C145(0.91); C137(0.81); C150(0.81)  LDD1137  [6]
 LDCM0259  AC14 HEK-293T C137(1.16)  LDD0857  [6]
 LDCM0260  AC140 PaTu 8988t C145(0.86); C137(0.89); C150(0.89)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C145(0.96); C137(0.85); C150(0.85)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C145(0.96); C137(0.89); C150(0.89)  LDD1141  [6]
 LDCM0263  AC143 HCT 116 C137(0.94); C150(0.94)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C137(1.15); C150(1.15)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C137(0.98); C150(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C137(1.34); C150(1.34)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C137(1.27); C150(1.27)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C137(2.13); C150(2.13)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C137(1.41); C150(1.41)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C137(1.25)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C137(1.21); C150(1.21)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C137(1.08); C150(1.08)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C137(1.47); C150(1.47)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C137(1.51); C150(1.51)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C137(1.15); C150(1.15)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C137(0.83); C150(0.83)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C137(0.77); C150(0.77)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C137(0.98); C150(0.98)  LDD2161  [6]
 LDCM0276  AC17 HEK-293T C137(1.12)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C137(1.06)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C137(1.03)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C137(1.25)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C137(1.18)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C137(0.95)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C137(1.31)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C137(1.42)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C137(1.11)  LDD0882  [6]
 LDCM0285  AC25 PaTu 8988t C145(1.45); C137(1.43); C150(1.43)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C145(0.95); C137(1.10); C150(1.10)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C145(1.07); C137(1.19); C150(1.19)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C145(0.87); C137(1.22); C150(1.22)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C145(1.09); C137(1.24); C150(1.24)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C137(1.17)  LDD0888  [6]
 LDCM0291  AC30 PaTu 8988t C145(1.54); C137(1.46); C150(1.46)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C145(1.46); C137(1.40); C150(1.40)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C145(1.05); C137(0.98); C150(0.98)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C145(0.88); C137(1.04); C150(1.04)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C145(1.37); C137(1.27); C150(1.27)  LDD1174  [6]
 LDCM0296  AC35 HCT 116 C137(1.00); C150(1.00)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C137(0.96); C150(0.96)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C137(0.71); C150(0.71)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C137(0.77); C150(0.77)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C137(0.99); C150(0.99)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C137(1.09)  LDD0899  [6]
 LDCM0302  AC40 HCT 116 C137(0.87); C150(0.87)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C137(0.90); C150(0.90)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C137(1.01); C150(1.01)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C137(1.03); C150(1.03)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C137(1.05); C150(1.05)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C137(1.03); C150(1.03)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C137(0.92)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C137(1.06)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C137(1.12)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C137(1.10)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C137(1.14)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C137(1.18)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C137(1.33)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C137(1.19)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C137(0.98)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C137(1.22)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C137(1.11)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C137(1.01)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C137(1.38); C150(1.38)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C137(1.09); C150(1.09)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C137(1.33); C150(1.33)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C137(0.90)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C137(1.27); C150(1.27)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C137(1.37); C150(1.37)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C137(1.16); C150(1.16)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C137(1.21); C150(1.21)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C137(1.41); C150(1.41)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C137(1.87); C150(1.87)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C137(1.82); C150(1.82)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C137(1.61); C150(1.61)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C137(1.09)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C137(1.00)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C137(0.98)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C137(1.15)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C137(1.04)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C137(1.02)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C137(1.11)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C137(1.00)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C137(1.12)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C137(1.22)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C137(1.46)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C137(1.13)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C137(1.04)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C137(1.18)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C137(1.36)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C137(2.37)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C137(1.46)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C137(0.96)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C137(1.23)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C137(1.24)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C137(1.01)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C137(1.10)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C137(1.07)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C137(1.17)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C137(1.11)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C137(1.13)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C137(1.08)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C137(1.07)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C137(1.29)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C137(1.22)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C137(1.22)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C137(2.79)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C137(6.00); C150(6.00)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C137(0.80); C150(0.80)  LDD0683  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C47(0.58)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C137(0.99)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C137(1.34)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C137(1.01)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C137(0.84); C150(0.84)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C47(0.74)  LDD2091  [3]
 LDCM0630  CCW28-3 231MFP C137(1.11)  LDD2214  [12]
 LDCM0367  CL1 HEK-293T C137(0.82)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C47(0.89); C137(0.95)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C137(1.29)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C137(1.10)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C137(1.03)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C137(1.22)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C137(1.10)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C137(1.15)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C137(1.12)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C137(0.91)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C137(1.12)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C137(1.00)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C137(0.91)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C137(1.08)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C137(2.07)  LDD0979  [6]
 LDCM0382  CL112 PaTu 8988t C145(1.17); C137(1.26); C150(1.26)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C145(1.18); C137(1.24); C150(1.24)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C145(1.44); C137(1.56); C150(1.56)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C145(1.73); C137(1.72); C150(1.72)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C145(0.50); C137(0.69); C150(0.69)  LDD1265  [6]
 LDCM0387  CL117 HCT 116 C137(1.62); C150(1.62)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C137(1.04); C150(1.04)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C137(0.88); C150(0.88)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C137(0.99)  LDD1594  [13]
 LDCM0391  CL120 HCT 116 C137(0.80); C150(0.80)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C137(1.11)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C137(1.28)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C137(0.88)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C137(0.94)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C137(1.59); C150(1.59)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C137(1.46); C150(1.46)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C137(1.26); C150(1.26)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C137(1.09); C150(1.09)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C137(0.65)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C137(0.90)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C137(0.70)  LDD1606  [13]
 LDCM0403  CL16 HCT 116 C137(0.90); C150(0.90)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C137(1.02); C150(1.02)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C137(0.36); C150(0.36)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C137(0.55); C150(0.55)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C137(1.00)  LDD1611  [13]
 LDCM0408  CL20 HCT 116 C137(0.93); C150(0.93)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C137(0.65); C150(0.65)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C137(0.67); C150(0.67)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C137(0.80); C150(0.80)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C137(0.83); C150(0.83)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C137(0.91); C150(0.91)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C137(0.86); C150(0.86)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C137(0.87); C150(0.87)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C137(0.78); C150(0.78)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C137(0.56); C150(0.56)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C137(0.95)  LDD1622  [13]
 LDCM0419  CL30 HCT 116 C137(0.80); C150(0.80)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C137(1.24); C150(1.24)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C137(1.64); C150(1.64)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C137(1.59); C150(1.59)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C137(1.78); C150(1.78)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C137(1.66); C150(1.66)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C137(1.62); C150(1.62)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C137(1.92); C150(1.92)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C137(1.58); C150(1.58)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C137(0.93)  LDD1633  [13]
 LDCM0430  CL40 HCT 116 C137(1.53); C150(1.53)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C137(1.72); C150(1.72)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C137(2.27); C150(2.27)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C137(1.75); C150(1.75)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C137(1.58); C150(1.58)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C137(1.91); C150(1.91)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C137(0.61); C150(0.61)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C137(0.80); C150(0.80)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C137(0.71); C150(0.71)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C137(0.82); C150(0.82)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C137(1.20)  LDD1644  [13]
 LDCM0441  CL50 HCT 116 C137(0.69); C150(0.69)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C137(0.60); C150(0.60)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C137(0.70); C150(0.70)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C137(0.65); C150(0.65)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C137(0.52); C150(0.52)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C137(0.66); C150(0.66)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C137(0.89); C150(0.89)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C137(0.82); C150(0.82)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C137(0.73); C150(0.73)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C137(0.73); C150(0.73)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C47(1.17); C137(0.80)  LDD1654  [13]
 LDCM0452  CL60 HCT 116 C137(0.93); C150(0.93)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C137(0.93); C150(0.93)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C137(0.88); C150(0.88)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C137(0.96); C150(0.96)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C137(1.12); C150(1.12)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C137(1.13); C150(1.13)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C137(1.12); C150(1.12)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C137(1.26); C150(1.26)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C137(0.95); C150(0.95)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C137(0.76); C150(0.76)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C137(0.83)  LDD1665  [13]
 LDCM0463  CL70 HCT 116 C137(1.07); C150(1.07)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C137(1.05); C150(1.05)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C137(0.86); C150(0.86)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C137(0.96); C150(0.96)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C137(1.03); C150(1.03)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C137(0.94)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C137(0.87)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C137(0.75)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C137(0.83)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C137(0.89)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C137(0.78)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C137(0.78)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C137(0.98)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C137(0.92)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C137(0.84)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C137(0.70)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C137(0.60)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C137(0.82)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C137(0.84)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C137(0.78)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C137(1.10)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C137(0.94)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C137(1.07)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C137(0.87)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C137(1.02)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C137(1.55)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C137(1.45)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C137(1.12)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C137(1.38)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C137(1.16)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C137(1.14)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C137(0.92)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C137(0.97)  LDD1702  [3]
 LDCM0572  Fragment10 MDA-MB-231 C137(3.48)  LDD1389  [14]
 LDCM0573  Fragment11 MDA-MB-231 C137(5.93)  LDD1391  [14]
 LDCM0574  Fragment12 MDA-MB-231 C137(1.60)  LDD1393  [14]
 LDCM0575  Fragment13 MDA-MB-231 C137(1.06)  LDD1395  [14]
 LDCM0576  Fragment14 MDA-MB-231 C137(1.17)  LDD1397  [14]
 LDCM0577  Fragment15 Ramos C137(1.00)  LDD1400  [14]
 LDCM0579  Fragment20 MDA-MB-231 C137(1.56)  LDD1402  [14]
 LDCM0580  Fragment21 MDA-MB-231 C137(1.13)  LDD1404  [14]
 LDCM0581  Fragment22 MDA-MB-231 C137(1.43)  LDD1406  [14]
 LDCM0582  Fragment23 MDA-MB-231 C137(0.84)  LDD1408  [14]
 LDCM0583  Fragment24 Ramos C137(1.15)  LDD1410  [14]
 LDCM0584  Fragment25 MDA-MB-231 C137(1.03)  LDD1411  [14]
 LDCM0585  Fragment26 Ramos C137(0.83)  LDD1412  [14]
 LDCM0578  Fragment27 MDA-MB-231 C137(0.34)  LDD1401  [14]
 LDCM0586  Fragment28 MDA-MB-231 C137(0.94)  LDD1415  [14]
 LDCM0587  Fragment29 MDA-MB-231 C137(1.29)  LDD1417  [14]
 LDCM0588  Fragment30 MDA-MB-231 C137(1.22)  LDD1419  [14]
 LDCM0589  Fragment31 MDA-MB-231 C137(1.06)  LDD1421  [14]
 LDCM0590  Fragment32 MDA-MB-231 C137(2.02)  LDD1423  [14]
 LDCM0468  Fragment33 HCT 116 C137(1.38); C150(1.38)  LDD0785  [6]
 LDCM0592  Fragment34 MDA-MB-231 C137(0.82)  LDD1427  [14]
 LDCM0593  Fragment35 MDA-MB-231 C137(1.02)  LDD1429  [14]
 LDCM0595  Fragment37 Ramos C137(0.97)  LDD1432  [14]
 LDCM0596  Fragment38 MDA-MB-231 C137(1.03)  LDD1433  [14]
 LDCM0566  Fragment4 MDA-MB-231 C137(1.11)  LDD1378  [14]
 LDCM0598  Fragment40 MDA-MB-231 C137(0.84)  LDD1436  [14]
 LDCM0599  Fragment41 MDA-MB-231 C137(1.16)  LDD1438  [14]
 LDCM0600  Fragment42 Ramos C137(0.86)  LDD1440  [14]
 LDCM0601  Fragment43 MDA-MB-231 C137(2.35)  LDD1441  [14]
 LDCM0602  Fragment44 MDA-MB-231 C137(0.78)  LDD1443  [14]
 LDCM0604  Fragment46 MDA-MB-231 C137(0.91)  LDD1445  [14]
 LDCM0607  Fragment49 MDA-MB-231 C137(2.40)  LDD1448  [14]
 LDCM0608  Fragment50 MDA-MB-231 C137(1.84)  LDD1449  [14]
 LDCM0427  Fragment51 HCT 116 C137(1.52); C150(1.52)  LDD0744  [6]
 LDCM0610  Fragment52 MDA-MB-231 C137(0.83)  LDD1452  [14]
 LDCM0611  Fragment53 MDA-MB-231 C137(0.90)  LDD1454  [14]
 LDCM0612  Fragment54 MDA-MB-231 C137(1.15)  LDD1456  [14]
 LDCM0613  Fragment55 MDA-MB-231 C137(1.52)  LDD1457  [14]
 LDCM0614  Fragment56 MDA-MB-231 C137(1.11)  LDD1458  [14]
 LDCM0568  Fragment6 MDA-MB-231 C137(1.42)  LDD1382  [14]
 LDCM0569  Fragment7 MDA-MB-231 C137(0.95)  LDD1383  [14]
 LDCM0570  Fragment8 MDA-MB-231 C137(2.08)  LDD1385  [14]
 LDCM0571  Fragment9 MDA-MB-231 C137(1.18)  LDD1387  [14]
 LDCM0116  HHS-0101 DM93 Y229(1.04)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y229(0.91)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y229(1.04)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y229(1.41)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y229(1.32)  LDD0268  [4]
 LDCM0022  KB02 HCT 116 C137(1.86); C150(1.86)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C137(1.37); C150(1.37)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C137(1.13); C150(1.13)  LDD0082  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C47(0.98)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C47(0.85)  LDD2089  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C47(1.02)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C47(1.07)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C47(1.64)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C47(0.30)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C47(0.73)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C47(0.90)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C47(0.89)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C47(0.71)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C47(0.59)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C47(1.17)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C47(0.76)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C47(0.84)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C47(0.61)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C47(0.76)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C47(0.89)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C47(0.63)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C47(0.43)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C47(0.73)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C47(0.78)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C47(2.14)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C47(0.93)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C47(0.41)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C47(0.76)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C47(0.35)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C47(0.83)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C47(0.63)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C47(0.87)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C47(1.00)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C47(1.00)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C47(1.01)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C47(1.11)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C47(0.80)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C47(1.17)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C47(0.89)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C47(0.69)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C47(1.00)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C47(2.64)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C47(0.48)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C47(0.80)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C47(2.56)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C47(0.44)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C47(0.58)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C47(1.14)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C47(0.42)  LDD2151  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C137(0.69)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C137(0.52)  LDD2207  [15]
 LDCM0131  RA190 MM1.R C137(1.29)  LDD0304  [16]
 LDCM0021  THZ1 HCT 116 C137(0.92); C150(0.92)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) GDSL lipolytic enzyme family Q2TAA2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.