Details of the Target

General Information of Target

Target ID LDTP04092
Target Name Crk-like protein (CRKL)
Gene Name CRKL
Gene ID 1399
Synonyms
Crk-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH
YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT
AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK
LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA
KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD
ENE
Target Bioclass
Other
Family
CRK family
Function May mediate the transduction of intracellular signals.
Uniprot ID
P46109
Ensemble ID
ENST00000354336.8
HGNC ID
HGNC:2363

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y92(20.00)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
BTD
 Probe Info  		C249(7.95)  LDD1699  [4]
Probe 1
 Probe Info  		Y127(9.24); Y132(17.18); Y177(25.35)  LDD3495  [5]
Sulforaphane-probe2
 Probe Info  		3.20  LDD0042  [6]
DA-P3
 Probe Info  		4.95  LDD0179  [7]
AHL-Pu-1
 Probe Info  		C44(2.25)  LDD0169  [8]
HHS-482
 Probe Info  		Y177(1.04); Y48(0.28); Y92(0.74)  LDD0285  [9]
HHS-475
 Probe Info  		Y48(0.15); Y105(0.58); Y251(0.72); Y92(0.82)  LDD0264  [10]
HHS-465
 Probe Info  		Y105(10.00); Y132(10.00); Y92(7.49)  LDD2237  [11]
DBIA
 Probe Info  		C249(1.08); C44(1.03)  LDD0078  [12]
ATP probe
 Probe Info  		K253(0.00); K145(0.00); K146(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C44(0.00); C249(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C44(0.00); C249(0.00)  LDD0036  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C44(0.00); C249(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
NAIA_5
 Probe Info  		C44(0.00); C249(0.00)  LDD2224  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		C249(0.00); C44(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		N.A.  LDD0005  [18]
SF
 Probe Info  		Y177(0.00); Y92(0.00); Y105(0.00)  LDD0028  [20]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
VSF
 Probe Info  		C249(0.00); C44(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		N.A.  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		9.65  LDD1937  [26]
FFF probe11
 Probe Info  		6.31  LDD0471  [27]
FFF probe13
 Probe Info  		18.25  LDD0475  [27]
FFF probe2
 Probe Info  		9.55  LDD0463  [27]
FFF probe3
 Probe Info  		12.82  LDD0464  [27]
FFF probe9
 Probe Info  		7.05  LDD0470  [27]
JN0003
 Probe Info  		20.00  LDD0469  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
DA-2
 Probe Info  		N.A.  LDD0070  [29]
OEA-DA
 Probe Info  		8.91  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C249(1.01)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C249(1.30)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C249(0.93)  LDD2095  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C249(1.14)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C249(1.02)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C249(0.90)  LDD2103  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C44(2.25)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C249(1.24); C44(1.07)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C249(1.25); C44(1.32)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C249(1.27)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C249(1.22)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C249(1.01)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C249(1.17)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C249(0.86)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C249(1.13)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C249(1.27)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C249(1.21)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C249(1.16)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C249(0.98)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C249(1.37); C44(0.82)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C249(1.26)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C249(1.06)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C249(1.20)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C249(0.99)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C249(0.84)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C249(0.92)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C249(1.21)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C249(0.96)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C249(1.17)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C249(1.34)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C249(1.04); C44(0.86)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C249(0.83)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C249(0.79)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C249(0.94)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C249(1.81)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C249(0.74)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C249(0.84)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C249(0.74)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C249(0.76)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C249(1.17)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C249(1.11)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C249(1.37)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C249(1.06)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C249(1.20)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C249(1.17)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C249(1.28)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C249(1.19)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C249(1.20)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C249(1.22)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C249(1.32)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C249(1.24)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C249(0.92); C44(1.24)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C249(1.46)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C249(1.40)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C249(1.09)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C249(1.21)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C249(1.20)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C249(1.25)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C249(1.30)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C249(1.37)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C249(1.83)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C249(1.55)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C44(0.90); C249(1.17)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C249(1.17)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C249(1.12)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C249(1.17)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C249(1.78)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C249(1.23)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C249(1.22)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C249(1.13)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C249(0.99)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C44(0.89); C249(1.23)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C44(1.15); C249(1.40)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C44(1.06); C249(1.24)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C249(1.12); C44(1.26)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C44(0.95); C249(1.19)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C44(0.87); C249(1.22)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C44(0.80); C249(1.22)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C44(0.81); C249(1.57)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C44(0.92); C249(1.10)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C249(1.16); C44(1.27)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C44(0.97); C249(1.35)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C44(0.82); C249(1.19)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C44(0.84); C249(1.45)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C44(0.47); C249(1.25)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C249(1.11); C44(1.18)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C44(1.21); C249(1.25)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C249(1.24); C44(2.28)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C249(1.62); C44(2.37)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C249(1.41); C44(1.78)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C44(1.17); C249(1.61)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C249(0.80)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C249(0.92)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C249(0.85)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C249(0.84)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C249(1.11)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C249(1.24); C44(1.44)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C249(1.13)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C249(1.09)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C249(1.09)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C249(0.98)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C249(1.05)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C249(1.37)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C44(0.91); C249(1.05)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C44(1.03); C249(1.09)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C44(1.14); C249(1.15)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C44(0.92); C249(1.36)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C249(1.34); C44(1.52)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C249(1.39); C44(1.46)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C44(0.84); C249(0.97)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C44(1.06); C249(1.09)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C44(1.09); C249(1.49)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C44(1.05); C249(1.11)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C249(1.29); C44(1.47)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C44(1.29); C249(1.80)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C44(0.80); C249(1.31)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C44(1.01); C249(1.37)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C44(0.92); C249(1.39)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C249(1.31); C44(1.33)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C44(0.94); C249(1.45)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C44(0.90); C249(1.20)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C44(0.86); C249(1.37)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C44(0.55); C249(1.26)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C44(0.66); C249(1.39)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C44(1.01); C249(1.61)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C44(0.90); C249(1.53)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C44(0.64); C249(1.75)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C249(0.83)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C249(0.82)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C44(1.20); C249(1.22)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C249(1.06)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C249(0.73)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C249(0.91)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C249(0.97)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C249(0.76)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C249(0.90)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C249(0.83)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C249(0.84)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C249(0.78)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C249(0.75)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C44(0.98); C249(1.34)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C249(0.70)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C249(0.81)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C249(0.87)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C249(1.27); C44(1.37)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C44(1.30); C249(1.33)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C44(1.13); C249(1.34)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C44(1.07); C249(1.28)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C44(0.98); C249(1.14)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C44(1.09); C249(1.20)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C249(1.06); C44(1.23)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C44(1.02); C249(1.18)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C44(0.94); C249(1.08)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C44(0.98); C249(1.26)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C44(0.92); C249(1.27)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C44(0.92); C249(1.19)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C44(0.92); C249(1.27)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C44(0.93); C249(1.53)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C44(0.84); C249(1.47)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C249(1.52)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C249(1.49)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C249(0.97); C44(0.88)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C44(1.11); C249(1.14)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C44(1.03); C249(1.71)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 13.15  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C249(1.08); C44(1.03)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C249(0.42)  LDD2091  [4]
 LDCM0087  Capsaicin HEK-293T 14.44  LDD0185  [7]
 LDCM0108  Chloroacetamide HeLa C44(0.00); H91(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C249(0.77)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C44(0.91); C249(1.59)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C44(0.92); C249(2.39)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C44(1.26); C249(1.43)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C44(1.10); C249(1.48)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C44(1.07); C249(1.48)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C44(0.74); C249(1.30)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C44(0.87); C249(1.12)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C44(1.16); C249(1.89)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C44(1.17); C249(2.04)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C44(1.28); C249(1.66)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C44(1.39); C249(1.76)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C44(1.05); C249(1.77)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C44(0.88); C249(2.53)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C44(1.07); C249(2.24)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C44(0.95); C249(2.18)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C249(1.59); C44(1.60)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C249(1.45); C44(1.52)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C44(0.90); C249(2.01)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C44(0.99); C249(1.81)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C44(1.30); C249(1.39)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C249(2.26)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C249(1.08)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C249(1.09)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C44(0.86); C249(1.45)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C249(1.11)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C249(0.92); C44(1.39)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C249(1.24); C44(1.61)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C44(1.18); C249(2.24)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C44(1.08); C249(1.81)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C44(0.71); C249(1.46)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C44(1.09); C249(1.43)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C44(0.84); C249(1.33)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C44(0.70); C249(1.39)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C44(1.04); C249(2.29)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C44(1.04); C249(1.74)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C44(0.84); C249(2.71)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C44(1.10); C249(1.11)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C44(0.98); C249(1.70)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C44(0.91); C249(1.03)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C44(0.89); C249(0.95)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C44(0.84); C249(1.37)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C249(1.12); C44(1.27)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C44(0.88); C249(2.56)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C44(1.11); C249(1.86)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C249(1.01); C44(1.26)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C44(1.00); C249(1.11)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C249(1.42); C44(1.09)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C249(1.08); C44(1.03)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C249(1.03); C44(1.13)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C249(1.33); C44(1.20)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C249(1.00); C44(1.16)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C249(1.12); C44(0.81)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C249(0.87); C44(1.01)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C249(1.39); C44(0.85)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C249(1.36); C44(1.09)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C249(2.14); C44(0.81)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C249(1.13); C44(0.92)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C249(1.16); C44(1.01)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C249(1.31); C44(1.04)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C249(0.96); C44(0.97)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C249(1.08); C44(0.92)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C249(1.72); C44(0.96)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C249(3.65); C44(0.89)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C249(1.20); C44(0.93)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C249(1.08); C44(0.87)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C249(1.79); C44(0.85)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C249(1.49); C44(0.90)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C249(1.26); C44(0.90)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C249(1.76); C44(1.06)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C249(1.31); C44(0.80)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C249(1.07); C44(0.78)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C249(0.98); C44(0.92)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C249(1.05); C44(0.95)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C249(1.25); C44(0.89)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C249(1.16); C44(0.94)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C249(1.06); C44(0.97)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C249(1.36); C44(0.79)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C249(1.17); C44(0.93)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C249(0.96); C44(0.86)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C249(1.23); C44(0.99)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C249(1.98); C44(1.07)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C249(1.20); C44(0.84)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C249(0.95); C44(0.99)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C249(1.54); C44(0.91)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C249(1.14); C44(0.77)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C249(1.26)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C249(1.55)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C249(1.80)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C249(1.75)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C249(1.33)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C249(1.86)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C249(1.32)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C249(1.42)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C249(1.50)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C249(1.25); C44(1.00)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C249(1.20)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C249(1.64)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C249(1.21)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C249(1.59)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C249(1.55)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C249(1.09); C44(1.70)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C249(1.56); C44(1.80)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C249(1.39); C44(1.37)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C249(1.28); C44(1.36)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C249(4.03); C44(0.92)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C249(1.02); C44(1.41)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C249(1.28); C44(1.22)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C249(1.45); C44(1.56)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C249(1.56); C44(1.27)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C249(2.32); C44(1.09)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C249(1.32); C44(2.21)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C249(1.22); C44(2.45)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C249(1.59); C44(1.36)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C249(1.40); C44(1.58)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C249(1.94); C44(1.34)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C249(2.18); C44(0.84)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C249(2.50); C44(1.47)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C249(1.44); C44(1.13)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C249(1.85); C44(0.92)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C249(1.27); C44(0.96)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C249(2.19); C44(1.06)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C249(3.01); C44(1.05)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C249(1.28); C44(1.21)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C249(1.66); C44(1.28)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C249(1.73); C44(1.09)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C249(1.99); C44(1.23)  LDD0811  [12]
 LDCM0185  Compound 17 HEK-293T 8.00  LDD0512  [27]
 LDCM0191  Compound 21 HEK-293T 6.68  LDD0508  [27]
 LDCM0190  Compound 34 HEK-293T 6.47  LDD0510  [27]
 LDCM0192  Compound 35 HEK-293T 3.19  LDD0509  [27]
 LDCM0193  Compound 36 HEK-293T 6.41  LDD0511  [27]
 LDCM0634  CY-0357 Hep-G2 C249(0.66); C249(0.50)  LDD2228  [17]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C249(4.70)  LDD0526  [31]
 LDCM0028  Dobutamine HEK-293T 6.01  LDD0180  [7]
 LDCM0027  Dopamine HEK-293T 4.95  LDD0179  [7]
 LDCM0495  E2913 HEK-293T C249(1.95); C44(1.02)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C249(2.20)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 25.60  LDD0183  [7]
 LDCM0625  F8 Ramos C44(0.88); C249(1.44)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C249(2.41)  LDD1390  [34]
 LDCM0573  Fragment11 Ramos C249(20.00)  LDD1392  [34]
 LDCM0574  Fragment12 Ramos C249(2.25)  LDD1394  [34]
 LDCM0575  Fragment13 MDA-MB-231 C249(2.04)  LDD1395  [34]
 LDCM0576  Fragment14 MDA-MB-231 C249(1.91)  LDD1397  [34]
 LDCM0577  Fragment15 Ramos C249(1.52)  LDD1400  [34]
 LDCM0579  Fragment20 MDA-MB-231 C249(0.99)  LDD1402  [34]
 LDCM0580  Fragment21 MDA-MB-231 C249(1.56)  LDD1404  [34]
 LDCM0581  Fragment22 MDA-MB-231 C249(2.70)  LDD1406  [34]
 LDCM0582  Fragment23 MDA-MB-231 C249(0.66)  LDD1408  [34]
 LDCM0583  Fragment24 Ramos C249(1.40)  LDD1410  [34]
 LDCM0584  Fragment25 MDA-MB-231 C249(0.79)  LDD1411  [34]
 LDCM0585  Fragment26 Ramos C249(0.69)  LDD1412  [34]
 LDCM0578  Fragment27 MDA-MB-231 C249(0.86)  LDD1401  [34]
 LDCM0586  Fragment28 MDA-MB-231 C249(1.17)  LDD1415  [34]
 LDCM0587  Fragment29 Ramos C249(1.69)  LDD1418  [34]
 LDCM0588  Fragment30 MDA-MB-231 C249(1.25)  LDD1419  [34]
 LDCM0589  Fragment31 MDA-MB-231 C249(1.84)  LDD1421  [34]
 LDCM0590  Fragment32 MDA-MB-231 C249(20.00)  LDD1423  [34]
 LDCM0468  Fragment33 HCT 116 C249(1.42)  LDD0785  [12]
 LDCM0592  Fragment34 Ramos C249(1.23)  LDD1428  [34]
 LDCM0593  Fragment35 Ramos C249(1.24)  LDD1430  [34]
 LDCM0595  Fragment37 Ramos C249(1.02)  LDD1432  [34]
 LDCM0596  Fragment38 MDA-MB-231 C249(1.23)  LDD1433  [34]
 LDCM0566  Fragment4 MDA-MB-231 C249(3.05)  LDD1378  [34]
 LDCM0599  Fragment41 MDA-MB-231 C249(1.11)  LDD1438  [34]
 LDCM0600  Fragment42 Ramos C249(0.84)  LDD1440  [34]
 LDCM0601  Fragment43 MDA-MB-231 C249(0.43)  LDD1441  [34]
 LDCM0602  Fragment44 MDA-MB-231 C249(0.71)  LDD1443  [34]
 LDCM0603  Fragment45 MDA-MB-231 C249(20.00)  LDD1482  [34]
 LDCM0604  Fragment46 MDA-MB-231 C249(0.77)  LDD1445  [34]
 LDCM0608  Fragment50 MDA-MB-231 C249(3.62)  LDD1449  [34]
 LDCM0427  Fragment51 HCT 116 C249(4.71); C44(0.94)  LDD0744  [12]
 LDCM0610  Fragment52 MDA-MB-231 C249(0.97)  LDD1452  [34]
 LDCM0611  Fragment53 Ramos C249(1.12)  LDD1455  [34]
 LDCM0612  Fragment54 MDA-MB-231 C249(1.40)  LDD1456  [34]
 LDCM0613  Fragment55 MDA-MB-231 C249(1.20)  LDD1457  [34]
 LDCM0614  Fragment56 MDA-MB-231 C249(1.10)  LDD1458  [34]
 LDCM0569  Fragment7 Ramos C44(0.72); C249(5.45)  LDD2186  [33]
 LDCM0570  Fragment8 MDA-MB-231 C249(16.18)  LDD1385  [34]
 LDCM0571  Fragment9 MDA-MB-231 C249(0.99)  LDD1387  [34]
 LDCM0116  HHS-0101 DM93 Y48(0.15); Y105(0.58); Y251(0.72); Y92(0.82)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y48(0.14); Y251(0.62); Y105(0.74); Y92(0.78)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y48(0.08); Y251(0.64); Y132(0.72); Y92(0.74)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y48(0.18); Y105(0.49); Y177(0.69); Y92(0.81)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y48(0.26); Y105(0.49); Y251(0.67); Y92(0.87)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y177(1.04); Y48(0.28); Y92(0.74)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y177(0.95); Y92(0.48)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y177(1.47); Y92(0.75)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y177(4.85); Y48(2.54); Y92(6.82)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y177(2.32); Y92(1.55)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y177(1.40); Y48(0.61); Y92(0.94)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y177(0.88); Y48(1.46); Y92(0.38)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y177(1.10); Y48(0.90); Y92(0.99)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C249(20.00)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C249(2.67)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C249(2.55)  LDD0082  [12]
 LDCM0169  KB63 Ramos 4.03  LDD0432  [35]
 LDCM0030  Luteolin HEK-293T 21.81  LDD0182  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C249(0.65)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C249(0.58)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C249(1.16)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C249(0.72)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C249(0.94)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C249(0.92)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C249(0.81)  LDD2099  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C249(0.96)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C249(1.37)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C249(0.93)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C249(0.88)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C249(1.06)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C249(0.95)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C249(1.03)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C249(0.84)  LDD2114  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C249(0.72)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C249(0.60)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C249(0.93)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C249(0.62)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C249(1.02)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C249(0.65)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C249(0.92)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C249(0.56)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C249(1.05)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C249(0.88)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C249(1.11)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C249(1.00)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C249(1.21)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C249(1.04)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C249(0.92)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C249(0.68)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C249(0.76)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C249(1.02)  LDD2143  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C249(1.52)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C249(1.04)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C249(0.39)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C249(1.24)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C249(1.72)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C249(0.89); C249(0.72)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C249(0.60); C249(0.57); C249(0.40)  LDD2207  [36]
 LDCM0029  Quercetin HEK-293T 19.47  LDD0181  [7]
 LDCM0131  RA190 MM1.R C249(1.24); C44(1.05)  LDD0304  [37]
 LDCM0170  Structure8 Ramos 18.03  LDD0433  [35]
 LDCM0003  Sulforaphane MCF-7 3.20  LDD0042  [6]
 LDCM0021  THZ1 HCT 116 C249(1.11)  LDD2173  [12]
 LDCM0112  W16 Hep-G2 C249(1.69)  LDD0239  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 10B (PSMC6) AAA ATPase family P62333
Inactive ubiquitin carboxyl-terminal hydrolase 53 (USP53) Peptidase C19 family Q70EK8
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) STE Ser/Thr protein kinase family Q92918
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Platelet-derived growth factor receptor alpha (PDGFRA) Tyr protein kinase family P16234
Receptor-type tyrosine-protein kinase FLT3 (FLT3) Tyr protein kinase family P36888
Vascular endothelial growth factor receptor 1 (FLT1) Tyr protein kinase family P17948
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Protein tyrosine phosphatase domain-containing protein 1 (PTPDC1) Protein-tyrosine phosphatase family A2A3K4
E3 ubiquitin-protein ligase CBL (CBL) . P22681
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin beta-1 (ITGB1) Integrin beta chain family P05556
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Crk-like protein (CRKL) CRK family P46109
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) . Q96PD2
Rap guanine nucleotide exchange factor 1 (RAPGEF1) . Q13905

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
35 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.