Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment29  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02733  Pyruvate kinase PKM (PKM) C423 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 4.8
 LDTP03786  Glutaredoxin-1 (GLRX) C23 2.6
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 2.6
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 2.0
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.6
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.6
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.5
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.5
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.5
 LDTP02502  Thioredoxin (TXN) C32 1.5
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.5
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.5
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.5
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.4
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.3
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.3
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.3
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.2
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.2
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.2
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.1
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.1
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.1
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.1
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.9
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.8
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.8
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.8
 LDTP04689  Adenosine kinase (ADK) C353 0.8
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.7
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 0.7
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 0.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.7
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.6
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.6
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.5
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.4
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.4
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.2
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.2
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.0
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.0
 LDTP00501  Exportin-1 (XPO1) C34 0.9
 LDTP04801  Gasdermin-D (GSDMD) C268 0.8
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 0.7
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.4
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.9
Other
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04092  Crk-like protein (CRKL) C249 1.7
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.5
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.4
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.3
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.3
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.3
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.3
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.3
 LDTP10864  Calponin-2 (CNN2) C164 1.2
 LDTP03244  Cofilin-1 (CFL1) C80 1.2
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.2
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.1
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP05867  Treacle protein (TCOF1) C1298 1.1
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.1
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.1
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.1
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.0
 LDTP10864  Calponin-2 (CNN2) C215 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 0.9
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 0.9
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.8
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.6
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 0.6
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 0.5
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.5
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.5
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.5
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.4
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.