Details of the Target

General Information of Target

Target ID LDTP05259
Target Name Heterogeneous nuclear ribonucleoprotein U (HNRNPU)
Gene Name HNRNPU
Gene ID 3192
Synonyms
C1orf199; HNRPU; SAFA; U21.1; Heterogeneous nuclear ribonucleoprotein U; hnRNP U; GRIP120; Nuclear p120 ribonucleoprotein; Scaffold-attachment factor A; SAF-A; p120; pp120
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDDEEAGGRPAMEPGNGSL
DLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGP
MEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAA
KEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRPGAPAAGDGKTEQKGG
DKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFK
ISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVR
IGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELS
YAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVP
LEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVA
GFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQ
RKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKE
EAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFR
GGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRG
NYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY
Target Bioclass
Other
Subcellular location
Nucleus
Function
DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression . Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation. Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator . Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus. Negatively regulates glucocorticoid-mediated transcriptional activation. Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling. Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression. Participates in the circadian regulation of the core clock component BMAL1 transcription. Plays a role in the regulation of telomere length. Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis. Plays a role in mRNA stability. Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR). Plays a role in mitotic cell cycle regulation. Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression. Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis. Contributes also to the targeting of AURKA to mitotic spindle MTs. Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides. Binds to chromatin-associated RNAs (caRNAs). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner. Binds to the Xist RNA. Binds the long non-coding H19 RNA. Binds to SMN1/2 pre-mRNAs at G/U-rich regions. Binds to small nuclear RNAs (snRNAs). Binds to the 3'-UTR of TNFA mRNA. Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi). Also negatively regulates embryonic stem cell differentiation upon LIF signaling. Required for embryonic development. Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis.; (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm.
Uniprot ID
Q00839
Ensemble ID
ENST00000444376.7
HGNC ID
HGNC:5048
ChEMBL ID
CHEMBL4296007

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.S192Ter DBIA    Probe Info 
HUH28 SNV: p.D130N DBIA    Probe Info 
LNCaP clone FGC SNV: p.R715C DBIA    Probe Info 
NCIH2170 Deletion: p.P468Ter; p.E472del DBIA    Probe Info 
SNGM SNV: p.P470H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 64 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.24  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		9.63  LDD0453  [2]
P3
 Probe Info  		10.00  LDD0454  [2]
A-EBA
 Probe Info  		3.66  LDD0215  [3]
CY-1
 Probe Info  		3.78  LDD0243  [4]
CY4
 Probe Info  		6.91  LDD0244  [4]
N1
 Probe Info  		3.98  LDD0242  [4]
C-Sul
 Probe Info  		2.27  LDD0066  [5]
TH211
 Probe Info  		Y266(20.00); Y327(20.00); Y802(20.00); Y820(20.00)  LDD0257  [6]
TH214
 Probe Info  		Y613(20.00); Y802(20.00); Y257(15.28); Y824(14.89)  LDD0258  [6]
TH216
 Probe Info  		Y824(16.84); Y669(15.07); Y825(14.60); Y613(14.43)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
BTD
 Probe Info  		C389(1.73); C335(2.41); C562(4.60); C607(7.85)  LDD1699  [8]
ONAyne
 Probe Info  		K181(0.00); K31(0.00); K186(0.00); K682(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K697(0.92); K609(1.53); K31(1.72); K551(1.98)  LDD3494  [10]
Probe 1
 Probe Info  		Y257(96.94); Y260(97.81); Y327(81.53); Y473(33.16)  LDD3495  [11]
AF-2
 Probe Info  		2.84  LDD0422  [12]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [13]
THZ1-DTB
 Probe Info  		C389(1.01)  LDD0460  [13]
Sulforaphane-probe2
 Probe Info  		2.16  LDD0042  [14]
AZ-9
 Probe Info  		10.00  LDD2154  [15]
AHL-Pu-1
 Probe Info  		C648(2.19); C594(2.32); C408(2.27)  LDD0169  [16]
HHS-482
 Probe Info  		Y257(0.52); Y260(0.99); Y266(0.99); Y525(0.13)  LDD0285  [17]
HHS-475
 Probe Info  		Y260(0.38); Y257(0.81); Y820(0.83); Y825(0.94)  LDD0264  [18]
HHS-465
 Probe Info  		Y257(10.00); Y260(10.00); Y525(10.00); Y613(10.00)  LDD2237  [19]
DBIA
 Probe Info  		C594(1.09); C607(0.97); C562(0.88)  LDD0078  [20]
AMP probe
 Probe Info  		K635(0.00); K620(0.00); K626(0.00); K565(0.00)  LDD0200  [21]
ATP probe
 Probe Info  		K635(0.00); K620(0.00); K626(0.00); K565(0.00)  LDD0199  [21]
4-Iodoacetamidophenylacetylene
 Probe Info  		C562(0.00); C607(0.00); C497(0.00); C335(0.00)  LDD0038  [22]
IA-alkyne
 Probe Info  		C453(0.00); C648(0.00); C497(0.00); C607(0.00)  LDD0032  [23]
IPIAA_H
 Probe Info  		C648(0.00); C497(0.00)  LDD0030  [24]
IPIAA_L
 Probe Info  		C594(0.00); C450(0.00); C335(0.00); C648(0.00)  LDD0031  [24]
Lodoacetamide azide
 Probe Info  		C562(0.00); C607(0.00); C497(0.00); C450(0.00)  LDD0037  [22]
ATP probe
 Probe Info  		K814(0.00); K551(0.00); K265(0.00); K637(0.00)  LDD0035  [25]
JW-RF-010
 Probe Info  		C648(0.00); C594(0.00); C497(0.00); C607(0.00)  LDD0026  [26]
NAIA_4
 Probe Info  		C497(0.00); C594(0.00); C607(0.00); C648(0.00)  LDD2226  [27]
TFBX
 Probe Info  		C497(0.00); C607(0.00); C562(0.00); C594(0.00)  LDD0027  [26]
WYneN
 Probe Info  		C562(0.00); C335(0.00); C607(0.00); C594(0.00)  LDD0021  [28]
WYneO
 Probe Info  		C562(0.00); C607(0.00)  LDD0022  [28]
aHNE
 Probe Info  		N.A.  LDD0001  [28]
1d-yne
 Probe Info  		K186(0.00); K637(0.00); K544(0.00); K516(0.00)  LDD0356  [29]
Compound 10
 Probe Info  		C497(0.00); C562(0.00); C594(0.00); C607(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		C497(0.00); C594(0.00)  LDD2213  [30]
ENE
 Probe Info  		C497(0.00); C389(0.00); C562(0.00); C594(0.00)  LDD0006  [28]
IPM
 Probe Info  		C607(0.00); C497(0.00); C594(0.00); C562(0.00)  LDD0005  [28]
NHS
 Probe Info  		K12(0.00); K551(0.00); K626(0.00); K186(0.00)  LDD0010  [28]
OSF
 Probe Info  		H357(0.00); H517(0.00); H631(0.00)  LDD0029  [31]
PF-06672131
 Probe Info  		C562(0.00); C607(0.00)  LDD0017  [32]
PPMS
 Probe Info  		N.A.  LDD0008  [28]
SF
 Probe Info  		K524(0.00); Y260(0.00); K17(0.00); K565(0.00)  LDD0028  [31]
STPyne
 Probe Info  		K516(0.00); K670(0.00); K215(0.00); K352(0.00)  LDD0009  [28]
VSF
 Probe Info  		C562(0.00); C497(0.00); C389(0.00)  LDD0007  [28]
Phosphinate-6
 Probe Info  		C335(0.00); C594(0.00); C648(0.00); C607(0.00)  LDD0018  [33]
Ox-W18
 Probe Info  		N.A.  LDD2175  [34]
1c-yne
 Probe Info  		K609(0.00); K626(0.00); K544(0.00); K524(0.00)  LDD0228  [29]
Acrolein
 Probe Info  		C497(0.00); H357(0.00); H631(0.00); C607(0.00)  LDD0217  [35]
Cinnamaldehyde
 Probe Info  		C607(0.00); C391(0.00)  LDD0220  [35]
Crotonaldehyde
 Probe Info  		H357(0.00); C607(0.00); H631(0.00); C335(0.00)  LDD0219  [35]
Methacrolein
 Probe Info  		C497(0.00); C389(0.00); H357(0.00); C607(0.00)  LDD0218  [35]
W1
 Probe Info  		C562(0.00); C497(0.00); C607(0.00); C389(0.00)  LDD0236  [36]
NAIA_5
 Probe Info  		C562(0.00); C607(0.00); C497(0.00); C450(0.00)  LDD2223  [27]
TER-AC
 Probe Info  		N.A.  LDD0426  [37]
TPP-AC
 Probe Info  		N.A.  LDD0427  [37]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.26  LDD0471  [38]
FFF probe13
 Probe Info  		6.79  LDD0475  [38]
FFF probe2
 Probe Info  		5.18  LDD0463  [38]
FFF probe3
 Probe Info  		6.11  LDD0464  [38]
STS-1
 Probe Info  		1.30  LDD0136  [39]
STS-2
 Probe Info  		1.19  LDD0138  [39]
VE-P
 Probe Info  		N.A.  LDD0396  [40]
Alk-rapa
 Probe Info  		5.22  LDD0213  [41]
DA-2
 Probe Info  		N.A.  LDD0072  [42]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C607(0.57); C497(0.70); C562(0.88); C594(1.20)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C607(0.65); C497(0.79); C562(1.06); C594(0.94)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C607(0.82); C497(0.78); C335(0.61); C562(0.55)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C607(0.87); C497(0.98); C335(0.81); C562(0.79)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C607(0.79); C497(1.05); C335(1.30); C562(0.64)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C607(1.09); C497(1.33); C335(1.88); C562(1.11)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C607(1.13); C497(1.03); C562(0.96)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C607(0.71); C497(0.84); C335(0.63); C562(0.54)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C607(0.88); C497(0.71); C335(0.76); C562(0.88)  LDD2131  [8]
 LDCM0025  4SU-RNA DM93 C594(4.88); C562(3.25)  LDD0170  [16]
 LDCM0026  4SU-RNA+native RNA HEK-293T C648(2.19); C594(2.32); C408(2.27)  LDD0169  [16]
 LDCM0214  AC1 HCT 116 C289(1.27); C295(1.27); C389(1.76); C391(1.71)  LDD0531  [20]
 LDCM0215  AC10 HCT 116 C289(0.97); C295(0.97); C389(1.21); C391(1.31)  LDD0532  [20]
 LDCM0216  AC100 HCT 116 C289(1.03); C295(1.03); C389(0.75); C391(0.60)  LDD0533  [20]
 LDCM0217  AC101 HCT 116 C289(0.67); C295(0.67); C389(0.67); C391(0.53)  LDD0534  [20]
 LDCM0218  AC102 HCT 116 C289(0.79); C295(0.79); C389(0.69); C391(0.61)  LDD0535  [20]
 LDCM0219  AC103 HCT 116 C289(1.18); C295(1.18); C389(0.66); C391(0.57)  LDD0536  [20]
 LDCM0220  AC104 HCT 116 C289(1.25); C295(1.25); C389(0.69); C391(0.62)  LDD0537  [20]
 LDCM0221  AC105 HCT 116 C289(0.92); C295(0.92); C389(0.74); C391(0.60)  LDD0538  [20]
 LDCM0222  AC106 HCT 116 C289(1.23); C295(1.23); C389(0.77); C391(0.67)  LDD0539  [20]
 LDCM0223  AC107 HCT 116 C289(1.30); C295(1.30); C389(0.87); C391(0.55)  LDD0540  [20]
 LDCM0224  AC108 HCT 116 C289(1.39); C295(1.39); C389(0.76); C391(0.65)  LDD0541  [20]
 LDCM0225  AC109 HCT 116 C289(0.96); C295(0.96); C389(0.66); C391(0.64)  LDD0542  [20]
 LDCM0226  AC11 HCT 116 C289(1.13); C295(1.13); C389(1.39); C391(1.60)  LDD0543  [20]
 LDCM0227  AC110 HCT 116 C289(1.26); C295(1.26); C389(0.69); C391(0.59)  LDD0544  [20]
 LDCM0228  AC111 HCT 116 C289(1.33); C295(1.33); C389(0.66); C391(0.60)  LDD0545  [20]
 LDCM0229  AC112 HCT 116 C289(1.22); C295(1.22); C389(0.69); C391(0.53)  LDD0546  [20]
 LDCM0230  AC113 HCT 116 C289(0.95); C295(1.11); C389(1.15); C391(1.16)  LDD0547  [20]
 LDCM0231  AC114 HCT 116 C289(1.02); C295(1.06); C389(1.15); C391(1.25)  LDD0548  [20]
 LDCM0232  AC115 HCT 116 C289(1.13); C295(1.30); C389(1.22); C391(1.23)  LDD0549  [20]
 LDCM0233  AC116 HCT 116 C289(0.97); C295(1.06); C389(1.12); C391(1.10)  LDD0550  [20]
 LDCM0234  AC117 HCT 116 C289(0.94); C295(1.10); C389(1.12); C391(1.11)  LDD0551  [20]
 LDCM0235  AC118 HCT 116 C289(1.09); C295(1.14); C389(1.14); C391(1.22)  LDD0552  [20]
 LDCM0236  AC119 HCT 116 C289(1.00); C295(1.01); C389(1.05); C391(1.12)  LDD0553  [20]
 LDCM0237  AC12 HCT 116 C289(1.25); C295(1.25); C389(1.14); C391(1.23)  LDD0554  [20]
 LDCM0238  AC120 HCT 116 C289(1.26); C295(1.41); C389(0.89); C391(0.98)  LDD0555  [20]
 LDCM0239  AC121 HCT 116 C289(0.88); C295(1.00); C389(1.16); C391(1.22)  LDD0556  [20]
 LDCM0240  AC122 HCT 116 C289(1.12); C295(1.15); C389(1.16); C391(1.19)  LDD0557  [20]
 LDCM0241  AC123 HCT 116 C289(1.26); C295(1.32); C389(1.32); C391(1.43)  LDD0558  [20]
 LDCM0242  AC124 HCT 116 C289(1.02); C295(1.18); C389(1.20); C391(1.28)  LDD0559  [20]
 LDCM0243  AC125 HCT 116 C289(0.97); C295(1.10); C389(1.11); C391(1.19)  LDD0560  [20]
 LDCM0244  AC126 HCT 116 C289(1.11); C295(1.17); C389(1.13); C391(1.22)  LDD0561  [20]
 LDCM0245  AC127 HCT 116 C289(0.99); C295(1.11); C389(1.28); C391(1.34)  LDD0562  [20]
 LDCM0246  AC128 HCT 116 C289(1.03); C295(1.03); C389(1.44); C391(1.29)  LDD0563  [20]
 LDCM0247  AC129 HCT 116 C289(0.80); C295(0.80); C389(1.28); C391(1.04)  LDD0564  [20]
 LDCM0249  AC130 HCT 116 C289(0.93); C295(0.93); C389(1.43); C391(1.13)  LDD0566  [20]
 LDCM0250  AC131 HCT 116 C289(0.82); C295(0.82); C389(0.99); C391(0.87)  LDD0567  [20]
 LDCM0251  AC132 HCT 116 C289(0.75); C295(0.75); C389(1.37); C391(0.88)  LDD0568  [20]
 LDCM0252  AC133 HCT 116 C289(0.85); C295(0.85); C389(1.26); C391(1.26)  LDD0569  [20]
 LDCM0253  AC134 HCT 116 C289(0.75); C295(0.75); C389(1.05); C391(0.79)  LDD0570  [20]
 LDCM0254  AC135 HCT 116 C289(0.79); C295(0.79); C389(1.23); C391(1.14)  LDD0571  [20]
 LDCM0255  AC136 HCT 116 C289(0.84); C295(0.84); C389(1.08); C391(0.94)  LDD0572  [20]
 LDCM0256  AC137 HCT 116 C289(0.83); C295(0.83); C389(1.08); C391(1.06)  LDD0573  [20]
 LDCM0257  AC138 HCT 116 C289(0.76); C295(0.76); C389(1.06); C391(0.85)  LDD0574  [20]
 LDCM0258  AC139 HCT 116 C289(0.79); C295(0.79); C389(1.13); C391(0.91)  LDD0575  [20]
 LDCM0259  AC14 HCT 116 C289(0.93); C295(0.93); C389(1.54); C391(1.71)  LDD0576  [20]
 LDCM0260  AC140 HCT 116 C289(0.75); C295(0.75); C389(1.12); C391(0.90)  LDD0577  [20]
 LDCM0261  AC141 HCT 116 C289(0.71); C295(0.71); C389(0.97); C391(0.79)  LDD0578  [20]
 LDCM0262  AC142 HCT 116 C289(0.87); C295(0.87); C389(1.05); C391(0.92)  LDD0579  [20]
 LDCM0263  AC143 HCT 116 C289(0.93); C295(0.93); C389(1.06); C391(0.97)  LDD0580  [20]
 LDCM0264  AC144 HCT 116 C648(0.91); C295(0.93); C497(0.95); C289(0.98)  LDD0581  [20]
 LDCM0265  AC145 HCT 116 C408(0.78); C648(0.79); C453(0.85); C450(0.90)  LDD0582  [20]
 LDCM0266  AC146 HCT 116 C295(0.90); C648(0.94); C408(0.95); C453(1.00)  LDD0583  [20]
 LDCM0267  AC147 HCT 116 C453(0.65); C450(0.80); C295(0.94); C408(0.94)  LDD0584  [20]
 LDCM0268  AC148 HCT 116 C295(1.02); C408(1.02); C497(1.11); C289(1.12)  LDD0585  [20]
 LDCM0269  AC149 HCT 116 C453(0.71); C295(0.81); C408(0.84); C450(0.90)  LDD0586  [20]
 LDCM0270  AC15 HCT 116 C408(0.83); C289(0.99); C295(0.99); C497(0.99)  LDD0587  [20]
 LDCM0271  AC150 HCT 116 C408(0.69); C453(0.73); C648(0.83); C450(0.84)  LDD0588  [20]
 LDCM0272  AC151 HCT 116 C648(0.81); C408(0.83); C391(0.88); C295(0.92)  LDD0589  [20]
 LDCM0273  AC152 HCT 116 C295(0.97); C648(1.02); C408(1.03); C497(1.03)  LDD0590  [20]
 LDCM0274  AC153 HCT 116 C453(0.80); C450(1.03); C295(1.12); C408(1.18)  LDD0591  [20]
 LDCM0621  AC154 HCT 116 C289(1.11); C295(1.09); C389(1.04); C391(0.97)  LDD2158  [20]
 LDCM0622  AC155 HCT 116 C289(1.06); C295(0.91); C389(1.07); C391(0.95)  LDD2159  [20]
 LDCM0623  AC156 HCT 116 C289(1.06); C295(1.08); C389(1.02); C391(0.97)  LDD2160  [20]
 LDCM0624  AC157 HCT 116 C289(0.98); C295(0.91); C389(0.94); C391(0.86)  LDD2161  [20]
 LDCM0276  AC17 HCT 116 C453(0.85); C450(0.87); C289(0.91); C295(0.91)  LDD0593  [20]
 LDCM0277  AC18 HCT 116 C408(0.71); C607(1.06); C562(1.10); C497(1.22)  LDD0594  [20]
 LDCM0278  AC19 HCT 116 C607(0.88); C453(0.95); C450(0.96); C289(1.03)  LDD0595  [20]
 LDCM0279  AC2 HCT 116 C289(0.81); C295(0.81); C408(0.81); C648(0.84)  LDD0596  [20]
 LDCM0280  AC20 HCT 116 C607(0.86); C453(0.92); C450(0.93); C391(0.97)  LDD0597  [20]
 LDCM0281  AC21 HCT 116 C497(1.01); C607(1.11); C408(1.14); C562(1.16)  LDD0598  [20]
 LDCM0282  AC22 HCT 116 C408(0.96); C497(1.06); C607(1.06); C289(1.07)  LDD0599  [20]
 LDCM0283  AC23 HCT 116 C389(0.84); C391(0.85); C453(0.93); C408(0.94)  LDD0600  [20]
 LDCM0284  AC24 HCT 116 C607(0.89); C289(1.01); C295(1.01); C453(1.02)  LDD0601  [20]
 LDCM0285  AC25 HCT 116 C648(0.84); C450(0.84); C497(0.89); C453(0.91)  LDD0602  [20]
 LDCM0286  AC26 HCT 116 C453(0.68); C450(0.71); C408(0.82); C648(0.85)  LDD0603  [20]
 LDCM0287  AC27 HCT 116 C450(0.65); C453(0.66); C391(0.84); C497(0.85)  LDD0604  [20]
 LDCM0288  AC28 HCT 116 C648(0.85); C497(0.86); C389(0.87); C453(0.88)  LDD0605  [20]
 LDCM0289  AC29 HCT 116 C453(0.57); C450(0.65); C389(0.83); C391(0.83)  LDD0606  [20]
 LDCM0290  AC3 HCT 116 C408(0.86); C648(0.88); C289(0.94); C295(0.94)  LDD0607  [20]
 LDCM0291  AC30 HCT 116 C453(0.62); C450(0.75); C389(0.78); C391(0.79)  LDD0608  [20]
 LDCM0292  AC31 HCT 116 C453(0.76); C450(0.83); C648(0.84); C391(0.90)  LDD0609  [20]
 LDCM0293  AC32 HCT 116 C453(0.65); C450(0.73); C648(0.84); C408(0.91)  LDD0610  [20]
 LDCM0294  AC33 HCT 116 C450(0.76); C648(0.81); C453(0.86); C497(0.88)  LDD0611  [20]
 LDCM0295  AC34 HCT 116 C450(0.55); C453(0.75); C389(0.81); C391(0.81)  LDD0612  [20]
 LDCM0296  AC35 HCT 116 C497(0.94); C648(0.95); C594(0.98); C289(0.99)  LDD0613  [20]
 LDCM0297  AC36 HCT 116 C408(0.80); C648(0.83); C289(0.84); C295(0.84)  LDD0614  [20]
 LDCM0298  AC37 HCT 116 C408(0.80); C648(0.85); C289(0.90); C295(0.90)  LDD0615  [20]
 LDCM0299  AC38 HCT 116 C450(0.82); C648(0.88); C497(0.92); C289(0.94)  LDD0616  [20]
 LDCM0300  AC39 HCT 116 C450(0.57); C453(0.75); C408(0.79); C594(0.87)  LDD0617  [20]
 LDCM0301  AC4 HCT 116 C408(0.82); C497(0.95); C648(1.00); C289(1.02)  LDD0618  [20]
 LDCM0302  AC40 HCT 116 C408(0.82); C648(0.91); C497(1.00); C562(1.04)  LDD0619  [20]
 LDCM0303  AC41 HCT 116 C408(0.71); C450(0.82); C648(0.84); C497(0.94)  LDD0620  [20]
 LDCM0304  AC42 HCT 116 C408(0.87); C648(0.88); C391(0.93); C389(0.93)  LDD0621  [20]
 LDCM0305  AC43 HCT 116 C408(0.81); C648(0.87); C450(0.89); C497(0.97)  LDD0622  [20]
 LDCM0306  AC44 HCT 116 C408(0.76); C289(0.85); C295(0.85); C648(0.88)  LDD0623  [20]
 LDCM0307  AC45 HCT 116 C408(0.83); C450(0.92); C648(0.93); C497(1.04)  LDD0624  [20]
 LDCM0308  AC46 HCT 116 C453(0.61); C450(0.61); C389(0.83); C391(0.84)  LDD0625  [20]
 LDCM0309  AC47 HCT 116 C453(0.62); C450(0.64); C408(0.84); C389(0.85)  LDD0626  [20]
 LDCM0310  AC48 HCT 116 C453(0.37); C450(0.38); C594(0.98); C497(1.08)  LDD0627  [20]
 LDCM0311  AC49 HCT 116 C453(0.47); C450(0.48); C391(0.96); C389(0.98)  LDD0628  [20]
 LDCM0312  AC5 HCT 116 C408(0.65); C289(0.84); C295(0.84); C648(0.93)  LDD0629  [20]
 LDCM0313  AC50 HCT 116 C453(0.58); C450(0.59); C391(0.92); C389(0.95)  LDD0630  [20]
 LDCM0314  AC51 HCT 116 C453(0.51); C450(0.53); C391(0.84); C389(0.86)  LDD0631  [20]
 LDCM0315  AC52 HCT 116 C453(0.56); C450(0.57); C391(0.82); C389(0.83)  LDD0632  [20]
 LDCM0316  AC53 HCT 116 C450(0.70); C453(0.70); C391(0.76); C389(0.77)  LDD0633  [20]
 LDCM0317  AC54 HCT 116 C453(0.66); C450(0.67); C389(0.80); C391(0.81)  LDD0634  [20]
 LDCM0318  AC55 HCT 116 C453(0.84); C450(0.85); C389(0.97); C391(1.01)  LDD0635  [20]
 LDCM0319  AC56 HCT 116 C453(0.69); C450(0.71); C389(0.91); C391(0.91)  LDD0636  [20]
 LDCM0320  AC57 HCT 116 C408(0.82); C497(1.04); C562(1.10); C594(1.12)  LDD0637  [20]
 LDCM0321  AC58 HCT 116 C408(0.82); C391(1.02); C389(1.06); C562(1.06)  LDD0638  [20]
 LDCM0322  AC59 HCT 116 C408(0.73); C594(1.08); C497(1.11); C562(1.13)  LDD0639  [20]
 LDCM0323  AC6 HCT 116 C408(0.75); C289(0.93); C295(0.93); C497(0.93)  LDD0640  [20]
 LDCM0324  AC60 HCT 116 C408(0.84); C497(1.12); C562(1.21); C594(1.25)  LDD0641  [20]
 LDCM0325  AC61 HCT 116 C408(1.00); C453(1.07); C450(1.11); C594(1.17)  LDD0642  [20]
 LDCM0326  AC62 HCT 116 C408(0.88); C289(1.07); C295(1.07); C562(1.19)  LDD0643  [20]
 LDCM0327  AC63 HCT 116 C408(0.88); C497(1.08); C289(1.12); C295(1.12)  LDD0644  [20]
 LDCM0328  AC64 HCT 116 C408(0.86); C289(1.08); C295(1.08); C594(1.11)  LDD0645  [20]
 LDCM0329  AC65 HCT 116 C289(0.70); C295(0.70); C408(0.75); C594(0.89)  LDD0646  [20]
 LDCM0330  AC66 HCT 116 C289(0.82); C295(0.82); C408(0.91); C594(0.97)  LDD0647  [20]
 LDCM0331  AC67 HCT 116 C408(0.68); C289(0.96); C295(0.96); C594(0.99)  LDD0648  [20]
 LDCM0332  AC68 HCT 116 C408(0.96); C562(0.99); C594(1.04); C497(1.05)  LDD0649  [20]
 LDCM0333  AC69 HCT 116 C497(1.01); C408(1.14); C389(1.14); C562(1.15)  LDD0650  [20]
 LDCM0334  AC7 HCT 116 C408(0.75); C497(0.98); C389(1.01); C648(1.01)  LDD0651  [20]
 LDCM0335  AC70 HCT 116 C497(0.92); C450(1.01); C408(1.05); C289(1.06)  LDD0652  [20]
 LDCM0336  AC71 HCT 116 C289(0.92); C295(0.92); C497(0.92); C408(1.02)  LDD0653  [20]
 LDCM0337  AC72 HCT 116 C497(0.97); C391(1.00); C389(1.03); C562(1.10)  LDD0654  [20]
 LDCM0338  AC73 HCT 116 C450(0.60); C391(1.09); C497(1.17); C389(1.22)  LDD0655  [20]
 LDCM0339  AC74 HCT 116 C408(1.14); C497(1.20); C562(1.32); C391(1.34)  LDD0656  [20]
 LDCM0340  AC75 HCT 116 C408(1.27); C391(1.30); C497(1.33); C389(1.35)  LDD0657  [20]
 LDCM0341  AC76 HCT 116 C497(0.97); C408(1.03); C594(1.14); C289(1.17)  LDD0658  [20]
 LDCM0342  AC77 HCT 116 C289(0.95); C295(0.95); C497(1.00); C408(1.08)  LDD0659  [20]
 LDCM0343  AC78 HCT 116 C497(1.04); C391(1.06); C450(1.08); C289(1.08)  LDD0660  [20]
 LDCM0344  AC79 HCT 116 C391(0.96); C289(0.98); C295(0.98); C497(0.99)  LDD0661  [20]
 LDCM0345  AC8 HCT 116 C408(0.80); C391(1.00); C389(1.00); C497(1.00)  LDD0662  [20]
 LDCM0346  AC80 HCT 116 C408(0.91); C497(1.08); C389(1.10); C594(1.10)  LDD0663  [20]
 LDCM0347  AC81 HCT 116 C391(0.95); C389(0.97); C607(1.11); C408(1.12)  LDD0664  [20]
 LDCM0348  AC82 HCT 116 C408(1.19); C391(1.26); C389(1.32); C497(1.34)  LDD0665  [20]
 LDCM0349  AC83 HCT 116 C408(0.94); C497(0.94); C450(1.00); C453(1.06)  LDD0666  [20]
 LDCM0350  AC84 HCT 116 C450(0.77); C497(0.91); C389(1.01); C391(1.02)  LDD0667  [20]
 LDCM0351  AC85 HCT 116 C450(0.71); C453(0.76); C408(0.81); C391(0.84)  LDD0668  [20]
 LDCM0352  AC86 HCT 116 C450(0.64); C497(0.75); C453(0.76); C408(0.81)  LDD0669  [20]
 LDCM0353  AC87 HCT 116 C450(0.72); C453(0.85); C497(0.90); C389(0.96)  LDD0670  [20]
 LDCM0354  AC88 HCT 116 C450(0.58); C453(0.66); C389(0.73); C391(0.76)  LDD0671  [20]
 LDCM0355  AC89 HCT 116 C450(0.69); C453(0.79); C497(0.87); C562(0.95)  LDD0672  [20]
 LDCM0357  AC90 HCT 116 C450(0.52); C453(0.54); C497(0.79); C594(0.83)  LDD0674  [20]
 LDCM0358  AC91 HCT 116 C497(0.92); C453(0.96); C408(1.00); C391(1.07)  LDD0675  [20]
 LDCM0359  AC92 HCT 116 C453(0.77); C497(0.83); C389(0.98); C408(0.98)  LDD0676  [20]
 LDCM0360  AC93 HCT 116 C453(0.75); C497(0.84); C389(0.86); C391(0.89)  LDD0677  [20]
 LDCM0361  AC94 HCT 116 C497(0.87); C607(0.90); C391(0.97); C562(1.00)  LDD0678  [20]
 LDCM0362  AC95 HCT 116 C450(0.46); C497(1.21); C594(1.23); C607(1.24)  LDD0679  [20]
 LDCM0363  AC96 HCT 116 C497(0.85); C562(0.95); C607(1.06); C289(1.07)  LDD0680  [20]
 LDCM0364  AC97 HCT 116 C450(0.51); C453(0.74); C497(0.80); C391(0.85)  LDD0681  [20]
 LDCM0365  AC98 HCT 116 C453(0.31); C408(0.48); C391(0.66); C289(0.73)  LDD0682  [20]
 LDCM0366  AC99 HCT 116 C453(0.34); C391(0.52); C408(0.56); C389(0.68)  LDD0683  [20]
 LDCM0545  Acetamide MDA-MB-231 C607(0.49); C335(0.54); C562(0.26)  LDD2138  [8]
 LDCM0166  Afatinib A431 2.84  LDD0422  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C497(0.62); C562(0.72)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C289(1.04); C295(1.04); C389(1.01); C391(1.07)  LDD0565  [20]
 LDCM0356  AKOS034007680 HCT 116 C408(0.88); C497(0.90); C648(1.02); C594(1.05)  LDD0673  [20]
 LDCM0275  AKOS034007705 HCT 116 C408(0.85); C450(1.03); C391(1.03); C389(1.03)  LDD0592  [20]
 LDCM0156  Aniline NCI-H1299 C648(0.00); C594(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C594(1.09); C607(0.97); C562(0.88)  LDD0078  [20]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [15]
 LDCM0102  BDHI 8 Jurkat C497(33.36); C594(4.49)  LDD0204  [43]
 LDCM0498  BS-3668 MDA-MB-231 C607(0.56); C497(0.61); C335(0.60); C562(0.30)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C648(1.52); C607(1.52); C594(0.95)  LDD2214  [44]
 LDCM0108  Chloroacetamide HeLa C497(0.00); C607(0.00); H631(0.00); C562(0.00)  LDD0222  [35]
 LDCM0632  CL-Sc Hep-G2 C648(11.51); C594(3.47); C594(1.90); C607(1.43)  LDD2227  [27]
 LDCM0367  CL1 HCT 116 C391(0.79); C389(0.80); C450(0.91); C453(0.96)  LDD0684  [20]
 LDCM0368  CL10 HCT 116 C450(0.79); C289(0.91); C295(0.91); C453(0.93)  LDD0685  [20]
 LDCM0369  CL100 HCT 116 C408(0.84); C648(0.91); C289(0.92); C295(0.92)  LDD0686  [20]
 LDCM0370  CL101 HCT 116 C408(0.84); C648(0.90); C607(0.91); C497(1.02)  LDD0687  [20]
 LDCM0371  CL102 HCT 116 C408(0.67); C497(0.94); C648(0.98); C607(1.02)  LDD0688  [20]
 LDCM0372  CL103 HCT 116 C408(0.74); C289(0.84); C295(0.84); C450(0.93)  LDD0689  [20]
 LDCM0373  CL104 HCT 116 C497(1.00); C289(1.00); C295(1.00); C648(1.04)  LDD0690  [20]
 LDCM0374  CL105 HCT 116 C408(0.81); C607(1.02); C289(1.05); C295(1.05)  LDD0691  [20]
 LDCM0375  CL106 HCT 116 C408(1.14); C497(1.28); C607(1.30); C289(1.35)  LDD0692  [20]
 LDCM0376  CL107 HCT 116 C408(1.00); C289(1.01); C295(1.01); C497(1.16)  LDD0693  [20]
 LDCM0377  CL108 HCT 116 C453(0.92); C450(0.98); C607(1.00); C408(1.03)  LDD0694  [20]
 LDCM0378  CL109 HCT 116 C408(0.87); C453(0.97); C607(1.01); C289(1.02)  LDD0695  [20]
 LDCM0379  CL11 HCT 116 C450(0.69); C453(0.83); C408(1.06); C497(1.11)  LDD0696  [20]
 LDCM0380  CL110 HCT 116 C453(0.95); C607(0.96); C450(0.97); C408(0.97)  LDD0697  [20]
 LDCM0381  CL111 HCT 116 C607(0.95); C453(1.01); C450(1.06); C289(1.08)  LDD0698  [20]
 LDCM0382  CL112 HCT 116 C648(0.80); C408(0.80); C389(0.89); C497(0.90)  LDD0699  [20]
 LDCM0383  CL113 HCT 116 C391(0.79); C389(0.79); C648(0.85); C453(0.86)  LDD0700  [20]
 LDCM0384  CL114 HCT 116 C453(0.64); C450(0.72); C648(0.77); C391(0.78)  LDD0701  [20]
 LDCM0385  CL115 HCT 116 C453(0.72); C391(0.74); C389(0.76); C450(0.79)  LDD0702  [20]
 LDCM0386  CL116 HCT 116 C450(0.66); C453(0.70); C648(0.75); C408(0.78)  LDD0703  [20]
 LDCM0387  CL117 HCT 116 C648(0.84); C408(0.94); C450(1.04); C562(1.15)  LDD0704  [20]
 LDCM0388  CL118 HCT 116 C408(0.83); C648(0.88); C453(0.92); C594(0.92)  LDD0705  [20]
 LDCM0389  CL119 HCT 116 C450(0.93); C648(0.97); C408(0.99); C453(1.00)  LDD0706  [20]
 LDCM0390  CL12 HCT 116 C450(0.73); C453(0.92); C408(1.01); C648(1.04)  LDD0707  [20]
 LDCM0391  CL120 HCT 116 C450(0.74); C408(0.76); C648(0.82); C289(0.91)  LDD0708  [20]
 LDCM0392  CL121 HCT 116 C562(0.73); C607(0.84); C594(0.99); C497(1.03)  LDD0709  [20]
 LDCM0393  CL122 HCT 116 C453(0.67); C450(0.68); C391(0.78); C389(0.79)  LDD0710  [20]
 LDCM0394  CL123 HCT 116 C450(0.63); C453(0.66); C389(0.79); C391(0.81)  LDD0711  [20]
 LDCM0395  CL124 HCT 116 C453(0.52); C450(0.54); C391(0.89); C389(0.89)  LDD0712  [20]
 LDCM0396  CL125 HCT 116 C408(0.75); C289(0.92); C295(0.92); C453(0.94)  LDD0713  [20]
 LDCM0397  CL126 HCT 116 C408(0.59); C453(0.92); C450(0.94); C497(0.97)  LDD0714  [20]
 LDCM0398  CL127 HCT 116 C408(0.84); C289(0.97); C295(0.97); C453(0.97)  LDD0715  [20]
 LDCM0399  CL128 HCT 116 C408(0.75); C594(0.95); C562(1.02); C497(1.03)  LDD0716  [20]
 LDCM0400  CL13 HCT 116 C450(0.97); C453(1.00); C391(1.13); C389(1.15)  LDD0717  [20]
 LDCM0401  CL14 HCT 116 C450(0.73); C453(0.77); C391(0.90); C648(0.95)  LDD0718  [20]
 LDCM0402  CL15 HCT 116 C391(1.11); C497(1.12); C408(1.14); C389(1.14)  LDD0719  [20]
 LDCM0403  CL16 HCT 116 C648(0.81); C453(0.94); C391(0.95); C389(0.95)  LDD0720  [20]
 LDCM0404  CL17 HCT 116 C289(0.81); C295(0.81); C648(0.92); C594(0.95)  LDD0721  [20]
 LDCM0405  CL18 HCT 116 C453(1.02); C497(1.20); C562(1.32); C594(1.41)  LDD0722  [20]
 LDCM0406  CL19 HCT 116 C453(0.96); C607(1.00); C562(1.01); C594(1.05)  LDD0723  [20]
 LDCM0407  CL2 HCT 116 C408(0.86); C648(0.95); C453(0.95); C391(0.96)  LDD0724  [20]
 LDCM0408  CL20 HCT 116 C648(0.90); C607(0.92); C408(1.03); C497(1.08)  LDD0725  [20]
 LDCM0409  CL21 HCT 116 C453(0.86); C607(0.99); C648(1.00); C289(1.03)  LDD0726  [20]
 LDCM0410  CL22 HCT 116 C453(0.73); C408(1.06); C607(1.26); C562(1.26)  LDD0727  [20]
 LDCM0411  CL23 HCT 116 C453(0.63); C391(0.97); C389(0.97); C497(1.04)  LDD0728  [20]
 LDCM0412  CL24 HCT 116 C453(0.93); C594(1.08); C497(1.17); C289(1.18)  LDD0729  [20]
 LDCM0413  CL25 HCT 116 C289(1.22); C295(1.22); C389(1.13); C391(1.11)  LDD0730  [20]
 LDCM0414  CL26 HCT 116 C289(1.16); C295(1.16); C389(0.95); C391(0.89)  LDD0731  [20]
 LDCM0415  CL27 HCT 116 C289(1.13); C295(1.13); C389(1.17); C391(1.18)  LDD0732  [20]
 LDCM0416  CL28 HCT 116 C289(1.21); C295(1.21); C389(1.09); C391(1.04)  LDD0733  [20]
 LDCM0417  CL29 HCT 116 C289(1.18); C295(1.18); C389(1.22); C391(1.27)  LDD0734  [20]
 LDCM0418  CL3 HCT 116 C289(1.07); C295(1.07); C389(1.01); C391(1.01)  LDD0735  [20]
 LDCM0419  CL30 HCT 116 C289(1.19); C295(1.19); C389(1.10); C391(1.09)  LDD0736  [20]
 LDCM0420  CL31 HCT 116 C289(0.92); C295(0.92); C389(0.98); C391(0.96)  LDD0737  [20]
 LDCM0421  CL32 HCT 116 C289(1.32); C295(1.32); C389(1.24); C391(1.21)  LDD0738  [20]
 LDCM0422  CL33 HCT 116 C289(0.93); C295(0.93); C389(0.95); C391(0.95)  LDD0739  [20]
 LDCM0423  CL34 HCT 116 C289(1.04); C295(1.04); C389(1.12); C391(1.07)  LDD0740  [20]
 LDCM0424  CL35 HCT 116 C289(1.17); C295(1.17); C389(1.05); C391(1.03)  LDD0741  [20]
 LDCM0425  CL36 HCT 116 C289(0.96); C295(0.96); C389(0.98); C391(0.95)  LDD0742  [20]
 LDCM0426  CL37 HCT 116 C289(1.15); C295(1.15); C389(1.12); C391(1.14)  LDD0743  [20]
 LDCM0428  CL39 HCT 116 C289(1.18); C295(1.18); C389(0.97); C391(0.97)  LDD0745  [20]
 LDCM0429  CL4 HCT 116 C289(1.06); C295(1.06); C389(0.96); C391(0.95)  LDD0746  [20]
 LDCM0430  CL40 HCT 116 C289(0.97); C295(0.97); C389(0.93); C391(0.94)  LDD0747  [20]
 LDCM0431  CL41 HCT 116 C289(0.85); C295(0.85); C389(1.07); C391(1.07)  LDD0748  [20]
 LDCM0432  CL42 HCT 116 C289(1.15); C295(1.15); C389(1.14); C391(1.12)  LDD0749  [20]
 LDCM0433  CL43 HCT 116 C289(1.22); C295(1.22); C389(1.11); C391(1.11)  LDD0750  [20]
 LDCM0434  CL44 HCT 116 C289(1.02); C295(1.02); C389(1.10); C391(1.12)  LDD0751  [20]
 LDCM0435  CL45 HCT 116 C289(1.06); C295(1.06); C389(1.14); C391(1.14)  LDD0752  [20]
 LDCM0436  CL46 HCT 116 C289(0.86); C295(0.86); C389(0.87); C391(0.88)  LDD0753  [20]
 LDCM0437  CL47 HCT 116 C289(0.79); C295(0.79); C389(0.78); C391(0.78)  LDD0754  [20]
 LDCM0438  CL48 HCT 116 C289(0.82); C295(0.82); C389(0.92); C391(0.95)  LDD0755  [20]
 LDCM0439  CL49 HCT 116 C289(0.80); C295(0.80); C389(1.00); C391(1.01)  LDD0756  [20]
 LDCM0440  CL5 HCT 116 C289(1.09); C295(1.09); C389(1.22); C391(1.14)  LDD0757  [20]
 LDCM0441  CL50 HCT 116 C289(0.74); C295(0.74); C389(0.85); C391(0.83)  LDD0758  [20]
 LDCM0442  CL51 HCT 116 C289(0.84); C295(0.84); C389(0.93); C391(0.96)  LDD0759  [20]
 LDCM0443  CL52 HCT 116 C289(0.85); C295(0.85); C389(0.76); C391(0.78)  LDD0760  [20]
 LDCM0444  CL53 HCT 116 C289(0.77); C295(0.77); C389(0.82); C391(0.81)  LDD0761  [20]
 LDCM0445  CL54 HCT 116 C289(0.80); C295(0.80); C389(1.08); C391(1.11)  LDD0762  [20]
 LDCM0446  CL55 HCT 116 C289(0.78); C295(0.78); C389(0.88); C391(0.91)  LDD0763  [20]
 LDCM0447  CL56 HCT 116 C289(0.87); C295(0.87); C389(1.00); C391(0.96)  LDD0764  [20]
 LDCM0448  CL57 HCT 116 C289(0.77); C295(0.77); C389(0.92); C391(0.94)  LDD0765  [20]
 LDCM0449  CL58 HCT 116 C289(0.94); C295(0.94); C389(0.90); C391(0.91)  LDD0766  [20]
 LDCM0450  CL59 HCT 116 C289(0.89); C295(0.89); C389(0.97); C391(0.90)  LDD0767  [20]
 LDCM0451  CL6 HCT 116 C289(1.44); C295(1.44); C389(1.36); C391(1.30)  LDD0768  [20]
 LDCM0452  CL60 HCT 116 C289(0.86); C295(0.86); C389(0.91); C391(0.87)  LDD0769  [20]
 LDCM0453  CL61 HCT 116 C289(0.96); C295(0.96); C389(1.06); C391(1.05)  LDD0770  [20]
 LDCM0454  CL62 HCT 116 C289(1.15); C295(1.15); C389(1.01); C391(0.99)  LDD0771  [20]
 LDCM0455  CL63 HCT 116 C289(1.14); C295(1.14); C389(1.08); C391(1.07)  LDD0772  [20]
 LDCM0456  CL64 HCT 116 C289(1.19); C295(1.19); C389(1.09); C391(1.10)  LDD0773  [20]
 LDCM0457  CL65 HCT 116 C289(1.17); C295(1.17); C389(1.08); C391(1.07)  LDD0774  [20]
 LDCM0458  CL66 HCT 116 C289(1.40); C295(1.40); C389(1.25); C391(1.25)  LDD0775  [20]
 LDCM0459  CL67 HCT 116 C289(1.29); C295(1.29); C389(1.10); C391(1.15)  LDD0776  [20]
 LDCM0460  CL68 HCT 116 C289(1.19); C295(1.19); C389(1.31); C391(1.45)  LDD0777  [20]
 LDCM0461  CL69 HCT 116 C289(1.59); C295(1.59); C389(1.21); C391(1.12)  LDD0778  [20]
 LDCM0462  CL7 HCT 116 C289(1.43); C295(1.43); C389(1.26); C391(1.22)  LDD0779  [20]
 LDCM0463  CL70 HCT 116 C289(1.35); C295(1.35); C389(1.07); C391(1.06)  LDD0780  [20]
 LDCM0464  CL71 HCT 116 C289(1.14); C295(1.14); C389(0.99); C391(1.07)  LDD0781  [20]
 LDCM0465  CL72 HCT 116 C289(1.17); C295(1.17); C389(0.94); C391(0.97)  LDD0782  [20]
 LDCM0466  CL73 HCT 116 C289(1.20); C295(1.20); C389(1.01); C391(1.04)  LDD0783  [20]
 LDCM0467  CL74 HCT 116 C289(1.15); C295(1.15); C389(1.05); C391(1.09)  LDD0784  [20]
 LDCM0469  CL76 HCT 116 C389(1.24); C391(1.24); C408(0.54); C450(1.36)  LDD0786  [20]
 LDCM0470  CL77 HCT 116 C389(0.90); C391(0.90); C408(0.76); C450(1.38)  LDD0787  [20]
 LDCM0471  CL78 HCT 116 C389(0.97); C391(0.97); C408(0.50); C450(0.98)  LDD0788  [20]
 LDCM0472  CL79 HCT 116 C389(0.98); C391(0.98); C408(0.40); C450(1.16)  LDD0789  [20]
 LDCM0473  CL8 HCT 116 C289(1.09); C295(1.09); C389(0.96); C391(0.94)  LDD0790  [20]
 LDCM0474  CL80 HCT 116 C389(1.31); C391(1.31); C408(0.56); C450(1.57)  LDD0791  [20]
 LDCM0475  CL81 HCT 116 C389(0.99); C391(0.99); C408(0.51); C450(1.12)  LDD0792  [20]
 LDCM0476  CL82 HCT 116 C389(1.19); C391(1.19); C408(0.57); C450(1.35)  LDD0793  [20]
 LDCM0477  CL83 HCT 116 C389(1.09); C391(1.09); C408(0.97); C450(0.98)  LDD0794  [20]
 LDCM0478  CL84 HCT 116 C389(1.34); C391(1.34); C408(0.54); C450(1.28)  LDD0795  [20]
 LDCM0479  CL85 HCT 116 C389(1.01); C391(1.01); C408(0.49); C450(1.03)  LDD0796  [20]
 LDCM0480  CL86 HCT 116 C389(0.97); C391(0.97); C408(0.38); C450(0.97)  LDD0797  [20]
 LDCM0481  CL87 HCT 116 C389(0.97); C391(0.97); C408(0.41); C450(1.04)  LDD0798  [20]
 LDCM0482  CL88 HCT 116 C389(1.11); C391(1.11); C408(0.45); C450(0.93)  LDD0799  [20]
 LDCM0483  CL89 HCT 116 C389(1.15); C391(1.15); C408(0.88); C450(1.19)  LDD0800  [20]
 LDCM0484  CL9 HCT 116 C289(1.11); C295(1.11); C389(1.10); C391(1.07)  LDD0801  [20]
 LDCM0485  CL90 HCT 116 C389(0.77); C391(0.77); C408(0.51); C450(0.88)  LDD0802  [20]
 LDCM0486  CL91 HCT 116 C289(0.94); C295(0.94); C389(1.19); C391(1.17)  LDD0803  [20]
 LDCM0487  CL92 HCT 116 C289(0.81); C295(0.81); C389(1.08); C391(1.09)  LDD0804  [20]
 LDCM0488  CL93 HCT 116 C289(0.87); C295(0.87); C389(1.39); C391(1.38)  LDD0805  [20]
 LDCM0489  CL94 HCT 116 C289(0.93); C295(0.93); C389(1.76); C391(1.62)  LDD0806  [20]
 LDCM0490  CL95 HCT 116 C289(1.34); C295(1.34); C389(1.00); C391(1.01)  LDD0807  [20]
 LDCM0491  CL96 HCT 116 C289(0.98); C295(0.98); C389(1.30); C391(1.28)  LDD0808  [20]
 LDCM0492  CL97 HCT 116 C289(0.81); C295(0.81); C389(1.09); C391(1.07)  LDD0809  [20]
 LDCM0493  CL98 HCT 116 C289(0.82); C295(0.82); C389(1.33); C391(1.35)  LDD0810  [20]
 LDCM0494  CL99 HCT 116 C289(0.85); C295(0.85); C389(1.52); C391(1.55)  LDD0811  [20]
 LDCM0634  CY-0357 Hep-G2 C607(50.00); C594(50.00); C607(0.67); C648(0.58)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C562(0.99); C607(1.03); C497(1.08); C594(0.87)  LDD1698  [45]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C562(25.89); C594(2.73); C497(2.22); C607(1.81)  LDD1702  [8]
 LDCM0625  F8 Ramos C562(1.01); C607(1.28); C335(0.89); C497(2.31)  LDD2187  [46]
 LDCM0572  Fragment10 MDA-MB-231 C562(2.67)  LDD1389  [47]
 LDCM0573  Fragment11 MDA-MB-231 C562(2.28)  LDD1391  [47]
 LDCM0574  Fragment12 MDA-MB-231 C562(7.83)  LDD1393  [47]
 LDCM0575  Fragment13 MDA-MB-231 C562(1.56)  LDD1395  [47]
 LDCM0576  Fragment14 Ramos C562(0.88); C607(0.71); C335(0.56); C497(0.99)  LDD2193  [46]
 LDCM0577  Fragment15 MDA-MB-231 C562(7.43)  LDD1399  [47]
 LDCM0579  Fragment20 MDA-MB-231 C562(4.14)  LDD1402  [47]
 LDCM0580  Fragment21 MDA-MB-231 C562(4.88)  LDD1404  [47]
 LDCM0582  Fragment23 MDA-MB-231 C562(3.97)  LDD1408  [47]
 LDCM0584  Fragment25 MDA-MB-231 C562(1.36)  LDD1411  [47]
 LDCM0578  Fragment27 MDA-MB-231 C562(1.06)  LDD1413  [47]
 LDCM0586  Fragment28 MDA-MB-231 C562(1.07)  LDD1415  [47]
 LDCM0587  Fragment29 MDA-MB-231 C562(1.05)  LDD1417  [47]
 LDCM0588  Fragment30 MDA-MB-231 C562(1.09)  LDD1419  [47]
 LDCM0589  Fragment31 MDA-MB-231 C562(10.25)  LDD1421  [47]
 LDCM0590  Fragment32 MDA-MB-231 C562(2.46)  LDD1423  [47]
 LDCM0468  Fragment33 HCT 116 C289(1.20); C295(1.20); C389(1.11); C391(1.13)  LDD0785  [20]
 LDCM0593  Fragment35 Ramos C562(1.25)  LDD1430  [47]
 LDCM0595  Fragment37 Ramos C562(1.34)  LDD1432  [47]
 LDCM0596  Fragment38 MDA-MB-231 C562(1.32)  LDD1433  [47]
 LDCM0597  Fragment39 MDA-MB-231 C562(1.83)  LDD1435  [47]
 LDCM0566  Fragment4 MDA-MB-231 C562(3.07)  LDD1378  [47]
 LDCM0598  Fragment40 MDA-MB-231 C562(1.00)  LDD1436  [47]
 LDCM0599  Fragment41 MDA-MB-231 C562(1.31)  LDD1438  [47]
 LDCM0601  Fragment43 MDA-MB-231 C562(2.89)  LDD1441  [47]
 LDCM0604  Fragment46 MDA-MB-231 C562(1.10)  LDD1445  [47]
 LDCM0605  Fragment47 MDA-MB-231 C562(1.30)  LDD1446  [47]
 LDCM0606  Fragment48 MDA-MB-231 C562(1.16)  LDD1447  [47]
 LDCM0608  Fragment50 MDA-MB-231 C562(8.77)  LDD1449  [47]
 LDCM0427  Fragment51 HCT 116 C289(1.46); C295(1.46); C389(1.19); C391(1.17)  LDD0744  [20]
 LDCM0610  Fragment52 MDA-MB-231 C562(1.47)  LDD1452  [47]
 LDCM0611  Fragment53 Ramos C562(1.09)  LDD1455  [47]
 LDCM0612  Fragment54 MDA-MB-231 C562(1.13)  LDD1456  [47]
 LDCM0613  Fragment55 MDA-MB-231 C562(1.06)  LDD1457  [47]
 LDCM0614  Fragment56 Ramos C562(1.63); C607(1.49); C335(1.25); C497(0.56)  LDD2205  [46]
 LDCM0568  Fragment6 MDA-MB-231 C562(1.07)  LDD1382  [47]
 LDCM0569  Fragment7 Ramos C562(2.25); C607(0.71); C335(0.96); C497(0.82)  LDD2186  [46]
 LDCM0570  Fragment8 MDA-MB-231 C562(2.19)  LDD1385  [47]
 LDCM0571  Fragment9 MDA-MB-231 C562(1.99)  LDD1387  [47]
 LDCM0116  HHS-0101 DM93 Y260(0.38); Y257(0.81); Y820(0.83); Y825(0.94)  LDD0264  [18]
 LDCM0117  HHS-0201 DM93 Y260(0.63); Y824(0.68); Y802(0.82); Y825(0.91)  LDD0265  [18]
 LDCM0118  HHS-0301 DM93 Y825(0.59); Y260(0.64); Y824(0.67); Y802(0.67)  LDD0266  [18]
 LDCM0119  HHS-0401 DM93 Y824(0.74); Y260(0.82); Y820(0.83); Y825(0.94)  LDD0267  [18]
 LDCM0120  HHS-0701 DM93 Y825(1.04); Y802(1.24); Y266(1.25); Y257(1.29)  LDD0268  [18]
 LDCM0015  HNE MDA-MB-231 C594(0.95); C497(1.11)  LDD0346  [46]
 LDCM0107  IAA HeLa H357(0.00); H517(0.00); H631(0.00); C607(0.00)  LDD0221  [35]
 LDCM0123  JWB131 DM93 Y257(0.52); Y260(0.99); Y266(0.99); Y525(0.13)  LDD0285  [17]
 LDCM0124  JWB142 DM93 Y260(0.69); Y266(0.77); Y525(1.83); Y669(0.66)  LDD0286  [17]
 LDCM0125  JWB146 DM93 Y260(0.98); Y266(1.08); Y525(1.91); Y669(0.70)  LDD0287  [17]
 LDCM0126  JWB150 DM93 Y260(2.34); Y266(2.63); Y525(6.21); Y669(1.25)  LDD0288  [17]
 LDCM0127  JWB152 DM93 Y260(2.04); Y266(2.25); Y525(2.13); Y669(1.61)  LDD0289  [17]
 LDCM0128  JWB198 DM93 Y260(1.34); Y266(1.34); Y525(1.89); Y669(0.77)  LDD0290  [17]
 LDCM0129  JWB202 DM93 Y260(0.79); Y266(0.60); Y525(0.53); Y669(0.43)  LDD0291  [17]
 LDCM0130  JWB211 DM93 Y260(0.77); Y266(0.86); Y525(1.21); Y669(0.71)  LDD0292  [17]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [13]
 LDCM0022  KB02 HCT 116 C389(5.56); C391(5.56); C562(2.21); C497(1.53)  LDD0080  [20]
 LDCM0023  KB03 HCT 116 C389(3.90); C391(3.90); C562(3.38); C497(1.74)  LDD0081  [20]
 LDCM0024  KB05 HCT 116 C389(4.80); C391(4.80); C562(2.80); C497(2.66)  LDD0082  [20]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C607(1.59); C497(1.00); C562(0.89)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C497(0.74); C335(0.79); C562(0.38)  LDD2121  [8]
 LDCM0109  NEM HeLa H631(0.00); H357(0.00); H517(0.00); C607(0.00)  LDD0223  [35]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C607(0.47); C335(0.69); C562(0.35)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C607(1.23); C497(1.23); C562(1.35)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C497(0.98); C562(0.83)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C607(0.85); C497(1.15); C335(1.83); C562(0.79)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C607(1.71); C497(1.03); C562(0.92)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C607(0.69); C497(0.94); C335(0.29); C562(0.47)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C607(1.09); C497(0.86); C562(0.82)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C607(0.43); C497(1.12); C335(0.22); C562(1.05)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C607(0.88); C497(1.06); C335(1.87); C562(0.60)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C607(0.40); C497(0.75); C562(1.50); C391(0.98)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C607(1.23); C497(0.64); C335(1.31); C562(0.80)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C607(0.73); C497(0.64); C562(0.83)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C607(2.07); C497(1.52); C562(1.32)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C607(0.61); C562(0.83)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C607(0.90); C497(0.97); C335(1.49); C562(0.78)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C607(0.26); C497(0.69); C562(0.79)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C607(0.62); C497(0.90); C335(0.63); C562(0.57)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C607(1.17); C497(1.27); C562(1.95)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C607(0.82); C497(0.99); C335(1.35); C562(0.68)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C497(0.65); C562(0.71); C389(1.02); C594(0.95)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C607(0.89); C497(0.44); C562(0.53)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C607(1.02); C497(1.34); C335(1.02); C562(0.88)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C607(0.94); C497(1.22); C335(0.77); C562(1.06)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C607(1.99); C497(1.81); C335(1.73); C562(2.84)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C607(0.90); C497(0.74); C335(0.59); C562(0.87)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C607(0.57); C497(1.03); C335(0.32); C562(1.02)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C607(0.73); C497(0.96); C335(1.06); C562(0.61)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C607(0.95); C497(1.06); C335(0.45); C562(0.80)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C607(0.63); C497(0.82); C335(1.21); C562(0.53)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C607(0.99); C497(1.40); C335(0.44); C562(1.98)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C607(0.88); C497(1.02); C335(1.24); C562(0.70)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C497(0.73); C335(0.66); C562(0.84)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C607(0.91); C497(0.98); C335(2.43); C562(0.68)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C607(0.84); C562(0.55)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C607(0.51); C497(0.63); C562(0.51)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C607(1.10); C497(1.06); C335(2.27); C562(0.83)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C607(0.93); C497(1.17); C335(1.61); C562(0.89)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C607(0.78); C497(0.95); C335(1.04); C562(0.76)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C335(4.08); C497(1.28); C607(0.91); C562(0.88)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C607(0.56); C497(0.79); C335(1.13); C562(0.47)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C497(0.68); C562(0.74); C391(1.30)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C607(1.29); C497(0.72); C335(0.72); C562(0.94)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C607(2.25); C335(1.43); C562(3.26); C389(1.47)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C497(1.98); C335(0.29); C562(11.12)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C607(0.74); C497(1.01); C335(1.25); C562(0.67)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C607(4.31); C497(0.92); C335(1.25); C562(3.55)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C607(0.69); C497(0.47); C335(0.91); C562(0.57)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C607(1.07); C497(1.60); C335(0.51); C562(0.87)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C497(0.46); C335(0.47); C562(0.30)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C607(1.10); C335(0.34); C562(1.81)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C607(1.39); C497(2.10); C562(2.04)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C594(15.00); C497(2.67); C607(0.95); C562(0.94)  LDD2206  [48]
 LDCM0628  OTUB2-COV-1 HEK-293T C648(1.11); C562(0.81); C594(0.78); C607(0.77)  LDD2207  [48]
 LDCM0131  RA190 MM1.R C497(1.72); C594(1.67); C648(1.43); C408(1.30)  LDD0304  [49]
 LDCM0090  Rapamycin JHH-7 5.22  LDD0213  [41]
 LDCM0003  Sulforaphane MCF-7 2.16  LDD0042  [14]
 LDCM0021  THZ1 HeLa S3 C389(1.01)  LDD0460  [13]
 LDCM0110  W12 Hep-G2 K343(0.64); C562(0.92)  LDD0237  [36]
 LDCM0111  W14 Hep-G2 C607(0.55); C562(1.01)  LDD0238  [36]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High mobility group protein B1 (HMGB1) HMGB family P09429
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribosome biogenesis protein BRX1 homolog (BRIX1) BRX1 family Q8TDN6
Cyclin-dependent kinase inhibitor 2A (CDKN2A) CDKN2 cyclin-dependent kinase inhibitor family P42771
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) . Q14103
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
TAR DNA-binding protein 43 (TARDBP) . Q13148
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
15 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
16 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
17 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
18 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
21 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
22 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
23 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
24 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
25 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
26 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
27 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
28 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
32 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
33 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
34 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
35 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
36 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
37 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
38 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
39 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
40 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
41 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
42 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
43 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
44 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
45 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
46 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
47 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
48 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
49 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.