Details of the Target

General Information of Target

Target ID LDTP01011
Target Name Protein diaphanous homolog 1 (DIAPH1)
Gene Name DIAPH1
Gene ID 1729
Synonyms
DIAP1; Protein diaphanous homolog 1; Diaphanous-related formin-1; DRF1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKE
KEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIII
KREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWV
QTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEG
ILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLD
GLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRV
QLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLV
RNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAK
AAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAE
VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP
APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG
VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPL
PGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLR
RPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKS
VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPE
PEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSV
TAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLL
HFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAAT
DEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHN
FRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMD
SLLEALQSGAAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTI
LEEAKELVGRAS
Target Bioclass
Other
Family
Formin homology family, Diaphanous subfamily
Subcellular location
Cell membrane
Function
Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Plays a role in brain development. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.
Uniprot ID
O60610
Ensemble ID
ENST00000389054.8
HGNC ID
HGNC:2876
ChEMBL ID
CHEMBL4295668

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.Q138H DBIA    Probe Info 
CAL51 SNV: p.A251T DBIA    Probe Info 
CCK81 Insertion: p.P705dup DBIA    Probe Info 
CORL88 Substitution: p.L221Ter DBIA    Probe Info 
HCT15 SNV: p.V312I .
MELHO SNV: p.R1142Q DBIA    Probe Info 
MFE319 Insertion: p.H1043QfsTer11 .
NCIH1048 Deletion: p.L1146CfsTer17 DBIA    Probe Info 
NUGC3 Deletion: p.P693del DBIA    Probe Info 
RVH421 SNV: p.G754Ter DBIA    Probe Info 
SF295 SNV: p.D329V DBIA    Probe Info 
SKMEL30 SNV: p.P704L DBIA    Probe Info 
SNU423 Deletion: p.P693del DBIA    Probe Info 
SUDHL4 SNV: p.P608S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.86  LDD0402  [1]
A-EBA
 Probe Info  		4.30  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y773(20.00)  LDD0257  [4]
TH216
 Probe Info  		Y773(20.00)  LDD0259  [4]
ONAyne
 Probe Info  		K1046(2.27)  LDD0274  [5]
STPyne
 Probe Info  		K1011(1.41); K1103(8.80); K1150(10.00); K116(10.00)  LDD0277  [5]
Probe 1
 Probe Info  		Y130(5.87); Y209(880.42); Y374(18.45); Y1101(282.06)  LDD3495  [6]
THZ1-DTB
 Probe Info  		C796(1.07)  LDD0460  [7]
BTD
 Probe Info  		C454(1.12)  LDD2099  [8]
DA-P3
 Probe Info  		13.59  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C1227(2.66)  LDD0170  [10]
HHS-475
 Probe Info  		Y424(0.81)  LDD0264  [11]
DBIA
 Probe Info  		C1227(2.32); C796(3.02)  LDD0080  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K1046(0.00); K527(0.00); K35(0.00); K37(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1227(0.00); C164(0.00); C437(0.00); C267(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C164(0.00); C437(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		C1027(0.00); C796(0.00); C964(0.00); C437(0.00)  LDD0030  [17]
IPIAA_L
 Probe Info  		C1227(0.00); C437(0.00); C964(0.00); C1027(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C1227(0.00); C164(0.00); C437(0.00); C267(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
WYneN
 Probe Info  		C796(0.00); C1227(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		C1227(0.00); C437(0.00); C796(0.00)  LDD2216  [21]
Compound 11
 Probe Info  		C1227(0.00); C796(0.00)  LDD2213  [21]
IPM
 Probe Info  		N.A.  LDD0005  [20]
PF-06672131
 Probe Info  		C796(0.00); C1227(0.00)  LDD0017  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
TFBX
 Probe Info  		C437(0.00); C164(0.00); C1227(0.00)  LDD0148  [24]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [25]
1c-yne
 Probe Info  		K1224(0.00); K855(0.00)  LDD0228  [26]
Acrolein
 Probe Info  		C796(0.00); C1227(0.00); C437(0.00); H199(0.00)  LDD0217  [27]
Methacrolein
 Probe Info  		C796(0.00); C437(0.00); C1227(0.00)  LDD0218  [27]
W1
 Probe Info  		C1227(0.00); C796(0.00)  LDD0236  [28]
AOyne
 Probe Info  		7.20  LDD0443  [29]
NAIA_5
 Probe Info  		C1227(0.00); C164(0.00); C437(0.00); C964(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		N.A.  LDD2240  [30]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.38  LDD0475  [31]
FFF probe3
 Probe Info  		6.53  LDD0465  [31]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [32]
DA-2
 Probe Info  		N.A.  LDD0073  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C454(1.61)  LDD2117  [8]
 LDCM0025  4SU-RNA DM93 C1227(2.66)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA DM93 C1227(4.02)  LDD0171  [10]
 LDCM0214  AC1 HCT 116 C1227(0.88); C164(0.89); C437(1.26); C796(0.93)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C1227(0.99); C164(0.93); C437(0.72); C796(0.99)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C1227(0.91); C164(0.58); C796(0.93)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C1227(0.93); C164(0.64); C796(0.88)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C1227(0.94); C164(0.60); C796(0.86)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C1227(1.16); C164(0.56); C796(0.93)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C1227(1.09); C164(0.51); C796(0.85)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C1227(1.09); C164(0.49); C796(0.92)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C1227(1.16); C164(0.57); C796(0.96)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C1227(1.02); C164(0.59); C796(0.89)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C1227(0.87); C164(0.65); C796(0.89)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C1227(0.83); C164(0.59); C796(0.83)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C1227(0.98); C164(0.85); C437(0.72); C796(1.08)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C1227(0.88); C164(0.58); C796(0.80)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C1227(0.95); C164(0.60); C796(0.77)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C1227(1.10); C164(0.60); C796(0.84)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C1227(1.08); C164(1.18); C796(1.01)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C1227(1.29); C164(1.19); C796(1.09)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C1227(1.45); C164(0.87); C796(1.10)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C1227(1.46); C164(0.93); C796(1.00)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C1227(1.17); C164(0.86); C796(1.06)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C1227(1.12); C164(0.89); C796(1.07)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C1227(1.14); C164(0.93); C796(1.12)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C1227(0.91); C164(0.95); C437(0.81); C796(1.06)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C1227(1.27); C164(0.87); C796(1.03)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C1227(1.16); C164(0.97); C796(1.24)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C1227(1.14); C164(0.97); C796(1.16)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C1227(1.07); C164(0.99); C796(1.23)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C1227(1.06); C164(0.95); C796(1.20)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C1227(1.20); C164(0.81); C796(1.07)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C1227(1.42); C164(0.75); C796(1.21)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C1227(1.42); C164(0.78); C796(1.17)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C1227(1.19); C164(0.96); C796(1.14)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C1227(0.83); C164(1.07); C796(0.99)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C1227(1.12); C164(0.95); C796(1.01)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C1227(0.98); C164(0.85); C796(1.00)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C1227(0.82); C164(0.87); C796(0.96)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C1227(0.94); C164(0.88); C796(0.94)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C1227(1.02); C164(0.85); C796(1.03)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C1227(1.05); C164(0.93); C796(1.04)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C1227(1.03); C164(1.03); C796(0.99)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C1227(0.89); C164(0.99); C796(0.94)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C1227(0.98); C164(0.95); C796(1.05)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C1227(0.96); C164(1.10); C796(1.04)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C1227(0.90); C164(1.00); C437(0.80); C796(0.88)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C1227(1.03); C164(1.04); C796(1.15)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C1227(0.96); C164(1.05); C796(1.04)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C1227(0.82); C164(1.31); C796(0.89)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C1227(1.16); C796(0.95)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C796(0.95); C1227(1.60)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C796(0.99); C1227(1.38)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C796(0.91); C1227(1.52)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C796(0.97); C1227(1.54)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C796(1.27); C1227(2.21)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C796(1.04); C1227(1.80)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C964(0.61); C437(0.67); C164(0.88); C796(0.98)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C796(0.96); C1227(1.18)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C796(0.91); C1227(1.22)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C796(1.02); C1227(1.72)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C796(1.40); C1227(2.75)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C1227(1.49); C796(0.94)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C1227(1.55); C796(0.94)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C1227(1.11); C796(0.92)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C1227(1.17); C796(0.84)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C164(0.89); C1227(0.99); C796(1.03)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C164(0.70); C1227(1.09); C796(1.11)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C164(0.76); C796(0.92); C1227(1.10)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C964(0.75); C796(0.90); C164(0.99); C1227(1.01)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C164(0.71); C1227(1.03); C796(1.04)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C164(0.69); C796(1.05); C1227(1.39)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C164(0.80); C796(1.10); C1227(1.13)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C164(0.74); C796(1.10); C1227(1.14)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C164(0.81); C1227(0.96); C796(0.97)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C437(0.81); C164(0.83); C796(0.96); C1227(1.11)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C164(0.66); C437(0.76); C796(0.93); C1227(1.28)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C164(0.66); C437(0.72); C796(0.96); C1227(1.39)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C437(0.61); C164(0.62); C796(1.03); C1227(1.44)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C164(0.67); C437(0.78); C796(1.00); C1227(1.27)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C964(0.71); C1227(0.85); C796(0.90); C164(0.99)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C164(0.64); C437(0.68); C796(0.98); C1227(1.19)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C164(0.65); C437(0.69); C796(0.96); C1227(1.26)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C437(0.59); C164(0.61); C796(1.11); C1227(1.54)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C437(0.58); C164(0.66); C796(1.03); C1227(1.40)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C437(0.60); C164(0.61); C796(1.17); C1227(1.64)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C964(0.48); C1227(0.80); C796(0.96); C164(0.97)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C964(0.42); C1227(0.78); C796(0.89); C164(1.01)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C1227(0.81); C796(0.85); C164(0.99); C964(1.17)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C1227(0.87); C796(0.95); C964(1.03); C164(1.04)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C964(0.91); C1227(0.94); C164(0.98); C796(1.08)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C964(0.64); C164(0.82); C1227(0.83); C796(0.98)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C964(0.59); C164(0.98); C796(1.05); C1227(1.06)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C964(0.43); C796(0.95); C1227(0.99); C164(1.02)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C964(0.50); C164(0.96); C796(1.02); C1227(1.03)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C964(0.59); C1227(0.96); C164(1.00); C796(1.02)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C964(0.58); C1227(0.95); C796(1.00); C164(1.03)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C964(0.76); C164(0.98); C796(1.10); C1227(1.24)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C437(0.97); C164(1.03); C1227(1.12); C796(1.17)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C437(0.99); C164(1.00); C796(1.09); C1227(1.10)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C1227(1.06); C796(1.09); C437(1.12); C164(1.17)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C164(0.94); C437(1.01); C796(1.32); C1227(1.60)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C964(0.55); C1227(0.76); C164(0.82); C437(0.97)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C164(0.98); C437(1.01); C796(1.28); C1227(1.63)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C1227(1.03); C796(1.04); C164(1.07); C437(1.22)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C164(0.95); C796(1.09); C1227(1.15); C437(1.21)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C437(0.90); C164(0.95); C796(1.10); C1227(1.26)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C164(0.95); C437(1.09); C796(1.11); C1227(1.24)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C164(0.92); C437(1.07); C796(1.28); C1227(1.34)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C164(0.97); C437(1.02); C796(1.60); C1227(1.95)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C164(0.72); C796(1.09); C1227(1.22)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C164(0.78); C796(1.18); C1227(1.39)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C164(0.81); C1227(1.18); C796(1.20)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C437(0.60); C964(0.67); C164(0.82); C796(0.98)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C164(0.78); C796(1.14); C1227(1.17)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C164(0.92); C796(1.04); C1227(1.11)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C164(0.77); C796(1.21); C1227(1.32)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C164(0.78); C1227(1.11); C796(1.24)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C164(0.82); C1227(1.17); C796(1.23)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C1227(0.86); C164(0.98); C796(1.22)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C1227(0.81); C164(0.94); C796(1.22)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C164(0.82); C1227(0.87); C796(1.33)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C164(0.85); C796(1.12); C1227(1.51)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C164(0.90); C796(1.21); C1227(1.55)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C964(0.57); C437(0.73); C164(0.92); C1227(0.99)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C164(0.80); C796(1.29); C1227(1.90)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C164(0.93); C796(1.08); C1227(1.31)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C164(0.92); C796(1.16); C1227(1.73)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C164(0.93); C796(1.52); C1227(2.18)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C164(0.91); C796(1.51); C1227(1.58)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C164(0.93); C796(1.55); C1227(2.07)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C164(0.85); C796(1.26); C1227(1.43)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C164(0.81); C796(1.33); C1227(1.63)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C164(0.93); C796(1.21); C1227(1.43)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C164(0.92); C796(1.23); C1227(1.82)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C964(0.64); C437(0.69); C164(0.85); C796(1.06)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C164(0.85); C796(1.14); C1227(1.37)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C164(0.77); C796(1.08); C1227(1.42)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C164(1.10); C796(1.74); C1227(1.83)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C796(1.32); C1227(1.63)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C796(1.25); C1227(1.55)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C1227(1.04); C796(1.15)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C796(1.06); C1227(1.19)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C1227(0.98); C796(1.14)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C1227(1.00); C796(1.10)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C796(1.08); C1227(1.33)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C1227(0.72); C796(1.14)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C796(1.17); C1227(1.61)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C796(1.19); C1227(1.62)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C796(1.05); C1227(1.14)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C796(1.11); C1227(1.12)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C796(1.04); C1227(1.18)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C796(1.07); C1227(1.34)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C796(1.08); C1227(1.57)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C164(0.52); C796(0.97); C1227(1.53)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C164(0.67); C1227(0.92); C796(1.01)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C1227(0.92); C164(1.14); C437(0.84); C796(1.00)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C964(0.59); C437(0.69); C164(0.93); C1227(0.95)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C437(0.69); C964(0.73); C164(0.91); C796(1.24)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.37  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 14.12  LDD0185  [9]
 LDCM0630  CCW28-3 231MFP C1227(1.78)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C1227(0.00); C796(0.00); C437(0.00); C267(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C964(1.34); C437(1.13); C796(1.12); C1227(0.96)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C796(0.93); C1227(1.00); C164(1.06); C437(1.29)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C437(0.86); C164(1.11); C796(1.12); C1227(1.28)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C964(0.68); C164(0.77); C1227(0.89); C796(0.96)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C964(0.49); C437(0.68); C796(0.86); C164(0.91)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C964(0.64); C437(0.80); C796(0.85); C1227(0.89)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C964(0.70); C437(0.78); C796(0.84); C164(0.96)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C964(0.76); C437(0.78); C796(0.92); C1227(0.93)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C164(0.59); C796(0.99); C1227(1.18)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C164(0.63); C796(1.24); C1227(1.44)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C164(0.61); C796(1.19); C1227(1.27)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C164(0.63); C796(1.13); C1227(1.31)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C164(0.65); C796(0.94); C1227(1.22)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C437(1.04); C164(1.05); C796(1.42); C1227(1.44)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C164(0.61); C796(0.97); C1227(1.31)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C164(0.67); C796(0.97); C1227(1.17)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C164(0.80); C437(0.91); C796(0.96); C1227(1.05)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C437(0.59); C164(0.62); C796(1.06); C1227(1.40)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C437(0.72); C164(0.73); C796(0.95); C1227(1.26)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C164(0.71); C437(0.73); C796(0.96); C1227(1.22)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C164(0.72); C437(0.76); C796(1.03); C1227(1.11)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C964(0.83); C164(1.05); C796(1.37); C1227(1.63)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C964(0.63); C1227(0.97); C796(0.97); C164(0.98)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C964(0.86); C164(0.94); C796(1.00); C1227(1.17)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C437(0.89); C164(1.25); C1227(1.30); C796(1.36)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C964(0.81); C796(0.94); C1227(0.96); C164(0.99)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C796(0.70); C1227(0.92); C164(0.94); C437(1.41)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C164(0.93); C1227(1.06); C796(1.07); C437(1.14)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C437(0.90); C164(0.99); C796(1.03); C1227(1.21)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C164(1.06); C437(1.09); C796(1.26); C1227(1.37)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C164(0.94); C1227(0.98); C796(1.06)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C164(0.74); C1227(0.88); C796(1.04)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C164(0.83); C1227(0.97); C796(1.02)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C164(0.80); C796(1.04); C1227(1.27)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C437(0.93); C1227(1.10); C796(1.13); C164(1.22)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C437(0.85); C1227(0.99); C796(1.01); C164(1.03)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C437(0.93); C1227(1.08); C796(1.08); C164(1.12)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C437(0.68); C164(0.87); C796(0.87); C1227(1.11)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C437(0.70); C796(0.85); C164(1.00); C1227(1.19)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C437(0.81); C796(0.88); C164(0.95); C1227(1.14)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C164(0.92); C796(0.92); C437(0.95); C1227(1.20)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C1227(0.95); C796(1.03); C164(1.05); C437(1.07)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C437(0.65); C164(0.78); C796(0.94); C1227(1.30)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C437(0.77); C164(0.82); C796(0.93); C1227(1.48)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C437(0.91); C164(1.04); C796(1.25); C1227(1.70)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C437(0.70); C164(0.79); C796(0.95); C1227(1.26)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C164(0.79); C437(0.81); C796(1.02); C1227(1.45)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C1227(1.38); C164(0.79); C437(0.78); C796(0.94)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C1227(1.29); C164(0.83); C437(0.78); C796(0.96)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C1227(1.17); C164(0.84); C437(0.83); C796(0.92)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C1227(1.47); C164(0.90); C437(0.86); C796(0.89)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C1227(1.14); C164(0.83); C437(0.84); C796(0.94)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C1227(1.02); C164(1.10); C437(0.91); C796(1.02)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C1227(1.19); C164(0.85); C437(0.76); C796(0.87)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C1227(1.11); C164(0.73); C796(0.99); C964(0.81)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C1227(1.23); C164(0.96); C796(0.97); C964(0.78)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C1227(1.63); C164(0.76); C796(0.91); C964(0.74)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C1227(1.80); C164(0.74); C796(1.10); C964(0.82)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C1227(1.56); C164(0.68); C796(1.06); C964(1.24)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C1227(1.54); C164(0.64); C796(1.00); C964(0.95)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C1227(1.89); C164(0.68); C796(1.13); C964(1.16)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C1227(1.74); C164(0.67); C796(1.15); C964(0.96)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C1227(0.93); C164(1.14); C437(0.93); C796(0.88)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C1227(1.59); C164(0.66); C796(1.07); C964(0.91)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C1227(1.60); C164(0.70); C796(1.01); C964(0.81)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C1227(3.04); C164(0.82); C796(1.49); C964(1.13)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C1227(2.14); C164(0.74); C796(1.28); C964(1.11)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C1227(1.93); C164(0.72); C796(1.10); C964(0.90)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C1227(2.38); C164(0.69); C796(1.23); C964(0.81)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C1227(0.82); C164(1.11); C437(1.21); C796(0.89)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C1227(0.89); C164(1.12); C437(1.18); C796(0.94)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C1227(1.00); C164(1.04); C437(1.24); C796(0.95)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C1227(0.94); C164(0.94); C437(0.98); C796(0.90)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C1227(0.91); C164(1.31); C437(0.95); C796(0.99)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C1227(1.02); C164(0.86); C437(1.12); C796(0.89)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C1227(0.96); C164(1.00); C437(1.02); C796(0.93)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C1227(0.94); C164(1.04); C437(0.96); C796(0.89)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C1227(0.93); C164(0.94); C437(1.15); C796(0.86)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C1227(0.89); C164(0.99); C437(1.10); C796(0.88)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C1227(0.93); C164(1.06); C437(1.23); C796(0.96)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C1227(0.96); C164(0.84); C437(1.02); C796(0.98)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C1227(0.90); C164(0.97); C437(1.02); C796(0.80)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C1227(0.92); C164(1.01); C437(1.11); C796(0.89)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C1227(0.99); C164(0.93); C437(1.02); C796(0.96)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C1227(1.03); C164(1.17); C437(0.87); C796(1.00)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C1227(1.02); C164(0.91); C437(0.95); C796(0.95)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C1227(1.21); C164(0.88); C796(1.06); C964(0.98)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C1227(1.32); C164(0.85); C796(1.13); C964(0.94)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C1227(1.29); C164(0.75); C796(1.07); C964(0.90)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C1227(1.49); C164(0.73); C796(1.06); C964(0.97)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C1227(1.19); C164(0.89); C796(1.12); C964(0.92)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C1227(1.67); C164(0.71); C796(1.20); C964(0.97)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C1227(1.54); C164(0.71); C796(1.15); C964(0.90)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C1227(1.45); C164(0.70); C796(1.06); C964(0.85)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C1227(1.29); C164(1.03); C796(0.96); C964(0.93)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C1227(1.04); C164(1.16); C437(0.94); C796(1.15)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C1227(1.51); C164(0.79); C796(1.13); C964(1.10)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C1227(1.52); C164(0.67); C796(1.23); C964(0.76)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C1227(1.15); C164(0.85); C796(1.10); C964(0.74)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C1227(1.42); C164(0.72); C796(1.06); C964(0.84)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C1227(1.48); C164(0.70); C796(1.12); C964(0.95)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C1227(1.19); C164(0.93); C437(0.93); C796(0.99)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C1227(1.35); C164(0.83); C437(0.77); C796(0.99)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C1227(1.19); C164(0.81); C437(0.91); C796(1.07)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C1227(1.22); C164(0.79); C437(0.73); C796(1.10)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C1227(1.65); C164(1.29); C437(0.86); C796(1.18)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C1227(1.18); C164(1.08); C437(1.01); C796(1.01)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C1227(1.15); C164(0.75); C437(0.95); C796(1.09)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C1227(0.93); C164(0.82); C437(0.95); C796(1.27)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C1227(1.45); C164(0.80); C437(0.92); C796(1.21)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C1227(1.14); C164(0.85); C437(1.08); C796(1.32)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C1227(1.47); C164(0.83); C437(0.88); C796(1.09)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C1227(1.57); C164(0.85); C437(0.95); C796(1.14)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C1227(1.68); C164(0.82); C437(0.88); C796(1.04)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C1227(1.44); C164(0.78); C437(1.13); C796(1.17)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C1227(1.25); C164(0.98); C437(1.22); C796(1.47)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C1227(1.14); C164(1.15); C437(0.90); C796(1.11)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C1227(1.46); C164(1.09); C437(0.91); C796(1.03)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C1227(1.07); C164(0.94); C437(1.13); C796(0.92)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C1227(1.03); C164(0.98); C437(1.10); C796(0.97)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C1227(0.84); C164(0.85); C437(0.96); C796(0.95)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C1227(0.94); C164(0.70); C437(1.11); C796(0.90)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C1227(0.97); C164(0.71); C437(0.82); C796(0.88)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C1227(1.05); C164(0.89); C437(1.09); C796(0.88)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C1227(1.04); C164(0.89); C437(1.06); C796(0.86)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C1227(0.90); C164(0.92); C437(1.17); C796(0.97)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C1227(0.85); C164(0.82); C437(1.15); C796(0.91)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C796(1.02); C964(0.95); C437(1.04); C1227(1.02)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C796(3.63); C437(1.91); C964(1.25)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 13.59  LDD0183  [9]
 LDCM0625  F8 Ramos C1227(0.86)  LDD2187  [36]
 LDCM0572  Fragment10 MDA-MB-231 C1227(0.69)  LDD1389  [37]
 LDCM0573  Fragment11 MDA-MB-231 C1227(2.11)  LDD1391  [37]
 LDCM0574  Fragment12 MDA-MB-231 C1227(0.81)  LDD1468  [37]
 LDCM0575  Fragment13 MDA-MB-231 C1227(0.73)  LDD1395  [37]
 LDCM0576  Fragment14 MDA-MB-231 C1227(1.08)  LDD1397  [37]
 LDCM0577  Fragment15 Ramos C1227(1.11)  LDD1400  [37]
 LDCM0579  Fragment20 MDA-MB-231 C1227(1.36)  LDD1402  [37]
 LDCM0580  Fragment21 MDA-MB-231 C1227(20.00)  LDD1404  [37]
 LDCM0582  Fragment23 MDA-MB-231 C1227(1.07)  LDD1408  [37]
 LDCM0583  Fragment24 Ramos C1227(1.17)  LDD1410  [37]
 LDCM0584  Fragment25 MDA-MB-231 C1227(0.90)  LDD1411  [37]
 LDCM0578  Fragment27 MDA-MB-231 C1227(1.47)  LDD1401  [37]
 LDCM0586  Fragment28 MDA-MB-231 C1227(1.08)  LDD1415  [37]
 LDCM0587  Fragment29 MDA-MB-231 C1227(1.27)  LDD1417  [37]
 LDCM0588  Fragment30 MDA-MB-231 C1227(0.71)  LDD1419  [37]
 LDCM0589  Fragment31 Ramos C1227(0.97)  LDD1422  [37]
 LDCM0590  Fragment32 Ramos C1227(2.34)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C1227(1.57); C164(0.70); C796(1.05); C964(0.82)  LDD0785  [12]
 LDCM0592  Fragment34 Ramos C1227(1.14)  LDD1428  [37]
 LDCM0593  Fragment35 MDA-MB-231 C1227(0.51)  LDD1429  [37]
 LDCM0595  Fragment37 Ramos C1227(0.75)  LDD1432  [37]
 LDCM0596  Fragment38 Ramos C1227(1.49)  LDD1434  [37]
 LDCM0566  Fragment4 Ramos C1227(1.71)  LDD1379  [37]
 LDCM0598  Fragment40 MDA-MB-231 C1227(1.09)  LDD1436  [37]
 LDCM0599  Fragment41 MDA-MB-231 C1227(1.21)  LDD1438  [37]
 LDCM0601  Fragment43 MDA-MB-231 C1227(1.82)  LDD1441  [37]
 LDCM0602  Fragment44 MDA-MB-231 C1227(0.76)  LDD1443  [37]
 LDCM0603  Fragment45 MDA-MB-231 C1227(2.98)  LDD1482  [37]
 LDCM0605  Fragment47 MDA-MB-231 C1227(0.75)  LDD1446  [37]
 LDCM0607  Fragment49 MDA-MB-231 C1227(0.51)  LDD1448  [37]
 LDCM0427  Fragment51 HCT 116 C1227(2.62); C164(0.78); C796(1.31); C964(1.08)  LDD0744  [12]
 LDCM0610  Fragment52 MDA-MB-231 C1227(1.18)  LDD1452  [37]
 LDCM0614  Fragment56 MDA-MB-231 C1227(1.24)  LDD1484  [37]
 LDCM0569  Fragment7 Ramos C1227(1.28)  LDD1384  [37]
 LDCM0570  Fragment8 MDA-MB-231 C1227(1.48)  LDD1385  [37]
 LDCM0571  Fragment9 MDA-MB-231 C1227(1.00)  LDD1387  [37]
 LDCM0116  HHS-0101 DM93 Y424(0.81)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y424(0.38)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y424(0.69)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y424(0.46)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y424(0.88)  LDD0268  [11]
 LDCM0107  IAA HeLa H199(0.00); C267(0.00); C437(0.00); H444(0.00)  LDD0221  [27]
 LDCM0022  KB02 HCT 116 C1227(2.32); C796(3.02)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C1227(1.61); C796(2.91)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C1227(2.08); C796(1.99)  LDD0082  [12]
 LDCM0109  NEM HeLa H199(0.00); H1108(0.00); H524(0.00); H215(0.00)  LDD0223  [27]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C454(1.12)  LDD2099  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C454(0.91)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C454(0.76)  LDD2109  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C220(0.13)  LDD2116  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C454(1.07)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C454(1.00)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C454(1.21)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C454(0.93)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C454(1.21)  LDD2129  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C454(1.14)  LDD2136  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C454(1.02)  LDD2140  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C454(2.54)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C454(0.95)  LDD2146  [8]
 LDCM0032  Oleacein HEK-293T 5.78  LDD0184  [9]
 LDCM0131  RA190 MM1.R C1227(1.19)  LDD0304  [38]
 LDCM0021  THZ1 HeLa S3 C796(1.07)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein phosphatase 1F (PPM1F) PP2C family P49593
Transforming protein RhoA (RHOA) Rho family P61586
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Advanced glycosylation end product-specific receptor (AGER) . Q15109

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
30 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
33 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
34 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.