Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment34					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.8
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.6
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.4
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.4
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.4
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.4
LDTP02502	Thioredoxin (TXN)				C32	1.3
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	1.3
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	1.3
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.3
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	1.3
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.3
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.3
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.2
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.2
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.2
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	1.2
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	1.2
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.2
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.2
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	1.2
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.2
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.1
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.1
LDTP04689	Adenosine kinase (ADK)				C353	1.1
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.1
LDTP02672	Elongation factor 2 (EEF2)				C41	1.1
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.1
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	1.1
LDTP02672	Elongation factor 2 (EEF2)				C136	1.1
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.1
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.1
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.1
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	1.1
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.1
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.1
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.1
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.0
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.0
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.4
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.2
LDTP00501	Exportin-1 (XPO1)				C528	1.1
LDTP00501	Exportin-1 (XPO1)				C34	1.1
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.1
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.0
LDTP13661	Sorting nexin-6 (SNX6)				C264	1.0
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.1

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	2.2
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	1.8
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	1.8
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.7
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.4
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.3
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.3
LDTP01532	ZW10 interactor (ZWINT)				C54	1.3
LDTP04092	Crk-like protein (CRKL)				C249	1.2
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.2
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.2
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	1.2
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.2
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	1.2
LDTP10864	Calponin-2 (CNN2)				C215	1.2
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.1
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.1
LDTP07755	Dynamin-binding protein (DNMBP)				C691	1.1
LDTP02205	Tubulin beta chain (TUBB)				C354	1.1
LDTP10864	Calponin-2 (CNN2)				C164	1.1
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.1
LDTP13837	Trafficking protein particle complex subunit 4 (TRAPPC4)				C195	1.1
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	1.1
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.1
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.1
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	1.0
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	1.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.0
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	1.0
LDTP11212	Tubulin-specific chaperone D (TBCD)				C850	1.0
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.0
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	0.7

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.