Details of the Target

General Information of Target

Target ID LDTP18926
Target Name Zinc finger protein 736 (ZNF736)
Gene Name ZNF736
Gene ID 728927
Synonyms
Zinc finger protein 736
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQYAPSPDFKRALDSSPEANTEDDKTEEDVPMPKNYLWLTIVSCFCPAYPINIVALVFS
IMSLNSYNDGDYEGARRLGRNAKWVAIASIIIGLLIIGISCAVHFTRNA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
B4DX44
Ensemble ID
ENST00000355095.8
HGNC ID
HGNC:32467

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AF-1
 Probe Info  		2.23; 5.96  LDD0421  [1]
AF-2
 Probe Info  		2.81  LDD0422  [1]
NAIA_5
 Probe Info  		C268(4.12)  LDD2227  [2]
DBIA
 Probe Info  		C123(1.06)  LDD1508  [3]
HHS-465
 Probe Info  		K283(0.00); K286(0.00); Y285(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C123(1.06)  LDD1508  [3]
 LDCM0277  AC18 HEK-293T C123(0.97)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C123(1.04)  LDD1518  [3]
 LDCM0286  AC26 HEK-293T C123(0.71)  LDD1525  [3]
 LDCM0295  AC34 HEK-293T C123(0.97)  LDD1534  [3]
 LDCM0304  AC42 HEK-293T C123(1.13)  LDD1543  [3]
 LDCM0313  AC50 HEK-293T C123(1.31)  LDD1552  [3]
 LDCM0321  AC58 HEK-293T C123(1.16)  LDD1560  [3]
 LDCM0166  Afatinib A431 2.23; 5.96  LDD0421  [1]
 LDCM0632  CL-Sc Hep-G2 C268(4.12)  LDD2227  [2]
 LDCM0405  CL18 HEK-293T C123(1.04)  LDD1609  [3]
 LDCM0419  CL30 HEK-293T C123(0.99)  LDD1623  [3]
 LDCM0432  CL42 HEK-293T C123(0.95)  LDD1636  [3]
 LDCM0445  CL54 HEK-293T C123(1.26)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C123(1.65)  LDD1654  [3]
 LDCM0458  CL66 HEK-293T C123(1.18)  LDD1661  [3]
 LDCM0471  CL78 HEK-293T C123(1.36)  LDD1674  [3]
 LDCM0485  CL90 HEK-293T C123(1.12)  LDD1688  [3]

References

1 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010