Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment4  Competitor Info 
Competitor Concentration 250 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 82 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 20.0
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 20.0
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 12.0
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 5.1
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 4.8
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 3.5
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 2.7
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 2.5
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 2.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.3
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 2.3
 LDTP04424  Galactokinase (GALK1) C182 2.3
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.1
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.8
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.7
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.5
 LDTP04374  Dynamin-2 (DNM2) C27 1.5
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 1.5
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.5
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.5
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 1.4
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.4
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 1.3
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.3
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.2
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.2
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.2
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.2
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 1.1
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.1
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.9
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 0.9
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.9
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 0.9
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.8
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 0.7
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.7
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.7
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 0.6
 LDTP02502  Thioredoxin (TXN) C32 0.6
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.5
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.5
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.5
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.4
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.4
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.4
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.3
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.3
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 0.3
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.3
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.3
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.3
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.3
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 0.3
 LDTP02672  Elongation factor 2 (EEF2) C41 0.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.3
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.3
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.3
 LDTP02672  Elongation factor 2 (EEF2) C136 0.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.2
 LDTP04689  Adenosine kinase (ADK) C353 0.2
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 0.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.2
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.2
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.2
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.2
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 0.2
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.2
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 2.9
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 2.9
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.5
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.1
 LDTP00501  Exportin-1 (XPO1) C528 1.1
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.1
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.0
 LDTP04662  Exportin-2 (CSE1L) C842 0.8
 LDTP04801  Gasdermin-D (GSDMD) C268 0.6
 LDTP04707  Protein SEC13 homolog (SEC13) C187 0.6
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 0.5
 LDTP00501  Exportin-1 (XPO1) C34 0.2
 LDTP01574  Importin-7 (IPO7) C757 0.2
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.5
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.5
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.3
Other
Click to Show/Hide to Show 78 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 20.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 20.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 13.2
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 9.7
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 4.8
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 3.4
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 3.1
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) C513 3.0
 LDTP01532  ZW10 interactor (ZWINT) C54 2.9
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.5
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.5
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 2.5
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 2.4
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 2.4
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 2.3
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 2.3
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 2.2
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 2.1
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 2.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.8
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.8
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.8
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.8
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.8
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.7
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.7
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.6
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.6
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.6
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 1.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.5
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.5
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.5
 LDTP10864  Calponin-2 (CNN2) C164 1.5
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.5
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.4
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.3
 LDTP05867  Treacle protein (TCOF1) C38 1.3
 LDTP13580  Coronin-1C (CORO1C) C420 1.2
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 1.2
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.2
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.2
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 1.1
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.1
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 1.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 0.9
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 0.9
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 0.9
 LDTP04902  Actin-related protein 3 (ACTR3) C235 0.9
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 0.9
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 0.9
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 0.7
 LDTP03244  Cofilin-1 (CFL1) C80 0.6
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.5
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.5
 LDTP04092  Crk-like protein (CRKL) C249 0.4
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.4
 LDTP10864  Calponin-2 (CNN2) C215 0.4
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 0.4
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 0.4
 LDTP00202  AH receptor-interacting protein (AIP) C122 0.3
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.3
 LDTP02205  Tubulin beta chain (TUBB) C239 0.3
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.3
 LDTP02205  Tubulin beta chain (TUBB) C354 0.2
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.2
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.2
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.2
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.2
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.2

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.