Details of the Target

General Information of Target

Target ID LDTP04265
Target Name Serine--tRNA ligase, cytoplasmic (SARS1)
Gene Name SARS1
Gene ID 6301
Synonyms
SARS; SERS; Serine--tRNA ligase, cytoplasmic; EC 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
Target Bioclass
Enzyme
Family
Class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily
Subcellular location
Cytoplasm
Function
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Uniprot ID
P49591
Ensemble ID
ENST00000234677.7
HGNC ID
HGNC:10537
ChEMBL ID
CHEMBL4523232

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.03  LDD0402  [1]
A-EBA
 Probe Info  		5.23  LDD0215  [2]
TH211
 Probe Info  		Y220(20.00); Y263(20.00); Y267(20.00); Y224(15.45)  LDD0257  [3]
TH216
 Probe Info  		Y294(20.00)  LDD0259  [3]
STPyne
 Probe Info  		K12(10.00); K55(10.00)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K12(0.95)  LDD3494  [5]
Probe 1
 Probe Info  		Y263(239.51); Y267(19.88); Y294(28.02); Y329(12.03)  LDD3495  [6]
BTD
 Probe Info  		C300(1.78)  LDD1700  [7]
Jackson_14
 Probe Info  		2.04  LDD0123  [8]
HHS-475
 Probe Info  		Y263(1.15)  LDD0264  [9]
HHS-465
 Probe Info  		Y248(10.00); Y263(10.00); Y267(7.14)  LDD2237  [10]
DBIA
 Probe Info  		C438(5.88); C300(1.95); C398(1.18)  LDD0080  [11]
ATP probe
 Probe Info  		K12(0.00); K62(0.00); K38(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C162(0.00); C438(0.00); C300(0.00); C431(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C395(0.00); C438(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		C438(0.00); C395(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C395(0.00); C398(0.00); C162(0.00); C431(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		C117(0.00); C438(0.00)  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
TFBX
 Probe Info  		C398(0.00); C395(0.00); C438(0.00); C117(0.00)  LDD0027  [16]
WYneN
 Probe Info  		C300(0.00); C162(0.00)  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		C300(0.00); C438(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		C300(0.00); C438(0.00)  LDD2213  [19]
IPM
 Probe Info  		C300(0.00); C438(0.00)  LDD0005  [18]
SF
 Probe Info  		Y263(0.00); Y267(0.00); K12(0.00)  LDD0028  [20]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Ox-W18
 Probe Info  		W382(0.00); W284(0.00)  LDD2175  [21]
1c-yne
 Probe Info  		K12(0.00); K266(0.00); K231(0.00); K376(0.00)  LDD0228  [22]
1d-yne
 Probe Info  		N.A.  LDD0357  [22]
Acrolein
 Probe Info  		C438(0.00); C300(0.00); C398(0.00); C162(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
Methacrolein
 Probe Info  		C438(0.00); C300(0.00); C162(0.00); C398(0.00)  LDD0218  [23]
AOyne
 Probe Info  		4.80  LDD0443  [24]
NAIA_5
 Probe Info  		C60(0.00); C300(0.00); C395(0.00); C431(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe2
 Probe Info  		5.49  LDD0463  [25]
STS-2
 Probe Info  		1.50  LDD0139  [26]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [27]
DA-2
 Probe Info  		N.A.  LDD0070  [28]
STS-1
 Probe Info  		N.A.  LDD0069  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C117(0.46)  LDD2142  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C117(1.61); C300(1.16); C438(1.16)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C300(0.95)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C117(0.84)  LDD2103  [7]
 LDCM0214  AC1 HCT 116 C162(2.08); C300(0.99); C395(1.08); C398(0.96)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C162(0.90); C300(1.46); C395(1.00); C398(1.23)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C162(0.74); C300(1.12); C395(1.57); C398(1.57)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C162(0.72); C300(1.01); C395(0.88); C398(0.88)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C162(0.94); C300(0.90); C395(0.72); C398(0.72)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C162(0.65); C300(1.17); C395(0.69); C398(0.69)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C162(0.70); C300(1.07); C395(0.92); C398(0.92)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C162(0.68); C300(1.21); C395(1.06); C398(1.06)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C162(1.24); C300(2.00); C395(0.91); C398(0.91)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C162(0.98); C300(1.70); C395(0.76); C398(0.76)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C162(1.11); C300(1.57); C395(0.71); C398(0.75)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C162(0.83); C300(0.93); C395(0.84); C398(0.75)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C162(0.78); C300(1.32); C395(1.01); C398(1.24)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C162(0.99); C300(2.40); C395(0.64); C398(0.68)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C162(0.75); C300(1.57); C395(0.67); C398(0.74)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C162(1.00); C300(2.03); C395(0.78); C398(0.80)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C162(1.09); C300(1.05); C395(0.90); C398(0.87)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C162(1.25); C300(1.12); C395(0.74); C398(0.81)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C162(1.04); C300(1.10); C395(0.80); C398(0.82)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C162(1.34); C300(1.08); C395(0.75); C398(0.76)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C162(1.38); C300(1.09); C395(0.89); C398(0.86)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C162(1.23); C300(1.20); C395(0.74); C398(0.78)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C162(1.43); C300(1.21); C395(0.81); C398(0.84)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C162(0.59); C300(0.93); C395(1.01); C398(1.13)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C162(1.16); C300(1.28); C395(0.79); C398(0.83)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C162(1.28); C300(1.11); C395(0.97); C398(0.87)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C162(1.26); C300(1.23); C395(0.75); C398(0.80)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C162(0.88); C300(1.13); C395(0.95); C398(0.87)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C162(0.93); C300(1.18); C395(0.85); C398(0.88)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C162(0.98); C300(1.19); C395(0.75); C398(0.80)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C162(0.93); C300(1.28); C395(0.70); C398(0.71)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C162(1.21); C300(1.20); C395(0.75); C398(0.79)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C162(1.23); C300(1.14); C395(1.07); C398(1.07)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C162(1.38); C300(0.79); C395(1.01); C398(1.01)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C162(1.50); C300(0.97); C395(0.99); C398(0.99)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C162(1.23); C300(0.79); C395(1.11); C398(1.11)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C162(2.03); C300(1.11); C395(1.19); C398(1.19)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C162(1.70); C300(1.01); C395(1.18); C398(1.18)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C162(1.12); C300(0.97); C395(1.07); C398(1.07)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C162(1.31); C300(1.08); C395(0.96); C398(0.96)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C162(1.33); C300(1.03); C395(1.09); C398(1.09)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C162(1.25); C300(1.15); C395(1.05); C398(1.05)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C162(1.18); C300(1.22); C395(1.04); C398(1.04)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C162(1.61); C300(0.96); C395(1.07); C398(1.07)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C162(0.78); C300(1.13); C395(1.10); C398(1.21)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C162(1.22); C300(1.01); C395(0.93); C398(0.93)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C162(1.20); C300(1.06); C395(1.01); C398(1.01)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C162(1.38); C300(0.92); C395(1.08); C398(1.08)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C398(0.83); C395(0.86); C438(0.94); C300(1.03)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C395(0.80); C162(0.85); C398(0.86); C438(1.11)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C395(0.69); C398(0.70); C162(0.84); C300(0.93)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C395(0.86); C398(0.97); C162(0.99); C300(1.12)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C395(0.75); C398(0.82); C162(0.87); C300(1.15)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C395(0.62); C398(0.65); C162(0.72); C300(1.24)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C395(0.72); C398(0.81); C162(0.94); C300(1.12)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C431(0.68); C162(0.78); C395(0.94); C398(1.14)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C395(0.73); C398(0.90); C300(0.99); C162(1.02)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C395(0.69); C398(0.78); C162(0.81); C300(0.91)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C398(0.66); C395(0.67); C300(1.09); C162(1.09)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C395(0.48); C398(0.50); C162(1.04); C300(1.31)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C162(0.92); C300(0.87); C395(0.68); C398(0.85)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C162(1.10); C300(0.88); C395(0.67); C398(0.87)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C162(0.77); C300(0.92); C395(0.79); C398(0.79)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C162(0.87); C300(0.75); C395(0.72); C398(0.65)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C300(0.98); C431(1.07); C398(1.09); C395(1.10)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C395(0.97); C398(1.00); C431(1.11); C300(1.48)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C398(1.05); C395(1.08); C431(1.20); C300(1.57)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C300(1.07); C398(1.09); C395(1.19); C431(1.25)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C300(0.96); C431(1.01); C395(1.02); C398(1.04)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C398(1.02); C395(1.03); C431(1.03); C300(1.04)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C431(1.02); C300(1.03); C398(1.04); C395(1.05)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C431(0.94); C300(1.13); C398(1.15); C395(1.16)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C431(1.02); C395(1.12); C300(1.14); C398(1.18)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C162(0.81); C431(0.99); C395(1.03); C398(1.12)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C162(0.74); C395(0.78); C398(0.90); C431(0.90)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C162(0.70); C395(0.84); C398(0.96); C431(1.00)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C395(0.79); C398(0.94); C431(0.96); C162(0.97)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C162(0.84); C395(0.85); C398(1.03); C431(1.19)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C300(0.78); C398(0.92); C431(1.02); C395(1.21)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C162(0.73); C395(0.77); C398(0.88); C431(1.06)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C395(0.83); C162(0.86); C398(0.99); C431(1.03)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C395(0.80); C398(0.96); C162(1.11); C431(1.18)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C162(0.76); C395(0.79); C398(0.91); C431(1.17)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C395(0.84); C398(0.95); C162(1.10); C431(1.13)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C395(1.02); C398(1.02); C162(1.16); C300(1.29)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C395(1.04); C398(1.04); C162(1.17); C300(1.34)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C162(1.10); C395(1.12); C398(1.12); C300(1.29)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C395(0.87); C398(0.87); C162(1.27); C300(1.38)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C395(1.09); C398(1.09); C162(1.26); C300(1.49)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C300(0.32); C398(0.75); C395(0.95); C431(1.01)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C395(0.93); C398(0.93); C300(1.13); C162(1.15)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C395(0.96); C398(0.96); C162(1.18); C300(1.54)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C395(0.95); C398(0.95); C162(1.17); C300(1.37)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C395(1.12); C398(1.12); C162(1.23); C300(1.41)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C395(1.17); C398(1.17); C300(1.28); C162(1.33)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C395(1.19); C398(1.19); C162(1.19); C300(1.71)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C162(0.98); C438(0.98); C395(1.01); C300(1.03)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C162(0.87); C395(0.91); C398(0.94); C438(0.96)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C438(0.96); C162(1.02); C398(1.09); C395(1.10)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C162(0.81); C395(1.03); C398(1.15); C438(1.21)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C300(0.31); C431(0.91); C398(0.92); C395(1.23)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C162(0.90); C395(0.94); C398(1.04); C438(1.11)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C438(0.77); C300(0.87); C395(0.96); C398(0.99)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C162(0.86); C438(0.93); C395(1.05); C300(1.06)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C162(0.89); C398(0.94); C395(0.97); C438(1.06)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C162(0.89); C395(1.08); C438(1.09); C398(1.12)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C162(0.69); C398(0.92); C395(0.96); C438(1.13)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C162(0.52); C398(1.01); C395(1.03); C438(1.06)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C395(0.95); C398(0.95); C300(1.20); C162(1.23)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C395(0.96); C398(0.96); C162(1.17); C438(1.42)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C395(1.06); C398(1.06); C162(1.33); C438(1.40)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C162(0.79); C395(0.95); C438(1.16); C398(1.17)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C395(0.90); C398(0.90); C162(1.32); C438(1.37)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C395(0.92); C398(0.92); C162(1.37); C438(1.53)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C395(0.85); C398(0.85); C162(1.20); C300(1.57)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C395(0.80); C398(0.80); C162(1.23); C438(1.34)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C395(1.29); C398(1.29); C162(1.37); C438(1.79)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C395(1.07); C398(1.07); C438(1.63); C162(1.65)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C395(0.90); C398(0.90); C438(1.70); C162(1.71)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C395(0.95); C398(0.95); C162(0.97); C438(1.58)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C398(0.87); C395(0.97); C438(1.10); C300(1.29)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C398(0.95); C395(1.01); C300(1.30); C438(1.30)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C162(0.86); C395(0.97); C438(0.97); C431(1.06)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C438(0.93); C395(0.98); C398(1.08); C300(1.45)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C398(0.89); C395(0.90); C438(1.15); C300(1.20)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C395(0.90); C398(0.92); C438(1.10); C300(1.14)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C395(0.85); C398(0.93); C438(1.11); C300(1.42)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C398(0.77); C395(0.80); C438(1.26); C300(1.26)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C438(1.04); C398(1.05); C395(1.09); C300(1.63)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C395(0.83); C398(0.86); C438(1.21); C300(1.53)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C395(0.86); C398(0.88); C438(1.12); C300(1.40)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C398(0.97); C395(1.05); C438(1.29); C300(1.46)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C395(0.84); C398(0.85); C438(1.10); C300(1.61)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C162(0.70); C431(0.88); C395(1.19); C300(1.26)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C395(0.75); C398(0.89); C438(1.05); C300(1.22)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C398(0.96); C395(0.97); C438(1.09); C300(1.40)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C438(0.81); C395(0.93); C398(1.00); C300(1.74)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C395(0.79); C398(0.79); C300(1.08); C438(1.39)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C395(0.88); C398(0.88); C300(0.96); C162(1.13)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C300(0.93); C395(0.96); C398(0.96); C438(1.04)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C300(0.88); C395(0.90); C398(0.90); C438(1.14)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C395(1.00); C398(1.00); C300(1.01); C162(1.02)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C395(0.88); C398(0.88); C438(0.98); C162(1.06)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C395(0.85); C398(0.85); C300(0.96); C438(1.14)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C438(1.04); C395(1.13); C398(1.13); C162(1.23)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C395(0.71); C398(0.71); C162(1.11); C300(1.28)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C395(0.68); C398(0.68); C300(0.96); C162(1.12)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C395(0.87); C398(0.87); C438(1.05); C162(1.07)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C300(0.81); C162(0.97); C395(1.01); C398(1.01)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C438(1.05); C395(1.07); C398(1.07); C162(1.16)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C300(0.76); C395(0.94); C398(0.94); C438(1.12)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C395(0.81); C398(0.81); C162(1.11); C300(1.16)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C395(0.49); C398(0.49); C438(0.69); C431(0.80)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C395(0.67); C398(0.67); C162(0.67); C438(0.75)  LDD0683  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C117(1.08)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C162(1.15); C300(1.05); C395(1.04); C398(1.19)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C162(0.76); C438(0.93); C395(0.99); C300(1.09)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C162(0.83); C395(0.87); C431(0.88); C398(1.18)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C300(1.02); C162(1.03)  LDD2171  [11]
 LDCM0103  BDHI 10 Jurkat C395(9.20); C398(9.20)  LDD0205  [30]
 LDCM0498  BS-3668 MDA-MB-231 C300(0.57)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C438(0.00); C300(0.00); C162(0.00); C395(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C300(20.00); C438(20.00); C431(0.94); C117(0.68)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C300(0.85); C398(1.06); C162(1.14); C395(1.32)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C398(0.98); C395(1.02); C162(1.09); C300(1.09)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C300(0.85); C398(0.98); C431(1.06); C395(1.09)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C162(0.66); C395(1.00); C431(1.03); C438(1.08)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C162(0.74); C431(1.05); C395(1.06); C300(1.07)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C431(0.88); C162(1.02); C300(1.08); C398(1.12)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C162(0.72); C438(1.00); C395(1.15); C300(1.15)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C300(0.89); C398(0.93); C395(0.97); C431(1.02)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C398(0.95); C395(0.95); C431(1.05); C300(1.06)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C398(0.95); C395(0.96); C431(1.07); C300(1.10)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C398(0.86); C395(0.92); C300(0.94); C431(1.14)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C431(1.00); C398(1.07); C300(1.16); C395(1.29)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C398(0.97); C395(1.04); C162(1.17); C300(1.31)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C300(0.96); C431(0.99); C398(1.07); C395(1.19)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C300(0.98); C431(0.98); C398(1.01); C395(1.03)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C162(0.85); C395(0.89); C431(0.90); C398(1.02)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C162(0.65); C395(0.85); C398(0.98); C431(1.10)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C162(0.69); C395(0.97); C431(1.00); C398(1.18)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C162(0.95); C431(0.99); C395(1.15); C398(1.30)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C162(0.66); C395(0.81); C431(0.93); C398(1.02)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C162(0.98); C395(1.05); C398(1.05); C300(1.38)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C162(1.01); C395(1.18); C398(1.18); C300(1.47)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C162(1.10); C395(1.11); C398(1.11); C300(1.40)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C398(0.97); C395(0.98); C162(1.01); C300(1.19)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C395(1.00); C398(1.00); C162(1.08); C300(1.32)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C162(0.83); C398(0.97); C395(0.98); C300(1.03)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C162(0.83); C395(1.01); C438(1.07); C398(1.08)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C162(0.86); C395(1.09); C398(1.11); C438(1.48)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C162(0.84); C395(1.11); C438(1.13); C300(1.13)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C395(1.04); C398(1.04); C438(1.08); C300(1.11)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C162(0.88); C395(1.04); C398(1.04); C438(1.11)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C162(1.01); C438(1.11); C395(1.21); C398(1.21)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C395(0.99); C398(0.99); C162(1.13); C300(1.32)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C162(0.89); C300(0.98); C395(1.02); C398(1.02)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C300(0.89); C398(1.00); C395(1.14); C162(1.28)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C162(0.82); C398(1.02); C395(1.14); C300(1.32)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C395(0.82); C398(0.97); C300(1.01)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C395(1.01); C300(1.06); C398(1.07); C162(1.18)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C395(1.03); C398(1.19); C162(1.25); C300(1.37)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C395(0.86); C398(1.02); C300(1.09); C162(1.82)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C300(0.87); C398(1.03); C162(1.05); C395(1.21)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C395(0.75); C398(0.89); C300(1.16); C162(1.38)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C395(0.96); C398(0.96); C162(1.21); C300(1.25)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C395(0.50); C398(0.52); C162(1.13); C300(1.51)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C395(0.83); C398(0.86); C300(1.14); C162(1.29)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C162(1.02); C300(1.34); C395(0.80); C398(0.93)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C162(1.26); C300(1.18); C395(0.84); C398(0.90)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C162(1.37); C300(1.11); C395(0.82); C398(0.94)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C162(1.02); C300(1.09); C395(0.86); C398(0.96)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C162(1.03); C300(1.18); C395(0.89); C398(0.98)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C162(1.25); C300(1.19); C395(0.85); C398(0.93)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C162(1.10); C300(0.94); C395(1.17); C398(1.06)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C162(1.17); C300(1.10); C395(0.84); C398(0.90)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C162(1.07); C300(1.03); C395(0.87); C398(0.88)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C162(0.98); C300(1.24); C395(1.03); C398(1.18)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C162(1.29); C300(1.43); C395(0.97); C398(1.02)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C162(0.99); C300(1.34); C395(0.74); C398(0.86)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C162(0.84); C300(1.25); C395(0.78); C398(0.88)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C162(0.97); C300(1.22); C395(0.70); C398(0.83)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C162(1.01); C300(1.30); C395(0.59); C398(0.71)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C162(0.96); C300(1.31); C395(0.81); C398(0.95)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C162(1.24); C300(1.08); C395(1.32); C398(1.25)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C162(0.87); C300(1.31); C395(0.93); C398(1.02)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C162(0.97); C300(1.11); C395(0.84); C398(1.10)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C162(0.75); C300(1.58); C395(0.55); C398(0.54)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C162(0.98); C300(1.50); C395(0.66); C398(0.73)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C162(0.76); C300(1.50); C395(0.90); C398(0.97)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C162(1.04); C300(1.57); C395(0.82); C398(0.86)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C162(0.86); C300(1.17); C395(1.07); C398(1.08)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C162(0.81); C300(0.98); C395(1.02); C398(1.10)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C162(0.91); C300(1.12); C395(1.12); C398(1.09)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C162(0.85); C300(1.41); C395(1.36); C398(1.26)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C162(1.01); C300(1.06); C395(1.09); C398(0.99)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C162(0.94); C300(1.02); C395(1.10); C398(1.10)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C162(0.65); C300(1.05); C395(1.10); C398(1.08)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C162(1.04); C300(0.89); C395(1.15); C398(1.14)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C162(0.90); C300(1.35); C395(1.14); C398(1.19)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C162(1.06); C300(1.53); C395(1.25); C398(1.23)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C162(0.88); C300(1.42); C395(1.21); C398(1.19)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C162(0.92); C300(0.95); C395(1.11); C398(1.15)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C162(0.86); C300(1.21); C395(1.14); C398(1.12)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C162(0.82); C300(1.09); C395(1.13); C398(1.17)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C162(1.20); C300(0.97); C395(1.14); C398(1.13)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C162(1.09); C300(0.99); C395(1.32); C398(1.13)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C162(0.83); C300(1.07); C395(0.99); C398(1.02)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C162(1.21); C300(0.91); C395(0.80); C398(0.88)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C162(1.24); C300(0.90); C395(0.85); C398(0.83)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C162(1.21); C300(0.77); C395(0.79); C398(0.79)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C162(1.07); C300(0.97); C395(0.77); C398(0.80)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C162(1.29); C300(0.76); C395(0.85); C398(0.85)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C162(1.16); C300(0.90); C395(0.79); C398(0.76)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C162(1.06); C300(0.88); C395(0.73); C398(0.83)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C162(1.40); C300(0.97); C395(0.84); C398(0.93)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C162(1.34); C300(1.57); C395(1.02); C398(1.01)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C162(1.23); C300(1.00); C395(1.17); C398(1.07)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C162(1.34); C300(1.23); C395(0.82); C398(0.89)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C162(1.22); C300(1.06); C395(0.79); C398(0.81)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C162(1.37); C300(1.15); C395(0.98); C398(0.94)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C162(1.25); C300(1.08); C395(0.92); C398(0.93)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C162(1.23); C300(0.73); C395(0.81); C398(0.81)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C300(1.08); C395(0.80); C398(0.80); C438(1.11)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C300(0.78); C395(1.04); C398(1.04); C438(0.77)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C300(0.87); C395(0.93); C398(0.93); C438(0.95)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C300(1.01); C395(0.76); C398(0.76); C438(1.07)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C162(1.01); C300(1.33); C395(1.04); C398(0.94)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C300(1.11); C395(0.96); C398(0.96); C438(1.42)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C300(0.86); C395(0.76); C398(0.76); C438(1.00)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C300(0.87); C395(0.74); C398(0.74); C438(0.96)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C300(0.90); C395(0.85); C398(0.85); C438(0.90)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C300(0.89); C395(0.62); C398(0.62); C438(0.91)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C300(0.99); C395(0.82); C398(0.82); C438(0.87)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C300(0.82); C395(1.08); C398(1.08); C438(0.70)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C300(1.00); C395(1.01); C398(1.01); C438(0.92)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C300(0.86); C395(0.76); C398(0.76); C438(0.92)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C300(1.05); C395(0.61); C398(0.61); C438(0.99)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C162(1.00); C300(1.11); C395(1.08); C398(0.96)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C300(1.19); C395(0.94); C398(0.94); C438(1.20)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C162(1.17); C300(1.14); C395(1.07); C398(0.88)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C162(0.85); C300(1.13); C395(1.37); C398(1.08)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C162(0.88); C300(0.78); C395(1.50); C398(1.03)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C162(1.00); C300(0.89); C395(1.48); C398(1.12)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C162(1.03); C300(0.86); C395(1.33); C398(1.10)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C162(2.04); C300(1.07); C395(1.27); C398(1.07)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C162(1.87); C300(0.67); C395(1.09); C398(1.06)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C162(2.44); C300(1.40); C395(1.08); C398(1.06)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C162(2.35); C300(1.31); C395(1.21); C398(1.09)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C162(0.92); C300(0.95); C431(0.94); C438(1.01)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C300(2.17); C438(1.33)  LDD1702  [7]
 LDCM0625  F8 Ramos C300(1.90); C438(1.23); 1.41; C162(1.31)  LDD2187  [32]
 LDCM0572  Fragment10 MDA-MB-231 C438(1.68)  LDD1389  [33]
 LDCM0573  Fragment11 MDA-MB-231 C438(0.78)  LDD1391  [33]
 LDCM0574  Fragment12 MDA-MB-231 C438(0.65)  LDD1393  [33]
 LDCM0575  Fragment13 MDA-MB-231 C438(0.87)  LDD1395  [33]
 LDCM0576  Fragment14 MDA-MB-231 C438(0.67)  LDD1397  [33]
 LDCM0577  Fragment15 Ramos C438(0.80)  LDD1400  [33]
 LDCM0579  Fragment20 MDA-MB-231 C438(0.75)  LDD1402  [33]
 LDCM0580  Fragment21 MDA-MB-231 C438(2.10)  LDD1404  [33]
 LDCM0581  Fragment22 MDA-MB-231 C438(1.10)  LDD1406  [33]
 LDCM0582  Fragment23 MDA-MB-231 C438(1.52)  LDD1408  [33]
 LDCM0583  Fragment24 Ramos C438(1.40)  LDD1410  [33]
 LDCM0584  Fragment25 MDA-MB-231 C438(0.86)  LDD1411  [33]
 LDCM0585  Fragment26 Ramos C438(0.73)  LDD1412  [33]
 LDCM0578  Fragment27 MDA-MB-231 C438(1.00)  LDD1401  [33]
 LDCM0586  Fragment28 MDA-MB-231 C438(0.80)  LDD1415  [33]
 LDCM0588  Fragment30 Ramos C438(1.77)  LDD1420  [33]
 LDCM0589  Fragment31 MDA-MB-231 C438(0.83)  LDD1421  [33]
 LDCM0590  Fragment32 MDA-MB-231 C438(0.79)  LDD1423  [33]
 LDCM0468  Fragment33 HCT 116 C162(1.18); C300(0.95); C395(0.85); C398(0.89)  LDD0785  [11]
 LDCM0592  Fragment34 Ramos C438(1.19)  LDD1428  [33]
 LDCM0593  Fragment35 Ramos C438(0.92)  LDD1430  [33]
 LDCM0594  Fragment36 MDA-MB-231 C438(0.92)  LDD1431  [33]
 LDCM0595  Fragment37 Ramos C438(0.73)  LDD1432  [33]
 LDCM0596  Fragment38 MDA-MB-231 C438(0.89)  LDD1433  [33]
 LDCM0566  Fragment4 MDA-MB-231 C438(0.90)  LDD1378  [33]
 LDCM0598  Fragment40 MDA-MB-231 C438(0.66)  LDD1436  [33]
 LDCM0599  Fragment41 MDA-MB-231 C438(1.10)  LDD1438  [33]
 LDCM0600  Fragment42 Ramos C438(0.88)  LDD1440  [33]
 LDCM0601  Fragment43 MDA-MB-231 C438(20.00)  LDD1441  [33]
 LDCM0602  Fragment44 MDA-MB-231 C438(0.72)  LDD1443  [33]
 LDCM0604  Fragment46 MDA-MB-231 C438(0.68)  LDD1445  [33]
 LDCM0605  Fragment47 MDA-MB-231 C438(1.36)  LDD1446  [33]
 LDCM0606  Fragment48 MDA-MB-231 C438(0.96)  LDD1447  [33]
 LDCM0608  Fragment50 MDA-MB-231 C438(1.11)  LDD1449  [33]
 LDCM0427  Fragment51 HCT 116 C162(0.92); C300(1.47); C395(0.62); C398(0.50)  LDD0744  [11]
 LDCM0610  Fragment52 MDA-MB-231 C438(1.69)  LDD1452  [33]
 LDCM0611  Fragment53 MDA-MB-231 C438(0.73)  LDD1454  [33]
 LDCM0612  Fragment54 MDA-MB-231 C438(1.37)  LDD1456  [33]
 LDCM0613  Fragment55 MDA-MB-231 C438(0.79)  LDD1457  [33]
 LDCM0614  Fragment56 MDA-MB-231 C438(0.70)  LDD1458  [33]
 LDCM0569  Fragment7 MDA-MB-231 C438(2.87)  LDD1383  [33]
 LDCM0570  Fragment8 MDA-MB-231 C438(1.12)  LDD1385  [33]
 LDCM0571  Fragment9 MDA-MB-231 C438(0.96)  LDD1387  [33]
 LDCM0116  HHS-0101 DM93 Y263(1.15)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y263(0.57)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y263(0.54)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y263(0.84)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y263(1.16)  LDD0268  [9]
 LDCM0015  HNE MDA-MB-231 C300(0.89)  LDD0346  [32]
 LDCM0107  IAA HeLa C438(0.00); C162(0.00); H280(0.00); C398(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C438(5.88); C300(1.95); C398(1.18)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C438(1.60); C300(2.24); C398(1.23)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C438(1.62); C300(1.38); C398(1.38)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C117(0.97); C300(0.84)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C300(0.65)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C300(0.92)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C117(0.89); C300(1.24)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C117(0.87); C300(1.00)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C300(1.12)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C117(1.20); C300(0.80)  LDD2094  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C117(0.65); C300(0.90)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C117(1.69); C300(1.06)  LDD2099  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C117(0.47); C300(1.29)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C117(0.89); C300(1.12)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C117(0.60); C300(0.96)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C117(1.37)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C117(0.67)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C117(0.72); C300(0.66); C438(1.03)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C117(1.10)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C117(1.21); C300(0.93)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C117(0.50); C300(0.81)  LDD2114  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C117(0.24)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C117(1.81); C300(1.51)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C117(0.98); C300(1.05); C162(1.07)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C117(0.31)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C117(1.06); C438(1.12)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C117(1.05); C300(0.87); C438(1.16); C162(0.98)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C300(1.05)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C117(1.02); C300(0.91)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C117(1.41); C300(1.08)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C117(0.51)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C300(1.22)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C117(1.97); C300(1.09); C438(1.10)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C117(1.22); C438(0.98)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C300(1.78)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C117(0.61); C300(0.93); C162(1.13)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C300(0.74)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C300(0.85)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C300(1.28); C162(1.82)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C117(4.83)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C117(1.15); C300(1.02)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C117(0.36); C300(0.72)  LDD2148  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C117(1.37); C300(1.62)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C300(1.22); C438(1.13)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C438(0.85); C300(0.81)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C300(2.18); C438(1.99)  LDD0304  [35]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.04  LDD0123  [8]
 LDCM0021  THZ1 HCT 116 C300(1.02); C162(1.03)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase alpha subunit B (POLA2) DNA polymerase alpha subunit B family Q14181
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) Krueppel C2H2-type zinc-finger protein family Q9BRR0
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A4 (ANXA4) Annexin family P09525
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
La-related protein 4B (LARP4B) . Q92615
Period circadian protein homolog 1 (PER1) . O15534
Proline-rich protein 3 (PRR3) . P79522
SERTA domain-containing protein 4 (SERTAD4) . Q9NUC0
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5
Spermatogenesis-associated serine-rich protein 1 (SPATS1) . Q496A3
Suppressor of cytokine signaling 6 (SOCS6) . O14544
Switch-associated protein 70 (SWAP70) . Q9UH65
Transmembrane protein 61 (TMEM61) . Q8N0U2
WW domain binding protein 1-like (WBP1L) . Q9NX94

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Serine Small molecular drug DB00133

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
30 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.