Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name AF-2  Probe Info 
Probe concentration 0.1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Afatinib  Competitor Info 
Competitor Concentration 0.5 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Skin
Disease Model Skin squamous cell carcinoma [ICD-11:2C31]
Model Name Human skin squamous cell carcinoma cells (A431)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) 10.0
 LDTP03242  Adenosylhomocysteinase (AHCY) 10.0
 LDTP05885  DNA topoisomerase 3-alpha (TOP3A) 10.0
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5) 10.0
 LDTP11733  Ras-related protein Rab-1B (RAB1B) 10.0
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) 2.4
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) 2.0
 LDTP01785  Epidermal growth factor receptor (EGFR) 1.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) 1.7
 LDTP02963  Phosphoglycerate mutase 1 (PGAM1) 1.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP18926  Zinc finger protein 736 (ZNF736) 2.8
Other
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06086  Lymphocyte antigen 6D (LY6D) 10.0
 LDTP02302  Small ribosomal subunit protein eS17 (RPS17) 10.0
 LDTP04966  Small ribosomal subunit protein uS9 (RPS16) 10.0
 LDTP08578  SURP and G-patch domain-containing protein 2 (SUGP2) 10.0
 LDTP09699  MAP kinase-activating death domain protein (MADD) 9.6
 LDTP05627  Transcriptional activator MN1 (MN1) 4.1
 LDTP09033  Pre-mRNA-splicing factor 38A (PRPF38A) 3.8
 LDTP03755  Keratin, type I cytoskeletal 9 (KRT9) 3.5
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 2.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) 2.8
 LDTP02031  Keratin, type II cytoskeletal 1 (KRT1) 2.4
 LDTP19326  Putative ribosomal protein eL39-like 5 (RPL39P5) 2.3
 LDTP05026  Large ribosomal subunit protein uL5 (RPL11) 2.2
 LDTP01930  Keratin, type I cytoskeletal 14 (KRT14) 2.0
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) 1.7
 LDTP04880  Small ribosomal subunit protein uS10 (RPS20) 1.7
 LDTP02676  Keratin, type II cytoskeletal 5 (KRT5) 1.7
 LDTP02674  Keratin, type I cytoskeletal 10 (KRT10) 1.6
 LDTP01931  Keratin, type II cytoskeletal 6A (KRT6A) 1.6
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) 1.6

References

1 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.