Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment54  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 74 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02502  Thioredoxin (TXN) C32 2.9
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.7
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 1.6
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.6
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 1.5
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) C691 1.5
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.4
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.4
 LDTP02672  Elongation factor 2 (EEF2) C41 1.4
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.3
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.3
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.3
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.3
 LDTP02223  Cathepsin B (CTSB) C211 1.3
 LDTP04374  Dynamin-2 (DNM2) C27 1.3
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 1.3
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.3
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.2
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.2
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.2
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.2
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.2
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.2
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.2
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.2
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.2
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.2
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 1.2
 LDTP06211  Caspase-8 (CASP8) C360 1.2
 LDTP13080  GMP reductase 2 (GMPR2) C186 1.2
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.2
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.2
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.1
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.1
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.1
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.1
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.1
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.1
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 1.1
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.1
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.1
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.1
 LDTP02672  Elongation factor 2 (EEF2) C136 1.1
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.1
 LDTP13147  Cathepsin Z (CTSZ) C173 1.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.1
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.1
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.1
 LDTP03496  Protein PML (PML) C389 1.1
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.0
 LDTP04689  Adenosine kinase (ADK) C353 1.0
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.0
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.7
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 1.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.1
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP04662  Exportin-2 (CSE1L) C842 1.0
 LDTP04801  Gasdermin-D (GSDMD) C268 1.0
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.0
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.0
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 1.2
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.2
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 1.2
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.0
Other
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 2.1
 LDTP04092  Crk-like protein (CRKL) C249 1.4
 LDTP02692  Plastin-3 (PLS3) C33 1.3
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.3
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.3
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.3
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 1.2
 LDTP10864  Calponin-2 (CNN2) C164 1.2
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.2
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.2
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 1.2
 LDTP13580  Coronin-1C (CORO1C) C420 1.2
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 1.2
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.2
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.2
 LDTP10864  Calponin-2 (CNN2) C215 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.1
 LDTP03620  Protein S100-A11 (S100A11) C91 1.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.1
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.1
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 1.1
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.1
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.1
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.1
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.1
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.1
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.1
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.1
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.1
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.1
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 1.1
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.1
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.1
 LDTP12412  Reticulon-4 (RTN4) C1101 1.1
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.1
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.1
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.0
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.0
 LDTP08885  Actin filament-associated protein 1 (AFAP1) C713 1.0
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 1.0
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.0
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.0

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.